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MVTTGLSDGERFTAKGRATRERILQAAAQVILEEGLSALSLDRVRQVASVSGSQLSHYFTDKRALVRAVL ERQMGLVLDFHRQPALGGLDSFDDFERWLNLTVRQLRKIGYTGTPTYHALAGQLAKSDAATRETLAAGYR EWMALLEASFERMRDRRLLVATARPRELAMVFVAGHQGAGMLTFTYRQEWPLSDTFRFMVNYLRLFATDP AERVPRPPRPVRDRRARSVANDVAAQRFTRKGLATRTRIIDGAADLMFRNGVLSTSLDDVRREVGVSGSQ LTHYFADKSDLIRQVVAARAAEATAQPELAGLDSIDALREWAKACGRQAETVYLRGGCIYGSLTGELLEQ RDVLDDLAAGYDRWLQLFRDGVDVMCRNGELGEGVEPRHLAVALLAAHQGGTMVAFAMGDREPVDVTVGA AVEYVASFAASQAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2179 | - | - | 100% (434) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4024 | - | e-135 | 57.28% (426) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5206 | - | 1e-17 | 32.99% (197) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0149 | - | 4e-07 | 33.70% (92) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2447 | - | 3e-08 | 31.37% (153) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0144 | - | 4e-07 | 33.70% (92) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02457 | - | 6e-07 | 33.00% (100) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3312 | - | 5e-30 | 36.87% (198) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4335 | - | 2e-07 | 28.57% (196) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2588 | - | 2e-10 | 24.77% (331) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0256 | - | 6e-08 | 31.85% (135) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_0145 | - | 2e-07 | 30.61% (147) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4594 | - | 5e-16 | 33.51% (185) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2179|M.smegmatis_MC2_155 ------------------------MVTTGLSDGE----------------
MAB_3312|M.abscessus_ATCC_1997 -----------------------MNGKTAVQRHR----------------
Mb0149|M.bovis_AF2122/97 MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAKLTSSV
Rv0144|M.tuberculosis_H37Rv MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAKLTSSV
MMAR_4335|M.marinum_M ---------------------------MSTDSHG----------------
MUL_0145|M.ulcerans_Agy99 ---------------------------MSTDSHG----------------
Mflv_2447|M.gilvum_PYR-GCK -----------------MSAPESVGSDLETSRRP----------------
TH_0256|M.thermoresistible__bu ----------------------------VTQTRP----------------
Mvan_4594|M.vanbaalenii_PYR-1 ---------------------------MDSQVHK----------------
MAV_2588|M.avium_104 --------------MARTPDKLRRSGYAPAANHG----------------
MLBr_02457|M.leprae_Br4923 ------------------MAEHIPAVAVKTDGRK----------------
MSMEG_2179|M.smegmatis_MC2_155 ------------------------------RFTAKGRATRERILQAAAQV
MAB_3312|M.abscessus_ATCC_1997 ------------------------------KLTEKGQATRARILEQAAEL
Mb0149|M.bovis_AF2122/97 ASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQV
Rv0144|M.tuberculosis_H37Rv ASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQV
MMAR_4335|M.marinum_M ------------------------------RRWAKTDATQRRILDAATEV
MUL_0145|M.ulcerans_Agy99 ------------------------------RRWAKTDATQRRILDAATEV
Mflv_2447|M.gilvum_PYR-GCK ----------------------------YAALFAKGEDRRQRILAVAERL
TH_0256|M.thermoresistible__bu ----------------------------YETLLAKGEDRRQRILAVAERL
Mvan_4594|M.vanbaalenii_PYR-1 -------------------------------LTVKGRATRDRIVEGAAAE
MAV_2588|M.avium_104 -------------------------------VGRRGLHTRERILGSAAEV
MLBr_02457|M.leprae_Br4923 -----------------------------RRWHQHKVERRNELVDGTIDA
: : .:: :
MSMEG_2179|M.smegmatis_MC2_155 ILEEGLSALSLDRVRQVASVSGSQLSHYFTD-KRALVRAVLERQMGLVLD
MAB_3312|M.abscessus_ATCC_1997 IHTKGVAATNNEQLRRVTGISGSQLNHYFPT-KESLVMAVIEWQTEQVMR
Mb0149|M.bovis_AF2122/97 FSERGYDGATFQEIAVRADLTRPAINHYFAN-KRVLYQEVVEQTHELVIV
Rv0144|M.tuberculosis_H37Rv FSERGYDGATFQEIAVRADLTRPAINHYFAN-KRVLYQEVVEQTHELVIV
MMAR_4335|M.marinum_M FATRGFNAATMAEVVASSGASIGSIYHHFGG-KTELFLAIFEQMAS-AVE
MUL_0145|M.ulcerans_Agy99 FATRGFNAATMAEVVASSGASIGSIYHHFGG-KTELFLAIFEQMAS-AVE
Mflv_2447|M.gilvum_PYR-GCK LARNGWRNTSLAQIAREAGVTPAGLLHHFES-KEQLLNAVLDARDADDDA
TH_0256|M.thermoresistible__bu LARNGWRNTSLAQIAKEAGVSPAGLLHHFES-KEALLNAVLDARDADDDA
Mvan_4594|M.vanbaalenii_PYR-1 IRERGVAATTLDDIRARTQTSKSQLFHYFPDGKDQLLLAVAEHEAHMVLE
MAV_2588|M.avium_104 FLANGFHATSLDAIAKTAGASRATVYQYFAG-KEEIFRELSALAERDVLA
MLBr_02457|M.leprae_Br4923 IRRQGR-FLSMDEIAGKIGVSKTVLYRYFID-KNDLTTAVMMRFAQTTLI
: .* . : : : ::* * : :
MSMEG_2179|M.smegmatis_MC2_155 FHRQPALGGLDSFDDFERWLNLTVRQLRKIGYTGTPTYHALAGQLAKSDA
MAB_3312|M.abscessus_ATCC_1997 FY------------------------------------------------
Mb0149|M.bovis_AF2122/97 AG------------------------------------------------
Rv0144|M.tuberculosis_H37Rv AG------------------------------------------------
MMAR_4335|M.marinum_M GK------------------------------------------------
MUL_0145|M.ulcerans_Agy99 GK------------------------------------------------
Mflv_2447|M.gilvum_PYR-GCK HAD-----------------------------------------------
TH_0256|M.thermoresistible__bu HAD-----------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 DQQ-----------------------------------------------
MAV_2588|M.avium_104 HGEHLGELGPTVDGVDALHRWLVAWADIYDAHAAVFAEFPGIGTATGLAV
MLBr_02457|M.leprae_Br4923 PN------------------------------------------------
MSMEG_2179|M.smegmatis_MC2_155 ATRETLAAGYREWMALLEASFERMRDRRLLVATARPRELAMVFVAGHQGA
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0149|M.bovis_AF2122/97 --------------------------------------------------
Rv0144|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4335|M.marinum_M --------------------------------------------------
MUL_0145|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2447|M.gilvum_PYR-GCK --------------------------------------------------
TH_0256|M.thermoresistible__bu --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 IDASSAAAQFHQTVTDRLRRTRLRDLEADDAAAALGRIPHMVHLYRYRDM
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
MSMEG_2179|M.smegmatis_MC2_155 GMLTFTYRQEWPLSDTFRFMVNYLRLFATDPAERVPRPPRPVRDRRARSV
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0149|M.bovis_AF2122/97 --------------------------------------------------
Rv0144|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4335|M.marinum_M --------------------------------------------------
MUL_0145|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2447|M.gilvum_PYR-GCK --------------------------------------------------
TH_0256|M.thermoresistible__bu --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 LPLPARATVTWSLTGALQLMLFPETPADVLQVVAPARDGCARTTPRALDY
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
MSMEG_2179|M.smegmatis_MC2_155 ANDVAAQRFTRKGLATRTRIIDGAADLMFRNGVLSTSLDDVRREVGVSGS
MAB_3312|M.abscessus_ATCC_1997 ------------------------------------------------GS
Mb0149|M.bovis_AF2122/97 --------------------------------------------------
Rv0144|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4335|M.marinum_M --------------------------------------------------
MUL_0145|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2447|M.gilvum_PYR-GCK --------------------------------------------------
TH_0256|M.thermoresistible__bu --------------------------------------------------
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2588|M.avium_104 AAATPAAVEASGSPIPQDVLSVSSALFAERG-------------------
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
MSMEG_2179|M.smegmatis_MC2_155 QLTHYFADKSDLIRQVVAARAAEATAQPELAGLDSIDALREWAKACGRQA
MAB_3312|M.abscessus_ATCC_1997 ---------------------------EQFAGFDTIEALRSWVDYY-VTH
Mb0149|M.bovis_AF2122/97 --------------------------IERARREPTLMGRLAVVVDFAMEA
Rv0144|M.tuberculosis_H37Rv --------------------------IERARREPTLMGRLAVVVDFAMEA
MMAR_4335|M.marinum_M --------------------------IEEALQQAGDETDRRRIFELGVRA
MUL_0145|M.ulcerans_Agy99 --------------------------IEEALQQAGDETDRRRIFELGVRA
Mflv_2447|M.gilvum_PYR-GCK ------------------------------RGGDLVTELARVPERFERSP
TH_0256|M.thermoresistible__bu ------------------------------RSGDLIAEIARVAERFDRAP
Mvan_4594|M.vanbaalenii_PYR-1 ---------------------------PHLGELTSWAAWRRWRDAVVDRY
MAV_2588|M.avium_104 ------------YYAIGMEEIAAAADVSRATLYRYFSTKDKILAELTRRA
MLBr_02457|M.leprae_Br4923 ------------------------MAAALSTNLDGFDLTREIIRVYVKTV
MSMEG_2179|M.smegmatis_MC2_155 ETVYLRGGCIYGSLTGELLE-QRDVLDDLAAGYDRWLQLFRDGVDVMCR-
MAB_3312|M.abscessus_ATCC_1997 ESAY-RDGCTLGSLASQIIKSDLQVHDELARAFDQWRNIFRDGLRRMQS-
Mb0149|M.bovis_AF2122/97 DAQYPASTAFLATTVLESQR-----HPELSRTENDAVRATREFLVWAVND
Rv0144|M.tuberculosis_H37Rv DAQYPASTAFLATTVLESQR-----HPELSRTENDAVRATREFLVWAVND
MMAR_4335|M.marinum_M YLDGLWEHRRVARLLASGDR-----PTDFGITRRD--RMTSAFRSWMA--
MUL_0145|M.ulcerans_Agy99 YLDGLWEHRRVARLLASGDR-----PTDFGITRRD--RMTSAFRSWMA--
Mflv_2447|M.gilvum_PYR-GCK ELVGTFMVLLAENIAPDAPL-----HDRLHKRYRDAVDIIEDIITRGQR-
TH_0256|M.thermoresistible__bu HLVGTFTVLLVENIQPEAPL-----HDRMLARQRAAIDIVADLIRRGQE-
Mvan_4594|M.vanbaalenii_PYR-1 RRQG--QHCPLAVLMSEIGRTTPGAEAVSAALVTKWHGEIATGIRDMQA-
MAV_2588|M.avium_104 VAEIEKHAAALPAKAADSLTEWMLGYVRFHRTYRGVIRAWFDGAVAEQLS
MLBr_02457|M.leprae_Br4923 AAEPEPYQFVMANSSASKSKVIADSERIIARMLAVMIRRRMQEAGMDAGG
.
MSMEG_2179|M.smegmatis_MC2_155 -----------NGELGEGVEPRHLAVALLAAHQGGTMVAFAMGDREPVDV
MAB_3312|M.abscessus_ATCC_1997 -----------LGRLSATADPTQLADLLLSAFQGGMLLTQVQRDVTPLKN
Mb0149|M.bovis_AF2122/97 --------AIERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMAT
Rv0144|M.tuberculosis_H37Rv --------AIERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMAT
MMAR_4335|M.marinum_M -----------VLELDSSLHGQFLSRALLAIMEESSLMVAACEEPEQVKP
MUL_0145|M.ulcerans_Agy99 -----------VLELDSSLHGQFLSRALLR--------------------
Mflv_2447|M.gilvum_PYR-GCK -----------KGLYRTDFDAASKATEILAFINGMETLWLLDPSIPLTEV
TH_0256|M.thermoresistible__bu -----------SGRYRSDFDAATKAVEIIAFVNGMETSWLLDPSIPVAEV
Mvan_4594|M.vanbaalenii_PYR-1 -----------QGKIADRVDADRTAAALLAGIQGGVGIMLSTGDLGFLEA
MAV_2588|M.avium_104 NADVDHGIGAIFQAVAALLSTVDLPPGIDADVAGAVFVAVLGRMSEPTGA
MLBr_02457|M.leprae_Br4923 ---VEPWAYLIVGGVQLATHSWMSDPRMSADELIDYLTMLSWNALCGIVE
:
MSMEG_2179|M.smegmatis_MC2_155 TVGAAVEYVASFAASQAR-------
MAB_3312|M.abscessus_ATCC_1997 ALHAAIDHVQTFAE-----------
Mb0149|M.bovis_AF2122/97 ITDSFQQLLAGTLWRPPT-------
Rv0144|M.tuberculosis_H37Rv ITDSFQQLLAGTLWRPPT-------
MMAR_4335|M.marinum_M VIDATIEWIGRLTE-----------
MUL_0145|M.ulcerans_Agy99 ------SWRSRH-------------
Mflv_2447|M.gilvum_PYR-GCK FKGYAESLGRDLAL-----------
TH_0256|M.thermoresistible__bu FKGYAEMLERDFAPPNPT-------
Mvan_4594|M.vanbaalenii_PYR-1 ALDVGIAALRD--------------
MAV_2588|M.avium_104 SGPNSDEQAAELMVKLLRRSLLREA
MLBr_02457|M.leprae_Br4923 VGGSLEKFRKQPHPSPIIPPRGP--