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TAADALPTRGFTAKGLATRDRILRCAADVLLSGGLQGFNVEKVRQAASVSGSQINHYFGDRGDLIRAVLR RQLDIVLDFHRQPALGGLDTFEDWQRWADLNVRYLRKIGYRGTATYHALAGQLAKTDEDTRKTFAEGYWR WITLLEDGFHRMRSAGLLRPDADPRHLAVIVVGIHQGAGLLAFTYRQEWPLVDATQFLVNYIRMFAKDPQ QRRVQPIPRRRDRPRGRPPQETAALGFTRKGLATRSRILEGAAQLILQHGVNGTSLDDVRAEVGVSGSQM SHYFATKQDLVRQVIAARTDFVLAFHAQPEMGGLRNISSLHKWAELCWLQGGENYLRNGCVYGSLTSELL EADDEVLDDIAAGYDRWLALFYDGMTAMVRQHDLRDDADPRHLAAVLVIAHQGSTMLTHITSSSEPFKAA MTGALNYVGNFATSKSPRRERRRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4024 | - | - | 100% (445) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2179 | - | e-135 | 57.28% (426) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_5206 | - | 9e-16 | 30.53% (190) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2184c | - | 2e-06 | 23.47% (196) | hypothetical protein Mb2184c |
| M. gilvum PYR-GCK | Mflv_0013 | - | 5e-07 | 22.53% (293) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1685c | - | 1e-05 | 42.31% (52) | hypothetical protein Rv1685c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3312 | - | 1e-34 | 38.97% (195) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4674 | - | 3e-07 | 35.06% (77) | transcriptional regulator |
| M. avium 104 | MAV_2588 | - | 2e-09 | 29.82% (171) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4015 | - | 2e-07 | 25.41% (185) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0293 | - | 2e-07 | 35.06% (77) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4594 | - | 1e-14 | 31.82% (176) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4024|M.smegmatis_MC2_155 -------------------MTAADALPTRGFTAKGLATRDRILRCAADVL
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4674|M.marinum_M --------------------------------------------------
MUL_0293|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 ----------MARTPDKLRRSGYAPAANHGVGRRGLHTRERILGSAAEVF
Rv1685c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK MAVRKKPTRARGAGRSVRVCRMAASVGVRDARRRPKDRKQQIARASAEAF
Mb2184c|M.bovis_AF2122/97 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 LSGGLQGFNVEKVRQAASVSGSQINHYFGDRGDLIRAVLRRQLDIVLDFH
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4674|M.marinum_M --------------------------------------------------
MUL_0293|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 LANGFHATSLDAIAKTAGASRATVYQYFAGKEEIFRELSALAERDVLAHG
Rv1685c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK SELGYHAVSMEDIASRVGVTAASLYRHYSGKYDLFRAAVLNLGEQLVSAT
Mb2184c|M.bovis_AF2122/97 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 RQPALGGLDTFEDWQRWADLNVRYLRKIGYRGTATYHALAGQLAKTDEDT
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4674|M.marinum_M --------------------------------------------------
MUL_0293|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 EHLGELG-PTVDGVDALHRWLVAWADIYDAHAAVFAEFPGIGTATGLAVI
Rv1685c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK AFADDESGDSPEELWERIVAALADAAIKTRASGGLYRWEARFLQESDQAI
Mb2184c|M.bovis_AF2122/97 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 RKTFAEGYWRWITLLEDGFHRMRSAGLLRPDADPRHLAVIVVGIHQGAGL
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4674|M.marinum_M --------------------------------------------------
MUL_0293|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 DASSAAAQFHQTVTDRLRRTRLRDLEADDAAAALGRIPHMVHLYRYRDML
Rv1685c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK SNEQIR-LVNRRLQRPLSALRPELDSRQRWTVTASVLSAIGSICDHRAKL
Mb2184c|M.bovis_AF2122/97 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 LAFTYRQEWPLVDATQFLVNYIRMFAKDPQQRRVQPIPRRRDRPRGRPPQ
MAB_3312|M.abscessus_ATCC_1997 -----------------------MNGKTAVQR------HRK---------
MMAR_4674|M.marinum_M --------------------------------------------------
MUL_0293|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 -------------------------MDSQVHK------------------
MAV_2588|M.avium_104 PLPARATVTWSLTGALQLMLFPETPADVLQVVAPARDGCARTTPRALDYA
Rv1685c|M.tuberculosis_H37Rv -----------------------MAAPDNSRRRP----------------
Mflv_0013|M.gilvum_PYR-GCK PVNDMRRLLVSLARRLRDADLPPVSAREKPGRR-----------------
Mb2184c|M.bovis_AF2122/97 --------------------------------------------------
TH_4015|M.thermoresistible__bu ----VVPRRRVDNGSNEQGVASDATGGDRMNRP-----------------
MSMEG_4024|M.smegmatis_MC2_155 ETAALGFTRKGLATRSRILEGAAQLILQHGVNGTSLDDVRAEVGVSGSQM
MAB_3312|M.abscessus_ATCC_1997 ------LTEKGQATRARILEQAAELIHTKGVAATNNEQLRRVTGISGSQL
MMAR_4674|M.marinum_M ------MTKPRSDTRRRIQEVARELFLRQGVRGTSLQDIADRLGITKPAL
MUL_0293|M.ulcerans_Agy99 -----MVTKPRSDTRRRIQEVARELFLRQGVRGTSLQDIADRLGITKPAL
Mvan_4594|M.vanbaalenii_PYR-1 ------LTVKGRATRDRIVEGAAAEIRERGVAATTLDDIRARTQTSKSQL
MAV_2588|M.avium_104 AATPAAVEASGSPIPQDVLSVSSALFAERGYYAIGMEEIAAAADVSRATL
Rv1685c|M.tuberculosis_H37Rv -----GRPAGSSDTRERILSSARELFAHNGIDRTSIRAVAAKAGVDAALV
Mflv_0013|M.gilvum_PYR-GCK ----AAPSVGPAGEYEAILAAALRLFHEHGFRETGMDDIASAIGLPASTI
Mb2184c|M.bovis_AF2122/97 ----MPSADVGRQTRAQILRAAMDIASVKGLSGLSIGELAGRLGMSKSGL
TH_4015|M.thermoresistible__bu ----LPPTARGRRSRRALLDAAKEVFARDGFADARITDIADAAGTAHGSF
: : * : .
MSMEG_4024|M.smegmatis_MC2_155 SHYFATKQDLVRQVIAARTDFVLAFHAQ-PEMGG----LRNISSLHKWAE
MAB_3312|M.abscessus_ATCC_1997 NHYFPTKESLVMAVIEWQTEQVMRFYGS-EQFAG----FDTIEALRSWVD
MMAR_4674|M.marinum_M YYHFASREDLVRSIVVPLIEEGERFVAERERLAD----GNVRGLLEGYFD
MUL_0293|M.ulcerans_Agy99 YYHFASREDLVRSIVVPLIEEGERFVAERERLAD----GNVRGLLEGYFD
Mvan_4594|M.vanbaalenii_PYR-1 FHYFPDGKDQLLLAVAEHEAH-MVLEDQQPHLGE----LTSWAAWRRWRD
MAV_2588|M.avium_104 YRYFSTKDKILAELTRRAVAEIEKHAAALPAKAA----DSLTEWMLGYVR
Rv1685c|M.tuberculosis_H37Rv HHYFGTKQQLFAAAIHIPIDPMVIIGPIREAPVE----ELGYKLPSLLLP
Mflv_0013|M.gilvum_PYR-GCK YRYFSGKSAVLSTIYRRAADRVSGDMGAILAMAP----DERTAVGQLIDA
Mb2184c|M.bovis_AF2122/97 FRHFGAKEQLQLATVEAAVSVFEAEVVAPAMAAPPG-VDRVRALMHAWVG
TH_4015|M.thermoresistible__bu YRYFDSKEEIFIELLRELVEELRQPVRTDAGTEPKNPYERILRANRTYLE
:* .
MSMEG_4024|M.smegmatis_MC2_155 LCWLQGGENYLRNGCVYGSLTSELLEADDEVLDDIAAGYDRWLALFYDGM
MAB_3312|M.abscessus_ATCC_1997 YYVTH--ESAYRDGCTLGSLASQIIKSDLQVHDELARAFDQWRNIFRDGL
MMAR_4674|M.marinum_M FHYRH-------------RQDLMLVVVELTLLSDLG--------LIDTVL
MUL_0293|M.ulcerans_Agy99 FHYRH-------------RQDLMLVVVELTLLSDLG--------LIDTVL
Mvan_4594|M.vanbaalenii_PYR-1 AVVDR--YRRQGQHCPLAVLMSEIGRTTPGAEAVSAALVTKWHGEIATGI
MAV_2588|M.avium_104 FHRTYR-------GVIRAWFDGAVAEQLSNADVDHG------IGAIFQAV
Rv1685c|M.tuberculosis_H37Rv IWDSELG------AGLIATLRSLISGSDVGLARSFLEEVVT--VELGSRV
Mflv_0013|M.gilvum_PYR-GCK YVWRT---------FAEPELAYVYYAEQLNVPAEDRAALHNIQRSIVEGW
Mb2184c|M.bovis_AF2122/97 YLERDVFPG----GCFFAAAAADVDSQPGPVRDRIAATGRAGIAAITADV
TH_4015|M.thermoresistible__bu AYRAN---------RAIMIVWEQVASLNEHVEQLRREYSDRFAARIERAI
:
MSMEG_4024|M.smegmatis_MC2_155 TAMVRQHDLRDDADPRHLAAVLVIAHQGSTMLTHITSSSEPFKAAMTGAL
MAB_3312|M.abscessus_ATCC_1997 RRMQSLGRLSATADPTQLADLLLSAFQGGMLLTQVQRDVTPLKNALHAAI
MMAR_4674|M.marinum_M AWRERLGRLVFGAAPTLGQATRAVLAFGGLQDCCMQFPDEPYAQLRQYSV
MUL_0293|M.ulcerans_Agy99 ARRERLGRLVFGAAPTLGQATRAVLAFGGLQDCCMQFPDEPYAQLRQYSV
Mvan_4594|M.vanbaalenii_PYR-1 RDMQAQGKIADRVDADRTAAALLAGIQGGVGIMLSTGDLGFLEAALDVGI
MAV_2588|M.avium_104 AALLSTVDLPPGIDADVAGAVFVAVLGRMSEPTGASGPNSDEQAAELMVK
Rv1685c|M.tuberculosis_H37Rv DNPPGTGKIRTQFVASQLMGVVMARYIVRIEPFASLPAEQIVQTIAPNLQ
Mflv_0013|M.gilvum_PYR-GCK ARQVVAARPDLSVREARFAVHAGLGLVVDIGRLERFADTESSRRLIGRLL
Mb2184c|M.bovis_AF2122/97 ETAQRRGEIRADIEARQLAFELHAYAMEANWALLLLDDDGAGERARTAID
TH_4015|M.thermoresistible__bu IRWQEAGLADPAIDPRYAAAALSGMLSNFAYRWSVQDADYDLDTAAEQLS
MSMEG_4024|M.smegmatis_MC2_155 NYVGNFATSKSPRRERRRG-
MAB_3312|M.abscessus_ATCC_1997 DHVQTFAE------------
MMAR_4674|M.marinum_M EAALAALGV-----------
MUL_0293|M.ulcerans_Agy99 EAALAALGV-----------
Mvan_4594|M.vanbaalenii_PYR-1 AALRD---------------
MAV_2588|M.avium_104 LLRRSLLREA----------
Rv1685c|M.tuberculosis_H37Rv RYLTGELPDDLAP-------
Mflv_0013|M.gilvum_PYR-GCK RVLLLPEHA-----------
Mb2184c|M.bovis_AF2122/97 AALARVGTTQEGVES-----
TH_4015|M.thermoresistible__bu LLWANALGVRVPAHHEPAHA