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MCSDPIAARYDFVVCGSGSAGSVVARRLSENSNVAVLLLEAGGTDDVAEVMDPAQWPVNLGSARDWGFAS APSAHLNGRSIPLSMGKVLGGGSSINVMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRRIEDWHGRCD GDRRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYDSNNGIMMEGPGGASLLDLQLRNRLRESVFRSY VHPYLQQRNLTVLTGATVRRLTFSGSRVTGVEFSHANAIRTVSATQEVVVSLGAVNTPKVLMQSGIGDAN DLRGFGIPVVTHLRGVGHNYQDHPRIDCVWESHEALAPRNNGAEVTVFWKSHPKLATPDLQICVAEFPLS SPENAARYGLPAHGWTMCVGVVRPQSRGRVRLTGAHPGAPVLIEAEMLAHPDDMKAAAAGVQLCREIGNS APLRPFAKREVMPGGLAGAELERFVRDGASTYWHQSGTAKMGRDDMSVVDAKLKVHGMENLRVADSSIMP RITTGNTMAPCVVIGERAAEIVKADHGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4427 | - | - | 100% (518) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. marinum M | MMAR_4141 | - | 3e-78 | 36.64% (535) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. marinum M | MMAR_2954 | - | 9e-63 | 31.40% (570) | dehydrogenase fad flavoprotein GMC oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 2e-76 | 36.47% (532) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 3e-63 | 32.34% (535) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 2e-76 | 36.47% (532) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 2e-67 | 33.27% (526) | GMC-type oxidoreductase |
| M. avium 104 | MAV_4980 | - | 7e-68 | 35.23% (440) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0281 | - | 0.0 | 64.57% (508) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 1e-67 | 33.21% (545) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 7e-77 | 36.45% (535) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 0.0 | 64.51% (510) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 --------------MDTQS---------DYVVVGTGSAGAVVASRLSTDP
Rv1279|M.tuberculosis_H37Rv --------------MDTQS---------DYVVVGTGSAGAVVASRLSTDP
MUL_4004|M.ulcerans_Agy99 --------------MDIEC---------DYVVVGTGSAGAAVVNRLSADS
MAB_0250|M.abscessus_ATCC_1997 ------------MVEDLAA---------DFVIVGAGSAGAPLATRLSERT
MSMEG_0281|M.smegmatis_MC2_155 ----------MNVEINQR---------YDFIVCGSGSSGSVVARRLAENP
Mvan_1606|M.vanbaalenii_PYR-1 MGDHGHTDLAERIRLNQNRLRQNLRPQYDFIVCGAGSAGSVIARRLAENP
MMAR_4427|M.marinum_M ---------MCSDPIAAR---------YDFVVCGSGSAGSVVARRLSENS
MAV_4980|M.avium_104 --------------------------------------------------
TH_3275|M.thermoresistible__bu ---------MGVVMMGRRS------NLHDYIVVGAGSSGCTVAGRLAEGK
Mflv_1255|M.gilvum_PYR-GCK --------------MAVTG--------YDYIVVGAGSAGCVLANRLSADP
Mb1310|M.bovis_AF2122/97 ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIY
Rv1279|M.tuberculosis_H37Rv ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIY
MUL_4004|M.ulcerans_Agy99 GTSVVALEAGPSDKNRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIY
MAB_0250|M.abscessus_ATCC_1997 NDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIY
MSMEG_0281|M.smegmatis_MC2_155 DADVLLLEAGGSDDVPEVQQAVQWPENLGSPRDWQFEAQANPHLNGRAIP
Mvan_1606|M.vanbaalenii_PYR-1 DVSVLLLEAGGDDDDESVVRADQWPLNLGTSRDWNFVAEASPHVNGRSLP
MMAR_4427|M.marinum_M NVAVLLLEAGGTDDVAEVMDPAQWPVNLGSARDWGFASAPSAHLNGRSIP
MAV_4980|M.avium_104 ----------------------------------------MQTAIGRAVP
TH_3275|M.thermoresistible__bu RHSVLVLEAGGSD-LSPFIRIPAGLMRVNPRNYWHFRLEPDPTRNGAVDT
Mflv_1255|M.gilvum_PYR-GCK AIRVLLLEAGRGDRNLWLHIPKGAGKLFDSERHMWHYETTPFGPDAHVEQ
Mb1310|M.bovis_AF2122/97 WPRGKVLGGSSSMNAMMWVRGFASDYDEWAARA-GPRWSYADVLGYFRRI
Rv1279|M.tuberculosis_H37Rv WPRGKVLGGSSSMNAMMWVRGFASDYDEWAARA-GPRWSYADVLGYFRRI
MUL_4004|M.ulcerans_Agy99 WPRDKVLGGSSSMNAMMWVRGFAADYDEWARLA-GSHWSYGELLGYFRQI
MAB_0250|M.abscessus_ATCC_1997 WPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVA-GEQWSFANIAPYFKRI
MSMEG_0281|M.smegmatis_MC2_155 MNMGKVLGGGSSINVMMWSRGHRNDWDFFAAEADDEGWGYEAVLDIYRRI
Mvan_1606|M.vanbaalenii_PYR-1 MNMGKVLGGGSSINVMMWSRGHRSDWDFFAAEASDPGWGYDAVLDIYRRI
MMAR_4427|M.marinum_M LSMGKVLGGGSSINVMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRRI
MAV_4980|M.avium_104 FARGRGIGGSSTINAMVFARGHRDSYSRWRDNG-AAGWSFDELLPYFKRS
TH_3275|M.thermoresistible__bu WAAGRVVGGGSSVNAMLWVRGNRADFDTWAKLG-AQGWDYESLLPAMRSL
Mflv_1255|M.gilvum_PYR-GCK WMRGKVIGGSSAVNGMIYNRGHRADYDALEQMG-NKGWGWDEILPIFKGF
.: :**.*::* * : ** .: . *.: : :
Mb1310|M.bovis_AF2122/97 ENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARP
Rv1279|M.tuberculosis_H37Rv ENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARP
MUL_4004|M.ulcerans_Agy99 EDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQP
MAB_0250|M.abscessus_ATCC_1997 EAVEG----ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERA
MSMEG_0281|M.smegmatis_MC2_155 EDWQGKP---DPQYRGTDGNVYVQPAPDPNPIADAAVAAAASVGIPAFDH
Mvan_1606|M.vanbaalenii_PYR-1 EDWHGSP---DPDYRGSGGEVFVQPAPDPNPVAPAAVDAAAAVGIPTFDH
MMAR_4427|M.marinum_M EDWHGRC---DGDRRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYDS
MAV_4980|M.avium_104 ESTCGK----DPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAAD
TH_3275|M.thermoresistible__bu ETWEGG----ADRYRGGTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILAD
Mflv_1255|M.gilvum_PYR-GCK EDHEFGP----SATRGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRD
* * * : . : .. *
Mb1310|M.bovis_AF2122/97 NSP----RPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT
Rv1279|M.tuberculosis_H37Rv NSP----RPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT
MUL_4004|M.ulcerans_Agy99 NSA----EPEGFCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATAT
MAB_0250|M.abscessus_ATCC_1997 NTP----EPKGFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQAR
MSMEG_0281|M.smegmatis_MC2_155 PNGAMMEGAGGAALSDIRVRDGIRQSVFRSYVHPYLGRPNLTVLTGAVVT
Mvan_1606|M.vanbaalenii_PYR-1 PNGKMMEGCGGAAISDMRVRDGLRESVFRSYTYPYLDRPNLTVLTGAVVT
MMAR_4427|M.marinum_M NNGIMMEGPGGASLLDLQLRNRLRESVFRSYVHPYLQQRNLTVLTGATVR
MAV_4980|M.avium_104 ISGGLEVGFG---FTDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVH
TH_3275|M.thermoresistible__bu YNG---ESQFGAAWSQLSQKNGLRHSAAQAFLAPARRRGEVDVESHAVVD
Mflv_1255|M.gilvum_PYR-GCK INE---SDGERIGYATSTIRGGRRVSAATAFLKPVLHRPNLTVRTGATVR
. * *. .: * : :: . : * .
Mb1310|M.bovis_AF2122/97 RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDR
Rv1279|M.tuberculosis_H37Rv RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDR
MUL_4004|M.ulcerans_Agy99 RIVIHGTRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGDR
MAB_0250|M.abscessus_ATCC_1997 RVLFDGIRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSGIGEA
MSMEG_0281|M.smegmatis_MC2_155 RVTLDGHRASGVEFVRDGVTFRVAAGSEVVLGLGAINTPKVLMLSGIGDS
Mvan_1606|M.vanbaalenii_PYR-1 RVPVHMQRATGVEFEMAGTTHRIDAGVETVLCLGAIHTPKVLMHSGIGDA
MMAR_4427|M.marinum_M RLTFSGSRVTGVEFSHANAIRTVSATQEVVVSLGAVNTPKVLMQSGIGDA
MAV_4980|M.avium_104 RLRIRGSRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGPP
TH_3275|M.thermoresistible__bu KVIIENGRAVGVEYVRRGTRKVAYAAKEVILSAGALCSPLILLRSGIGPA
Mflv_1255|M.gilvum_PYR-GCK RVLFDGERADGVEIATGAGTEQVRAAREVVLSLGSLNSPKLLQLSGIGPS
:: . * *** * * :: *:: :* :* ****
Mb1310|M.bovis_AF2122/97 DHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQL---
Rv1279|M.tuberculosis_H37Rv DHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQL---
MUL_4004|M.ulcerans_Agy99 SHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQL---
MAB_0250|M.abscessus_ATCC_1997 TRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQL---
MSMEG_0281|M.smegmatis_MC2_155 AELARHGIKTVVHLPGVGRNLQDHPAFGCVWEYDV-----ALEP------
Mvan_1606|M.vanbaalenii_PYR-1 AELHRLGIAPVQHLPGVGANLQDHPGFGCVWEYRD-----PLPP------
MMAR_4427|M.marinum_M NDLRGFGIPVVTHLRGVGHNYQDHPRIDCVWESHE-----ALAP------
MAV_4980|M.avium_104 NHLRSFRVDVALELPGVGANLQDHPIVPLVYRAAR-----PVPAG-----
TH_3275|M.thermoresistible__bu EELRDHGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLNQELTPL-----
Mflv_1255|M.gilvum_PYR-GCK DVLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGYNKLLATNVGQA
* : . ** . :* : .
Mb1310|M.bovis_AF2122/97 ---ISYLLRRRGMLTSNVGEAYGFVRSRPELKLPD---------------
Rv1279|M.tuberculosis_H37Rv ---ISYLLRRRGMLTSNVGEAYGFVRSRPELKLPD---------------
MUL_4004|M.ulcerans_Agy99 ---INYLLRRRGMLTSNVGEAYGFVRSRPGLDLPD---------------
MAB_0250|M.abscessus_ATCC_1997 ---ANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPD---------------
MSMEG_0281|M.smegmatis_MC2_155 --------------RNTGSEATYFAKSDSRLDTPD---------------
Mvan_1606|M.vanbaalenii_PYR-1 --------------RNTASEATYFWKSDPQLPTPD---------------
MMAR_4427|M.marinum_M --------------RNNGAEVTVFWKSHPKLATPD---------------
MAV_4980|M.avium_104 --------------RYNHGELLGLIRRHATGGPPE---------------
TH_3275|M.thermoresistible__bu --------------SILKGAFDFVLRRRGPATAPLSHAMLFGPPLEPEGW
Mflv_1255|M.gilvum_PYR-GCK LTGMKYLATRKGPLAAPSFDVVGFVKDRPDSERPLG--------------
. : *
Mb1310|M.bovis_AF2122/97 ----------------LELIFAPAP--FYDEALVP-PAGHGVVFGPILVA
Rv1279|M.tuberculosis_H37Rv ----------------LELIFAPAP--FYDEALVP-PAGHGVVFGPILVA
MUL_4004|M.ulcerans_Agy99 ----------------LELIFAPAP--FYDEGLPAHPPGHGVVFGPILVA
MAB_0250|M.abscessus_ATCC_1997 ----------------LELIFAPAP--FFDEGIGV-ATEHAIVMGPILLK
MSMEG_0281|M.smegmatis_MC2_155 ----------------LQTCQIEAPFASAETIARFGLPQAAWTMFAGIVR
Mvan_1606|M.vanbaalenii_PYR-1 ----------------LQTCQVEVPLTSAENAARFGVPQAGWTMFAGVVR
MMAR_4427|M.marinum_M ----------------LQICVAEFPLSSPENAARYGLPAHGWTMCVGVVR
MAV_4980|M.avium_104 ----------------IQIFGVDS-----ADVPGLGG-ADGYVLGVSVMQ
TH_3275|M.thermoresistible__bu PQYHVLMAPLGTEQEKPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSPLH
Mflv_1255|M.gilvum_PYR-GCK ----------------QVMMGPWTLPPYNTGEPVVIEREPGISCLGMVLR
:
Mb1310|M.bovis_AF2122/97 PQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQAR
Rv1279|M.tuberculosis_H37Rv PQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQAR
MUL_4004|M.ulcerans_Agy99 PQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAP
MAB_0250|M.abscessus_ATCC_1997 PESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETP
MSMEG_0281|M.smegmatis_MC2_155 PESRGSVRLTGCSPDDPVRIDANMLSDPA--DMTAAMIAVELCREIGNAA
Mvan_1606|M.vanbaalenii_PYR-1 PASRGRVWLSSAQPSDPVHIDTGMLSDPA--DVAAAVAAVELCREIGNAA
MMAR_4427|M.marinum_M PQSRGRVRLTGAHPGAPVLIEAEMLAHPD--DMKAAAAGVQLCREIGNSA
MAV_4980|M.avium_104 PVSRGRVGLSGPTIQEPPAIDPNYLSDDR--DMGLMIEGLRIGRKIGMSQ
TH_3275|M.thermoresistible__bu PRGRGTVRLGSPDVDATPVIEHPMLADER--DVVDLTAAGRKVREIFQSP
Mflv_1255|M.gilvum_PYR-GCK PTSQGYVEITSADPGAALRITPNYLTTEH--DRTATAALVRRMRSIFEQS
* . * : : . * *: * . *
Mb1310|M.bovis_AF2122/97 PLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSD--EA
Rv1279|M.tuberculosis_H37Rv PLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSD--EA
MUL_4004|M.ulcerans_Agy99 ALRGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGSD--EA
MAB_0250|M.abscessus_ATCC_1997 SMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGAD--DA
MSMEG_0281|M.smegmatis_MC2_155 PLSAHAKREVMPGN---LKGRDLERFIRDAAVSYWHQSGTAKMGRD--EM
Mvan_1606|M.vanbaalenii_PYR-1 PLRPFTKREVMPGN---LRGPALEEFVRNAASTYWHPTGTAKMGRD--DM
MMAR_4427|M.marinum_M PLRPFAKREVMPGG---LAGAELERFVRDGASTYWHQSGTAKMGRD--DM
MAV_4980|M.avium_104 ALDPWRAEELAPGDDA-VDDAALRSYIQRSVASYFHPVGTCAMGTG--PE
TH_3275|M.thermoresistible__bu AMRPHVIAENAPSRGV-ETDDEWAEFIRNHCFGGSHWVGTARMGADSDPD
Mflv_1255|M.gilvum_PYR-GCK PIAERISHETYPGPRVDSDEELVDAALEGG-YCGYHAVGTCAMGPD--DD
.: * : * **. ** .
Mb1310|M.bovis_AF2122/97 SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS--
Rv1279|M.tuberculosis_H37Rv SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS--
MUL_4004|M.ulcerans_Agy99 SVVDRQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN--
MAB_0250|M.abscessus_ATCC_1997 SVVTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQ
MSMEG_0281|M.smegmatis_MC2_155 SVVDGNLRVHGIERLRIADASIMPRITTGNTMAPCVVIGERAAQLIRDTY
Mvan_1606|M.vanbaalenii_PYR-1 SVVDGALRVYGVAGLRVADGSIMPRVSTGNTMAPCVVIGERAAALLGATH
MMAR_4427|M.marinum_M SVVDAKLKVHGMENLRVADSSIMPRITTGNTMAPCVVIGERAAEIVKADH
MAV_4980|M.avium_104 SVVDNQLRLHGIDNLRVIDASVMPSLPSNNTAATVYAIAERGADLVRLG-
TH_3275|M.thermoresistible__bu AVVDPQLRVRGVSGLRVADASVMPTLTSGNTNAPCVLIGEKAAELIRGR-
Mflv_1255|M.gilvum_PYR-GCK DVVDSHLRVRGVDGLRVVDCSVMPTIVAGNLNGPIMAMAWRAADFILHGR
** * : *: **: * *::* .: .. :. :.* ::
Mb1310|M.bovis_AF2122/97 --------
Rv1279|M.tuberculosis_H37Rv --------
MUL_4004|M.ulcerans_Agy99 --------
MAB_0250|M.abscessus_ATCC_1997 P-------
MSMEG_0281|M.smegmatis_MC2_155 AAQEPAHE
Mvan_1606|M.vanbaalenii_PYR-1 GLRAA---
MMAR_4427|M.marinum_M GL------
MAV_4980|M.avium_104 --------
TH_3275|M.thermoresistible__bu --------
Mflv_1255|M.gilvum_PYR-GCK --------