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MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPE LDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDD SGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRR KNLRVLTGATATRVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDI DTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLP DLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMA GLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEASVVDPQLRVR GVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1279 | - | - | 100% (528) | PROBABLE DEHYDROGENASE FAD flavoprotein GMC oxidoreductase |
| M. tuberculosis H37Rv | Rv0697 | - | 2e-44 | 30.40% (546) | dehydrogenase |
| M. tuberculosis H37Rv | Rv0492c | - | 9e-17 | 26.76% (527) | oxidoreductase GMC-type |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 0.0 | 100.00% (528) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 4e-82 | 37.87% (536) | glucose-methanol-choline oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 0.0 | 63.95% (527) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4141 | - | 0.0 | 81.66% (529) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 1e-65 | 36.03% (458) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0526 | - | 2e-79 | 36.75% (536) | oxidoreductase, GMC family protein |
| M. thermoresistible (build 8) | TH_4204 | - | 6e-82 | 37.13% (536) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 0.0 | 81.66% (529) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 1e-77 | 37.83% (534) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1279|M.tuberculosis_H37Rv -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
Mb1310|M.bovis_AF2122/97 -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
MMAR_4141|M.marinum_M -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MUL_4004|M.ulcerans_Agy99 -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MAB_0250|M.abscessus_ATCC_1997 ---------------------MVEDLAADFVIVGAGSAGAPLATRLSERT
MAV_4980|M.avium_104 --------------------------------------------------
Mvan_1606|M.vanbaalenii_PYR-1 MGDHGHTDLAERIRLNQNRLRQNLRPQYDFIVCGAGSAGSVIARRLAENP
MSMEG_0526|M.smegmatis_MC2_155 ------------------------MTSYDYIIAGAGSAGCVLANRLSEDP
TH_4204|M.thermoresistible__bu ------------------------MSSYDYIIAGSGSAGCVLANRLSADP
Mflv_1255|M.gilvum_PYR-GCK ----------------------MAVTGYDYIVVGAGSAGCVLANRLSADP
Rv1279|M.tuberculosis_H37Rv ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIY
Mb1310|M.bovis_AF2122/97 ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIY
MMAR_4141|M.marinum_M GTSVVALEAGPSDKNRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIY
MUL_4004|M.ulcerans_Agy99 GTSVVALEAGPSDKNRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIY
MAB_0250|M.abscessus_ATCC_1997 NDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIY
MAV_4980|M.avium_104 ----------------------------------------MQTAIGRAVP
Mvan_1606|M.vanbaalenii_PYR-1 DVSVLLLEAGGDDDDESVVRADQWPLNLGTSRDWNFVAEASPHVNGRSLP
MSMEG_0526|M.smegmatis_MC2_155 RIKVLLLEAGGSDRNPLFSIPKGSGKLFDSEKHMWHYSTEPFGPNPHAEQ
TH_4204|M.thermoresistible__bu KVSVLLIEAGGFDRNPLFSIPKGSGKLFDSERHMWHYETTPFGPGRHTEQ
Mflv_1255|M.gilvum_PYR-GCK AIRVLLLEAGRGDRNLWLHIPKGAGKLFDSERHMWHYETTPFGPDAHVEQ
:
Rv1279|M.tuberculosis_H37Rv WPRGKVLGGSSSMNAMMWVRGFASDYDEWAARA-GPRWSYADVLGYFRRI
Mb1310|M.bovis_AF2122/97 WPRGKVLGGSSSMNAMMWVRGFASDYDEWAARA-GPRWSYADVLGYFRRI
MMAR_4141|M.marinum_M WPRGKVLGGSSSMNAMMWVRGFAADYDEWARLA-GSHWSYGELLGYFRQI
MUL_4004|M.ulcerans_Agy99 WPRDKVLGGSSSMNAMMWVRGFAADYDEWARLA-GSHWSYGELLGYFRQI
MAB_0250|M.abscessus_ATCC_1997 WPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVA-GEQWSFANIAPYFKRI
MAV_4980|M.avium_104 FARGRGIGGSSTINAMVFARGHRDSYSRWRDNG-AAGWSFDELLPYFKRS
Mvan_1606|M.vanbaalenii_PYR-1 MNMGKVLGGGSSINVMMWSRGHRSDWDFFAAEASDPGWGYDAVLDIYRRI
MSMEG_0526|M.smegmatis_MC2_155 WMRGKVLGGSSSINGMIYNRGTRADYDGLERLG-NKGWGWDDILPIFKRF
TH_4204|M.thermoresistible__bu WMRGKVLGGSSSVNGMIYNRGNRADYDGLEQLG-NKGWGWDDILPIFKQF
Mflv_1255|M.gilvum_PYR-GCK WMRGKVIGGSSAVNGMIYNRGHRADYDALEQMG-NKGWGWDEILPIFKGF
.: :**.*::* *:: ** .:. . *.: : ::
Rv1279|M.tuberculosis_H37Rv ENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFA-AAR
Mb1310|M.bovis_AF2122/97 ENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFA-AAR
MMAR_4141|M.marinum_M EDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFP-PVQ
MUL_4004|M.ulcerans_Agy99 EDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFA-PVQ
MAB_0250|M.abscessus_ATCC_1997 EAVEG----ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFD-VER
MAV_4980|M.avium_104 ESTCGK----DPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAAD
Mvan_1606|M.vanbaalenii_PYR-1 EDWHGSP---DPDYRGSGGEVFVQPAPDPNPVAPAAVDAAAAVGIPTFDH
MSMEG_0526|M.smegmatis_MC2_155 EDNEFGP----SATRGVGGPLHISIPRDPDPLCEEMLAAAEASGLTRVQD
TH_4204|M.thermoresistible__bu EDNEFGP----SPTRGAGGPLHISVPRDADPLCDEMIDAGTVAGLHRVED
Mflv_1255|M.gilvum_PYR-GCK EDHEFGP----SATRGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRD
* * * : : . . : * *
Rv1279|M.tuberculosis_H37Rv PNSPRPEGFCETVVTQR---RGARFSTADAYLKPAMRRKNLRVLTGATAT
Mb1310|M.bovis_AF2122/97 PNSPRPEGFCETVVTQR---RGARFSTADAYLKPAMRRKNLRVLTGATAT
MMAR_4141|M.marinum_M PNSAEPEGFCETIVTQR---RGSRWSTVDAYLRPAMGRRNLSILTGATAT
MUL_4004|M.ulcerans_Agy99 PNSAEPEGFCETIVTQR---RGSRWSTVDAYLRPAMGRRNLSILTGATAT
MAB_0250|M.abscessus_ATCC_1997 ANTPEPKGFSETMVCQH---GGRRWSTADGYLKPGLRRRNLNVVTDAQAR
MAV_4980|M.avium_104 ISGGLEVGFG---FTDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVH
Mvan_1606|M.vanbaalenii_PYR-1 PNGKMMEGCGGAAISDMRVRDGLRESVFRSYTYPYLDRPNLTVLTGAVVT
MSMEG_0526|M.smegmatis_MC2_155 INEHDTERIGYATSTIR---NGRRVSAATAFLKPALGRPNLTVRTSATVG
TH_4204|M.thermoresistible__bu INESDDERIGYATATIK---NGRRVSAARAFLKPALRRANLSVRTRAVAQ
Mflv_1255|M.gilvum_PYR-GCK INESDGERIGYATSTIR---GGRRVSAATAFLKPVLHRPNLTVRTGATVR
. * * *. .: * : * ** . : * .
Rv1279|M.tuberculosis_H37Rv RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDR
Mb1310|M.bovis_AF2122/97 RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDR
MMAR_4141|M.marinum_M RIVIHGTRATGIEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGDR
MUL_4004|M.ulcerans_Agy99 RIVIHGTRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGDR
MAB_0250|M.abscessus_ATCC_1997 RVLFDGIRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSGIGEA
MAV_4980|M.avium_104 RLRIRGSRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGPP
Mvan_1606|M.vanbaalenii_PYR-1 RVPVHMQRATGVEFEMAGTTHRIDAGVETVLCLGAIHTPKVLMHSGIGDA
MSMEG_0526|M.smegmatis_MC2_155 RILFEGTRAVGVDVTGTSGTTQVRASREVIVSLGSLNSPVLLQLSGIGPR
TH_4204|M.thermoresistible__bu RILLAGGRAVGLEIASRGRTGKVYATREVIIAMGSLNTPKLLQLSGIGPR
Mflv_1255|M.gilvum_PYR-GCK RVLFDGERADGVEIATGAGTEQVRAAREVVLSLGSLNSPKLLQLSGIGPS
*: . *. *:: * * ::. *:: :* :* ****
Rv1279|M.tuberculosis_H37Rv DHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEKP
Mb1310|M.bovis_AF2122/97 DHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEKP
MMAR_4141|M.marinum_M SHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LAAAEKP
MUL_4004|M.ulcerans_Agy99 SHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LAAAEKP
MAB_0250|M.abscessus_ATCC_1997 TRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDS------LFGAEKP
MAV_4980|M.avium_104 NHLRSFRVDVALELPGVGANLQDHPIVPL--------------VYRAARP
Mvan_1606|M.vanbaalenii_PYR-1 AELHRLGIAPVQHLPGVGANLQDHPGFGC--------------VWEYRDP
MSMEG_0526|M.smegmatis_MC2_155 EVLRSAGVQVFIEHDRVGRGLREHRCATLRFDLIEDLGYNKQLASSVAQA
TH_4204|M.thermoresistible__bu EVLDAAGVPVYLDRANVGRRMREHRCATLRFDLREDLGYNRLLATGTGQA
Mflv_1255|M.gilvum_PYR-GCK DVLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGYNKLLATNVGQA
* : . ** : :* .
Rv1279|M.tuberculosis_H37Rv GQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAP----FY
Mb1310|M.bovis_AF2122/97 GQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAP----FY
MMAR_4141|M.marinum_M MQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAP----FY
MUL_4004|M.ulcerans_Agy99 MQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAP----FY
MAB_0250|M.abscessus_ATCC_1997 LQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAP----FF
MAV_4980|M.avium_104 VPAG----------RYNHGELLGLIRRHATGGPPEIQIFGVDS-------
Mvan_1606|M.vanbaalenii_PYR-1 LPP-----------RNTASEATYFWKSDPQLPTPDLQTCQVEVPL--TSA
MSMEG_0526|M.smegmatis_MC2_155 LTGLRYLATRRGPLGAPSFDIVGFVKTRADVDRPDGQIMMGPYTLPPYN-
TH_4204|M.thermoresistible__bu LTGAKYLATRKGPLAAPSFDVVGFVKTQPGLDRPDGQIMLGPWTIPPYNQ
Mflv_1255|M.gilvum_PYR-GCK LTGMKYLATRKGPLAAPSFDVVGFVKDRPDSERPLGQVMMGPWTLPPYN-
: : : . * :
Rv1279|M.tuberculosis_H37Rv DEALVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLG
Mb1310|M.bovis_AF2122/97 DEALVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLG
MMAR_4141|M.marinum_M DEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSDPG
MUL_4004|M.ulcerans_Agy99 DEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSDPG
MAB_0250|M.abscessus_ATCC_1997 DEGIGV-ATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDPA
MAV_4980|M.avium_104 ADVPGLGG-ADGYVLGVSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSDDR
Mvan_1606|M.vanbaalenii_PYR-1 ENAARFGVPQAGWTMFAGVVRPASRGRVWLSSAQPSDPVHIDTGMLSDPA
MSMEG_0526|M.smegmatis_MC2_155 VGEPVTIQRQAGLSCLGMVLRPTSEGALEITSSGPRPSVRIEPNYLGSEH
TH_4204|M.thermoresistible__bu SGEPVVIPRQAGVSALGMALRPTSEGTVEITAVDPAAPLRIDPNYLGSDA
Mflv_1255|M.gilvum_PYR-GCK TGEPVVIEREPGISCLGMVLRPTSQGYVEITSADPGAALRITPNYLTTEH
. : * * * : : . * . *
Rv1279|M.tuberculosis_H37Rv GVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALAT
Mb1310|M.bovis_AF2122/97 GVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALAT
MMAR_4141|M.marinum_M GVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTT
MUL_4004|M.ulcerans_Agy99 GVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTT
MAB_0250|M.abscessus_ATCC_1997 GRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALEN
MAV_4980|M.avium_104 --DMGLMIEGLRIGRKIGMSQALDPWRAEELAPGDDA-VDDAALRSYIQR
Mvan_1606|M.vanbaalenii_PYR-1 --DVAAAVAAVELCREIGNAAPLRPFTKREVMPGN---LRGPALEEFVRN
MSMEG_0526|M.smegmatis_MC2_155 --DRTATADLLRRMRAVFAESPIAERISHETFPGPGVATDDELVDSALDG
TH_4204|M.thermoresistible__bu --DRETTANLLRRMRSVFEQSPIAERISHETFPGPHIRSDDELVDAALDG
Mflv_1255|M.gilvum_PYR-GCK --DRTATAALVRRMRSIFEQSPIAERISHETYPGPRVDSDEELVDAALEG
* :. : .: * : :
Rv1279|M.tuberculosis_H37Rv CSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHT
Mb1310|M.bovis_AF2122/97 CSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHT
MMAR_4141|M.marinum_M CSHTLYHPLGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHT
MUL_4004|M.ulcerans_Agy99 CSHTLYHPLGTCRMGSDEASVVDRQLRVRGVDGLRVADASVMPSTVRGHT
MAB_0250|M.abscessus_ATCC_1997 NSHTLYHPVGTCRMGADDASVVTPDLTVRGVQGLRVVDASVIPSLIRGHT
MAV_4980|M.avium_104 SVASYFHPVGTCAMGTGPESVVDNQLRLHGIDNLRVIDASVMPSLPSNNT
Mvan_1606|M.vanbaalenii_PYR-1 AASTYWHPTGTAKMGRDDMSVVDGALRVYGVAGLRVADGSIMPRVSTGNT
MSMEG_0526|M.smegmatis_MC2_155 G-YCGYHAVGTCAMGPGDDAVVDDRLRVRGVDGLRVVDCSVLPTMVAGNL
TH_4204|M.thermoresistible__bu G-YCGYHAIGTCAMGPSDDDVVDPQLRVRGVDGLRVVDCSVLPVMVAGNL
Mflv_1255|M.gilvum_PYR-GCK G-YCGYHAVGTCAMGPDDDDVVDSHLRVRGVDGLRVVDCSVMPTIVAGNL
:*. **. ** . ** * : *: .*** * *::* .:
Rv1279|M.tuberculosis_H37Rv HAPSVLIGEKAADLIRS-------
Mb1310|M.bovis_AF2122/97 HAPSVLIGEKAADLIRS-------
MMAR_4141|M.marinum_M HAPSVLIGAKAADLIRN-------
MUL_4004|M.ulcerans_Agy99 HAPSVLIGAKAADLIRN-------
MAB_0250|M.abscessus_ATCC_1997 HAPSVLLGEKAADLILSPQP----
MAV_4980|M.avium_104 AATVYAIAERGADLVRLG------
Mvan_1606|M.vanbaalenii_PYR-1 MAPCVVIGERAAALLGATHGLRAA
MSMEG_0526|M.smegmatis_MC2_155 NGPIMAVAWRAADFILDR------
TH_4204|M.thermoresistible__bu NGPIMAVAWRAADLIRQDL-----
Mflv_1255|M.gilvum_PYR-GCK NGPIMAMAWRAADFILHGR-----
.. :. :.* ::