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PGTEQHLDYLKRLTADLRRTRRRVAELEGRLSEPVAVVGMACRYAGGVDSPEALWDLVIEGRDTVSDFPV DRGWDVEGLYDPDPDAKGKMYTRQGSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGID PSALRGTATGVFAGVIHAGYGGEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVDTACSSSLVAMH LAAQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADA RRLGHPVWAVLRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTGTVLGDPIEAQ ALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQALRHGVMPKTMHVDVPSPHVDWSAGAVS LLTDPRPWPEHGGPRRAGVSSFGISGTNAHVIVEQAPAAAETEAAPASSTMPDAVVPWVVSARSAEALAG QARRLLDHVTADAQASPLDVGWSLVSTRAVFEHRAVVVGRERGALATGLAGLASGRPGPATVVGRARSTG KTVLVFPGQGSQTLGMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGADPELLQSTEFAQPALFV FEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLRDAARLVAARGALMAALPPGGVMVAVTAGESQ VGPLLGGGVSIAAVNGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAG IEPRPPRIPLVSNLTGQLAGPGYGTPQYWVDHVRRPVRFVDGVRLAESQGAGVFLEVGPGAALTSAVEQS LTSDRAMSVVTMPKGRPEVDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLSGDAVG SANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQPWLADHAVAGTVLFPGAGFVELALRAGDEV GCPVVEELTLSAPLSLPAGGTVQLQVVVADAAGQPGSRSVAVYSRVAQSEWTLHAEGVLSEAAPAPAAEL SVWPPADAEAVDVAGGYDDLAGRGYGYGPAFRGLRAVWRRGAETFAEVELPEQAGVSTGRFGIHPVLLDA ALHALGVADKRLETVLPFSWQGVSLHAAGASRVRVRLAPAGAGAVSVELADASGVPVLSVRELVTRAVSA EQLAAAVAVRSGSGELLDVAWSVIEPRNSLPDNPISEGVTVWEPAAVDGAGPAAVHAATHQALGVLQSRL AGEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQAEHPGRVVLVDTDGSLDLATVIGCGEPQLVV RDGVAYRARLRPAGRRALLELPGPPAVWRLAAGDAGTLEDLAVQEHPAAELAPGQVRVRVAAAGVNFRDV LVALGMYPGAAQLGAEGAGVVTEVGAGVTDVAVGDAVMGIFGLVGSEAAVDRRLVTRVPPGWSMAQAAGI PVVFLTAYYGLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTLRAMGFDDAHIA DSRTLDFEQKFGAAPGGMDVVLNSLAGEFNDASLRLLGPGGRFIEMGKTDLRDPDVVARAHPGVRYRAFD LMEAGPDRIAAMLAEVMELFAAGALTPLPVKAFDARCAADAYRFVSAARHIGKVVLTMPDGPAGLSGGTA LITGATGMAGAALARHLVARHRVPHLMLVGRRGEAAPGMAELAAELRGAGASVSVLSCDVGDRDAVAAML AQVPARYPLRSVFHAAGVLDDAVIASLTPARIDTVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGA PGQGNYAAANSFLDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKARMSRAGLSALSTRQALDLL DDALLGEQPLVVGTRLDRAALAQHRAALPPLLSELAGRPARRMLEHTDMVSLTGLRARLAGMNPEQRQAE LVELVCGNAAAVLGHSTADVDPGDAFSDLGFDSLTAVELRNRLKIATGLTLSPTVIFDHPTPAALAEHLG GQLTSAGPTPAAPAETAAPPDRSSRIDEVVSELQTLLTQPGLSPGDRAQLVTRLQSLLSTPPQPSGHPEF PEDAFDDDIATATDSQLFAILDDEAGP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3108 | - | - | 100% (2128) | erythronolide synthase, modules 3 and 4 |
M. avium 104 | MAV_3109 | - | 0.0 | 64.31% (2146) | RifB protein |
M. avium 104 | MAV_2450 | - | 0.0 | 58.79% (2133) | erythronolide synthase, modules 3 and 4 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2971c | pks1 | 0.0 | 62.77% (2079) | polyketide synthase PKS1 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 39.16% (2150) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 62.42% (2150) | polyketide synthase pks7 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 60.49% (2088) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 38.30% (2206) | polyketide synthase |
M. marinum M | MMAR_2472 | pks8 | 0.0 | 66.81% (2136) | polyketide synthase, Pks8 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 38.40% (2133) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 35.20% (1844) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 61.99% (2081) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 39.10% (2179) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK --------------MGSAAHQGE-SAHRFAIVGYAGRFPGARDAESFWEL MAB_0939|M.abscessus_ATCC_1997 --------------MDSAENPIE-STPRFAIIGYAARFPGAADAEEFWDV MSMEG_0408|M.smegmatis_MC2_155 --------------MVSAEHPIE-PTPSFAIIGYAARFPGAASAEEYWAL Mvan_1003|M.vanbaalenii_PYR-1 MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPGAADADEFWDV Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LADGRDAISEVPEDRWDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPF MAB_0939|M.abscessus_ATCC_1997 LREGRDAISEVPADRWDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPF MSMEG_0408|M.smegmatis_MC2_155 LRDGREAISDVPKDRWDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPF Mvan_1003|M.vanbaalenii_PYR-1 LRGGRDAISEVPQDRWDADEFFDADPEAAGKMVTRRAGFVEDVAGFDAPF Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTNTGVFVGLATH MAB_0939|M.abscessus_ATCC_1997 FGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATH MSMEG_0408|M.smegmatis_MC2_155 FGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSNTGVFVGLATH Mvan_1003|M.vanbaalenii_PYR-1 FGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTRTGVFMGLSTH Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS MAB_0939|M.abscessus_ATCC_1997 DYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACS MSMEG_0408|M.smegmatis_MC2_155 DYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS Mvan_1003|M.vanbaalenii_PYR-1 DYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQGPAVAVDTACS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSNAHMLAPDGRC MAB_0939|M.abscessus_ATCC_1997 SSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFSHAHMLAPDGKC MSMEG_0408|M.smegmatis_MC2_155 SSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSNAHMLAPDGRC Mvan_1003|M.vanbaalenii_PYR-1 SSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSRARMLAPDGRC Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASG MAB_0939|M.abscessus_ATCC_1997 KTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASG MSMEG_0408|M.smegmatis_MC2_155 KTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASG Mvan_1003|M.vanbaalenii_PYR-1 KTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRGSAVNQDGASG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAG MAB_0939|M.abscessus_ATCC_1997 GLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAG MSMEG_0408|M.smegmatis_MC2_155 GLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAG Mvan_1003|M.vanbaalenii_PYR-1 GLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPLGDPIEVQAAG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALGPGREPQRPLLIGSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHL MAB_0939|M.abscessus_ATCC_1997 AAYGIGRETNDPLLIGSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHR MSMEG_0408|M.smegmatis_MC2_155 EVLGAGRAPEEPLLIGSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHL Mvan_1003|M.vanbaalenii_PYR-1 AVLGVGREPDRPLLIGSVKTNIGHLEAASGIAGLLKVILSLEHQVLPKHL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAH MAB_0939|M.abscessus_ATCC_1997 NFQNPSPHIPWDRLPVEVVREARPWGR---NGRPRIAGVSSFGFAGTNAH MSMEG_0408|M.smegmatis_MC2_155 NFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGVSSFGFAGTNAH Mvan_1003|M.vanbaalenii_PYR-1 NFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGISSFGFSGTNAH Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VILEEAPLAAEPAQES---VDDGRFTLLPLSARTPAALMAVADRYRDWLV MAB_0939|M.abscessus_ATCC_1997 VILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAALAQLADKYRAWLN MSMEG_0408|M.smegmatis_MC2_155 VILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTPEALVRLAGEYRDWLR Mvan_1003|M.vanbaalenii_PYR-1 VLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTPDALAATAHRLRTWLA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLLGALADDRPAPG MAB_0939|M.abscessus_ATCC_1997 AHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVELLSAVADDRPAPG MSMEG_0408|M.smegmatis_MC2_155 AHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELLGALADDRPAPG Mvan_1003|M.vanbaalenii_PYR-1 ANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELLGALAEDRPGPG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAETLRECAAAVDG MAB_0939|M.abscessus_ATCC_1997 LGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFADTLNRCAAAVAD MSMEG_0408|M.smegmatis_MC2_155 LVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAETVRKCAEAVAD Mvan_1003|M.vanbaalenii_PYR-1 LARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYREVMTRCAEAVAD Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVEMGLARLWQSWG MAB_0939|M.abscessus_ATCC_1997 VLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAVEMGLARLWQSWG MSMEG_0408|M.smegmatis_MC2_155 ILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVELGLARLWQSWG Mvan_1003|M.vanbaalenii_PYR-1 VLERPLLDVVFDAD------GGEALRHTSYAQPALYAVEMGLARLWQSWG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLFGSLPSGGRMAA MAB_0939|M.abscessus_ATCC_1997 FEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAA MSMEG_0408|M.smegmatis_MC2_155 FEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAA Mvan_1003|M.vanbaalenii_PYR-1 IEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLFGSLPEGGRMAA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VFAAAERVEALTDEYPALSVAAYNGANTVLSGPATDLERAVAGLVADGVR MAB_0939|M.abscessus_ATCC_1997 VFTDAERAERLTDEFPSLSVAAYNGANTVLSGPAQDLEKAIAALVADGVR MSMEG_0408|M.smegmatis_MC2_155 VFTAPERAERLTDEYPSLSVAAYNGANTVLSGPAKDLESAVATLVADGVR Mvan_1003|M.vanbaalenii_PYR-1 VFAPADRVESCTVDSPLLSVAAYNGDNTVLSGPAGDLERAVAGFSAAGVR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK CDWLETSHAFHSALLDPILDDFESYARGITFTAPQRILIDNRTGAALGRS MAB_0939|M.abscessus_ATCC_1997 CDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQRILIDNRTGTALGRS MSMEG_0408|M.smegmatis_MC2_155 CDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRILIDNRTGSALGRS Mvan_1003|M.vanbaalenii_PYR-1 CDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRTLVCNRSGEVLSRH Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEIGPRPVLTAAALSAW MAB_0939|M.abscessus_ATCC_1997 VKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAW MSMEG_0408|M.smegmatis_MC2_155 TRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEIGPRPVLTATALAAW Mvan_1003|M.vanbaalenii_PYR-1 ARLDGQYWRRHARQPVRFAESVRTLADLGCRLLMEIGPQPVLTAAAMRTW Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PDPATSPRVIASLRRTTADQRQITEAVADAYVLGHLPRFAAFRRDGARVL MAB_0939|M.abscessus_ATCC_1997 PDPATAPRAIASLRRNTADHRQITEAAADAYVLGHLPDFGAFQHAPARKL MSMEG_0408|M.smegmatis_MC2_155 PDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHLPDFRAFRQPDARKL Mvan_1003|M.vanbaalenii_PYR-1 PGTVTAPRVAASMRRKGSDRRQITEALAQAYVAGHRPETAARQHGRGRLL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DLPTYPFEHRQYWFSDSRE---PVAAAPQR---GARTETVRLLEDGRIEE MAB_0939|M.abscessus_ATCC_1997 DLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEE MSMEG_0408|M.smegmatis_MC2_155 DLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEE Mvan_1003|M.vanbaalenii_PYR-1 DLPTYPFQHRAYWFP--------QGQARTAPTDPVHTETVRFLDEERIDE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LAALLGGTVDDPFTFDVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPP MAB_0939|M.abscessus_ATCC_1997 LANLLGGVDGDQQTLNVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPL MSMEG_0408|M.smegmatis_MC2_155 LAALIDGETVDEQTLRVLNKLAARHNQQRSTHVDPDARYEIRWDAIASAA Mvan_1003|M.vanbaalenii_PYR-1 LAALLDGPTGSAQTVDVLSKLAARHRQQRGAQSIADARYQIRWEKSEAPG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VGADAADGITWLLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHEL MAB_0939|M.abscessus_ATCC_1997 SGSQAAGGVTWLLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAEL MSMEG_0408|M.smegmatis_MC2_155 ASTGAAA--DWILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADEAQL Mvan_1003|M.vanbaalenii_PYR-1 AARPTTEATTWLLVTHDSRAAQPIAEVLERRGHPYHIVGLPGSDADAAPA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ADTLRDAAADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFG MAB_0939|M.abscessus_ATCC_1997 VEALRSAADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFR MSMEG_0408|M.smegmatis_MC2_155 VDTLRAASAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFR Mvan_1003|M.vanbaalenii_PYR-1 EEALRATVSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQ Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAVAAQLRSPMWLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWG MAB_0939|M.abscessus_ATCC_1997 AAAAAELRAPIWIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWG MSMEG_0408|M.smegmatis_MC2_155 AANDAELRSPIWLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWG Mvan_1003|M.vanbaalenii_PYR-1 LAATAGARAPIWLITAGAQRITGDETVEPAQTSLWGFGRAAALEQPELWG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDT MAB_0939|M.abscessus_ATCC_1997 GLADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREE MSMEG_0408|M.smegmatis_MC2_155 GLADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPRLVRRTG Mvan_1003|M.vanbaalenii_PYR-1 GLADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVARLTRCAE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LPSGKPLHLRADATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDE MAB_0939|M.abscessus_ATCC_1997 LPSGKPLEVRSDATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGE MSMEG_0408|M.smegmatis_MC2_155 EPSDTPLPVREDRTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGD Mvan_1003|M.vanbaalenii_PYR-1 KANAAALELRREATYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRSASD Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHA MAB_0939|M.abscessus_ATCC_1997 AARQRIDALAA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHA MSMEG_0408|M.smegmatis_MC2_155 DARRRLDGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHA Mvan_1003|M.vanbaalenii_PYR-1 TVRQRIDAMRERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGIVHA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSS MAB_0939|M.abscessus_ATCC_1997 AGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSS MSMEG_0408|M.smegmatis_MC2_155 AGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSS Mvan_1003|M.vanbaalenii_PYR-1 AGEIGTSPLRTLDDAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLATSS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IASVWGGFGQAAYGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQ MAB_0939|M.abscessus_ATCC_1997 IAAVWGGYGQTAYSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAE MSMEG_0408|M.smegmatis_MC2_155 IASVWGGFGQTAYGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAE Mvan_1003|M.vanbaalenii_PYR-1 IASVWGSHGQTAYGAANAFLDGLADSLRARGIPGISVNFGPWAAGMADAK Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SRARLEQRGIKTLSPADALAGLSDAVISAAP---HPVVARVDWSRFLPLY MAB_0939|M.abscessus_ATCC_1997 SRARLEQRGIKTLSPTDALAGLADVVAASGSNAVQGVIARIDWARFLPLY MSMEG_0408|M.smegmatis_MC2_155 SRARLEQRGVRTLSPAEALAGMADVVAGPVQ----GVVAKIDWSRFLPLY Mvan_1003|M.vanbaalenii_PYR-1 AREQLSRRGVKTLAPADALAGMADVIAASTA---HAVVARIDWATFLPVY Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QQAGRRGFLAELERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRL MAB_0939|M.abscessus_ATCC_1997 QQAGKRGFLAELDREVPSHLA--GVAGAQSGSTQLVERLANAPVQQRKKL MSMEG_0408|M.smegmatis_MC2_155 QQAGRRAFLSELESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSL Mvan_1003|M.vanbaalenii_PYR-1 QLQRRRAFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTLAPVEQRRKL Mb2971c|M.bovis_AF2122/97 -------------------------------MIEEQRTMSVEGADQQSEK MLBr_00135|M.leprae_Br4923 ------------------------------------MTASVEGADQKSEK MUL_2005|M.ulcerans_Agy99 ------------------------------------MTTSGESADQQNDK MAV_3108|M.avium_104 -------------------------------------------MPGT-EQ MMAR_2472|M.marinum_M -------------------------------------------MTET-TK Rv1661|M.tuberculosis_H37Rv -------------------------------------------MNSTPED TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LTDYLRDAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKE MAB_0939|M.abscessus_ATCC_1997 LTDYLRDAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKE MSMEG_0408|M.smegmatis_MC2_155 ITNYLRNAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKD Mvan_1003|M.vanbaalenii_PYR-1 VLEYLRAAVAEVTRVDAAEIRDEAGFFDLGMDSLMAIELRRRLEQGLGKE Mb2971c|M.bovis_AF2122/97 LFHYLKKVAVELD------------------------ETRARLRE----- MLBr_00135|M.leprae_Br4923 LISYLKKVVVELD------------------------ETRARLRE----- MUL_2005|M.ulcerans_Agy99 LFRYLKKVAVELD------------------------EARARLRE----- MAV_3108|M.avium_104 HLDYLKRLTADLR------------------------RTRRRVAE----- MMAR_2472|M.marinum_M HVDYLKRLTADLR------------------------RTRRRVAE----- Rv1661|M.tuberculosis_H37Rv LVKALRRSLKQNE------------------------RLKRENRD----- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IPVTLVMDHPRLSDAADYLLGDVLGLTEAAT-APKAATVVSTAADEPIAI MAB_0939|M.abscessus_ATCC_1997 IPVTLVMDHPRISDVADYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAI MSMEG_0408|M.smegmatis_MC2_155 IPVTLVMDHPRLSDAADYLLVEVLGLGEQTN--VRQASTVTARTDDPIAV Mvan_1003|M.vanbaalenii_PYR-1 LPVTLAMDHPHLSDAAEYVLGDVLGLSEHTV--AQPDTPSTVRTDDPIAI Mb2971c|M.bovis_AF2122/97 ---------------------------------------YEQRATEPVAV MLBr_00135|M.leprae_Br4923 ---------------------------------------YEQRATEPVAV MUL_2005|M.ulcerans_Agy99 ---------------------------------------YEQRATEPVAV MAV_3108|M.avium_104 ---------------------------------------LEGRLSEPVAV MMAR_2472|M.marinum_M ---------------------------------------LEDKLSEPVAL Rv1661|M.tuberculosis_H37Rv ---------------------------------------LLARTTEPVAV TH_4621|M.thermoresistible__bu ------------------------------------VNIVGDTPVNAVAV :.:*: Mflv_0405|M.gilvum_PYR-GCK VAVSCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAA MAB_0939|M.abscessus_ATCC_1997 VAVSCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVA MSMEG_0408|M.smegmatis_MC2_155 VAVSCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTP Mvan_1003|M.vanbaalenii_PYR-1 VGMACRFPG-ADDTDAFWSVLAEGADLIREIPDDR-FDINEFYDPDPEAA Mb2971c|M.bovis_AF2122/97 VGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAE MLBr_00135|M.leprae_Br4923 VGIGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAE MUL_2005|M.ulcerans_Agy99 VGIGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAE MAV_3108|M.avium_104 VGMACRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAK MMAR_2472|M.marinum_M VGMGCRYPGGADSPESLWEMLTQGRDAVSEFPSDRGWDIDAMFDPDPDAR Rv1661|M.tuberculosis_H37Rv VGMGCRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAV TH_4621|M.thermoresistible__bu IGMACRLPGGIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVP :.:.** .* ..: :*. : * : :.* ** :* :**:* . Mflv_0405|M.gilvum_PYR-GCK GKTYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERA MAB_0939|M.abscessus_ATCC_1997 GKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERA MSMEG_0408|M.smegmatis_MC2_155 GKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERA Mvan_1003|M.vanbaalenii_PYR-1 GKIYSRYGGFLDGVDGFDPEFFGISPREAVWIDPQQRLVLETAWEGLERA Mb2971c|M.bovis_AF2122/97 GKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHA MLBr_00135|M.leprae_Br4923 GKTYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYA MUL_2005|M.ulcerans_Agy99 GKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHA MAV_3108|M.avium_104 GKMYTRQGSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERA MMAR_2472|M.marinum_M GKTYTRRGGFLADAGDFDAGFFGVGPNEALAMDPQQRLMLEVSWEALERS Rv1661|M.tuberculosis_H37Rv GKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERA TH_4621|M.thermoresistible__bu GRTVSRWGAFLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHA *: :* *.*: **. ***: *.: ::****::** **.:* : Mflv_0405|M.gilvum_PYR-GCK GYAPSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISG MAB_0939|M.abscessus_ATCC_1997 GYSPAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISG MSMEG_0408|M.smegmatis_MC2_155 GYAPSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISG Mvan_1003|M.vanbaalenii_PYR-1 GYSAAALRGSRSGVYVGVGANEYSHLLSGGSLDGIEAQFITGNALNVIAG Mb2971c|M.bovis_AF2122/97 GIDPLSLRGSATGVYTGIFAASYGN----RDTGGLQGYGLTGTSISVASG MLBr_00135|M.leprae_Br4923 GIDPLSLRGSATGVFTGIFAPSYGS----RDTGGLQGYGLTGTAVSVASG MUL_2005|M.ulcerans_Agy99 GIDPMSLRGSSTGVFTGIFAPSYGG----KDVGALQGYGLTGSPVSVASG MAV_3108|M.avium_104 GIDPSALRGTATGVFAGVIHAGYGG----EVKGELEGYGLTGSTLSVTSG MMAR_2472|M.marinum_M GIDPTTLRGSATGVFVGVIHAGYGG----EVKGELEGYGLTGSTLSVASG Rv1661|M.tuberculosis_H37Rv GIDPITLRGSQTGVFAGVFHGSYGGQG--RVPGDLERYGLRGSTLSVASG TH_4621|M.thermoresistible__bu GLTPADVEGSSTGVFVGLSHDDYALLTS-DAGALEEAYGFTGSAFSMASG * . :.*: :*::.*: *. : : *.... :* Mflv_0405|M.gilvum_PYR-GCK RVAFALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLL MAB_0939|M.abscessus_ATCC_1997 RVAFALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLL MSMEG_0408|M.smegmatis_MC2_155 RVAFALGFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLL Mvan_1003|M.vanbaalenii_PYR-1 RVSFTLGLEGPAVAVDTACSSSLVAVHQACQGLQSGDCDLALAGGVNVLL Mb2971c|M.bovis_AF2122/97 RVSYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMG MLBr_00135|M.leprae_Br4923 RVSYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMG MUL_2005|M.ulcerans_Agy99 RVAYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMG MAV_3108|M.avium_104 RVSYVLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMA MMAR_2472|M.marinum_M RVAYVLGLEGPAVSVDTACSSSLVALHLAAQSLRSRECDLALVGGVTVMA Rv1661|M.tuberculosis_H37Rv RVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMA TH_4621|M.thermoresistible__bu RIAYRLGVHGPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVML *::: **..***::*******:*:*:* * .*: :.*:**.**. *: Mflv_0405|M.gilvum_PYR-GCK SPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRD MAB_0939|M.abscessus_ATCC_1997 SPVTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERD MSMEG_0408|M.smegmatis_MC2_155 SPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRD Mvan_1003|M.vanbaalenii_PYR-1 SPATTIATSRARMLSPDGRCKTFDAAADGYVRGEGCGILVLKRLSDAVRD Mb2971c|M.bovis_AF2122/97 LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRL MLBr_00135|M.leprae_Br4923 LPSIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRL MUL_2005|M.ulcerans_Agy99 LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRN MAV_3108|M.avium_104 TPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRL MMAR_2472|M.marinum_M TPAAFVEFSRQRALAADGLCKAYAGAADGTTWSEGAGVLVVERLADAQRL Rv1661|M.tuberculosis_H37Rv TPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRL TH_4621|M.thermoresistible__bu EPRKYTSASGLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRD * * *:. * *:.: :*** .**. :::: **.** * Mflv_0405|M.gilvum_PYR-GCK GDRVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDY MAB_0939|M.abscessus_ATCC_1997 GDRVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDY MSMEG_0408|M.smegmatis_MC2_155 GDRVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDY Mvan_1003|M.vanbaalenii_PYR-1 GDRIQAVIRGSAVNQDGASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDY Mb2971c|M.bovis_AF2122/97 GHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDV MLBr_00135|M.leprae_Br4923 GHTVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDV MUL_2005|M.ulcerans_Agy99 GHNVLAVVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDV MAV_3108|M.avium_104 GHPVWAVLRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDV MMAR_2472|M.marinum_M GHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLGVADVDV Rv1661|M.tuberculosis_H37Rv GHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDV TH_4621|M.thermoresistible__bu NDRILAVVRGTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGM .. : *:: .:: **** : .::.*. :* : :.*: . : :. Mflv_0405|M.gilvum_PYR-GCK LEAHGTGTPLGDPIEVQAAAAAYAGARDADRPLLMGSVKTNIGHTESASG MAB_0939|M.abscessus_ATCC_1997 LEAHGTGTPLGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASG MSMEG_0408|M.smegmatis_MC2_155 LEAHGTGTPLGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASG Mvan_1003|M.vanbaalenii_PYR-1 LEAHGTGTSLGDPIEVQAAGAVLGAGRDPDRPLLMGSVKTNVGHLESASG Mb2971c|M.bovis_AF2122/97 VEAHGTATTLGDPIEAQALLSTYGQGRPAEQPLWVGSIKSNMGHTQAAAG MLBr_00135|M.leprae_Br4923 VEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAG MUL_2005|M.ulcerans_Agy99 VEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAG MAV_3108|M.avium_104 VEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAG MMAR_2472|M.marinum_M VEGHGTGTVLGDPIEAQAILATYGQDR--TEPLWLGSIKSNIGHTSAAAG Rv1661|M.tuberculosis_H37Rv VEGHGTGTTLGDPIEAQAILATYGQRP-ADRPLWLGSIKSNIGHTSAAAG TH_4621|M.thermoresistible__bu VEAHGTGTPVGDPIEYNSLTQVYGKTG----PCALTSVKTNFGHAESAAG :*.***.* :***** :: . . * : *:*:*.** .:*:* Mflv_0405|M.gilvum_PYR-GCK AAGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQP-NG MAB_0939|M.abscessus_ATCC_1997 AAGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQA-NG MSMEG_0408|M.smegmatis_MC2_155 AAGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQT-NG Mvan_1003|M.vanbaalenii_PYR-1 VAGLIKVVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWRA-DG Mb2971c|M.bovis_AF2122/97 VAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSV-DG MLBr_00135|M.leprae_Br4923 VAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSV-EG MUL_2005|M.ulcerans_Agy99 VAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPD-AG MAV_3108|M.avium_104 VAGVIKMVQALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPE-HG MMAR_2472|M.marinum_M VAGLIKMVLAMQHGVLPQTLHVDVPTPHVDWSAGAVSLLTESRPWPD-LG Rv1661|M.tuberculosis_H37Rv VAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHV-PG TH_4621|M.thermoresistible__bu ALGMMKAILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREG . *::* : :::: :* :*. . .: : : . * * Mflv_0405|M.gilvum_PYR-GCK RPRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPA MAB_0939|M.abscessus_ATCC_1997 RPRRAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQ MSMEG_0408|M.smegmatis_MC2_155 RVRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGT Mvan_1003|M.vanbaalenii_PYR-1 RPRRAGVSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATA Mb2971c|M.bovis_AF2122/97 RPRRAAVSSFGISGTNAHLILEEAPVPAPAE------APVEASESTGGP- MLBr_00135|M.leprae_Br4923 RPRRAGVSSFGISGTNAHVILEEAPT------------PVEASYSTADQQ MUL_2005|M.ulcerans_Agy99 RPRRAGVSSFGISGTNAHVILEEAPAP----------EAVPDSESNKGEP MAV_3108|M.avium_104 GPRRAGVSSFGISGTNAHVIVEQAPAA-----------AETEAAPASSTM MMAR_2472|M.marinum_M RPRRAGVSSFGISGTNAHVILEQAPTA-----------EHDLAEPDRG-- Rv1661|M.tuberculosis_H37Rv RPRRAGVSSFGISGTNAHVILEEAPAV-----------EPVGAAHGND-- TH_4621|M.thermoresistible__bu CPRRAAVSSYGMSGTNVHAVLEQAPEP------------VQRPEESADTD ***.***:*::***.* ::*:.* Mflv_0405|M.gilvum_PYR-GCK PAPVEVLPLSARSPEALVALAQRYETWLTAH-PEADLADVCRTAGTGRSH MAB_0939|M.abscessus_ATCC_1997 SAPVSVLPLSARSPEALAAVAQRYESWLAAH-PDVDLEDVCLTAGRGRSH MSMEG_0408|M.smegmatis_MC2_155 DDSPQVLALSARSPEALVELARRYDDWLSAT-PGLDIADVCHTAGVGRSH Mvan_1003|M.vanbaalenii_PYR-1 PEPAGVLPISARSPEALTALARRYESWLTAH-PDADIADVCYTAGAGRSH Mb2971c|M.bovis_AF2122/97 RPSMVPWVISARSAEALTAQAGRLMAHVQAN-PGLDPIDVGCSLAS-RSV MLBr_00135|M.leprae_Br4923 RLSVVPWVVSGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSV MUL_2005|M.ulcerans_Agy99 SLPVVPWVISARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSA MAV_3108|M.avium_104 PDAVVPWVVSARSAEALAGQARRLLDHVTAD-AQASPLDVGWSLVSTRAV MMAR_2472|M.marinum_M -APTVPWVLSARSAPALANQAQRLLSWAEEH-PDLDPVDVGWSLAATRSL Rv1661|M.tuberculosis_H37Rv -PVAVPWVLSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSL TH_4621|M.thermoresistible__bu AAGPLVFALSSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAH :*. *. * * * *: : *: Mflv_0405|M.gilvum_PYR-GCK FEHRAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQG MAB_0939|M.abscessus_ATCC_1997 FEHRAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTTAWLFTGQG MSMEG_0408|M.smegmatis_MC2_155 FEYRAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTTAWLFTGQG Mvan_1003|M.vanbaalenii_PYR-1 FEHRAALVVDSVDGARDLLAGLAEDRLGPGAVRGVCGDPPKTAWLFTGQG Mb2971c|M.bovis_AF2122/97 FEHRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQG MLBr_00135|M.leprae_Br4923 FEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQG MUL_2005|M.ulcerans_Agy99 FEHRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQG MAV_3108|M.avium_104 FEHRAVVVGRERGALATGLAGLASGRPGPATVVGRARSTGKTVLVFPGQG MMAR_2472|M.marinum_M FEHRAVVVGTDRTQLMDGLAGVVAGEPGAGVVVGRARSTGKTVFVFPGQG Rv1661|M.tuberculosis_H37Rv FDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQG TH_4621|M.thermoresistible__bu RPVRTTVIADGVEALTAGLREVADGDAPYQPAVG--MDDKAPVWVFSGQG *:.:: * :. . . * .. :*.*** Mflv_0405|M.gilvum_PYR-GCK SQYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVP MAB_0939|M.abscessus_ATCC_1997 SQYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGK MSMEG_0408|M.smegmatis_MC2_155 SQYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET--- Mvan_1003|M.vanbaalenii_PYR-1 SQYPGMARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN--- Mb2971c|M.bovis_AF2122/97 AQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGAD------ MLBr_00135|M.leprae_Br4923 AQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD------ MUL_2005|M.ulcerans_Agy99 SQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSD------ MAV_3108|M.avium_104 SQTLGMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGAD------ MMAR_2472|M.marinum_M AQYLGMGRVLYERFSAFSTAFDAAAAELDAHLRLPLRQVMWGTD------ Rv1661|M.tuberculosis_H37Rv AQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPG----- TH_4621|M.thermoresistible__bu SQWAGMGAELLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET----- :* **. * .* . : .: :.: Mflv_0405|M.gilvum_PYR-GCK PTETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVA MAB_0939|M.abscessus_ATCC_1997 AGEALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA MSMEG_0408|M.smegmatis_MC2_155 -ADLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVA Mvan_1003|M.vanbaalenii_PYR-1 -GQTLRHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVA Mb2971c|M.bovis_AF2122/97 -ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAA MLBr_00135|M.leprae_Br4923 -AGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVA MUL_2005|M.ulcerans_Agy99 -VALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVA MAV_3108|M.avium_104 -PELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVA MMAR_2472|M.marinum_M -EGLLESTEFAQPALFAVEVALAALLSQLGVVPDLVLGHSVGEISAAHVA Rv1661|M.tuberculosis_H37Rv -APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVA TH_4621|M.thermoresistible__bu ----VTGIDRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVA : . .*.:*:.. :. .: *. *:*** *: :** .* Mflv_0405|M.gilvum_PYR-GCK GVFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRV-EQVAADFPR-V MAB_0939|M.abscessus_ATCC_1997 GVFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHV-EQIAGEFPR-V MSMEG_0408|M.smegmatis_MC2_155 GVFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHV-EQVAGEFPR-V Mvan_1003|M.vanbaalenii_PYR-1 GVFGLEDGARLVADRGRLFGGLPVGGRMVAVFTDAEVV-EDFADEFPQ-V Mb2971c|M.bovis_AF2122/97 GVLTLADAAMLVVARGRLMQALPAGGAMVAVAASE----DEVEPLLGEGV MLBr_00135|M.leprae_Br4923 GVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASE----DEVVSLLGEGV MUL_2005|M.ulcerans_Agy99 GVLTLVDAAMLVVARGRLMQALPAGGAMVAVAAAE----DEVLPSLTDGV MAV_3108|M.avium_104 GVLSLRDAARLVAARGALMAALPPGGVMVAVTAGE----SQVGPLLGGGV MMAR_2472|M.marinum_M GVLSLPDAARLVAARGRLMAGLAAGGAMVAVAASE----QEVTPLLGSGV Rv1661|M.tuberculosis_H37Rv GALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQA-EKLASQWGDRL TH_4621|M.thermoresistible__bu GALSLEDGVKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDV *.: *.. :: *. : : .* * :: . . : Mflv_0405|M.gilvum_PYR-GCK SVGAYNGPN-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDP MAB_0939|M.abscessus_ATCC_1997 SVGAYNGPN-TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDP MSMEG_0408|M.smegmatis_MC2_155 SVGAYNGPN-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDP Mvan_1003|M.vanbaalenii_PYR-1 SVAAYNGPN-TVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDP Mb2971c|M.bovis_AF2122/97 GIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEP MLBr_00135|M.leprae_Br4923 GIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEP MUL_2005|M.ulcerans_Agy99 GIAAINAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEP MAV_3108|M.avium_104 SIAAVNGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEP MMAR_2472|M.marinum_M AVAAVNGPDSVVISGPEAAVGEVVDRIAALGRRTHRLAVSHAFHSELMDP Rv1661|M.tuberculosis_H37Rv NIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDA TH_4621|M.thermoresistible__bu VLSVIASPESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDP :.. . . .*:.* * : .. * ** ::. Mflv_0405|M.gilvum_PYR-GCK VLDEFESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPV MAB_0939|M.abscessus_ATCC_1997 ILDEFESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPV MSMEG_0408|M.smegmatis_MC2_155 VLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPV Mvan_1003|M.vanbaalenii_PYR-1 VLDEFESCAARLAYAAPTRPLVCNRTGAVVTGPG-VIDAQYWRRHARQPV Mb2971c|M.bovis_AF2122/97 MLEEFARVAARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPV MLBr_00135|M.leprae_Br4923 MLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAV MUL_2005|M.ulcerans_Agy99 MLEEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAV MAV_3108|M.avium_104 MLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPV MMAR_2472|M.marinum_M MLPDFAEVLKGVSASQPRISLVSNVTGQLAEAG--YGSAAYWVEHVRKPV Rv1661|M.tuberculosis_H37Rv IREELIAALRGIEPRTSTVAFFSTVTGELMDTA--GVNAEYWYRSIRQPV TH_4621|M.thermoresistible__bu ILDELEEILADLQPMTPTVPYYSATSYDPREKP--VCDADYWVDNLRHEV : : . . . : ** : * Mflv_0405|M.gilvum_PYR-GCK QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEH----LAAPRAIAS MAB_0939|M.abscessus_ATCC_1997 QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEH----LAPPRAIVS MSMEG_0408|M.smegmatis_MC2_155 QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEH----MAAPRAVAS Mvan_1003|M.vanbaalenii_PYR-1 QFAESVRTLADLGCSVLMEIGPQPFLIAAALRVWPES----AATPRAIPS Mb2971c|M.bovis_AF2122/97 RFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAP------AEAMVVSM MLBr_00135|M.leprae_Br4923 RFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAP------AEAVVVSM MUL_2005|M.ulcerans_Agy99 RFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAP------AEAVVVSM MAV_3108|M.avium_104 RFVDGVRLAESQGAGVFLEVGPGAALTSAVEQSLT------SDRAMSVVT MMAR_2472|M.marinum_M RFADSVALAESLGAAAFVEVGPSGGLTALVEQSLT------RETP-AVPL Rv1661|M.tuberculosis_H37Rv QFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPT TH_4621|M.thermoresistible__bu RFAAAVQAALEDGFRVFGELSPHPLLTRAVEQTARG----LDMPVAALPA :* .. * : * .* * . : Mflv_0405|M.gilvum_PYR-GCK LRKGVADRRQIADALAAAYIGGHKPDFAALHEQRG-VRLELPTYPFQRRR MAB_0939|M.abscessus_ATCC_1997 LRKGVEDRRQIADALASAYVSGHRPNFAALQRHPR-RTVELPTYPFQRRR MSMEG_0408|M.smegmatis_MC2_155 LRKGVADRRQIADALASAYVGGHRPDFAAVHRQPR-RPVELPTYPFQRRR Mvan_1003|M.vanbaalenii_PYR-1 LRKGPDARRQLAEAVAAAYIAGHRLDFTGHDGGPH-RRLPLPTYPFQHRS Mb2971c|M.bovis_AF2122/97 LGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRR MLBr_00135|M.leprae_Br4923 MGKDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRR MUL_2005|M.ulcerans_Agy99 LGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRR MAV_3108|M.avium_104 MPKGRPEVDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRR MMAR_2472|M.marinum_M LIKDRPENDALLLGLGQLFADGRALDWREAFAGLGAQRTDLPTYGFVRRR Rv1661|M.tuberculosis_H37Rv LGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQR TH_4621|M.thermoresistible__bu MRREQEMPHGVRTMVGDLFAAGAAVDFAALYPSGRLVDAPLPTWTRRKLV : : . . * : ***: : Mflv_0405|M.gilvum_PYR-GCK FWPKSAGMA---IDGRVGASAGSGILGSGKD-LASGD-SVYTSRLSVKTQ MAB_0939|M.abscessus_ATCC_1997 FWPKSSGTA---IEG--GGGLPSGILGRGED-LASGD-SVYISRLSVRSQ MSMEG_0408|M.smegmatis_MC2_155 FWPKASSIA---VDG---GTAASGILGSGKD-LASGD-TIYTSRLSVKSQ Mvan_1003|M.vanbaalenii_PYR-1 YWPKTAGIR---SDG----SSGSGLLGSAQD-LASGD-IVHTSRLSVKTQ Mb2971c|M.bovis_AF2122/97 FWETPGADGPADAAGLGLGATEHALLGAVVERPDSDE-VVLTGRLSLADQ MLBr_00135|M.leprae_Br4923 FWETPGTDGTASVSGLGLGSTEHALLGAVVERPDSGG-VVLTGRLSLANQ MUL_2005|M.ulcerans_Agy99 FWEVPGADGPADATGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALADQ MAV_3108|M.avium_104 FWLSGDAVGSANIASLGLAEAEHPLLGAVLDRPDSGG-VVLTGRLSTAAQ MMAR_2472|M.marinum_M YWLKELGVDQTKLTGAGLTGVGHPLLGAVVERPDVGG-LVLTGVLSPELH Rv1661|M.tuberculosis_H37Rv FWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGG-VVLTGRISVVAA TH_4621|M.thermoresistible__bu LSRENGEQQ----TRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGAQ :*. : . :. Mflv_0405|M.gilvum_PYR-GCK PWLSDHVIYGTVVVPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKS MAB_0939|M.abscessus_ATCC_1997 PWLSDHVIYGTVVVPGATYAAMALAAVGTP--ARAKDVFFYEPIILPEKS MSMEG_0408|M.smegmatis_MC2_155 PWLADHVIYGTVVVPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKA Mvan_1003|M.vanbaalenii_PYR-1 PWLSDHVIYGTVVVPGATYAAMALAAMPTP--ARVQEVFFYEPIILGDKD Mb2971c|M.bovis_AF2122/97 PWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGV MLBr_00135|M.leprae_Br4923 PWLADHVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGS MUL_2005|M.ulcerans_Agy99 PWLADHVIGGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGM MAV_3108|M.avium_104 PWLADHAVAGTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGG MMAR_2472|M.marinum_M PWLRDHTVDGVVLFPGAGFVELALRAGDEVGCPLVQELTLLAPLALPQTG Rv1661|M.tuberculosis_H37Rv PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG TH_4621|M.thermoresistible__bu PWLADHQIHTVAALPGAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLD *** ** : .. .**: : :.: * . :: : Mflv_0405|M.gilvum_PYR-GCK SREVQLTVHPSV-DGE-SKFQVHSRPYGERG-AEWALNAEGVVASGVGD- MAB_0939|M.abscessus_ATCC_1997 SREVQLTLHPLE-DGSGSKFQVHSRPYGERD-VDWSLNAEGTVVTGIGDD MSMEG_0408|M.smegmatis_MC2_155 SREVQLTLHPAD-GGSVLSFQIHSRPYGERG-ADWSLNAEGTVDTAGSD- Mvan_1003|M.vanbaalenii_PYR-1 SREVQLMLHRTD-DADGWTFEVHSRPYGDRD-ADWSRNASGTVAAGVGD- Mb2971c|M.bovis_AF2122/97 GVQVQVVVGAAD-ESGHRAVSVYSRGDQSQG---WLLNAEGMLG------ MLBr_00135|M.leprae_Br4923 GVQVQVVVAAAD-ESSRRAVSVYSRGDQSHGG--WLLNAEGLLE------ MUL_2005|M.ulcerans_Agy99 GVQVQVIVGTAD-DSGNRALSVYSRGDKSED---WLLNAEGMLG------ MAV_3108|M.avium_104 TVQLQVVVADAAGQPGSRSVAVYSRVAQS----EWTLHAEGVLS------ MMAR_2472|M.marinum_M TVRMQLVVGGAD-ESGRRTVSVFSSTADGD---SWVLHAEGVLR------ Rv1661|M.tuberculosis_H37Rv -VRVQVVVGGVE-QSGTRNVWVYSAAGQADSSPGWTLHAQGVLG------ TH_4621|M.thermoresistible__bu EQTEVSAVASAVEPGTLEFAVETAKDGEHERRATAVLGAADDTE------ : : * . Mflv_0405|M.gilvum_PYR-GCK --SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLKS MAB_0939|M.abscessus_ATCC_1997 AEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLKS MSMEG_0408|M.smegmatis_MC2_155 --PDAAADEQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKS Mvan_1003|M.vanbaalenii_PYR-1 ----AAPDAAADPVDNAIERLTRTRPQQLFDAFADNDLAWGPAWCSSLRS Mb2971c|M.bovis_AF2122/97 ---VAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQG-LVA MLBr_00135|M.leprae_Br4923 ---VDAAEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQG-LVA MUL_2005|M.ulcerans_Agy99 ---VEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVG MAV_3108|M.avium_104 ---EAAPAPAAELSVWPPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRA MMAR_2472|M.marinum_M ---ASGVGHGVDLSVWPPVGASAVDVSDVYDRFAARGYGYGPAFRG-LRS Rv1661|M.tuberculosis_H37Rv ---VGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRG-LQA TH_4621|M.thermoresistible__bu ------PPQAHDIDALLAEHPTRIEGDELRQWFDQRGVQFGPAFTGLTAA : : :** : . . Mflv_0405|M.gilvum_PYR-GCK LWLGE--GEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLA MAB_0939|M.abscessus_ATCC_1997 LWLGE--GEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLA MSMEG_0408|M.smegmatis_MC2_155 LWLGD--GEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLA Mvan_1003|M.vanbaalenii_PYR-1 LWVGT--GEAVGDIAVGAELGEHLGREPIHPVLLDLCTGIAGAALLAAAA Mb2971c|M.bovis_AF2122/97 IWRRG--SELFAEVVAPGEAGVAVDRMGMHPAVLD----AVLHALGLAVE MLBr_00135|M.leprae_Br4923 IWRRG--SELFAEVVAP--TGVVVDGMGMHPALLD----AVLHALGLAIE MUL_2005|M.ulcerans_Agy99 VWRRD--SELFAEVVAP--SGVAVDKMGMHPVVLD----AVLHALGLTAE MAV_3108|M.avium_104 VWRRG--AETFAEVELPEQAGVSTGRFGIHPVLLD----AALHALGVAD- MMAR_2472|M.marinum_M VWRRG--REIYAEVVAPEDATVQG--FGIHPAVLD----AALHAWGFAT- Rv1661|M.tuberculosis_H37Rv LWRRG--AEVFADVTLPEGVPIRG--FGIHPAVLD----AALHAWGIVE- TH_4621|M.thermoresistible__bu RIPEGTVTSVLAEVGLPGQIRSQQAPYGIHPALLD----ACFQSVAAHPD . .:: :**.::* : Mflv_0405|M.gilvum_PYR-GCK AEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYL MAB_0939|M.abscessus_ATCC_1997 AEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYL MSMEG_0408|M.smegmatis_MC2_155 AEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFV Mvan_1003|M.vanbaalenii_PYR-1 QTDADPELFLPLRYGRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDFL Mb2971c|M.bovis_AF2122/97 KTQASTETRLPFCWRGVSLHAGGAGRVRARFAS------AGADAISVDVC MLBr_00135|M.leprae_Br4923 NTQATTEMRLPFCWRGVSLHAGGAGRVRARFTS------AGADAIAVDIA MUL_2005|M.ulcerans_Agy99 QNPDSDETKLPFCWRGVSLHAGGAGRVRARLTM------SGPDSISVEIA MAV_3108|M.avium_104 ---KRLETVLPFSWQGVSLHAAGASRVRVRLAP------AGAGAVSVELA MMAR_2472|M.marinum_M ---ATDQLMLPFSWQGVSLHAAGAARLRVRITP------ADAGSVSLELA Rv1661|M.tuberculosis_H37Rv ---GEQQTMLPFSWQGVCLHASGAARVRVRLAP------VGRGAVSVELA TH_4621|M.thermoresistible__bu VQGAGSGLLLPLGVRRLQAFGPTRGARYCYARVTDAD--GSKAEADLDVL **: : :: Mflv_0405|M.gilvum_PYR-GCK DRDGRHLGGVREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVPVP MAB_0939|M.abscessus_ATCC_1997 DRDGRHLGGIREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVAVP MSMEG_0408|M.smegmatis_MC2_155 DLGGRALGGIREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVPPP Mvan_1003|M.vanbaalenii_PYR-1 DHDGRNLGGIREFTVKRAPREALLRGLGADAT----RLIYRVGWRETSPP Mb2971c|M.bovis_AF2122/97 DATGLPVLTVRSLVTRPITAEQLRAAVTAAGG-ASDQGPLEVVWSPISVV MLBr_00135|M.leprae_Br4923 DSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGG-ALEQGPMDLVWSPIPLS MUL_2005|M.ulcerans_Agy99 DAAGLPVLTVGALVTRAMSAAQLRAAVAEAGGGAPDQGPLDVIWSPIPLS MAV_3108|M.avium_104 DASGVPVLSVRELVTRAVSAEQLAAAVAVRSG--SGE-LLDVAWSVIEPR MMAR_2472|M.marinum_M DPRGLPVLSVKQLVVRAVSGEALSAAVIAAGGTISGR-LLEVAWPPTSPE Rv1661|M.tuberculosis_H37Rv DPQGLPVLSVRQLMVRPVSAAALSRSTAGDRG------LLEMIWTPVPLE TH_4621|M.thermoresistible__bu DEHGNVLLRVQGLLMGGAAADGDDRDRVLGER------LLTIEWQRRDLP * * : : : . : * Mflv_0405|M.gilvum_PYR-GCK ----ESGDGAAPQGTWLIGGFDELAVSVPGCIPADR-------------- MAB_0939|M.abscessus_ATCC_1997 PVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRE------------- MSMEG_0408|M.smegmatis_MC2_155 ------PSADDAVGTWLIAGFDELAAKVPGCVPIDRN------------- Mvan_1003|M.vanbaalenii_PYR-1 ---VRDDGALGPSSTWLVAGLDALADDVPGSIRIGFDRIWDPDRDGRVVL Mb2971c|M.bovis_AF2122/97 S------GGANGSAPPAPVSWADFCAGSDG-------------------- MLBr_00135|M.leprae_Br4923 S------DGHGG-GLPSVVSWADYCAGRGN-------------------- MUL_2005|M.ulcerans_Agy99 G------SGTNGSAQPAVVSWADFCAGGDGGA------------------ MAV_3108|M.avium_104 N------SLPDNPISEGVTVWEPAAVDGAG-------------------- MMAR_2472|M.marinum_M L------SASDS--ARDVVVWESGSADGD--------------------- Rv1661|M.tuberculosis_H37Rv GG-----DIGDDAVVWELPPHAGAQAGGDV-------------------- TH_4621|M.thermoresistible__bu -------EADSAAGKWLLVSTSATADVSATRLSDALKQAG---------- Mflv_0405|M.gilvum_PYR-GCK --TNPESLRQLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAE MAB_0939|M.abscessus_ATCC_1997 --TDPELLGEVLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGE MSMEG_0408|M.smegmatis_MC2_155 --TDLQVLGEVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAE Mvan_1003|M.vanbaalenii_PYR-1 DPADDEHWRRLFALADERRAPVAGVVLGVTGRARPEE-PSADFAARLEAQ Mb2971c|M.bovis_AF2122/97 ---------------------DASVVVWELESAGGQASS---VVGSVYAA MLBr_00135|M.leprae_Br4923 ---------------------DTGVVVWEFGSASAGAQAPVDSVAAVYSA MUL_2005|M.ulcerans_Agy99 -------------------AGDAGVVVWEPNPAG------EDVVGPVYAA MAV_3108|M.avium_104 -------------------------------------------PAAVHAA MMAR_2472|M.marinum_M --------------------------------------------VAVGQR Rv1661|M.tuberculosis_H37Rv -------------------------------------------LAAVYRG TH_4621|M.thermoresistible__bu AESTSMCWPQQADHADNVDRFRAGIADGVTGVVVLTGPKNGNPDDAAARR Mflv_0405|M.gilvum_PYR-GCK IAELLGAVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWG MAB_0939|M.abscessus_ATCC_1997 IAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWG MSMEG_0408|M.smegmatis_MC2_155 ITNLLSAVHAAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWG Mvan_1003|M.vanbaalenii_PYR-1 IRDVLGAVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSALWG Mb2971c|M.bovis_AF2122/97 THTALEVLQSWLG-----ADRAATLVVLTHGGVGLAGEDISDLAAAAVWG MLBr_00135|M.leprae_Br4923 THAALQVLQFWFG-----QDRAGTLVVLTRGAVGLVGEGISDLAAAAVWG MUL_2005|M.ulcerans_Agy99 THAALEVLQSWFD-----GDRAGTLVVLTHGAVAMPGENVSDLAGAAVWG MAV_3108|M.avium_104 THQALGVLQSRLA-----GEAGGVLVVSTRGAVGLPGEDVADLAGAAVWG MMAR_2472|M.marinum_M VNEALAKLQSWLA-----GDDPGVLVVLTRGAVGLAGEGVTDLAGAAVWG Rv1661|M.tuberculosis_H37Rv VHEVLEVLQSWLA-----SDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG TH_4621|M.thermoresistible__bu GSDYVRHLVRITRELAEIDGDAPRLFVVTRGAQAVLPQDRPNLEQAGLRG : : : *. . . : :.: * Mflv_0405|M.gilvum_PYR-GCK FGRTAINEEPALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKL MAB_0939|M.abscessus_ATCC_1997 FGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKL MSMEG_0408|M.smegmatis_MC2_155 FGRTTINEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKL Mvan_1003|M.vanbaalenii_PYR-1 LGRTLIAEEPGLRCLLVDLDGSEDAGPALARLLGAP-GDEPELALRQGRL Mb2971c|M.bovis_AF2122/97 MARSAQAENP-GRIVLIDTDAAVDASVLAGV-------GEPQLLVRGGTV MLBr_00135|M.leprae_Br4923 MVRSAQSEHS-GKIVLIDTDSAVDVAVLADL-------GESQLLVRCNTV MUL_2005|M.ulcerans_Agy99 IVRSAQAENP-GRIVLVDADAAVEAAELVAV-------GEPQLVVRSGAA MAV_3108|M.avium_104 LVRSAQAEHP-GRVVLVDTDGSLDLATVIGC-------GEPQLVVRDGVA MMAR_2472|M.marinum_M LTRSAQAEHP-GRVVLVDTDDSVDIADAVAC-------GEPQLVVRSGVV Rv1661|M.tuberculosis_H37Rv LVRSAQAEHP-GRVVLVDTDGSVAVEDAVGFG---ARSGEPQLVVRRGRV TH_4621|M.thermoresistible__bu LLRVIGAEHPHLRTTQIDIADDADLDRVAVQLLGGG--AEDETAWRDGQW : * *.. : :* * : * . Mflv_0405|M.gilvum_PYR-GCK LASRLLPWSRSGHLTVPRGGD-----YVLAPTERGAIDNLRLTDSEVP-- MAB_0939|M.abscessus_ATCC_1997 LASRLLPWSRTGHLTVPRGSD-----YVLAPTERGAIDNLRITEKEVP-- MSMEG_0408|M.smegmatis_MC2_155 LASRLLPWARSGHLTLPRGGD-----FVLAPTERGAIDNLRLTETDVP-- Mvan_1003|M.vanbaalenii_PYR-1 LVPRLLPWSRSGQLAIPRGTD-----YVLAPTERGVLDNLRVSETEVT-- Mb2971c|M.bovis_AF2122/97 HAPRLSP--APALLALPAAESA----WRLAAGGGGTLEDLVIQPCPEVQA MLBr_00135|M.leprae_Br4923 HAARLSP--APQLLALPVGESM----WRLAADGGGTLEDLVIQPCPEVQA MUL_2005|M.ulcerans_Agy99 HAARLAP--AAPLLAVPADESA----WRLAAGGGGTLEDLVIEPCPEVQA MAV_3108|M.avium_104 YRARLRPAGRRALLELPGPPAV----WRLAAGDAGTLEDLAVQEHPA--A MMAR_2472|M.marinum_M HGARLRFIDSGSGLELPEGP------WRLAVGGGGTLEDVLVQPCPR--A Rv1661|M.tuberculosis_H37Rv YAARLAPVAAG--LTLPSASAGG---WRLVAGGGGTLADVVVAPVAP--V TH_4621|M.thermoresistible__bu YTARLSLSPLRPEERKQAVVDCERDGMRLEIRTPGDLETMELAAFDR--V .** * * : : : Mflv_0405|M.gilvum_PYR-GCK PPAEGYVQVRVEAAGLNFRDVLNVLGLYP---GDPGPIGGDFAGTVTQLG MAB_0939|M.abscessus_ATCC_1997 APDEGYVQVRVEAAGLNFRDVLNVLGLYP---GDPGPIGGDFAGIVTQLG MSMEG_0408|M.smegmatis_MC2_155 EPDEGYVQVRVEAAGLNFRDVLNVLGLYP---GDPGPIGGDFAGTVTQLG Mvan_1003|M.vanbaalenii_PYR-1 APPEGHVQVRVEAAGLNFRDVLNALGLYP---GDPGPIGGELAGVVTAPG Mb2971c|M.bovis_AF2122/97 PLQAGQVRVAVAAVGVNFRDVVAALGMYP---GQAPPLGAEGAGVVLETG MLBr_00135|M.leprae_Br4923 PLQAGHMRVAVAAVGVNFRDVVAALGMYP---GQAPPLGAEGAGVVIEIG MUL_2005|M.ulcerans_Agy99 PLAAGQVRVAVRAVGVNFRDVVAALGMYP---GAAPPLGAEGAGVVLEVG MAV_3108|M.avium_104 ELAPGQVRVRVAAAGVNFRDVLVALGMYP---GAAQ-LGAEGAGVVTEVG MMAR_2472|M.marinum_M DLAAGQVRVAVGAAGVNFRDVLVALGMYP---GGGA-LGAEGAGVVVEVG Rv1661|M.tuberculosis_H37Rv ELATGQVRVAVGAVGVNFRDVLVALGMYP---GGGE-LGVDGAGVVVEVG TH_4621|M.thermoresistible__bu PPGPGQIEVAVTASSINFADVLIAFGRYPTFDGRRPQLGTDFAGVVTAVG * :.* * * .:** **: .:* ** * :* : ** * * Mflv_0405|M.gilvum_PYR-GCK EGVTGLDVGQRVYGS-MQGAFASRFNVPGQFLAPIPDGVSAVEAATIPAA MAB_0939|M.abscessus_ATCC_1997 EGVTGVEVGQRVYGS-MQGAFGSRFNVPAQFLAPIPDGISGVEAATIPAA MSMEG_0408|M.smegmatis_MC2_155 AGVSGLEIGQRVYGS-MQGAFASRFNVPAQFLAPIPDGIGAVEAATIPAA Mvan_1003|M.vanbaalenii_PYR-1 PDVDGFDVGQRVFGF-AVGAFASRVNVPVQFLAPVPEGISAVAAATTPAA Mb2971c|M.bovis_AF2122/97 PEVTDLAVGDAVMG--FLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV MLBr_00135|M.leprae_Br4923 PEVTGVAVGDAVMG--FLGGAGPLAVVHQQLITQMPQGWSLAEAAAVPVV MUL_2005|M.ulcerans_Agy99 PQVSGVAVGDSVMG--FLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVV MAV_3108|M.avium_104 AGVTDVAVGDAVMG--IFGLVGSEAAVDRRLVTRVPPGWSMAQAAGIPVV MMAR_2472|M.marinum_M PGVEGLAVGDAVMG--LVGVVGSEAVVDERLVTTVPAGWSLAQAAGVPVV Rv1661|M.tuberculosis_H37Rv PGVTGLAVGDRVMG--LLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVA TH_4621|M.thermoresistible__bu PDVTSHRVGDRVGGLSPNGCWSTFVTCDADLAVPLPDGLTEGQAAAVSTA * . :*: * * * .. : . :* * ** ... Mflv_0405|M.gilvum_PYR-GCK ALTVRLSFD-WAQVKSGDKVLIHAASGGVGLAAVQMAQQCGAEVYATAST MAB_0939|M.abscessus_ATCC_1997 ALTVRLSFD-WAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEVFATAST MSMEG_0408|M.smegmatis_MC2_155 ALTVRLAFD-WAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEVFATAST Mvan_1003|M.vanbaalenii_PYR-1 VLTAGLAFD-WAALRAGDRVLIHAASGGVGLAAVQLARQRGATVFATASG Mb2971c|M.bovis_AF2122/97 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASR MLBr_00135|M.leprae_Br4923 FLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASR MUL_2005|M.ulcerans_Agy99 FLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASR MAV_3108|M.avium_104 FLTAYYGLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASR MMAR_2472|M.marinum_M FLTAFYGLSVLAGLKAGERVLIHAGAGGVGMAAVALAKYWGAEIFVTASR Rv1661|M.tuberculosis_H37Rv FLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASR TH_4621|M.thermoresistible__bu HATAWYGLHDLARLGAGEKVLIHSATGGVGLAAIAIARSVGAQIYATAGS *. .: * : .*: **:*:.:****:**: :*: *. ::.**. Mflv_0405|M.gilvum_PYR-GCK -FKRATLRKLGVK--HVYDSRTTDFAEQILADTDGAGVDVVLNSLTSEGF MAB_0939|M.abscessus_ATCC_1997 -FKRATLRKLGVK--YVYDSRTTDFADQILADTDGAGVDVVLNSLTSEGF MSMEG_0408|M.smegmatis_MC2_155 -FKRSTLRRLGVK--YVYDSRTTDFADQILADTNGAGVDVVLNSLTSAGF Mvan_1003|M.vanbaalenii_PYR-1 -YKRPMLRAMGVD--HVYDSRTTDFADQILADTDGAGVDVVLNSLTNDGF Mb2971c|M.bovis_AF2122/97 -GKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGE-F MLBr_00135|M.leprae_Br4923 -GKWDTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGD-F MUL_2005|M.ulcerans_Agy99 -GKWDTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGD-F MAV_3108|M.avium_104 -GKWDTLRAMGFDDAHIADSRTLDFEQKFGAAPG--GMDVVLNSLAGE-F MMAR_2472|M.marinum_M -GKWDTLRAMGFDDEHIGDSRSLEFEEKFRKTSGGAGVDVVLNSLAGE-F Rv1661|M.tuberculosis_H37Rv -AKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGE-F TH_4621|M.thermoresistible__bu PARRDLLRDMGIE--HVYDSRSTAFADEIRRDTDGYGVDVVLNSLPGA-A : ** :*.. :: ***: * : : . *:****:**.. Mflv_0405|M.gilvum_PYR-GCK IEATLRATAQHGRFAEIAKRDIWTVEQMAAA--RPDLAYEIVALDTVMFT MAB_0939|M.abscessus_ATCC_1997 IEATLRATAKNGRFAEIAKRDIWTTEQMAQS--RPDIAYEIVALDTVMFQ MSMEG_0408|M.smegmatis_MC2_155 VEATLKATAQGGRFAEIAKRDIWSHEQMAEA--RPDIAYEIVALDTVMFT Mvan_1003|M.vanbaalenii_PYR-1 VAATVRATARNGRFAEIAKRDIWSPEQMAAA--RPDIDYEVLALDAVMQQ Mb2971c|M.bovis_AF2122/97 VDASLRLLVRGGRFLEMGKTDIRDAQEIAAN--YPGVQYRAFDLSEAG-- MLBr_00135|M.leprae_Br4923 VDASLRLLVRGGRFLEMGKTDIRDAQEIAAN--YPGVQYRAFDLSEAG-- MUL_2005|M.ulcerans_Agy99 VDASLRLLVRGGRFLEMGKTDIRDADKIAAN--YPGVWYRAFDLSEAG-- MAV_3108|M.avium_104 NDASLRLLGPGGRFIEMGKTDLRDPDVVARA--HPGVRYRAFDLMEAG-- MMAR_2472|M.marinum_M TDASLRLLVSGGRFIEMGKTDLRDPQAVADE--YPGVSYRAFDLMEAG-- Rv1661|M.tuberculosis_H37Rv TDASLRLLPSGGRFIELGKTDIRDGQTVAER--HRGVRYRAFDLVEAG-- TH_4621|M.thermoresistible__bu QRAGLELLSFGGRFIEIGKRDIYGDTRLGLFPFRRNLAFHGVDLGLMADS * :. *** *:.* *: :. .: :. . * Mflv_0405|M.gilvum_PYR-GCK EPDRIRDLLTEVSAGLRDGAWTPLPAEVYPLTEARAAFRRMQQARHIGKI MAB_0939|M.abscessus_ATCC_1997 EPDRIRVLLTEVSEGLAKGEWTPLPAEIYPLTEARTAFRRMQQARHIGKI MSMEG_0408|M.smegmatis_MC2_155 EPDRIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAFRRMQQARHIGKI Mvan_1003|M.vanbaalenii_PYR-1 DPDRIQLLLADLADSLARGETAPLPFEAYPLAEATTAFRRMQQARHTGKI Mb2971c|M.bovis_AF2122/97 -PARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKV MLBr_00135|M.leprae_Br4923 -PVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARHIGKV MUL_2005|M.ulcerans_Agy99 -PVRMQEMLAEVRELFDTAVLHRLPVTTWDVRCAPAAFRFMSQARHIGKV MAV_3108|M.avium_104 -PDRIAAMLAEVMELFAAGALTPLPVKAFDARCAADAYRFVSAARHIGKV MMAR_2472|M.marinum_M -PDAIARMLSEVVGLLQEGILKAPPLKLFDVRSAQQAYRYVSQARHIGKV Rv1661|M.tuberculosis_H37Rv -PDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKV TH_4621|M.thermoresistible__bu HPHKIRELLETVYRLTADGVLPMPQSTHYPLAEAATAIRVMSAAEHVGKL * : :* : : * * * :. *.* **: Mflv_0405|M.gilvum_PYR-GCK VVQIPNPLQPQ---PDRSYLITGGLGAIGLHTAGYLAQ-LGAGDIVLTSR MAB_0939|M.abscessus_ATCC_1997 VCQMPNPLAPR---PDRTYLITGGLGAIGLHTAAYLAQ-LGAGDIVLTSR MSMEG_0408|M.smegmatis_MC2_155 VLQVPKPLQPQ---QDRSYLITGGLGAIGLHTAAYLAQ-LGAGDIVLTSR Mvan_1003|M.vanbaalenii_PYR-1 ILQMPKPLQPH---GDRSYLITGGLGALGLHAAAYLAQ-LGAGDIVLTGR Mb2971c|M.bovis_AF2122/97 VLTMPSALADR--LADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASR MLBr_00135|M.leprae_Br4923 VLTMPSALADG--LAEGTVLITGASGAIGGVLARHMVSAYGVRHLVLASR MUL_2005|M.ulcerans_Agy99 VLTMPSALADG--LADATVLITGATGAVGAVLARHMLDGYGVRHLVLASR MAV_3108|M.avium_104 VLTMPDGPAG---LSGGTALITGATGMAGAALARHLVARHRVPHLMLVGR MMAR_2472|M.marinum_M VLTLPQGPAAQSVLSGGTVLITGGTGMAGAAVARHLVQRYGVGHVVLVSR Rv1661|M.tuberculosis_H37Rv VLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSR TH_4621|M.thermoresistible__bu VLDVPHTGRAD------VVVPPEQASPFRSDGAYIVTGGMGGLGLYLAGE : :* : . . * : : *... Mflv_0405|M.gilvum_PYR-GCK RAPDAAAQQAIADIADRTKARLHVFTADVGVEADVAALLERIRAELPPLA MAB_0939|M.abscessus_ATCC_1997 RAPDTDAQRVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLA MSMEG_0408|M.smegmatis_MC2_155 RDPDESAQRAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLA Mvan_1003|M.vanbaalenii_PYR-1 RMPDAATERAISEIAERYHCRIHTFAADVGDESAVRDLLERIRTELPPLA Mb2971c|M.bovis_AF2122/97 RGDRAEGAAELAADLTEAGAKGQVVACDVADRAAVAGLFAQLSREYPPVR MLBr_00135|M.leprae_Br4923 RGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVR MUL_2005|M.ulcerans_Agy99 RGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVR MAV_3108|M.avium_104 RGEAAPGMAELAAELRGAGASVSVLSCDVGDRDAVAAMLAQVPARYP-LR MMAR_2472|M.marinum_M AGTQAPGIADLVAELQQGGAQVSVTACDVADRDAVAALLAQLPDRYP-LK Rv1661|M.tuberculosis_H37Rv SGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYP-LK TH_4621|M.thermoresistible__bu MAAAGAGCIVLNGRSAPSGEALRTIEQLRAAGTEVIVECGXX------XR : . . : Mflv_0405|M.gilvum_PYR-GCK GVAHLAGVLDDALLSQQSVERFRTALAPKAFGAVH-LDRLTRVDDLDFFL MAB_0939|M.abscessus_ATCC_1997 GVAHLAGVLDDALLGQQSVERFRTTLAPKAFGAEY-LDRLTKGDDLDFFI MSMEG_0408|M.smegmatis_MC2_155 GIAHLAGVLDDALLSAQNPERFRTTLAPKAYGASH-LDRLTRDDDLDFFI Mvan_1003|M.vanbaalenii_PYR-1 GVAHLAGVLDDALLPQQSPERFRTTLAPKAFGAWH-LHRLTRDTELEFFI Mb2971c|M.bovis_AF2122/97 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWN-LHQATSDLDLSMFV MLBr_00135|M.leprae_Br4923 GVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWN-LHEATRDLDLLMFV MUL_2005|M.ulcerans_Agy99 GVIHAAGVLDDAVISSLTPERIDTVLRAKVDAAWN-LHEATLDLDLSMFV MAV_3108|M.avium_104 SVFHAAGVLDDAVIASLTPARIDTVLRAKVDGAWN-LHELTKDLDLSAFV MMAR_2472|M.marinum_M GIFHAAGVLDDAVLASLTPDRVEPVLRAKAAGAWN-LHELTHGMDLAAFV Rv1661|M.tuberculosis_H37Rv GVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWN-LHELTEDMDLSAFV TH_4621|M.thermoresistible__bu GQPVEVAVPTELRHADEHPDRRGAQLCDEFARGEQGAQRNQHRTDAGEGQ . ..* : * . * : . .. : Mflv_0405|M.gilvum_PYR-GCK VSSSVSSLFGSPGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGG MAB_0939|M.abscessus_ATCC_1997 VSSSVSSLFGSPGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQGG MSMEG_0408|M.smegmatis_MC2_155 VSSSVSSLFGSPGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQGG Mvan_1003|M.vanbaalenii_PYR-1 VYSSGSSVLGSPGQANYATANAVLDGLVAHRKARGLPATGVNWGPWAQGG Mb2971c|M.bovis_AF2122/97 LCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPG MLBr_00135|M.leprae_Br4923 LCSSIAATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPG MUL_2005|M.ulcerans_Agy99 LCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSG MAV_3108|M.avium_104 VFSSMAGIVGAPGQGNYAAANSFLDALAIHRHAHGLPALSVAWGMWEEPS MMAR_2472|M.marinum_M MFSSLAGIAGAPGQGNYAAANAFLDGLAAYRRGQDLPAVSIAWGLWEQPS Rv1661|M.tuberculosis_H37Rv VFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQAS TH_4621|M.thermoresistible__bu RDAHPPGAVGHDQPDPGALSDTGLD-----ERGGQFPGVGVQIPVADPGV : .. * : ::: ** .:. : . .: Mflv_0405|M.gilvum_PYR-GCK ---MASSEAAAANISAQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQ MAB_0939|M.abscessus_ATCC_1997 ---MASSEAATANISAQGLIPLDPSAALAALAEVVANGTGQATILKANWQ MSMEG_0408|M.smegmatis_MC2_155 ---MASSEAATANITAQGLIPLDPSAALHALAEVIANGSGQATVLKANWQ Mvan_1003|M.vanbaalenii_PYR-1 ---MATSDAARANLGAQGLIPLEPTAALNALGEIVAHGIASAVVLKANWQ Mb2971c|M.bovis_AF2122/97 GMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAID--HPLAVATLLD MLBr_00135|M.leprae_Br4923 GMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVID--HPFMVTALLD MUL_2005|M.ulcerans_Agy99 GMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAIN--HPLMVATLLD MAV_3108|M.avium_104 AMTAHLEERDKARMSRAGLSALSTRQALDLLDDALLGE--QPLVVGTRLD MMAR_2472|M.marinum_M TMTQHLGDRDLARMRQVGLDPLSTEHALHLLDAALLGE--RPGVVAAQLN Rv1661|M.tuberculosis_H37Rv AMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQAD--RAVVVAARLD TH_4621|M.thermoresistible__bu G--------------------IDHRGAVRVDSGVPAQQGVDGEVVRHRTL : *: : Mflv_0405|M.gilvum_PYR-GCK RAAKVLGS---SRPPILDLVLPS--------AVGEITGDSELLKQLQEIP MAB_0939|M.abscessus_ATCC_1997 RAAKVLGS---SRPPILDLVLPS--------AVGEVTGDSELLKQLMEIP MSMEG_0408|M.smegmatis_MC2_155 RAAKVLGS---ARPPILDLVLPS--------AAGEATGDSELLKQLMEIP Mvan_1003|M.vanbaalenii_PYR-1 RAAKLLGA---TRPPILDHVLPS--------AVAAGPGDSALLKQLQDVP Mb2971c|M.bovis_AF2122/97 RAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLA MLBr_00135|M.leprae_Br4923 RAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLA MUL_2005|M.ulcerans_Agy99 RPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLS MAV_3108|M.avium_104 RAALAQHR--AALPPLLSELAGRPARRMLE-HTD-MVSLTGLRARLAGMN MMAR_2472|M.marinum_M VAALSAN---PEVPPIWRDLVTRSVRRVVD-ANDNSASMTALISRLHTLS Rv1661|M.tuberculosis_H37Rv RAALAGAG--AALPALFSQLAAGPTRRRID-AADTAVSMSGLVSRLHALT TH_4621|M.thermoresistible__bu SSVRSGRSSRWTAPGSRCGSGRRYGGESCRRTTGPAAGAAARRGRTRRRR .. * . : Mflv_0405|M.gilvum_PYR-GCK VPQRAGFVTEFLQKEVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNR MAB_0939|M.abscessus_ATCC_1997 VPQRAGFVTEFLQREVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNR MSMEG_0408|M.smegmatis_MC2_155 IPQRAGFVTEFLQREVQNFLRLASPP--AASSRFLDLGTDSLMAIELRNR Mvan_1003|M.vanbaalenii_PYR-1 EAQRGSFVTEHLQRELQQILGLAQPP--AATGRFLELGMDSLMAVELRNR Mb2971c|M.bovis_AF2122/97 ADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNR MLBr_00135|M.leprae_Br4923 ANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNR MUL_2005|M.ulcerans_Agy99 AGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNR MAV_3108|M.avium_104 PEQRQAELVELVCGNAAAVLG-HSTADVDPGDAFSDLGFDSLTAVELRNR MMAR_2472|M.marinum_M PEQRSRELVDMICTNAATVLG-NASVDIDANKPFQDLGFDSLTAVELRNR Rv1661|M.tuberculosis_H37Rv PERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNR TH_4621|M.thermoresistible__bu RPRRPPPPPDRVRHRAGPAHGPVRR------------------------- .: : . Mflv_0405|M.gilvum_PYR-GCK LHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP------- MAB_0939|M.abscessus_ATCC_1997 LHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAP------ MSMEG_0408|M.smegmatis_MC2_155 LHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA-------- Mvan_1003|M.vanbaalenii_PYR-1 LVGQFGSGFTITATAVFDYPTIGALAEYLAAQTPESTEEGTEMK------ Mb2971c|M.bovis_AF2122/97 LKTATG--LTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESG-------- MLBr_00135|M.leprae_Br4923 LKSATG--LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESG-------- MUL_2005|M.ulcerans_Agy99 FKSATG--LTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAE-------- MAV_3108|M.avium_104 LKIATG--LTLSPTVIFDHPTPAALAEHLGGQLTSAGPTPAAPAETAAPP MMAR_2472|M.marinum_M LKSSTG--LTLSPTLIFDYPTPAALAEHLSTQLSSLSPAAAD-----EQP Rv1661|M.tuberculosis_H37Rv LKTATG--LTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQ-------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ------------QSESEPGPDVTE-------------------------- MAB_0939|M.abscessus_ATCC_1997 ------PAVESAEAESGAGPAAASDAVSELKE------------------ MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 ------TADPDGQPATVGHADVVLQTS----------------------- Mb2971c|M.bovis_AF2122/97 ------DPTSQVVEPAAAEVSVHA-------------------------- MLBr_00135|M.leprae_Br4923 ------DETSQAVEPKVEEVSVHA-------------------------- MUL_2005|M.ulcerans_Agy99 ------EE--KLPESDGEMVSVTA-------------------------- MAV_3108|M.avium_104 DRSSRIDEVVSELQTLLTQPGLSPGDRAQLVTRLQSLLSTPPQPSGHPEF MMAR_2472|M.marinum_M NRLARFDAVARELDSMINEPDWTAEDRERVSNRLHGLLADLTSPQSRGE- Rv1661|M.tuberculosis_H37Rv SLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTE------ TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --------------------------- MAB_0939|M.abscessus_ATCC_1997 --------------------------- MSMEG_0408|M.smegmatis_MC2_155 --------------------------- Mvan_1003|M.vanbaalenii_PYR-1 --------------------------- Mb2971c|M.bovis_AF2122/97 --------------------------- MLBr_00135|M.leprae_Br4923 --------------------------- MUL_2005|M.ulcerans_Agy99 --------------------------- MAV_3108|M.avium_104 PEDAFDDDIATATDSQLFAILDDEAGP MMAR_2472|M.marinum_M -DHSHDDDISSASESELFAILDEELGP Rv1661|M.tuberculosis_H37Rv -----DDDIAAATESQLFAILDEELGS TH_4621|M.thermoresistible__bu ---------------------------