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DIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFIGIPAAFPKLFRSEVDWDYTTEPEPQL GGREIYWPRDKVLGGSSSMNAMMWVRGFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGDDS GVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQPNSAEPEGFCETIVTQRRGSRWSTVDAYLRPAMGRR NLSILTGATATRIVIHGTRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIE TVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPD LELIFAPAPFYDEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMME GLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGSDEASVVDRQLRVR GVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4004 | - | - | 100% (529) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. ulcerans Agy99 | MUL_0777 | - | 2e-37 | 29.43% (547) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3435 | - | 1e-10 | 23.42% (555) | oxidoreductase GMC-type |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 0.0 | 81.66% (529) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3230 | - | 1e-81 | 36.46% (565) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 0.0 | 81.66% (529) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 0.0 | 62.17% (526) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4141 | - | 0.0 | 99.24% (529) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 5e-64 | 35.37% (458) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3375 | - | 6e-81 | 35.75% (565) | alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 1e-78 | 36.38% (547) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. vanbaalenii PYR-1 | Mvan_2938 | - | 2e-78 | 35.35% (563) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4004|M.ulcerans_Agy99 --------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKN
MMAR_4141|M.marinum_M --------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKN
Mb1310|M.bovis_AF2122/97 --------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKN
Rv1279|M.tuberculosis_H37Rv --------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKN
MAB_0250|M.abscessus_ATCC_1997 ------MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKD
MAV_4980|M.avium_104 --------------------------------------------------
TH_3275|M.thermoresistible__bu MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGKRHSVLVLEAGGSDLS
Mflv_3230|M.gilvum_PYR-GCK ---------MPEYDYIIVGAGSAGCLLANRLSADPDHRVLLIEAGGKDDW
Mvan_2938|M.vanbaalenii_PYR-1 ---MPEMSPVAEFDFIIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDDW
MSMEG_3375|M.smegmatis_MC2_155 ---------MAEFDYVIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDNW
MUL_4004|M.ulcerans_Agy99 RFIGIPAAFP-KLFRSEVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMN
MMAR_4141|M.marinum_M RFIGIPAAFP-KLFRSEVDWDYTTEPEPQLGGREIYWPRGKVLGGSSSMN
Mb1310|M.bovis_AF2122/97 RFIGVPAAFS-KLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMN
Rv1279|M.tuberculosis_H37Rv RFIGVPAAFS-KLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMN
MAB_0250|M.abscessus_ATCC_1997 MGIHIPAAFS-KLFRSDVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMN
MAV_4980|M.avium_104 ----MQTAIG-RAVP---------------------FARGRGIGGSSTIN
TH_3275|M.thermoresistible__bu PFIRIPAGLM-RVNPRNY-WHFRLEPDPTRNGAVDTWAAGRVVGGGSSVN
Mflv_3230|M.gilvum_PYR-GCK FWIKVPVGYLYTIANPRTDWCYTTEPDPGLAGRSILYARGRVVGGSSSIN
Mvan_2938|M.vanbaalenii_PYR-1 FWIKVPVGYLYTIANPRTDWCFTTEPDPGLAGRSIIYARGRVIGGCSSIN
MSMEG_3375|M.smegmatis_MC2_155 FWIKVPVGYLFTIANPRTDWCFNTEPDPGLAGRSIIYARGRVIGGCSSIN
: .. :. .: :** *::*
MUL_4004|M.ulcerans_Agy99 AMMWVRGFAADYDEWARLAG-SHWSYG------ELLGYFRQIEDVTAAWH
MMAR_4141|M.marinum_M AMMWVRGFAADYDEWARLAG-SHWSYG------ELLGYFRQIEDVTAAWH
Mb1310|M.bovis_AF2122/97 AMMWVRGFASDYDEWAARAG-PRWSYA------DVLGYFRRIENVTAAWH
Rv1279|M.tuberculosis_H37Rv AMMWVRGFASDYDEWAARAG-PRWSYA------DVLGYFRRIENVTAAWH
MAB_0250|M.abscessus_ATCC_1997 AMMWVRGFAADYDDWAQVAG-EQWSFA------NIAPYFKRIEAVEG---
MAV_4980|M.avium_104 AMVFARGHRDSYSRWRDNGA-AGWSFD------ELLPYFKRSESTCG---
TH_3275|M.thermoresistible__bu AMLWVRGNRADFDTWAKLGA-QGWDYE------SLLPAMRSLETWEG---
Mflv_3230|M.gilvum_PYR-GCK AMIHMRGQASDYELWAQATGDERWLWGGPDRPGDTLAIYKDLEDYFG---
Mvan_2938|M.vanbaalenii_PYR-1 AMIHMRGQASDYELWARATGDERWLWGGPDRAGETLEIYKELEDYFG---
MSMEG_3375|M.smegmatis_MC2_155 AMIHMRGQASDYELWARATGDDRWLWGGPDRPGQTLAIYKELENYFG---
**: ** .:. * . * : . : * .
MUL_4004|M.ulcerans_Agy99 FVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQPNSAEPE-G
MMAR_4141|M.marinum_M FVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFPPVQPNSAEPE-G
Mb1310|M.bovis_AF2122/97 FVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPE-G
Rv1279|M.tuberculosis_H37Rv FVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPE-G
MAB_0250|M.abscessus_ATCC_1997 -ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTPEPK-G
MAV_4980|M.avium_104 -KDPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVG
TH_3275|M.thermoresistible__bu -GADRYRGGTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILADYNGESQFG
Mflv_3230|M.gilvum_PYR-GCK -GADDWHGARGEIRVERPRVRWKILDAWQAAAAESGIAPIDEFNRGDNSG
Mvan_2938|M.vanbaalenii_PYR-1 -GADEWHGADGEIRVERPRVRWKILDAWQNAAAQLGIEPIDEFNRGDNSG
MSMEG_3375|M.smegmatis_MC2_155 -GADEWHGADGEIRVERPRVRWKILDAWQAAAAQFGITPIEEFNRGDNSG
* * : .. : * . : *
MUL_4004|M.ulcerans_Agy99 FCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHG-----
MMAR_4141|M.marinum_M FCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHG-----
Mb1310|M.bovis_AF2122/97 FCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDG-----
Rv1279|M.tuberculosis_H37Rv FCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDG-----
MAB_0250|M.abscessus_ATCC_1997 FSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDG-----
MAV_4980|M.avium_104 FGFTDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIRG-----
TH_3275|M.thermoresistible__bu AAWSQLSQKNGLRHSAAQAFLAPARRRGEVDVESHAVVDKVIIEN-----
Mflv_3230|M.gilvum_PYR-GCK SAYFHVNQRRGRRWSMADAFLHPVAHRPNLTVYTQTQALRLLTDDQVRDD
Mvan_2938|M.vanbaalenii_PYR-1 SAYFHVNQRRGRRWSMADAFLHPVTHRPNLTVYAQTQALQLLTDDQVHED
MSMEG_3375|M.smegmatis_MC2_155 SAYFHVNQRRGRRWSMADAFLHPVAHRRNLTVYTQTRALRLLMDDQVSEE
: * * * .:.:* * * :: . : : . :: .
MUL_4004|M.ulcerans_Agy99 ----------TRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSG
MMAR_4141|M.marinum_M ----------TRATGIEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSG
Mb1310|M.bovis_AF2122/97 ----------DRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSG
Rv1279|M.tuberculosis_H37Rv ----------DRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSG
MAB_0250|M.abscessus_ATCC_1997 ----------IRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSG
MAV_4980|M.avium_104 ----------SRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASG
TH_3275|M.thermoresistible__bu ----------GRAVGVEYVRRGTRKVAYAAKEVILSAGALCSPLILLRSG
Mflv_3230|M.gilvum_PYR-GCK QRCGAWTTATHRATGLRVLKDGQIVDVRARREVILSAGAIGSPHLMQVSG
Mvan_2938|M.vanbaalenii_PYR-1 QRRGAWTTAQRRVTGLRLLKEGQIVDVRARREVILSAGAIGSPHLMQVSG
MSMEG_3375|M.smegmatis_MC2_155 QRRGAWTTAQHRVTGVRLLKDGQIVDVRARREVILSAGAIGSPHLMQVSG
* .*:. . * :*::*..**: ** :: **
MUL_4004|M.ulcerans_Agy99 IGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQ
MMAR_4141|M.marinum_M IGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQ
Mb1310|M.bovis_AF2122/97 IGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQ
Rv1279|M.tuberculosis_H37Rv IGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQ
MAB_0250|M.abscessus_ATCC_1997 IGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQ
MAV_4980|M.avium_104 IGPPNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAARPVPAGRYNHGE
TH_3275|M.thermoresistible__bu IGPAEELRDHGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLNQELTPLS
Mflv_3230|M.gilvum_PYR-GCK LGPAELLARHDVPVTVDLPGVGENLQDHLQLRTVYRVRGARTVNTLYRNW
Mvan_2938|M.vanbaalenii_PYR-1 LGPAGLLTQHQVPVVVDLPGVGENLQDHLQLRTVYRVRGARTVNTLYRNW
MSMEG_3375|M.smegmatis_MC2_155 LGPAGLLAEHQVPVAVDLPGVGENLQDHLQLRTVFRVRGARTVNTLYRNW
:* * : . . * ** ** :* : .
MUL_4004|M.ulcerans_Agy99 LIN------YLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAPFY
MMAR_4141|M.marinum_M LIN------YLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAPFY
Mb1310|M.bovis_AF2122/97 LIS------YLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFY
Rv1279|M.tuberculosis_H37Rv LIS------YLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFY
MAB_0250|M.abscessus_ATCC_1997 LAN------YFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFF
MAV_4980|M.avium_104 LLG-------LIRR--HATGGPPEIQIFG--VDSADVPG-------LGG-
TH_3275|M.thermoresistible__bu ILKGAF--DFVLRRRGPATAPLSHAMLFGPPLEPEGWPQYHVLMAPLGTE
Mflv_3230|M.gilvum_PYR-GCK ITRAGMGIQYLLLRSGPLTMPPSTLGAFAKSDPVLASPDLEWHVQPLSLT
Mvan_2938|M.vanbaalenii_PYR-1 ITRAGMGIQYLLLRSGPMTMPPSTLGAFAKSDPALASPDLEWHVQPLSLP
MSMEG_3375|M.smegmatis_MC2_155 ITRAGMGIQYLLLRSGPMTMPPSTLGAFAKSDPTLASPDLEWHVQPLSLP
: .: : * * *
MUL_4004|M.ulcerans_Agy99 DEGLPAH--------PPGHGVVFG--------PILVAPQSRGQITLRSAD
MMAR_4141|M.marinum_M DEGLPAH--------PPGHGVVFG--------PILVAPQSRGQITLRSAD
Mb1310|M.bovis_AF2122/97 DEALVP---------PAGHGVVFG--------PILVAPQSRGQITLRSAD
Rv1279|M.tuberculosis_H37Rv DEALVP---------PAGHGVVFG--------PILVAPQSRGQITLRSAD
MAB_0250|M.abscessus_ATCC_1997 DEGIGV---------ATEHAIVMG--------PILLKPESSGEITLTSPD
MAV_4980|M.avium_104 -----------------ADGYVLG--------VSVMQPVSRGRVGLSGPT
TH_3275|M.thermoresistible__bu QEKPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSPLHPRGRGTVRLGSPD
Mflv_3230|M.gilvum_PYR-GCK KFGEPLH---------PYGAITPS--------VCNLRPTSRGHVRLADAD
Mvan_2938|M.vanbaalenii_PYR-1 KFGEPLH---------PFGAITPS--------VCNLRPTSRGYVRIADAD
MSMEG_3375|M.smegmatis_MC2_155 KFGEPLH---------PFAAITPS--------VCNLRPTSRGHVRMATAD
. : * . * : : .
MUL_4004|M.ulcerans_Agy99 PHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPH
MMAR_4141|M.marinum_M PHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPH
Mb1310|M.bovis_AF2122/97 PHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPR
Rv1279|M.tuberculosis_H37Rv PHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPR
MAB_0250|M.abscessus_ATCC_1997 PLAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPR
MAV_4980|M.avium_104 IQEPPAIDPNYLSD--DRDMGLMIEGLRIGRKIGMSQALDPWRAEELAP-
TH_3275|M.thermoresistible__bu VDATPVIEHPMLAD--ERDVVDLTAAGRKVREIFQSPAMRPHVIAENAP-
Mflv_3230|M.gilvum_PYR-GCK PLTHPKIFCNYLST--DADRDIAVRGLRMTRKIMASPVLARYRPEEMLP-
Mvan_2938|M.vanbaalenii_PYR-1 PLSHPKIFCNYLST--DADRDAAVRGLRMTRQIMAAPSLARYCPEEMLP-
MSMEG_3375|M.smegmatis_MC2_155 PLADPKILCNYLST--DDDRQKAVRGLRMTRQIMSAPALARYSPEEMLP-
* * *: * . * .* : : *
MUL_4004|M.ulcerans_Agy99 NSSELDEATLELALTTCSHTLYHPLGTCRMGSD--------EASVVDRQL
MMAR_4141|M.marinum_M NSSELDEATLELALTTCSHTLYHPLGTCRMGSD--------EASVVDPQL
Mb1310|M.bovis_AF2122/97 NSTELDEATLELALATCSHTLYHPMGTCRMGSD--------EASVVDPQL
Rv1279|M.tuberculosis_H37Rv NSTELDEATLELALATCSHTLYHPMGTCRMGSD--------EASVVDPQL
MAB_0250|M.abscessus_ATCC_1997 NPSDDLEETLVAALENNSHTLYHPVGTCRMGAD--------DASVVTPDL
MAV_4980|M.avium_104 GDDAVDDAALRSYIQRSVASYFHPVGTCAMGTG--------PESVVDNQL
TH_3275|M.thermoresistible__bu SRGVETDDEWAEFIRNHCFGGSHWVGTARMGADSD------PDAVVDPQL
Mflv_3230|M.gilvum_PYR-GCK GPHLVSDDDLQAAARELGTTIFHPVGTCAMGAFDARGLPRSATTVLDTDC
Mvan_2938|M.vanbaalenii_PYR-1 GPQLVSDDDLQAAARELGTTIFHPVGTCAMGAFDARGLPRSAATVLDTDC
MSMEG_3375|M.smegmatis_MC2_155 GPQLASDDDLQQAARELGTTIFHPVGTCAMGAFDTHGLPTSATTVLDTDL
. : * :**. **: :*: :
MUL_4004|M.ulcerans_Agy99 RVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN---
MMAR_4141|M.marinum_M RVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN---
Mb1310|M.bovis_AF2122/97 RVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS---
Rv1279|M.tuberculosis_H37Rv RVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS---
MAB_0250|M.abscessus_ATCC_1997 TVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP
MAV_4980|M.avium_104 RLHGIDNLRVIDASVMPSLPSNNTAATVYAIAERGADLVRLG--
TH_3275|M.thermoresistible__bu RVRGVSGLRVADASVMPTLTSGNTNAPCVLIGEKAAELIRGR--
Mflv_3230|M.gilvum_PYR-GCK RVFRVAGLRVVDASAMPTITSGNTNAPVMLIAERAARAILH---
Mvan_2938|M.vanbaalenii_PYR-1 RVFRVAGLRVADASAMPTITSGNTNAPVMLIAERAARAILK---
MSMEG_3375|M.smegmatis_MC2_155 RVFRVAGLRVADASAMPNITSGNTNAPVMLIAERAARAILG---
: : .*** ***.:*. .:* *. :. :.* :