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MELEGLTALVTGGTSGIGLESARLMAAEGADVVITGRDAQRGEQAAADIGHGARFVQADLGDLDSVADLA AQAPDVDILVNNAGIYPQASTFDQDVAGFQQLFDTNVRGTYFLVAAAAKGMVARGHGSIVNITTLAAHKG FPGTSVYGATKAALESLTRTWAAEFGANGVRVNSVSPGPTRTPTTLEQLGDFIDDVAAGLPLRRTAAPEE IAQAVLFLASPRASFVTGSTLYVDGGGYAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6753 | - | - | 100% (240) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_1689 | - | 1e-80 | 63.75% (240) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_5204 | - | 5e-46 | 45.31% (245) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 1e-36 | 38.93% (244) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 5e-37 | 37.34% (241) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2857c | - | 1e-36 | 38.93% (244) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-26 | 31.90% (232) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0164 | - | 3e-35 | 37.55% (245) | short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0629 | - | 1e-56 | 48.78% (246) | dehydrogenase |
| M. avium 104 | MAV_0886 | - | 3e-37 | 36.51% (252) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_2488 | - | 9e-70 | 56.67% (240) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 3e-37 | 37.39% (238) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_1212 | - | 3e-77 | 63.75% (240) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Mflv_4505|M.gilvum_PYR-GCK --------------MTGRLAGKVALISGAARGMGASHARVMAGHGAKVVC
MUL_1037|M.ulcerans_Agy99 ---------------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVI
MAV_0886|M.avium_104 --------------MVNELAGKVAIVTGGASGIGRGIVERFVAEGARVVI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
TH_2488|M.thermoresistible__bu ----------------MEFQGLHVLVTGGTGGIGLACARAFAEAGAEVTV
Mvan_1212|M.vanbaalenii_PYR-1 ----------------MELTGQTALITGGTAGIGLACAQLMAREGADVVI
MSMEG_6753|M.smegmatis_MC2_155 ----------------MELEGLTALVTGGTSGIGLESARLMAAEGADVVI
MMAR_0629|M.marinum_M ------------------MAGLTALITGATSGIGRATAHGLAELGATVLV
MAB_0164|M.abscessus_ATCC_1997 -------MNLTDFQSLYDLSGRTAIVTGGTRGIGYAIAEALGACGASVVV
. . :::*. *:* . : * :
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSG--L---FVPTDVCDEDAVNGLFDGAAETYG-RI
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSG--L---FVPTDVCDEDAVNGLFDGAAETYG-RI
Mflv_4505|M.gilvum_PYR-GCK GDILDSDGEAVAAELGDAAR---YVHLDVTSPDDWDRAVAAAVADFG-GL
MUL_1037|M.ulcerans_Agy99 GDILDEEGKALAEEIGDAAR---YVHLDVTQPDQWEAAVATAVDEFG-KL
MAV_0886|M.avium_104 ADIETERGERLAAELGGEAV---FRRTDVSDIEQVGALVAAAVEKFG-GL
MLBr_01807|M.leprae_Br4923 ----THRASVVPDWFFG-------VECDVTDNDAIGAAFKAVEEHQG-PV
TH_2488|M.thermoresistible__bu TGRDAGRGA-AAAGAHPRLR---FIRGDLADLASVQNLIRYAD-----AV
Mvan_1212|M.vanbaalenii_PYR-1 TGRDPGRGE-AAAASDPRLR---FLRCDLADRTSIESLVQQAP-----PV
MSMEG_6753|M.smegmatis_MC2_155 TGRDAQRGEQAAADIGHGAR---FVQADLGDLDSVADLAAQAP-----DV
MMAR_0629|M.marinum_M SGRDEARGREVVDEVTARGGRGIFLAAELRDVTGVRNLATAAADAGAGKV
MAB_0164|M.abscessus_ATCC_1997 SSRKSDACTAAAKELHDKGYRALGVPAHMGELGDIDALVTATVDEYG-GV
.: . . :
Mb2882c|M.bovis_AF2122/97 DIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLA
Rv2857c|M.tuberculosis_H37Rv DIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLA
Mflv_4505|M.gilvum_PYR-GCK DVLVNNAGILN-IGTVED-YELSEWHRILDVNLTGVFLGIRAATPTMKAA
MUL_1037|M.ulcerans_Agy99 DVLVNNVGIVA-LGQLKK-FDLGKWQKVIDVNLTGTFLGMRAAVEPMTAA
MAV_0886|M.avium_104 HVMVNNAGISSPLRRLLD-DDLADFHRVMGVNVLGVMAGTRDAARHMADN
MLBr_01807|M.leprae_Br4923 EVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQ
TH_2488|M.thermoresistible__bu DVLVNNAASFP--GALTVEQDAESFTRTFATNVTGTYFLTAGLIPGMLAR
Mvan_1212|M.vanbaalenii_PYR-1 DILVNNAASFP--GAMTVDQDAATFQRTFDTNVGGTYFLTAAVVPAMLLR
MSMEG_6753|M.smegmatis_MC2_155 DILVNNAGIYP--QASTFDQDVAGFQQLFDTNVRGTYFLVAAAAKGMVAR
MMAR_0629|M.marinum_M DILINSAGAFP--FGPTADTSPDDFDAVFALNVRAPYFLVGALAPTMAKR
MAB_0164|M.abscessus_ATCC_1997 DIVVNAAANPV--AQPMGSYTPEALGKSFDVNVRGPVFLVQAALPHLTAS
.: . .. *: . :
Mb2882c|M.bovis_AF2122/97 GKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVN
Rv2857c|M.tuberculosis_H37Rv GKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVN
Mflv_4505|M.gilvum_PYR-GCK GRGSIINIASIEGMAG-TVGCHGYTATKFAVRGLTKSTALELGPFGIRVN
MUL_1037|M.ulcerans_Agy99 GSGSIINVSSIEGLRG-APAVHPYVASKWAVRGLTKSAALELAPLNIRVN
MAV_0886|M.avium_104 GGGAIINLTSIGGIQA-GGGVMTYRASKAAVIQFTKAAAIELARYDIRVN
MLBr_01807|M.leprae_Br4923 RFGRYIFMGSVVGLSG-VPGQANYAASKSGLIGMARSLARELGSRSITAN
TH_2488|M.thermoresistible__bu GRGSIVNITSMVATKA-VPGASVYSSSKAAVESLTRSWAVEFAAHGIRVN
Mvan_1212|M.vanbaalenii_PYR-1 GRGAIVNVTSMVAWKG-VPGASVYSASKAAVESLTRTWAAEFAPH-VRVN
MSMEG_6753|M.smegmatis_MC2_155 GHGSIVNITTLAAHKG-FPGTSVYGATKAALESLTRTWAAEFGANGVRVN
MMAR_0629|M.marinum_M GRGSIVNVTTMVAEFG-AAGTGLYGASKAAIALLTKSWAAEYGPSGVRVN
MAB_0164|M.abscessus_ATCC_1997 EHASVLNVVSVAAFQY-VPMLSMYAAMKATLMSFTRSMAAEYTARGIRVN
. : :. . * : * : ::: . : : .*
Mb2882c|M.bovis_AF2122/97 ALCPGPVNTPLLQELFAKNPERAARR---------MVHVPLGRFAEPDEI
Rv2857c|M.tuberculosis_H37Rv ALCPGPVNTPLLQELFAKNPERAARR---------MVHVPLGRFAEPDEI
Mflv_4505|M.gilvum_PYR-GCK SVHPGLVKTPMADWVPEDIFQ-----------------SALGRIAQPHEV
MUL_1037|M.ulcerans_Agy99 SIHPGFIRTPMTANLPDDMVT-----------------IPLGRPAESREV
MAV_0886|M.avium_104 AIAPGNIPTPILGKSAGDMDPEQRERFEARIREGMREDRPLKREGTPDDV
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTRAMDSKYQEAALQA------------IPLGRIGAVEEI
TH_2488|M.thermoresistible__bu AVAPGPTSTDGVATEWGETNEALGRA------------LPIGRTADPDEI
Mvan_1212|M.vanbaalenii_PYR-1 SVAPGPTDTEGVVAEWGDTNDELGRA------------LPLGRTATPGEI
MSMEG_6753|M.smegmatis_MC2_155 SVSPGPTRTPTTLEQLGDFIDDVAAG------------LPLRRTAAPEEI
MMAR_0629|M.marinum_M AVSPGPTRTEG-TVEMGEALDQLAAA------------APAGRPADPTEI
MAB_0164|M.abscessus_ATCC_1997 ALAPGTVDTYMLQQNPQEIIDAMAAQ------------SFMGRVAHTDEM
: ** * . * . ::
Mb2882c|M.bovis_AF2122/97 AAAVAFLASDDASFITASTFLVDGGISSAYVTPL--------------
Rv2857c|M.tuberculosis_H37Rv AAAVAFLASDDASFITASTFLVDGGISSAYVTPL--------------
Mflv_4505|M.gilvum_PYR-GCK SNLVVYLASDESSYSTGAEFVVDGGTLAGLAHKDFSAVDVDQQPEWIT
MUL_1037|M.ulcerans_Agy99 STFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF-------------
MAV_0886|M.avium_104 AEAALYFATERSRYVTGTVLPVDGGTSAGKAMRSKRQG----------
MLBr_01807|M.leprae_Br4923 AGAVSFLASEDAGYISGAVIPVDGGLGMGH------------------
TH_2488|M.thermoresistible__bu AQAVVFLASSRASFITGAVLHVDGGGIAV-------------------
Mvan_1212|M.vanbaalenii_PYR-1 AQAVLFLASPRAGFVTGSVLHADGGGTAI-------------------
MSMEG_6753|M.smegmatis_MC2_155 AQAVLFLASPRASFVTGSTLYVDGGGYAV-------------------
MMAR_0629|M.marinum_M ASTIVYLASDAASFIHGAVVPVDGGRAAV-------------------
MAB_0164|M.abscessus_ATCC_1997 IGPALLLLSDAGSFITGQVIVADGGGGVQR------------------
: : . : . . ***