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MKAMAQRTWNPAEPLELIELPTPEPKAGEVRVQVQAIGVNPVDWKMRSSGPLRLAARLIGPKPPVVVGVD FAGVVEAVGPGVTRAAPGDRVVGGTNFSRGQRGSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWM AVVELGRIRQVPPADRRVLVLGASGGVGQLAVQIAKLQEAFVVGVCSTKNVEMVKDLGADLVLDYNQGDA LAQAKPHAPFHVVIDCVGSYSGAGCRALLSSRGRHIMVAGDEPSSALQVVVPPFKSKAILGRPNGARLEP LVDAVAAGKLRVSIAQKLPLTSAEEAHRLSQTSRMTGKLILEP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2950 | - | - | 100% (323) | oxidoreductase |
| M. marinum M | MMAR_2814 | fadB5 | 2e-27 | 30.99% (355) | oxidoreductase FadB5 |
| M. marinum M | MMAR_1738 | - | 5e-27 | 31.17% (324) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1947c | fadB5 | 5e-29 | 30.68% (352) | oxidoreductase FADB5 |
| M. gilvum PYR-GCK | Mflv_2124 | - | 5e-29 | 28.57% (329) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1912c | fadB5 | 4e-28 | 30.40% (352) | oxidoreductase FADB5 |
| M. leprae Br4923 | MLBr_00118 | - | 2e-19 | 25.54% (325) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_1486c | - | 2e-32 | 31.72% (331) | putative oxidoreductase |
| M. avium 104 | MAV_3325 | - | 1e-23 | 30.45% (335) | quinone oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4064 | - | 1e-30 | 30.34% (323) | zinc-binding alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_3440 | - | 5e-25 | 29.11% (347) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_2209 | - | 1e-180 | 98.45% (323) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5758 | - | 2e-32 | 34.25% (327) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1947c|M.bovis_AF2122/97 -----------------------------------------------MRA
Rv1912c|M.tuberculosis_H37Rv -----------------------------------------------MRA
MMAR_2950|M.marinum_M -----------------------------------------------MKA
MUL_2209|M.ulcerans_Agy99 -----------------------------------------------MKA
Mflv_2124|M.gilvum_PYR-GCK -------------------------------------------MSDRMKA
Mvan_5758|M.vanbaalenii_PYR-1 -----------------------------------------------MRA
MAB_1486c|M.abscessus_ATCC_199 ----------------------------------------------MTQA
MAV_3325|M.avium_104 -----------------------------------------------MHA
TH_3440|M.thermoresistible__bu VQTAAAQRRDEIGVIGVALRAVRTTGQNDPRMEHIRAGELHTGMIGAMKA
MSMEG_4064|M.smegmatis_MC2_155 ----------------------------MIRNSLRGIMSWRLGLFKGVKA
MLBr_00118|M.leprae_Br4923 -----------------------------------------------MHA
:*
Mb1947c|M.bovis_AF2122/97 VVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADHLARVG---
Rv1912c|M.tuberculosis_H37Rv VVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADHLARVG---
MMAR_2950|M.marinum_M MAQRTWNPAEPLELIELPTPEP-KAGEVRVQVQAIGVNPVDWKMRSSGPL
MUL_2209|M.ulcerans_Agy99 MAQRTWNPAEPLEFIELPTPEP-QAGEVRVQVQAIGVNPVDWKMRSSGPL
Mflv_2124|M.gilvum_PYR-GCK VVLARFGGADAFELRDVAVPHV-GPRQVRVRVHATAVNPLDYQIRRG---
Mvan_5758|M.vanbaalenii_PYR-1 AVLTAYN--SPLLVDELPDPEP-GPGEVLVRVMASGVNPLDIKIRRGE--
MAB_1486c|M.abscessus_ATCC_199 IVATSYGGADVLEFRDITTPGP-GPGQVLINVKAAGVNPIDWKLYSG---
MAV_3325|M.avium_104 IEVSETGGPEVLRYVETPTPTA-GPGQVLIKAEAIGVNYIDTYFRSG---
TH_3440|M.thermoresistible__bu IEVRETGGPEVLTYVDVPEPTP-GPGQVLIKAEAIGVNFIDTYFRSG---
MSMEG_4064|M.smegmatis_MC2_155 IGVYEFGGPDALEVIDLPEPQA-GPGEVRIRVYAAAVSPTDVLLRTGG--
MLBr_00118|M.leprae_Br4923 IVAESAN---QMVWREVPDVTA-GPGEVLIEVAASGVNRADVLQVAG---
. : : . . :: : . * .*. * .
Mb1947c|M.bovis_AF2122/97 ---LYPDAPKLPAVVGYEVAGTVEAVGDGVD-PNRVGERVL-----AGTR
Rv1912c|M.tuberculosis_H37Rv ---LYPDAPKLPAVVGYEVAGTVEAVGDGVD-PNRVGERVL-----AGTR
MMAR_2950|M.marinum_M RLAARLIGPKPPVVVGVDFAGVVEAVGPGVT-RAAPGDRVVGGTNFSRGQ
MUL_2209|M.ulcerans_Agy99 RLAARLIGPKPPVVVGVDFAGVVEAVGPGVT-RAAPGDRVVGGTNFSRGQ
Mflv_2124|M.gilvum_PYR-GCK ---DYTDLVPLPAIIGHDISGVIEEVGSHVT-EFRAGDAVY-YTPKIFGG
Mvan_5758|M.vanbaalenii_PYR-1 ---APHAQLPPPAVLGIDMAGVVEAVGPRVD-RFTVGDEVFGMTGGVGGL
MAB_1486c|M.abscessus_ATCC_199 --AFGTDPDKLPMRLGLEISGTIAAVGAGVD-GLVPGDDVI-----AAGQ
MAV_3325|M.avium_104 -----QYPRELPFIIGQELCGTVAAAGDGVD-GFKVGDRVV-----SAAA
TH_3440|M.thermoresistible__bu -----LYPREVPFIVGTEVCGTVEAVGDGVA-ALRVGDRVL-----TDKA
MSMEG_4064|M.smegmatis_MC2_155 -HAVRMPGRRPPFVPGMDAAGVIDQIGPGCDGRLHVGQRVIAMVMFVGEH
MLBr_00118|M.leprae_Br4923 ---KYPHPPGASAIIGMEVAGVVAAVSSGVT-EWSVGQEVC-----ALLA
. * : .*.: . *: *
Mb1947c|M.bovis_AF2122/97 FGGYCEIVNVAATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAG
Rv1912c|M.tuberculosis_H37Rv FGGYCEIVNVAATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAG
MMAR_2950|M.marinum_M RGSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVVELGRIRQV
MUL_2209|M.ulcerans_Agy99 RGSYADTVLVREDQLCRVPDTVDIAVAAALPVGGVTAWMAVVELGRIRQV
Mflv_2124|M.gilvum_PYR-GCK PGSYAEQHVADVDLVGRKPDNLDHLEAASLTLVGGTVWESLVTRAQLTVG
Mvan_5758|M.vanbaalenii_PYR-1 QGSLAELAAVDARLIAHKPRTLSMAQAAALPLGFITSWEGLVDRAGVGTG
MAB_1486c|M.abscessus_ATCC_199 IGGYATRVIAAADQVFKKPASLSFNEAAGFLLTGQTAVH-LLEATNVTEG
MAV_3325|M.avium_104 TGGYAEYATAPASLTAHVPDGVAADVAASALLKGLTAHYLLTSVYPVQAG
TH_3440|M.thermoresistible__bu NGAYAEYTVAPADYVAYVPDGVAPDTVASALLKGMTAHYLIKSVYEVQRG
MSMEG_4064|M.smegmatis_MC2_155 GGAYAEQVVVPAASVVPAPANADFAAASTLLMNAMTARLALDTLG-LRAG
MLBr_00118|M.leprae_Br4923 GGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAG
*. . . * : * : :
Mb1947c|M.bovis_AF2122/97 ----ERVLIHAAAGGVGIAAVQFAKAAKAEVHGTASPQKHQKLA-EFGVD
Rv1912c|M.tuberculosis_H37Rv ----ERVLIHAAAGGVGIAAVQFAKAAKAEVHGTASPQKHQKLA-EFGVD
MMAR_2950|M.marinum_M PPADRRVLVLGASGGVGQLAVQIAKLQEAFVVGVCSTKNVEMVK-DLGAD
MUL_2209|M.ulcerans_Agy99 PSADRRVLVLGASGGVGQLAVQIAKLQEAFVVGVCSTENVEMVK-DLGAD
Mflv_2124|M.gilvum_PYR-GCK ----ETILIHGGAGGVGTIAIQVAKAMGARVITTAKAGDHAFVN-SLGAD
Mvan_5758|M.vanbaalenii_PYR-1 ----QQVLIHGGAGGVGFLAVQLALARGAQVYATGSTSSQAVIR-AAGA-
MAB_1486c|M.abscessus_ATCC_199 ----DTVLIHGAAGGVGLLATQLAKARGATVVATASAARHDQLR-GYGA-
MAV_3325|M.avium_104 ----DTVLVHAGAGGVGLILTQWAHLLGARVITTVSTPEKARRSAQAGAN
TH_3440|M.thermoresistible__bu ----DTILVHAGAGGVGLILTQWATHLGARVITTVSTPQKAELSRKAGAA
MSMEG_4064|M.smegmatis_MC2_155 ----ETVAVTGAAGAVGGFAVELAKADGLRVIADAAERDVELVR-GFGAD
MLBr_00118|M.leprae_Br4923 ----QLLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRALGAQ
: : ..:..:* : * * *.
Mb1947c|M.bovis_AF2122/97 RAIDYRRDG--------WWQGLGPYDVVLDALGGTSLRRSYTLLRPGGRL
Rv1912c|M.tuberculosis_H37Rv RAIDYRRDG--------WWQGLGPYDVVLDALGGTSLRRSYTLLRPGGRL
MMAR_2950|M.marinum_M LVLDYNQG-----DALAQAKPHAPFHVVIDCVGSYSGAGCRALLSSRGRH
MUL_2209|M.ulcerans_Agy99 LVLDYNQG-----DALAQAKPHAPFHVVIDCVGSYSGAGCRALLSSRGRH
Mflv_2124|M.gilvum_PYR-GCK VAIDHTSTD--YVDAVAEATRGRGVDVVFDTIGGDTLTRSPLSLAD-SGR
Mvan_5758|M.vanbaalenii_PYR-1 VPIDYTATT--VDEYVAAHTGGEGFDVVADNVGGATLDASFTAVKRYTGH
MAB_1486c|M.abscessus_ATCC_199 LPVEYGPG------LQERVSAIGPVDAALDLVGTDEAADVSLALVADKGR
MAV_3325|M.avium_104 EVLSYPDDADEFGNRIRALTDGAGVAAVYDGVGASTFDASLASLAVRGTL
TH_3440|M.thermoresistible__bu EVLDYPTDPEEFGARIRDLTGGEGVPVVYDGVGRSTFDASLASLAVRGTL
MSMEG_4064|M.smegmatis_MC2_155 HVVERGAEV-------AARIRGLVPGGVPGLVDGSDQQGEVLGAIADGGM
MLBr_00118|M.leprae_Br4923 ITINYRDED----FVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQL
:. . :.
Mb1947c|M.bovis_AF2122/97 VGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRL
Rv1912c|M.tuberculosis_H37Rv VGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRL
MMAR_2950|M.marinum_M IMVAGDEP-----------SSALQVVVPPFKSKAILGRP-----------
MUL_2209|M.ulcerans_Agy99 IMVAGDEP-----------SSAVQVVVPPFKSKAILGRP-----------
Mflv_2124|M.gilvum_PYR-GCK VVSIVDIARPQNLIEAWGRNAAYHFVFTRQNRGKLDALT-----------
Mvan_5758|M.vanbaalenii_PYR-1 VVSALGWG-THSLAPLSFRGAAYSGVFTLMPLLTGRGRD-----------
MAB_1486c|M.abscessus_ATCC_199 IATIAGFG----------RAASDGFKALGGGPGADPGTE-----------
MAV_3325|M.avium_104 ALFGAASG-PVPPFDPQRLNAAGSVFLTRPSLAHFIRTG-----------
TH_3440|M.thermoresistible__bu ALFGAASG-PVPPFDPQRLNAAGSVYLTRPSLVHFTRTP-----------
MSMEG_4064|M.smegmatis_MC2_155 LVELRGWE---------GPGERGVRVVPVMVPDRITDTEG----------
MLBr_00118|M.leprae_Br4923 IVIGLQGGVKGELNLGKVLSKRARIIGSTLRARPVNGPNSK---------
Mb1947c|M.bovis_AF2122/97 WDDRRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILAARENVG
Rv1912c|M.tuberculosis_H37Rv WDDRRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILAARENVD
MMAR_2950|M.marinum_M ----NGARLEPLVDAVAAG--KLRVSIAQKLPLTSAEEAHRLSQTSRMTG
MUL_2209|M.ulcerans_Agy99 ----NGARLEPLVDAVAAG--KLRVSIAQKLPLTSAEEAHRLSQTSRMTG
Mflv_2124|M.gilvum_PYR-GCK ----MLVERGLVKPVLGATLPLARMGEAHELLENRRSYALRGKVAIDVAG
Mvan_5758|M.vanbaalenii_PYR-1 ----HHGEIVAEAAALADSGRLAPRLHPTTFPLDAVNDAHTAVESGSATG
MAB_1486c|M.abscessus_ATCC_199 ----IRLAARPELIRLAGNG-ELKVTVDRTYPLSDARQAHEYGQTGHARG
MAV_3325|M.avium_104 ----QEFSWRAEELFAAIAAGDITVEVGGRYPLADAARAHRDLQGRKTTG
TH_3440|M.thermoresistible__bu ----DEFGWRAGEFLSAVADGTLTITVGERYPLAEAERAHRDLEGRKTVG
MSMEG_4064|M.smegmatis_MC2_155 ----------LTTLSRQAEMGVLTLRVADVLPAEQAPKAHRMLEAGGLRG
MLBr_00118|M.leprae_Br4923 ---SEIVAAVTASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSG
* .
Mb1947c|M.bovis_AF2122/97 KVVLVP-------------
Rv1912c|M.tuberculosis_H37Rv KVVLVP-------------
MMAR_2950|M.marinum_M KLILEP-------------
MUL_2209|M.ulcerans_Agy99 KLILEP-------------
Mflv_2124|M.gilvum_PYR-GCK ETVALPPRIS---------
Mvan_5758|M.vanbaalenii_PYR-1 KVVVEPNV-----------
MAB_1486c|M.abscessus_ATCC_199 KIILLP-------------
MAV_3325|M.avium_104 SIVLLP-------------
TH_3440|M.thermoresistible__bu SVVLLP-------------
MSMEG_4064|M.smegmatis_MC2_155 RIVLDFS------------
MLBr_00118|M.leprae_Br4923 KIVLTVAGSGTETLLSRHH
: