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M. smegmatis MC2 155 MSMEG_4440 (-)

annotation: glucose-1-dehydrogenase
coordinates: 4524154 - 4524924
length: 256

HLEGKKVVVVGGSAGIGRRVAADVVDHGGSAVVVGHSKARVDETLDDLVNRGGDAWGISAELTDRDAVTD
IQRVLGEQHRDATLLVNAAGFFIPKPFLEYGQLDYDAYMELNYALFFLTQTVVRGMIAGGDGGSIVNIGS
MWAHQALGVTPSTGHSMQKAGLHALTHNLAIELARHKIRVNAVSPAAVRTPALQRWFPTDEIDATLGEFA
PLHPLGRVGTPTDIAGAIRYLLSDESSWITGMILNVDGGFTAGRN*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_4440--100% (256)glucose-1-dehydrogenase
M. smegmatis MC2 155MSMEG_4419-e-10571.54% (253) glucose-1-dehydrogenase
M. smegmatis MC2 155MSMEG_6753-4e-2732.67% (251) oxidoreductase, short chain dehydrogenase/reductase family

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1963c-3e-2930.56% (252) short chain dehydrogenase
M. gilvum PYR-GCKMflv_0661-1e-2530.36% (247) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv1928c-3e-2930.56% (252) short chain dehydrogenase
M. leprae Br4923MLBr_02565fabG4e-1831.08% (251) 3-ketoacyl-(acyl-carrier-protein) reductase
M. abscessus ATCC 19977MAB_4680c-4e-2735.09% (265) putative short-chain dehydrogenase/reductase
M. marinum MMMAR_0629-3e-2734.39% (253) dehydrogenase
M. avium 104MAV_2775-5e-2832.02% (253) short chain dehydrogenase
M. thermoresistible (build 8)TH_3505-1e-2936.90% (252) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99MUL_0336-7e-2331.72% (268) short chain dehydrogenase
M. vanbaalenii PYR-1Mvan_0489-1e-2530.36% (247) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mb1963c|M.bovis_AF2122/97           --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_2775|M.avium_104                --------------------------------------------------
MSMEG_4440|M.smegmatis_MC2_155      --------------------------------------------------
TH_3505|M.thermoresistible__bu      --------------------------------------------------
MMAR_0629|M.marinum_M               --------------------------------------------------
Mflv_0661|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0489|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199      --------------------------------------------------
MUL_0336|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02565|M.leprae_Br4923          MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
                                                                                      

Mb1963c|M.bovis_AF2122/97           --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_2775|M.avium_104                --------------------------------------------------
MSMEG_4440|M.smegmatis_MC2_155      --------------------------------------------------
TH_3505|M.thermoresistible__bu      --------------------------------------------------
MMAR_0629|M.marinum_M               --------------------------------------------------
Mflv_0661|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0489|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199      --------------------------------------------------
MUL_0336|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02565|M.leprae_Br4923          GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
                                                                                      

Mb1963c|M.bovis_AF2122/97           --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_2775|M.avium_104                --------------------------------------------------
MSMEG_4440|M.smegmatis_MC2_155      --------------------------------------------------
TH_3505|M.thermoresistible__bu      --------------------------------------------------
MMAR_0629|M.marinum_M               --------------------------------------------------
Mflv_0661|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0489|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199      --------------------------------------------------
MUL_0336|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02565|M.leprae_Br4923          GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
                                                                                      

Mb1963c|M.bovis_AF2122/97           --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_2775|M.avium_104                --------------------------------------------------
MSMEG_4440|M.smegmatis_MC2_155      --------------------------------------------------
TH_3505|M.thermoresistible__bu      --------------------------------------------------
MMAR_0629|M.marinum_M               --------------------------------------------------
Mflv_0661|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0489|M.vanbaalenii_PYR-1       ------------------------------------------MREVRPFT
MAB_4680c|M.abscessus_ATCC_199      --------------------------------------------------
MUL_0336|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02565|M.leprae_Br4923          ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
                                                                                      

Mb1963c|M.bovis_AF2122/97           --MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDAL
Rv1928c|M.tuberculosis_H37Rv        --MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDAL
MAV_2775|M.avium_104                ----MLDLFDLRGRRALVTGASTGIGKQVAQAYLQAGARVAIAARDFEAL
MSMEG_4440|M.smegmatis_MC2_155      --------MHLEGKKVVVVGGSAGIGRRVAADVVDHGGSAVVVGHSKARV
TH_3505|M.thermoresistible__bu      -LTIAPADILLTDRVAVVTGGGAGLGRGIAAGFAAFGARVAIWERDPDSC
MMAR_0629|M.marinum_M               ----------MAGLTALITGATSGIGRATAHGLAELGATVLVSGRDEARG
Mflv_0661|M.gilvum_PYR-GCK          -------MTAGDRRVAIVTAAAAGIGKAIALRWCREGGCCVMADT-DGEG
Mvan_0489|M.vanbaalenii_PYR-1       NRRRVSAVKAGDRRVAIVTAAAAGIGKAIALRWCREGGCCVMADT-DGEG
MAB_4680c|M.abscessus_ATCC_199      -MNGNSALLQG--KNVIVTGGARGLGAAFSRHIVSQGGRVVIADVLDGDG
MUL_0336|M.ulcerans_Agy99           ------MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERG
MLBr_02565|M.leprae_Br4923          STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
                                                   .::...  *:*          *.            

Mb1963c|M.bovis_AF2122/97           EKLADEIGTSG-GKVVPVCCDVSQHQQVTSMLDQVTAELG-GIDIAVCNA
Rv1928c|M.tuberculosis_H37Rv        EKLADEIGTSG-GKVVPVCCDVSQHQQVTSMLDQVTAELG-GIDIAVCNA
MAV_2775|M.avium_104                QRTADELTAGGTGGVVAIRCDVTQPDEVSGMVDRMIAELG-GIDIAVCNA
MSMEG_4440|M.smegmatis_MC2_155      DETLDDLVNRG-GDAWGISAELTDRDAVTDIQRVLGEQHR-DATLLVNAA
TH_3505|M.thermoresistible__bu      ARTAEEIG------ALGIVTDVRDSAAVSAALRQTTEQLG-SPTILVNNA
MMAR_0629|M.marinum_M               REVVDEVTARG-GRGIFLAAELRDVTGVRNLATAAADAGAGKVDILINSA
Mflv_0661|M.gilvum_PYR-GCK          LDAAVHELAESGAAVCGVAGDVCLSDVANSVVERALTEFG-RLDTLFNVV
Mvan_0489|M.vanbaalenii_PYR-1       LDAAVHELAESGAAVCGVAGDVCLSDVANSVVERALTEFG-RLDTLFNVV
MAB_4680c|M.abscessus_ATCC_199      RQLA----AELGDAARFTHLDVTDAEQWRELIDTTLAGFG-TITGLVNNA
MUL_0336|M.ulcerans_Agy99           ESLA----AALGADAMFCRTDVSQPEQVAAVVAAAVDNFG-GLHVMVNNA
MLBr_02565|M.leprae_Br4923          ALDETANRVGG----TTLSLDVTADDAVDKITEHLHDYQGGHADILVNNA
                                                        ::                        .  .

Mb1963c|M.bovis_AF2122/97           GII--TVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGVII
Rv1928c|M.tuberculosis_H37Rv        GII--TVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGVII
MAV_2775|M.avium_104                GII--SVSPMLEMPAAEFQRIQDTNVTGVFLTAQAAARAMVRQGRGGAII
MSMEG_4440|M.smegmatis_MC2_155      GFF--IPKPFLEYGQLDYDAYMELNY-ALFFLTQTVVRGMIAGGDGGSIV
TH_3505|M.thermoresistible__bu      GGT--FSSPLLETSENGWDALYRANLRHVLLCTQQVGRQLVAAGQPGSIV
MMAR_0629|M.marinum_M               GAF--PFGPTADTSPDDFDAVFALNVRAPYFLVGALAPTMAKRGR-GSIV
Mflv_0661|M.gilvum_PYR-GCK          GGS--LARNVEEISEEQWRSQIDMNLGSVFQMSKPVIPLLRQGGG-GSIV
Mvan_0489|M.vanbaalenii_PYR-1       GGS--LARNVEEISEEQWRSQIDMNLGSVFQMSKPVIPLLRQGGG-GSIV
MAB_4680c|M.abscessus_ATCC_199      GIS--SAAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGC-GSIV
MUL_0336|M.ulcerans_Agy99           GVSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAHGG-GSIV
MLBr_02565|M.leprae_Br4923          GIT--RDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKG-GRVI
                                    *          :     :      *                     * ::

Mb1963c|M.bovis_AF2122/97           NTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNSVSPG
Rv1928c|M.tuberculosis_H37Rv        NTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNSVSPG
MAV_2775|M.avium_104                TTASMSGHIINVPQQVGHYCASKAAVIQLTKAMAVEFAPHDIRVNSVSPG
MSMEG_4440|M.smegmatis_MC2_155      NIGSMWAHQALGVTPSTGHSMQKAGLHALTHNLAIELARHKIRVNAVSPA
TH_3505|M.thermoresistible__bu      NITSIEG--ARAAPGYAAYAAAKAGVINYTRTAAFELAPHRIRVNAIAPD
MMAR_0629|M.marinum_M               NVTTMVA--EFGAAGTGLYGASKAAIALLTKSWAAEYGPSGVRVNAVSPG
Mflv_0661|M.gilvum_PYR-GCK          NVASTAG--ILAENRCSAYSASKGGVVLLTKNMALDFARDNIRVNAIAPG
Mvan_0489|M.vanbaalenii_PYR-1       NVASTAG--ILAENRCSAYSASKGGVVLLTKNMALDFARDNIRVNAIAPG
MAB_4680c|M.abscessus_ATCC_199      NISSAAG--LVGLALTSGYGASKWGVRGLSKVAAIELGRERIRVNSVHPG
MUL_0336|M.ulcerans_Agy99           NLTSIGG--IQAGGGVMTYRASKGAVIQFTKSAAIELAHYEIRVNAIAPG
MLBr_02565|M.leprae_Br4923          VLSSMAG--IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPG
                                       :  .           :   * .:   ::  *   .   : :*:: * 

Mb1963c|M.bovis_AF2122/97           YILTELVEPYTEY-------------QPLWEPKIPLGRLGRPEELAGLYL
Rv1928c|M.tuberculosis_H37Rv        YILTELVEPYTEY-------------QPLWEPKIPLGRLGRPEELAGLYL
MAV_2775|M.avium_104                YIRTELVEPLHEY-------------HRQWQPKIPLGRMGRPDELAGIYL
MSMEG_4440|M.smegmatis_MC2_155      AVRTPALQRWFPTDE-------IDATLGEFAPLHPLGRVGTPTDIAGAIR
TH_3505|M.thermoresistible__bu      IAVTEGLQRMSP-----------DGIPPEVGHAIPLGRPGHVDEIAGAAV
MMAR_0629|M.marinum_M               PTRTEGTVEMGE-------------ALDQLAAAAPAGRPADPTEIASTIV
Mflv_0661|M.gilvum_PYR-GCK          GTRTPRIERFLAEH---------PEHASMMVDLCAMQRFAGPDEIAAPAV
Mvan_0489|M.vanbaalenii_PYR-1       GTRTPRIERFLAEH---------PEHASMMVDLCAMQRFAGPDEIAAPAV
MAB_4680c|M.abscessus_ATCC_199      VIYTPMTAKEGFRE---------GEGN---MPIAAMGRVGNADEVAGAVA
MUL_0336|M.ulcerans_Agy99           NIPTPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAAL
MLBr_02565|M.leprae_Br4923          FIETQMTAAIPLAT------------REVGRRLNSLLQGGLPVDVAETIA
                                       *                              .  : .   ::*    

Mb1963c|M.bovis_AF2122/97           YLASEASSYMTGSDIVIDGGYTCP--------------------
Rv1928c|M.tuberculosis_H37Rv        YLASEASSYMTGSDIVIDGGYTCP--------------------
MAV_2775|M.avium_104                YLASAASSYMTGSDIVIDGGYSCP--------------------
MSMEG_4440|M.smegmatis_MC2_155      YLLSDESSWITGMILNVDGGFTAG-------RN-----------
TH_3505|M.thermoresistible__bu      FLASEMSSYITGQTLHVDGGTQAAGGWYHHPRTGAPTLGPGPVR
MMAR_0629|M.marinum_M               YLASDAASFIHGAVVPVDGGRAAV--------------------
Mflv_0661|M.gilvum_PYR-GCK          FLASPEASYITGAVLPVDGGMTAGVTFRAFEAV-----------
Mvan_0489|M.vanbaalenii_PYR-1       FLASPEASYITGAVLPVDGGMTAGVTFRAFEAV-----------
MAB_4680c|M.abscessus_ATCC_199      YLLSDAASYVTGAELAVDGGWTAGPTLTTITGQ-----------
MUL_0336|M.ulcerans_Agy99           YFAGERSRYVTGTVLPVDGGTVAGKVIRRSR-------------
MLBr_02565|M.leprae_Br4923          YFAIPASNAVTGNVIRVCGQAMLGA-------------------
                                    ::    :  : *  : : *