For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_3275 (-)

annotation: putative oxidoreductase, GMC family protein
coordinates: 4384144 - 4385805
length: 554

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3275--100% (554)putative oxidoreductase, GMC family protein
M. thermoresistible (build 8)TH_4204-4e-8334.86% (545) PUTATIVE glucose-methanol-choline oxidoreductase
M. thermoresistible (build 8)TH_4588-7e-2532.64% (288) PUTATIVE glucose-methanol-choline oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1310-7e-8137.00% (546) dehydrogenase FAD flavoprotein GMC oxidoreductase
M. gilvum PYR-GCKMflv_1255-3e-7633.76% (542) glucose-methanol-choline oxidoreductase
M. tuberculosis H37RvRv1279-7e-8137.00% (546) dehydrogenase FAD flavoprotein GMC oxidoreductase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0250-2e-7535.05% (545) GMC-type oxidoreductase
M. marinum MMMAR_4141-4e-8136.75% (547) dehydrogenase fad flavoprotein GMC oxidoreductase
M. avium 104MAV_4980-2e-6033.82% (479) choline dehydrogenase
M. smegmatis MC2 155MSMEG_0526-1e-8135.23% (545) oxidoreductase, GMC family protein
M. ulcerans Agy99MUL_4004-1e-7836.38% (547) dehydrogenase fad flavoprotein GMC oxidoreductase
M. vanbaalenii PYR-1Mvan_5894-2e-7835.04% (548) glucose-methanol-choline oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1310|M.bovis_AF2122/97            --------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKN
Rv1279|M.tuberculosis_H37Rv         --------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKN
MMAR_4141|M.marinum_M               --------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKN
MUL_4004|M.ulcerans_Agy99           --------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKN
MAB_0250|M.abscessus_ATCC_1997      ------MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKD
TH_3275|M.thermoresistible__bu      MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGKRHSVLVLEAGGSDLS
MAV_4980|M.avium_104                --------------------------------------------------
Mflv_1255|M.gilvum_PYR-GCK          -------MAVTGYDYIVVGAGSAGCVLANRLSADPAIRVLLLEAGRGDRN
MSMEG_0526|M.smegmatis_MC2_155      ---------MTSYDYIIAGAGSAGCVLANRLSEDPRIKVLLLEAGGSDRN
Mvan_5894|M.vanbaalenii_PYR-1       ---------MTDFDYIIVGAGSAGCVLAHRLSEDPRVNVLLIEAGGRDRS
                                                                                      

Mb1310|M.bovis_AF2122/97            RFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNA
Rv1279|M.tuberculosis_H37Rv         RFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNA
MMAR_4141|M.marinum_M               RFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIYWPRGKVLGGSSSMNA
MUL_4004|M.ulcerans_Agy99           RFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMNA
MAB_0250|M.abscessus_ATCC_1997      MGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNA
TH_3275|M.thermoresistible__bu      PFIRIPAGLMRVNPRNY-WHFRLEPDPTRNGAVDTWAAGRVVGGGSSVNA
MAV_4980|M.avium_104                ----MQTAIGRAVP---------------------FARGRGIGGSSTINA
Mflv_1255|M.gilvum_PYR-GCK          LWLHIPKGAGKLFDSERHMWHYETTPFGPDAHVEQWMRGKVIGGSSAVNG
MSMEG_0526|M.smegmatis_MC2_155      PLFSIPKGSGKLFDSEKHMWHYSTEPFGPNPHAEQWMRGKVLGGSSSING
Mvan_5894|M.vanbaalenii_PYR-1       PMIRIPKGVGKILGDPKLTWHFPVRPIGPSQIVEQWVRGKTLGGSSSVNG
                                        :  .  :                        :  .: :**.*::*.

Mb1310|M.bovis_AF2122/97            MMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSG
Rv1279|M.tuberculosis_H37Rv         MMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSG
MMAR_4141|M.marinum_M               MMWVRGFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGDDSG
MUL_4004|M.ulcerans_Agy99           MMWVRGFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGDDSG
MAB_0250|M.abscessus_ATCC_1997      MMWVRGFAADYDDWAQVAGEQWSFANIAPYFKRIEAVEG----ATESDEG
TH_3275|M.thermoresistible__bu      MLWVRGNRADFDTWAKLGAQGWDYESLLPAMRSLETWEG----GADRYRG
MAV_4980|M.avium_104                MVFARGHRDSYSRWRDNGAAGWSFDELLPYFKRSESTCG----KDPSLRG
Mflv_1255|M.gilvum_PYR-GCK          MIYNRGHRADYDALEQMGNKGWGWDEILPIFKGFEDHEFG----PSATRG
MSMEG_0526|M.smegmatis_MC2_155      MIYNRGTRADYDGLERLGNKGWGWDDILPIFKRFEDNEFG----PSATRG
Mvan_5894|M.vanbaalenii_PYR-1       MVYNRGSAPDYDALAALGNPAWGWDHILPAFRAIENHELG----PDPTRG
                                    *:: **   .:.     .   *.:  :   ::  *              *

Mb1310|M.bovis_AF2122/97            VTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPE-GFCETVVTQ
Rv1279|M.tuberculosis_H37Rv         VTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPE-GFCETVVTQ
MMAR_4141|M.marinum_M               VTGPLQISRQRSPSPLTAAWLAATRDCGFPPVQPNSAEPE-GFCETIVTQ
MUL_4004|M.ulcerans_Agy99           VTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQPNSAEPE-GFCETIVTQ
MAB_0250|M.abscessus_ATCC_1997      TDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTPEPK-GFSETMVCQ
TH_3275|M.thermoresistible__bu      GTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILADYNGESQFGAAWSQLSQ
MAV_4980|M.avium_104                QDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFGFTDLNI
Mflv_1255|M.gilvum_PYR-GCK          TGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRDINESDGERIGYATSTI
MSMEG_0526|M.smegmatis_MC2_155      VGGPLHISIPRDPDPLCEEMLAAAEASGLTRVQDINEHDTERIGYATSTI
Mvan_5894|M.vanbaalenii_PYR-1       TGGPLEISVDAHLPRICHDVIAAGEKLGWSATDDVNGSDAARIGPAPRTI
                                      *.  ::            : .    *       .         :    

Mb1310|M.bovis_AF2122/97            RRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDGQ
Rv1279|M.tuberculosis_H37Rv         RRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDGQ
MMAR_4141|M.marinum_M               RRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHGTRATGIEYQREGQ
MUL_4004|M.ulcerans_Agy99           RRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHGTRATGVEYQREGQ
MAB_0250|M.abscessus_ATCC_1997      HGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRDGI
TH_3275|M.thermoresistible__bu      KNGLRHSAAQAFLAPARRRGEVDVESHAVVDKVIIENGRAVGVEYVRRGT
MAV_4980|M.avium_104                VDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIRGSRCTGVEYTTAEG
Mflv_1255|M.gilvum_PYR-GCK          RGGRRVSAATAFLKPVLHRPNLTVRTGATVRRVLFDGERADGVEIATGAG
MSMEG_0526|M.smegmatis_MC2_155      RNGRRVSAATAFLKPALGRPNLTVRTSATVGRILFEGTRAVGVDVTGTSG
Mvan_5894|M.vanbaalenii_PYR-1       RNGQRVSSARAFLHPVAHRPNLTIATDTTVNRILFKADKAIGVQATTSKG
                                      * * *:. .:* *   * :: . : : . :: :   :. *::      

Mb1310|M.bovis_AF2122/97            -TRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVG
Rv1279|M.tuberculosis_H37Rv         -TRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVG
MMAR_4141|M.marinum_M               -HCTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIETVYHAPEVG
MUL_4004|M.ulcerans_Agy99           -HCTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIETVYHAPEVG
MAB_0250|M.abscessus_ATCC_1997      -THTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVG
TH_3275|M.thermoresistible__bu      -RKVAYAAKEVILSAGALCSPLILLRSGIGPAEELRDHGIDVIADLPGVG
MAV_4980|M.avium_104                -RQVTAAAREIILCAGAIGSPHLLLASGIGPPNHLRSFRVDVALELPGVG
Mflv_1255|M.gilvum_PYR-GCK          -TEQVRAAREVVLSLGSLNSPKLLQLSGIGPSDVLGAAGVPVLVERDNVG
MSMEG_0526|M.smegmatis_MC2_155      -TTQVRASREVIVSLGSLNSPVLLQLSGIGPREVLRSAGVQVFIEHDRVG
Mvan_5894|M.vanbaalenii_PYR-1       GAAVCTAGREVLLSLGSISTPRLLQLSGIGDRSLLRGLGIDTLADSPNVG
                                          * :*:::. *:: :* :*  ****    *    : .  .   **

Mb1310|M.bovis_AF2122/97            CNLLDHLVTVLGFDVEKDSLFAAEKPGQLIS------YLLRRRGMLTSNV
Rv1279|M.tuberculosis_H37Rv         CNLLDHLVTVLGFDVEKDSLFAAEKPGQLIS------YLLRRRGMLTSNV
MMAR_4141|M.marinum_M               QNLLDHLITPLGFDVAGDSLAAAEKPMQLIN------YLLRRRGMLTSNV
MUL_4004|M.ulcerans_Agy99           QNLLDHLITPLGFDVAGDSLAAAEKPMQLIN------YLLRRRGMLTSNV
MAB_0250|M.abscessus_ATCC_1997      QNLLDHLCCPVGYAVKSDSLFGAEKPLQLAN------YFLRHRGMLTSNV
TH_3275|M.thermoresistible__bu      RNLQEHPAITMTFTVTDRTLNQELTPLSILKGAF--DFVLRRRGPATAPL
MAV_4980|M.avium_104                ANLQDHPIVPLVYRAARPVPAGRYNHGELLG-------LIRR--HATGGP
Mflv_1255|M.gilvum_PYR-GCK          RRMREHRCATLRYRLKEDLGYNKLLATNVGQALTGMKYLATRKGPLAAPS
MSMEG_0526|M.smegmatis_MC2_155      RGLREHRCATLRFDLIEDLGYNKQLASSVAQALTGLRYLATRRGPLGAPS
Mvan_5894|M.vanbaalenii_PYR-1       RRMREHRCFALQFRLDRPVGYNRQLSTPLRQAFTAARYLATRRGPLAGAA
                                      : :*    : :               :         .  :     .  

Mb1310|M.bovis_AF2122/97            GEAYGFVRSRPELKLPDLELIFAPAPFYDEALVP---------PAGHGVV
Rv1279|M.tuberculosis_H37Rv         GEAYGFVRSRPELKLPDLELIFAPAPFYDEALVP---------PAGHGVV
MMAR_4141|M.marinum_M               GEAYGFVRSRPGLDLPDLELIFAPAPFYDEGLPAH--------PPGHGVV
MUL_4004|M.ulcerans_Agy99           GEAYGFVRSRPGLDLPDLELIFAPAPFYDEGLPAH--------PPGHGVV
MAB_0250|M.abscessus_ATCC_1997      GEAYGFLRSHPNLTLPDLELIFAPAPFFDEGIGV---------ATEHAIV
TH_3275|M.thermoresistible__bu      SHAMLFGPPLEPEGWPQYHVLMAPLGTEQEKPHATQEEAEQNRYDKQNVS
MAV_4980|M.avium_104                PEIQIFG--VDSADVPG-------LGG------------------ADGYV
Mflv_1255|M.gilvum_PYR-GCK          FDVVGFVKDRPDSERPLGQVMMGPWTLPPYNTGEP----VVIEREPGISC
MSMEG_0526|M.smegmatis_MC2_155      FDIVGFVKTRADVDRPDGQIMMGPYTLPPYNVGEP----VTIQRQAGLSC
Mvan_5894|M.vanbaalenii_PYR-1       FDVIGFFKTSPELERPDAQILMAPFSLAPYEQGKE----ATVERDPGIQA
                                     .   *         *                                  

Mb1310|M.bovis_AF2122/97            FG--------PILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAA
Rv1279|M.tuberculosis_H37Rv         FG--------PILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAA
MMAR_4141|M.marinum_M               FG--------PILVAPQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAA
MUL_4004|M.ulcerans_Agy99           FG--------PILVAPQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAA
MAB_0250|M.abscessus_ATCC_1997      MG--------PILLKPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAA
TH_3275|M.thermoresistible__bu      LSRNSIVSAFMSPLHPRGRGTVRLGSPDVDATPVIEHPMLAD--ERDVVD
MAV_4980|M.avium_104                LG--------VSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSD--DRDMGL
Mflv_1255|M.gilvum_PYR-GCK          LG---------MVLRPTSQGYVEITSADPGAALRITPNYLTT--EHDRTA
MSMEG_0526|M.smegmatis_MC2_155      LG---------MVLRPTSEGALEITSSGPRPSVRIEPNYLGS--EHDRTA
Mvan_5894|M.vanbaalenii_PYR-1       IG---------YLLRPDSEGSVAITSSDPEAPLDIDPGFLIT--THDREK
                                    :.           : * . * : : ..       *    *      *   

Mb1310|M.bovis_AF2122/97            MMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLY
Rv1279|M.tuberculosis_H37Rv         MMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLY
MMAR_4141|M.marinum_M               MMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTTCSHTLY
MUL_4004|M.ulcerans_Agy99           MMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTTCSHTLY
MAB_0250|M.abscessus_ATCC_1997      MMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLY
TH_3275|M.thermoresistible__bu      LTAAGRKVREIFQSPAMRPHVIAENAPSR-GVETDDEWAEFIRNHCFGGS
MAV_4980|M.avium_104                MIEGLRIGRKIGMSQALDPWRAEELAPGD-DAVDDAALRSYIQRSVASYF
Mflv_1255|M.gilvum_PYR-GCK          TAALVRRMRSIFEQSPIAERISHETYPGPRVDSDEELVDAALEGG-YCGY
MSMEG_0526|M.smegmatis_MC2_155      TADLLRRMRAVFAESPIAERISHETFPGPGVATDDELVDSALDGG-YCGY
Mvan_5894|M.vanbaalenii_PYR-1       GAALFRTMRRLFSQSPVADHLVAETRPGADVSSDQAIIDAALTQG-YCGY
                                         *    :    .:         *       :      :        

Mb1310|M.bovis_AF2122/97            HPMGTCRMGSD--EASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPS
Rv1279|M.tuberculosis_H37Rv         HPMGTCRMGSD--EASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPS
MMAR_4141|M.marinum_M               HPLGTCRMGSD--EASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPS
MUL_4004|M.ulcerans_Agy99           HPLGTCRMGSD--EASVVDRQLRVRGVDGLRVADASVMPSTVRGHTHAPS
MAB_0250|M.abscessus_ATCC_1997      HPVGTCRMGAD--DASVVTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPS
TH_3275|M.thermoresistible__bu      HWVGTARMGADSDPDAVVDPQLRVRGVSGLRVADASVMPTLTSGNTNAPC
MAV_4980|M.avium_104                HPVGTCAMGTG--PESVVDNQLRLHGIDNLRVIDASVMPSLPSNNTAATV
Mflv_1255|M.gilvum_PYR-GCK          HAVGTCAMGPD--DDDVVDSHLRVRGVDGLRVVDCSVMPTIVAGNLNGPI
MSMEG_0526|M.smegmatis_MC2_155      HAVGTCAMGPG--DDAVVDDRLRVRGVDGLRVVDCSVLPTMVAGNLNGPI
Mvan_5894|M.vanbaalenii_PYR-1       HAIGTCAMGPE--DDDVVDSALRVRGVRNLRIMDCSVMPTMVSGNLNGPV
                                    * :**. **.      **   * ::*: .**: *.**:*:   .:  .. 

Mb1310|M.bovis_AF2122/97            VLIGEKAADLIRS---
Rv1279|M.tuberculosis_H37Rv         VLIGEKAADLIRS---
MMAR_4141|M.marinum_M               VLIGAKAADLIRN---
MUL_4004|M.ulcerans_Agy99           VLIGAKAADLIRN---
MAB_0250|M.abscessus_ATCC_1997      VLLGEKAADLILSPQP
TH_3275|M.thermoresistible__bu      VLIGEKAAELIRGR--
MAV_4980|M.avium_104                YAIAERGADLVRLG--
Mflv_1255|M.gilvum_PYR-GCK          MAMAWRAADFILHGR-
MSMEG_0526|M.smegmatis_MC2_155      MAVAWRAADFILDR--
Mvan_5894|M.vanbaalenii_PYR-1       MAMAWRASDLILSGG-
                                      :. :.::::