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MDQQVQKLTPKGAATRRRIIEGAAAEIHSRGVADTTLDDIRARTGTSKSQLFHYFPGGKDQLMLAVAEHE AQQVLADQQPYLGDLTSWTSWQRWRDAVVDRYRRQGQHCPLSTLMSELGRSTPGAQAVSRALLRQWHDEI TTGIRHMQGHGEITADLDAERMAAALLAGIQGGVNVMLVTGDLTYLEAALDSGIAALQRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5206 | - | - | 100% (200) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2179 | - | 4e-18 | 32.99% (197) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4024 | - | 3e-16 | 30.53% (190) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0202 | - | 8e-10 | 25.93% (189) | putative transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3287 | - | 1e-09 | 28.26% (184) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0196 | - | 9e-10 | 25.93% (189) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 3e-05 | 22.50% (160) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1881c | - | 1e-26 | 35.75% (193) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3560 | - | 1e-08 | 27.33% (172) | transcriptional regulatory protein |
| M. avium 104 | MAV_0149 | - | 3e-10 | 25.75% (167) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0641 | - | 2e-06 | 26.71% (161) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2793 | - | 6e-09 | 27.91% (172) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4594 | - | 2e-83 | 75.76% (198) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5206|M.smegmatis_MC2_155 --------------MDQQVQKLTPKGAATRRRIIEGAAAEIHSRGVADTT
Mvan_4594|M.vanbaalenii_PYR-1 --------------MDSQVHKLTVKGRATRDRIVEGAAAEIRERGVAATT
MAB_1881c|M.abscessus_ATCC_199 ---MLSGMVGKSSPPSAAKLPATAHGRRTRAAIIDAAAQMMYQKGVAATS
Mb0202|M.bovis_AF2122/97 -------------------------MQGPRERMVVSAALLIRERGAHATA
Rv0196|M.tuberculosis_H37Rv -------------------------MQGPRERMVVSAALLIRERGAHATA
Mflv_3287|M.gilvum_PYR-GCK -------------------------MTTPRERMVVSAALLIRERGAHPTA
MMAR_3560|M.marinum_M --------------------------MTARERLIESAIELLRRNGVAGTG
MUL_2793|M.ulcerans_Agy99 --------------------------MTARERLIESAIELLRRNGVAGTG
MAV_0149|M.avium_104 ------------------------MATATRERFLTAATGLFRRQGYSGTG
TH_0641|M.thermoresistible__bu ----------------MAAETLSSKGRQTRLALEQAARKLFAERGFHGTT
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
. : * : .
MSMEG_5206|M.smegmatis_MC2_155 LDDIRARTGTSKSQLFHYFPGGKDQLMLAVAEHEAQQVLADQQPYLGDLT
Mvan_4594|M.vanbaalenii_PYR-1 LDDIRARTQTSKSQLFHYFPDGKDQLLLAVAEHEAHMVLEDQQPHLGELT
MAB_1881c|M.abscessus_ATCC_199 LDDILAASSTGKSQLYHYFKD-RSELVKAVVERQTELVLAAQ-PTLTQID
Mb0202|M.bovis_AF2122/97 ISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAGEHVAAMIN-EAEGGL
Rv0196|M.tuberculosis_H37Rv ISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAGEHVAAMIN-EAEGGL
Mflv_3287|M.gilvum_PYR-GCK IADVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAAEFMAERLS-RASSSL
MMAR_3560|M.marinum_M LADLLEHSGTARRSVYVNFPGGKSELMTEATRTAGRLMDSTLASIAAGGD
MUL_2793|M.ulcerans_Agy99 LADLLEHSGTARRSVYVNFPGGKSELMTEATRTAGRLMDSTLASIAAGGG
MAV_0149|M.avium_104 LKQIVAESRAPLGSLYHFFPGGKQDLAVQAIAHTAERYRELLDRVFAKST
TH_0641|M.thermoresistible__bu LADITSAAGKSPAVFYRYFVD-KEDLLAALAESFLREVLAPGWLSVRLPD
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLPA
: :: : : * . . * .
MSMEG_5206|M.smegmatis_MC2_155 SWTS-WQRWRDAVVDRYRRQGQ--HCPLSTLMSELGR-----STPGAQAV
Mvan_4594|M.vanbaalenii_PYR-1 SWAA-WRRWRDAVVDRYRRQGQ--HCPLAVLMSEIGR-----TTPGAEAV
MAB_1881c|M.abscessus_ATCC_199 SMDG-VEQWAQAILANHDVPGGPFGCPLGSMAAELK------NDPAYQPA
Mb0202|M.bovis_AF2122/97 EL---LDALIDKYRQQLLSTDFRAGCPIAAVSVEAGDEQDRERMAPVIAR
Rv0196|M.tuberculosis_H37Rv EL---LDALIDKYRQQLLSTDFRAGCPIAAVSVEAGDEQDRERMAPVIAR
Mflv_3287|M.gilvum_PYR-GCK RV---LDDLFGYYRTQLQDSDFRAGCPVVAVAVESGDPDKPEQSAPVIER
MMAR_3560|M.marinum_M QP---LVAFADSWKQTLRASDYAAGCPIVAAALG------RTESPSAADA
MUL_2793|M.ulcerans_Agy99 QP---LVAFADSWKQTLRASDYAAGCPIVAAALG------RTESPSAADV
MAV_0149|M.avium_104 DIGQATVTWFNWAARALQETDYADGCPIGTVACEV-----ASSNEALRQA
TH_0641|M.thermoresistible__bu SPDD-DEFFTTVVGGYWNMFKQNIGIMIAVDQLA--------ATQQRFAD
MLBr_01070|M.leprae_Br4923 DP---AAVWRSAITAFFEVCGTHRAVAVAGAAAKA-------TSPEVRRL
:
MSMEG_5206|M.smegmatis_MC2_155 SRALLRQWHDEITTGIRHMQGHGEITADLDAERMAAALLAGIQG--GVNV
Mvan_4594|M.vanbaalenii_PYR-1 SAALVTKWHGEIATGIRDMQAQGKIADRVDADRTAAALLAGIQG--GVGI
MAB_1881c|M.abscessus_ATCC_199 LAAAFGQWQSLLADGLIRMQDRGHLDPHEDPQRLAAAVLATLQG--GMLM
Mb0202|M.bovis_AF2122/97 AAAVFDRWSDLTAQRFIADG-----IPPDRAHELAVLATSTLEG--AILL
Rv0196|M.tuberculosis_H37Rv AAAVFDRWSDLTAQRFIADG-----IPPDRAHELAVLATSTLEG--AILL
Mflv_3287|M.gilvum_PYR-GCK AAAALTRWSDIIEQRLIADG-----VPRADAAALAMLVLTSFEG--AIVV
MMAR_3560|M.marinum_M AGEVFGAWQTVLAGRFRAQG-----VGDDTAESLATTVVAAVEG--AVIL
MUL_2793|M.ulcerans_Agy99 AGEVFGAWQTVLAGRFRAQG-----VGDDTAESLATTVVAAVEG--AVIL
MAV_0149|M.avium_104 TQAVLASWQSRVAAELIGAG-----VPTAQARRLATFAVASLEG--AILL
TH_0641|M.thermoresistible__bu VQNEFRRFGMDIVAASVRHAQQQGYGTDLDPQHIAAAIALMFENFTAVFV
MLBr_01070|M.leprae_Br4923 WSTVMQQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTER--VMAA
. : . * : :
MSMEG_5206|M.smegmatis_MC2_155 MLVTGDLTYLEAALDSGIAALQRG------
Mvan_4594|M.vanbaalenii_PYR-1 MLSTGDLGFLEAALDVGIAALRD-------
MAB_1881c|M.abscessus_ATCC_199 GRATMDITVLRDSLEMALDSIRRALRD---
Mb0202|M.bovis_AF2122/97 ARVRRDLTPLDLVHRQLRNLLLAELPERSR
Rv0196|M.tuberculosis_H37Rv ARVRRDLTPLDLVHRQLRNLLLAELPERSR
Mflv_3287|M.gilvum_PYR-GCK ARATRDLKPLDLVAGQLASLIDARTVTRRK
MMAR_3560|M.marinum_M CLAARSTDPLDRTVPMLQQLIAQHTSRPSG
MUL_2793|M.ulcerans_Agy99 CLAARSTDPLDRTVPMLQQLIAQHTSRPSG
MAV_0149|M.avium_104 ARAHRSTRPLRETGRVVADTLRAATDRG--
TH_0641|M.thermoresistible__bu GRGGPGLQISDADAVRTLATIWKKTLYGC-
MLBr_01070|M.leprae_Br4923 TFSDEKPLIPDKKVIDTLVHIWLASIYGS-
: