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MADAGVFDYVIAGGGTAGCVLAARLSEDPDVTVCLLEAGPSDVGDDAILVLSDWMRLLDSGYDWDYPIEP QERGNSFMRHARAKVLGGCSSHNSCIAFHPPAEALDEWAAMGATGWSAAEVLPLVQRLTETVRLRDVPPD DPCGAAVLEAAARIGIPTVSFNRGQTVRNGAGWFQINATPEGARLSTSHAFLHPILGTRRNLEVRTDSWV SEILFDDASRATGVRYQRADLTGYDTVAARREVILTAGAIDTPKLLMLSGIGPTAHLREVGIDVRVDSPG VGANLDDHVEGLVFWEASRPMVTASTQWWEIGLFTTVDEIPEGVRAQPDLMMHYGSVPFDMNTLRHGYPT TDNGFCLTPNVTQGRSRGTVRLRSRDFRDRARVDPRYFTDPDSYDERIMLAGIKLARAIAAQAPLTPWVA RELAPGPDATTDDELLDYIHRCHNTVYHPAATARMGSPSDPMAVLDPQLRVKGVRGLRVVDASAMPKLPA VNPNITVMTMAEKCAELIRTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3085 | - | - | 100% (511) | glucose-methanol-choline oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3230 | - | 1e-53 | 32.41% (580) | glucose-methanol-choline oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 4e-51 | 32.16% (541) | glucose-methanol-choline oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 2e-67 | 35.57% (537) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 2e-67 | 35.57% (537) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 4e-62 | 34.65% (531) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4141 | - | 3e-64 | 34.89% (536) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 3e-56 | 35.36% (444) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3444 | - | 2e-67 | 34.67% (525) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_4204 | - | 4e-50 | 32.04% (540) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 2e-62 | 34.70% (536) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 8e-58 | 33.27% (523) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
Rv1279|M.tuberculosis_H37Rv -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
MMAR_4141|M.marinum_M -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MUL_4004|M.ulcerans_Agy99 -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MAB_0250|M.abscessus_ATCC_1997 ---------------------MVEDLAADFVIVGAGSAGAPLATRLSERT
MAV_4980|M.avium_104 --------------------------------------------------
MSMEG_3444|M.smegmatis_MC2_155 ---------------------MASEPGYDFVIVGAGTAGCVLAARLSAQE
Mvan_1606|M.vanbaalenii_PYR-1 MGDHGHTDLAERIRLNQNRLRQNLRPQYDFIVCGAGSAGSVIARRLAENP
Mflv_3085|M.gilvum_PYR-GCK ---------------------MADAGVFDYVIAGGGTAGCVLAARLSEDP
TH_4204|M.thermoresistible__bu ------------------------MSSYDYIIAGSGSAGCVLANRLSADP
Mb1310|M.bovis_AF2122/97 ATTVVALEAGPRDK-NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREI
Rv1279|M.tuberculosis_H37Rv ATTVVALEAGPRDK-NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREI
MMAR_4141|M.marinum_M GTSVVALEAGPSDK-NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREI
MUL_4004|M.ulcerans_Agy99 GTSVVALEAGPSDK-NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREI
MAB_0250|M.abscessus_ATCC_1997 NDQVLVLEAGPKDK-DMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQI
MAV_4980|M.avium_104 -----------------------------------------MQTAIGRAV
MSMEG_3444|M.smegmatis_MC2_155 DVRVLLIEAGSATL-PPASAAPPQWQTLLGSSADWG-GPTAVQDTLGRAI
Mvan_1606|M.vanbaalenii_PYR-1 DVSVLLLEAGGDDD-DESVVRADQWPLNLGTSRDWNFVAEASPHVNGRSL
Mflv_3085|M.gilvum_PYR-GCK DVTVCLLEAGPSDVGDDAILVLSDWMRLLDSGYDWDYPIEPQERGNS-FM
TH_4204|M.thermoresistible__bu KVSVLLIEAGGFDR-NPLFSIPKGSGKLFDSERHMWHYETTPFGPGRHTE
Mb1310|M.bovis_AF2122/97 YWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRR
Rv1279|M.tuberculosis_H37Rv YWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRR
MMAR_4141|M.marinum_M YWPRGKVLGGSSSMNAMMWVRGFAADYDEWARLAG-SHWSYGELLGYFRQ
MUL_4004|M.ulcerans_Agy99 YWPRDKVLGGSSSMNAMMWVRGFAADYDEWARLAG-SHWSYGELLGYFRQ
MAB_0250|M.abscessus_ATCC_1997 YWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAG-EQWSFANIAPYFKR
MAV_4980|M.avium_104 PFARGRGIGGSSTINAMVFARGHRDSYSRWRDNGA-AGWSFDELLPYFKR
MSMEG_3444|M.smegmatis_MC2_155 HVARGRGFGGSSAINAMMFARGHRESYDDWP-----EGWRFDDLLPYFMR
Mvan_1606|M.vanbaalenii_PYR-1 PMNMGKVLGGGSSINVMMWSRGHRSDWDFFAAEASDPGWGYDAVLDIYRR
Mflv_3085|M.gilvum_PYR-GCK RHARAKVLGGCSSHNSCIAFHPPAEALDEWAAMGA-TGWSAAEVLPLVQR
TH_4204|M.thermoresistible__bu QWMRGKVLGGSSSVNGMIYNRGNRADYDGLEQLGN-KGWGWDDILPIFKQ
: :** *: * : : . * : :
Mb1310|M.bovis_AF2122/97 IENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR
Rv1279|M.tuberculosis_H37Rv IENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR
MMAR_4141|M.marinum_M IEDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFPPVQ
MUL_4004|M.ulcerans_Agy99 IEDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQ
MAB_0250|M.abscessus_ATCC_1997 IEAVEG----ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVER
MAV_4980|M.avium_104 SESTCGK----DPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAA
MSMEG_3444|M.smegmatis_MC2_155 SEASRGG----NPALRGKNGPLRVGPASPVNPLLAAALDAAVECGYAAAE
Mvan_1606|M.vanbaalenii_PYR-1 IEDWHGSP---DPDYRGSGGEVFVQPAPDPNPVAPAAVDAAAAVGIPTFD
Mflv_3085|M.gilvum_PYR-GCK -----------------LTETVRLRDVPPDDPCGAAVLEAAARIGIPTVS
TH_4204|M.thermoresistible__bu FEDNEFG----PSPTRGAGGPLHISVPRDADPLCDEMIDAGTVAGLHRVE
: : . : * *
Mb1310|M.bovis_AF2122/97 PNSPRP----EGFCETVVTQRRGARFSTADAYLKPAMR-RKNLRVLTGAT
Rv1279|M.tuberculosis_H37Rv PNSPRP----EGFCETVVTQRRGARFSTADAYLKPAMR-RKNLRVLTGAT
MMAR_4141|M.marinum_M PNSAEP----EGFCETIVTQRRGSRWSTVDAYLRPAMG-RRNLSILTGAT
MUL_4004|M.ulcerans_Agy99 PNSAEP----EGFCETIVTQRRGSRWSTVDAYLRPAMG-RRNLSILTGAT
MAB_0250|M.abscessus_ATCC_1997 ANTPEP----KGFSETMVCQHGGRRWSTADGYLKPGLR-RRNLNVVTDAQ
MAV_4980|M.avium_104 DISGGLEVGFG---FTDLNIVDGKRQSAADAYLLPALD-RPNLEFHSGAT
MSMEG_3444|M.smegmatis_MC2_155 DISSGDETGFG---AADLTIDGRRRQTAADAYLVPAMD-RPNLDVISDAV
Mvan_1606|M.vanbaalenii_PYR-1 HPNGKMMEGCGGAAISDMRVRDGLRESVFRSYTYPYLD-RPNLTVLTGAV
Mflv_3085|M.gilvum_PYR-GCK FNRGQTVRNGAG-WFQINATPEGARLSTSHAFLHPILGTRRNLEVRTDSW
TH_4204|M.thermoresistible__bu DINESDD---ERIGYATATIKNGRRVSAARAFLKPALR-RANLSVRTRAV
* :. .: * : * ** . : :
Mb1310|M.bovis_AF2122/97 ATRVVIDGD-RAVGVEYQ--SDGQTRIVYARREVVLCAGAVNSPQLLMLS
Rv1279|M.tuberculosis_H37Rv ATRVVIDGD-RAVGVEYQ--SDGQTRIVYARREVVLCAGAVNSPQLLMLS
MMAR_4141|M.marinum_M ATRIVIHGT-RATGIEYQ--REGQHCTVHARREVVLCGGAVNSPQLLMLS
MUL_4004|M.ulcerans_Agy99 ATRIVIHGT-RATGVEYQ--REGQHCTVHARREVVLCGGAVNSPQLLMLS
MAB_0250|M.abscessus_ATCC_1997 ARRVLFDGI-RAVGVEYV--RDGITHTVHARREVILSGGAINSPQLLMLS
MAV_4980|M.avium_104 VHRLRIRGS-RCTGVEYT--TAEGRQVTAAAREIILCAGAIGSPHLLLAS
MSMEG_3444|M.smegmatis_MC2_155 VHRLVISEG-RCTGVEFHRSSSPSSTCVRSVGEIVLAAGAIGSAQLLMVS
Mvan_1606|M.vanbaalenii_PYR-1 VTRVPVHMQ-RATGVEFE--MAGTTHRIDAGVETVLCLGAIHTPKVLMHS
Mflv_3085|M.gilvum_PYR-GCK VSEILFDDASRATGVRYQRADLTGYDTVAARREVILTAGAIDTPKLLMLS
TH_4204|M.thermoresistible__bu AQRILLAGG-RAVGLEIAS--RGRTGKVYATREVIIAMGSLNTPKLLQLS
. .: . *..*:. : * :: *:: :.::* *
Mb1310|M.bovis_AF2122/97 GIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LF
Rv1279|M.tuberculosis_H37Rv GIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LF
MMAR_4141|M.marinum_M GIGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LA
MUL_4004|M.ulcerans_Agy99 GIGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LA
MAB_0250|M.abscessus_ATCC_1997 GIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDS------LF
MAV_4980|M.avium_104 GIGPPNHLRSFRVDVALELPGVGANLQDHPIVPL--------------VY
MSMEG_3444|M.smegmatis_MC2_155 GVGPEAHLRDVGVDVVHHLPGVGANFQDHPLSGV--------------IY
Mvan_1606|M.vanbaalenii_PYR-1 GIGDAAELHRLGIAPVQHLPGVGANLQDHPGFGC--------------VW
Mflv_3085|M.gilvum_PYR-GCK GIGPTAHLREVGIDVRVDSPGVGANLDDHVEGLV--------------FW
TH_4204|M.thermoresistible__bu GIGPREVLDAAGVPVYLDRANVGRRMREHRCATLRFDLREDLGYNRLLAT
*:* * : . . ** .: :*
Mb1310|M.bovis_AF2122/97 AAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELK----LPDLELIFA
Rv1279|M.tuberculosis_H37Rv AAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELK----LPDLELIFA
MMAR_4141|M.marinum_M AAEKPMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLD----LPDLELIFA
MUL_4004|M.ulcerans_Agy99 AAEKPMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLD----LPDLELIFA
MAB_0250|M.abscessus_ATCC_1997 GAEKPLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLT----LPDLELIFA
MAV_4980|M.avium_104 RAARPVPAG----------RYNHGELLGLIRRHATGG----PPEIQIFGV
MSMEG_3444|M.smegmatis_MC2_155 TAAQPIPTP----------EHNHGEVMGLIR-TASAG----APDLQILMV
Mvan_1606|M.vanbaalenii_PYR-1 EYRDPLPP-----------RNTASEATYFWKSDPQLP----TPDLQTCQV
Mflv_3085|M.gilvum_PYR-GCK EASRPMVTA----------STQWWEIGLFTTVDEIPEGVRAQPDLMMHYG
TH_4204|M.thermoresistible__bu GTGQALTGAKYLATRKGPLAAPSFDVVGFVKTQPGLD----RPDGQIMLG
. : : *:
Mb1310|M.bovis_AF2122/97 PAP----FYDEALVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVI
Rv1279|M.tuberculosis_H37Rv PAP----FYDEALVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVI
MMAR_4141|M.marinum_M PAP----FYDEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPII
MUL_4004|M.ulcerans_Agy99 PAP----FYDEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPII
MAB_0250|M.abscessus_ATCC_1997 PAP----FFDEGIGV-ATEHAIVMGPILLKPESSGEITLTSPDPLAKPRI
MAV_4980|M.avium_104 DS-------ADVPGLGGADG-YVLGVSVMQPVSRGRVGLSGPTIQEPPAI
MSMEG_3444|M.smegmatis_MC2_155 DS-------TEVTGLDIPNA-YLFGVSAMQPHSRGRVRLTGPTVNAAPLV
Mvan_1606|M.vanbaalenii_PYR-1 EVPLT--SAENAARFGVPQAGWTMFAGVVRPASRGRVWLSSAQPSDPVHI
Mflv_3085|M.gilvum_PYR-GCK SVPFD--MNTLRHGYPTTDNGFCLTPNVTQGRSRGTVRLRSRDFRDRARV
TH_4204|M.thermoresistible__bu PWTIPPYNQSGEPVVIPRQAGVSALGMALRPTSEGTVEITAVDPAAPLRI
* * : : . :
Mb1310|M.bovis_AF2122/97 EPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDE
Rv1279|M.tuberculosis_H37Rv EPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDE
MMAR_4141|M.marinum_M EARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDE
MUL_4004|M.ulcerans_Agy99 EARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDE
MAB_0250|M.abscessus_ATCC_1997 DPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLE
MAV_4980|M.avium_104 DPNYLSDDR--DMGLMIEGLRIGRKIGMSQALDPWRAEELAPGDDA-VDD
MSMEG_3444|M.smegmatis_MC2_155 DPNYLIDER--DWKTMLEGFRIAREIGAAAAMAPWCGGELAPGPAV-ADD
Mvan_1606|M.vanbaalenii_PYR-1 DTGMLSDPA--DVAAAVAAVELCREIGNAAPLRPFTKREVMPGN---LRG
Mflv_3085|M.gilvum_PYR-GCK DPRYFTDPDSYDERIMLAGIKLARAIAAQAPLTPWVARELAPGPDA-TTD
TH_4204|M.thermoresistible__bu DPNYLGSDA--DRETTANLLRRMRSVFEQSPIAERISHETFPGPHIRSDD
:. : . * .. : .: *
Mb1310|M.bovis_AF2122/97 ATLELALATCSHTLYHPMGTCRMGS--DEASVVDPQLRVRGVDGLRVADA
Rv1279|M.tuberculosis_H37Rv ATLELALATCSHTLYHPMGTCRMGS--DEASVVDPQLRVRGVDGLRVADA
MMAR_4141|M.marinum_M ATLELALTTCSHTLYHPLGTCRMGS--DEASVVDPQLRVRGVDGLRVADA
MUL_4004|M.ulcerans_Agy99 ATLELALTTCSHTLYHPLGTCRMGS--DEASVVDRQLRVRGVDGLRVADA
MAB_0250|M.abscessus_ATCC_1997 ETLVAALENNSHTLYHPVGTCRMGA--DDASVVTPDLTVRGVQGLRVVDA
MAV_4980|M.avium_104 AALRSYIQRSVASYFHPVGTCAMGT--GPESVVDNQLRLHGIDNLRVIDA
MSMEG_3444|M.smegmatis_MC2_155 ESLRRFICDSLSSYYHSSGTCAMGD--SDESVVDTALRVHGLAGLRVADA
Mvan_1606|M.vanbaalenii_PYR-1 PALEEFVRNAASTYWHPTGTAKMGR--DDMSVVDGALRVYGVAGLRVADG
Mflv_3085|M.gilvum_PYR-GCK DELLDYIHRCHNTVYHPAATARMGSPSDPMAVLDPQLRVKGVRGLRVVDA
TH_4204|M.thermoresistible__bu ELVDAALDGG-YCGYHAIGTCAMGP--SDDDVVDPQLRVRGVDGLRVVDC
: : :*. .*. ** . *: * : *: .*** *
Mb1310|M.bovis_AF2122/97 SVMPSTVRGHTHAPSVLIGEKAADLIRS-------
Rv1279|M.tuberculosis_H37Rv SVMPSTVRGHTHAPSVLIGEKAADLIRS-------
MMAR_4141|M.marinum_M SVMPSTVRGHTHAPSVLIGAKAADLIRN-------
MUL_4004|M.ulcerans_Agy99 SVMPSTVRGHTHAPSVLIGAKAADLIRN-------
MAB_0250|M.abscessus_ATCC_1997 SVIPSLIRGHTHAPSVLLGEKAADLILSPQP----
MAV_4980|M.avium_104 SVMPSLPSNNTAATVYAIAERGADLVRLG------
MSMEG_3444|M.smegmatis_MC2_155 SVMPSLPSNNPMATVYGIAERAADLIGG-------
Mvan_1606|M.vanbaalenii_PYR-1 SIMPRVSTGNTMAPCVVIGERAAALLGATHGLRAA
Mflv_3085|M.gilvum_PYR-GCK SAMPKLPAVNPNITVMTMAEKCAELIRTG------
TH_4204|M.thermoresistible__bu SVLPVMVAGNLNGPIMAVAWRAADLIRQDL-----
* :* : . :. : * *: