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M. smegmatis MC2 155 MSMEG_5164 (-)

annotation: zinc-binding alcohol dehydrogenase family protein
coordinates: 5265330 - 5266328
length: 332

MPTMTAIGSFAALPVDDPDSLQDITIEVPELRPHDVLVRVEAVSVNPVDIKRRRSLSPSAEPTILGFDAA
GVVEAVGSEVTTLSVGDEVWYAGDVSRPGTNAQLHAVDERIVARKPRSLSFRDAAALPLTTITAWETLFE
RFNLTADSRGDLLVLGAAGGVGSVMIQLAKKLTGVRVIATASRDESRQWARDLGADEVIDHHDLRTQALD
VAPDGVDYLFTPFSAGNVDVFADIVRPFGHITAIDEPEGLDLVGLKTKSIAWHWELMFTRPLTGYDIAAQ
QRLLADAADLVDRGELRTTLTTAIDGFTAANLREAHRMVESGRMVGKVVVSR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_5164--100% (332)zinc-binding alcohol dehydrogenase family protein
M. smegmatis MC2 155MSMEG_4146-6e-2230.72% (319) quinone oxidoreductase
M. smegmatis MC2 155MSMEG_5762-1e-2132.48% (234) zinc-binding oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3806-7e-2130.00% (320) putative oxidoreductase
M. gilvum PYR-GCKMflv_2124-3e-3233.94% (327) alcohol dehydrogenase
M. tuberculosis H37RvRv3777-2e-2029.69% (320) oxidoreductase
M. leprae Br4923MLBr_00118-3e-2029.34% (317) putative oxidireductase
M. abscessus ATCC 19977MAB_0207c-1e-2531.58% (342) quinone oxidoreductase
M. marinum MMMAR_2950-4e-2532.83% (329) oxidoreductase
M. avium 104MAV_3108-1e-2232.42% (330) erythronolide synthase, modules 3 and 4
M. thermoresistible (build 8)TH_1665-1e-1727.36% (318) PROBABLE OXIDOREDUCTASE
M. ulcerans Agy99MUL_2209-2e-2532.83% (329) oxidoreductase
M. vanbaalenii PYR-1Mvan_5758-9e-3637.58% (314) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MAV_3108|M.avium_104                MPGTEQHLDYLKRLTADLRRTRRRVAELEGRLSEPVAVVGMACRYAGGVD
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                SPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQGSFLQ
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                HAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSALRGTAT
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                GVFAGVIHAGYGGEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVD
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                TACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALAP
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                DGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWAVLRGSAVNQD
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                GASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTGTVLGDPIEA
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                QALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQALRHGVM
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                PKTMHVDVPSPHVDWSAGAVSLLTDPRPWPEHGGPRRAGVSSFGISGTNA
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                HVIVEQAPAAAETEAAPASSTMPDAVVPWVVSARSAEALAGQARRLLDHV
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                TADAQASPLDVGWSLVSTRAVFEHRAVVVGRERGALATGLAGLASGRPGP
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                ATVVGRARSTGKTVLVFPGQGSQTLGMGRQLYERFEVFAGALDEAVAVVD
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                EHSRLSVREVMWGADPELLQSTEFAQPALFVFEVALAALWESLGVTPDVV
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                MGHSVGEIAAACVAGVLSLRDAARLVAARGALMAALPPGGVMVAVTAGES
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                QVGPLLGGGVSIAAVNGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVS
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                HAFHSALMEPMLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGTPQYW
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                VDHVRRPVRFVDGVRLAESQGAGVFLEVGPGAALTSAVEQSLTSDRAMSV
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                VTMPKGRPEVDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFAR
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                RRFWLSGDAVGSANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAA
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                QPWLADHAVAGTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAG
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                GTVQLQVVVADAAGQPGSRSVAVYSRVAQSEWTLHAEGVLSEAAPAPAAE
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                LSVWPPADAEAVDVAGGYDDLAGRGYGYGPAFRGLRAVWRRGAETFAEVE
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                LPEQAGVSTGRFGIHPVLLDAALHALGVADKRLETVLPFSWQGVSLHAAG
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                ASRVRVRLAPAGAGAVSVELADASGVPVLSVRELVTRAVSAEQLAAAVAV
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                RSGSGELLDVAWSVIEPRNSLPDNPISEGVTVWEPAAVDGAGPAAVHAAT
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                HQALGVLQSRLAGEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQ
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                AEHPGRVVLVDTDGSLDLATVIGCGEPQLVVRDGVAYRARLRPAGRRALL
Mvan_5758|M.vanbaalenii_PYR-1       ---------------MRAAVLTAYNSP-----------------------
MSMEG_5164|M.smegmatis_MC2_155      ---------MPTMTAIGSFAALPVDDP-----------------------
MMAR_2950|M.marinum_M               ------------MKAMAQRTWNPAEP------------------------
MUL_2209|M.ulcerans_Agy99           ------------MKAMAQRTWNPAEP------------------------
Mb3806|M.bovis_AF2122/97            ------------MTIMRAVVAESSD-------------------------
Rv3777|M.tuberculosis_H37Rv         ------------MTIMRAVVAESSD-------------------------
MLBr_00118|M.leprae_Br4923          ---------------MHAIVAESAN-------------------------
TH_1665|M.thermoresistible__bu      ---------------MRAISVQTSG-------------------------
MAB_0207c|M.abscessus_ATCC_199      ---------------MHAITVDNPGGP-----------------------
Mflv_2124|M.gilvum_PYR-GCK          -----------MSDRMKAVVLARFGGA-----------------------
                                                   :                                  

MAV_3108|M.avium_104                ELPGPPAVWRLAAGDAGTLEDLAVQEHPAAELAPGQVRVRVAAAGVNFRD
Mvan_5758|M.vanbaalenii_PYR-1       ---------------------LLVDELPDPEPGPGEVLVRVMASGVNPLD
MSMEG_5164|M.smegmatis_MC2_155      -------------------DSLQDITIEVPELRPHDVLVRVEAVSVNPVD
MMAR_2950|M.marinum_M               ---------------------LELIELPTPEPKAGEVRVQVQAIGVNPVD
MUL_2209|M.ulcerans_Agy99           ---------------------LEFIELPTPEPQAGEVRVQVQAIGVNPVD
Mb3806|M.bovis_AF2122/97            --------------------RLVWQEVPDVSAGPGEVLIKVAASGVNRAD
Rv3777|M.tuberculosis_H37Rv         --------------------RLVWQEVPDVSAGPGEVLIKVAASGVNRAD
MLBr_00118|M.leprae_Br4923          --------------------QMVWREVPDVTAGPGEVLIEVAASGVNRAD
TH_1665|M.thermoresistible__bu      --------------------QLSWVEVPDIEPGESEVLIAVHTAGINRAD
MAB_0207c|M.abscessus_ATCC_199      -------------------EALRWTEVPDPVPGPGEILIDVTAAAANRAD
Mflv_2124|M.gilvum_PYR-GCK          -------------------DAFELRDVAVPHVGPRQVRVRVHATAVNPLD
                                                         :             :: : * : . *  *

MAV_3108|M.avium_104                VLVALG----------MYPGAAQLGAEGAGVVTEVGAGVTDVAVGDAVMG
Mvan_5758|M.vanbaalenii_PYR-1       IKIRRGE-----APHAQLPPPAVLGIDMAGVVEAVGPRVDRFTVGDEVFG
MSMEG_5164|M.smegmatis_MC2_155      IKRRRS--------LSPSAEPTILGFDAAGVVEAVGSEVTTLSVGDEVWY
MMAR_2950|M.marinum_M               WKMRSSGPLRLAARLIGPKPPVVVGVDFAGVVEAVGPGVTRAAPGDRVVG
MUL_2209|M.ulcerans_Agy99           WKMRSSGPLRLAARLIGPKPPVVVGVDFAGVVEAVGPGVTRAAPGDRVVG
Mb3806|M.bovis_AF2122/97            VLQAAGK------YPPPPGVSDIIGLEVSGIVAAVGPGVTEWSAGQEVC-
Rv3777|M.tuberculosis_H37Rv         VLQAAGK------YPPPPGVSDIIGLEVSGIVAAVGPGVTEWSAGQEVC-
MLBr_00118|M.leprae_Br4923          VLQVAGK------YPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVC-
TH_1665|M.thermoresistible__bu      LLQAAGK------YPPPPGASEILGLEVSGTVAAVGAGVSGWTVGQPVC-
MAB_0207c|M.abscessus_ATCC_199      LLQRRGL------YSPPPGASSILGLECSGTVAALGADVAHWSVGQPVC-
Mflv_2124|M.gilvum_PYR-GCK          YQIRRGD------YTDLVPLPAIIGHDISGVIEEVGSHVTEFRAGDAVYY
                                         .              .  :* : :* :  :.. *     *: *  

MAV_3108|M.avium_104                IFGLVG-------SEAAVDRRLVTRVPPGWSMAQAAGIPVVFLTAYYGLS
Mvan_5758|M.vanbaalenii_PYR-1       MTGGVGGLQGSLAELAAVDARLIAHKPRTLSMAQAAALPLGFITSWEGLV
MSMEG_5164|M.smegmatis_MC2_155      AGDVSR--PGTNAQLHAVDERIVARKPRSLSFRDAAALPLTTITAWETLF
MMAR_2950|M.marinum_M               GTNFSRGQRGSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVV
MUL_2209|M.ulcerans_Agy99           GTNFSRGQRGSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVV
Mb3806|M.bovis_AF2122/97            --ALLAG--GGYAEYVAVPADQVLPIPPSVNLVDSAALPEVACTVWSNLV
Rv3777|M.tuberculosis_H37Rv         --ALLAG--GGYAEYVAVPADQVLPIPPSVNLVDSAALPEVACTVWSNLV
MLBr_00118|M.leprae_Br4923          --ALLAG--GGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLV
TH_1665|M.thermoresistible__bu      --ALLAG--GGYAEYVAVPAEQVMPIPESVEIRYAAALPEVACTVWSNLV
MAB_0207c|M.abscessus_ATCC_199      --ALLSG--GGYAEKVVAPATQLLPVPTNVQLDVAAALPEVACTVWSNMM
Mflv_2124|M.gilvum_PYR-GCK          TPKIFGGP-GSYAEQHVADVDLVGRKPDNLDHLEAASLTLVGGTVWESLV
                                                 .   .    :   *   .   :*.:.    * :  : 

MAV_3108|M.avium_104                VLAGLRAGQR----VLVHAATGGVGMAAVQLARHWGAEVFATASRG-KWD
Mvan_5758|M.vanbaalenii_PYR-1       DRAGVGTGQQ----VLIHGGAGGVGFLAVQLALARGAQVYATGSTS-SQA
MSMEG_5164|M.smegmatis_MC2_155      ERFNLTADSRGD--LLVLGAAGGVGSVMIQLAKKLTGVRVIATASR-DES
MMAR_2950|M.marinum_M               ELGRIRQVPPADRRVLVLGASGGVGQLAVQIAKLQEAFVVGVCSTK-NVE
MUL_2209|M.ulcerans_Agy99           ELGRIRQVPSADRRVLVLGASGGVGQLAVQIAKLQEAFVVGVCSTE-NVE
Mb3806|M.bovis_AF2122/97            MTAHLRPGQL----VLIHGGASGIGSHAIQVARALAARVAITAGSPEKLE
Rv3777|M.tuberculosis_H37Rv         MTAHLRPGQL----VLIHGGASGIGSHAIQVVRALAARVAITAGSPEKLE
MLBr_00118|M.leprae_Br4923          MAAHLSAGQL----LLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLE
TH_1665|M.thermoresistible__bu      MTAGLSAGEW----VLIHGGASGVGSHAVQVARALDARVAVTAGTRHKLE
MAB_0207c|M.abscessus_ATCC_199      MTTKMSAGQS----ILIHGGASGIGTHTIQVAKALGLRVAVTAGTPEKLD
Mflv_2124|M.gilvum_PYR-GCK          TRAQLTVGET----ILIHGGAGGVGTIAIQVAKAMGARVITTAKAG-DHA
                                        :         :*: ..:.*:*   :*:.         .     .  

MAV_3108|M.avium_104                TLRAMGFDDAHIADSRTLDFEQKFGAAPGGMDVVLNSLAGEFNDASLRLL
Mvan_5758|M.vanbaalenii_PYR-1       VIRAAGAVPIDYTATTVDEYVAAHTGGEG-FDVVADNVGGATLDAS----
MSMEG_5164|M.smegmatis_MC2_155      RQWARDLGADEVIDHHDLRTQALDVAPDG-VDYLFTPFSAGNVDVF----
MMAR_2950|M.marinum_M               MVKDLGADLVLDYNQGDALAQAKPHAPFHVVIDCVGSYSGAGCR------
MUL_2209|M.ulcerans_Agy99           MVKDLGADLVLDYNQGDALAQAKPHAPFHVVIDCVGSYSGAGCR------
Mb3806|M.bovis_AF2122/97            LCRDLGAQITINYRDEDFVARLKQETDGSGADIILDIMGASYLDRN----
Rv3777|M.tuberculosis_H37Rv         LCRDLGAQITINYRDEDFVARLKQETDGSGADIILDIMGASYLDRN----
MLBr_00118|M.leprae_Br4923          FCRALGAQITINYRDEDFVARLQQQN--GGADVILDIMGAAYLDRN----
TH_1665|M.thermoresistible__bu      LCRELGAEVTICYREEDFVERVRAETDGAGADVVLDIMGAAYLGRN----
MAB_0207c|M.abscessus_ATCC_199      ACRDLGADLAINYRDTDFVQAVHSFTDGSGVDRILDIMGAKYLSRN----
Mflv_2124|M.gilvum_PYR-GCK          FVNSLGADVAIDHTSTDYVDAVAEATRGRGVDVVFDTIGGDTLTRS----
                                         .                                ..          

MAV_3108|M.avium_104                GPGGRFIEMGKTDLRDPDVVARAHPGVRYRAFDLMEAGPDRIAAMLAEVM
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                ELFAAGALTPLPVKAFDARCAADAYRFVSAARHIGKVVLTMPDGPAGLSG
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------FTAVKRYTGHVVSALGWGTHSLAP
MSMEG_5164|M.smegmatis_MC2_155      ---------------------------ADIVRPFGHITAIDEPEGLDLVG
MMAR_2950|M.marinum_M               ----------------------------ALLSSRGRHIMVAGDEPSSALQ
MUL_2209|M.ulcerans_Agy99           ----------------------------ALLSSRGRHIMVAGDEPSSAVQ
Mb3806|M.bovis_AF2122/97            ---------------------------IDALATDGQLIVIGMQGGVKAEL
Rv3777|M.tuberculosis_H37Rv         ---------------------------IDALATDGQLIVIGMQGGVKAEL
MLBr_00118|M.leprae_Br4923          ---------------------------IDALAIDGQLIVIGLQGGVKGEL
TH_1665|M.thermoresistible__bu      ---------------------------VDALATDGRLVVIGMQGGRRAEL
MAB_0207c|M.abscessus_ATCC_199      ---------------------------VDALGNDGHLVIIGMQGGVTAEL
Mflv_2124|M.gilvum_PYR-GCK          ---------------------------PLSLADSGRVVSIVDIARPQNLI
                                                                      *:              

MAV_3108|M.avium_104                GTALITGATGMAGAALARHLVARHRVPHLMLVGRRGEAAPGMAELAAELR
Mvan_5758|M.vanbaalenii_PYR-1       --------LSFRGAAYSGVFTLMP-----LLTGRGRDHHGEIVAEAAALA
MSMEG_5164|M.smegmatis_MC2_155      --------LKTKSIAWHWELMFTR-----PLTGYDIAAQQRLLADAADLV
MMAR_2950|M.marinum_M               ----------VVVPPFKSKAILGR-------------PNGARLEPLVDAV
MUL_2209|M.ulcerans_Agy99           ----------VVVPPFKSKAILGR-------------PNGARLEPLVDAV
Mb3806|M.bovis_AF2122/97            N-------LGKLLTKRARVIGTTLRARPVSGPHGKAAIAQAVAASVWPMI
Rv3777|M.tuberculosis_H37Rv         N-------LGKLLTKRARVIGTTLRARPVSGPHGKAAIAQAVAASVWPMI
MLBr_00118|M.leprae_Br4923          N-------LGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMI
TH_1665|M.thermoresistible__bu      D-------LGKLVAKRAAVFGTALRGRPVTGPHGKADIVRAVVENVWPMV
MAB_0207c|M.abscessus_ATCC_199      N-------IAKLIAKRGSLTATTLRARPIAGPCGKAAIVESVAQNLWPLV
Mflv_2124|M.gilvum_PYR-GCK          E-------AWGRNAAYHFVFTRQNRGK---------------LDALTMLV
                                                                                      

MAV_3108|M.avium_104                GAGASVSVLSCDVG--DRDAVAAMLAQVPAR---YPLRSVFHAAGVLDDA
Mvan_5758|M.vanbaalenii_PYR-1       DSGRLAPRLHPTTF--PLDAVNDAHTAVESG---SATGKVVVEPNV----
MSMEG_5164|M.smegmatis_MC2_155      DRGELRTTLTTAIDGFTAANLREAHRMVESG---RMVGKVVVSR------
MMAR_2950|M.marinum_M               AAGKLRVSIAQKLP---LTSAEEAHRLSQTS---RMTGKLILEP------
MUL_2209|M.ulcerans_Agy99           AAGKLRVSIAQKLP---LTSAEEAHRLSQTS---RMTGKLILEP------
Mb3806|M.bovis_AF2122/97            AANRVRPVIGTRLP---IQQAAQAHELMLSG---KTFGKILLTV------
Rv3777|M.tuberculosis_H37Rv         AANRVRPVIGTRLP---IQQAAQAHELMLSG---KTFGKILLTV------
MLBr_00118|M.leprae_Br4923          ADGSVRPIIGARMA---VQQAADAHQLLLSG---KVSGKIVLTVAGSGTE
TH_1665|M.thermoresistible__bu      ASDQVRPVVGAEFP---IQEAQAAHELLASG---DVYGKVLLCVED----
MAB_0207c|M.abscessus_ATCC_199      EAGKVRPVVGAEIP---LSQAAEAHRLLENG---AVVGKVLLTR------
Mflv_2124|M.gilvum_PYR-GCK          ERGLVKPVLGATLP---LARMGEAHELLENRRSYALRGKVAIDVAGETVA
                                      .     :                             .:          

MAV_3108|M.avium_104                VIASLTPARIDTVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGAPG
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          TLLSRHH-------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          LPPRIS--------------------------------------------
                                                                                      

MAV_3108|M.avium_104                QGNYAAANSFLDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKAR
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                MSRAGLSALSTRQALDLLDDALLGEQPLVVGTRLDRAALAQHRAALPPLL
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                SELAGRPARRMLEHTDMVSLTGLRARLAGMNPEQRQAELVELVCGNAAAV
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                LGHSTADVDPGDAFSDLGFDSLTAVELRNRLKIATGLTLSPTVIFDHPTP
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                AALAEHLGGQLTSAGPTPAAPAETAAPPDRSSRIDEVVSELQTLLTQPGL
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                SPGDRAQLVTRLQSLLSTPPQPSGHPEFPEDAFDDDIATATDSQLFAILD
Mvan_5758|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5164|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_2950|M.marinum_M               --------------------------------------------------
MUL_2209|M.ulcerans_Agy99           --------------------------------------------------
Mb3806|M.bovis_AF2122/97            --------------------------------------------------
Rv3777|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00118|M.leprae_Br4923          --------------------------------------------------
TH_1665|M.thermoresistible__bu      --------------------------------------------------
MAB_0207c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_2124|M.gilvum_PYR-GCK          --------------------------------------------------
                                                                                      

MAV_3108|M.avium_104                DEAGP
Mvan_5758|M.vanbaalenii_PYR-1       -----
MSMEG_5164|M.smegmatis_MC2_155      -----
MMAR_2950|M.marinum_M               -----
MUL_2209|M.ulcerans_Agy99           -----
Mb3806|M.bovis_AF2122/97            -----
Rv3777|M.tuberculosis_H37Rv         -----
MLBr_00118|M.leprae_Br4923          -----
TH_1665|M.thermoresistible__bu      -----
MAB_0207c|M.abscessus_ATCC_199      -----
Mflv_2124|M.gilvum_PYR-GCK          -----