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TAGDRRVAIVTAAAAGIGKAIALRWCREGGCCVMADTDGEGLDAAVHELAESGAAVCGVAGDVCLSDVAN SVVERALTEFGRLDTLFNVVGGSLARNVEEISEEQWRSQIDMNLGSVFQMSKPVIPLLRQGGGGSIVNVA STAGILAENRCSAYSASKGGVVLLTKNMALDFARDNIRVNAIAPGGTRTPRIERFLAEHPEHASMMVDLC AMQRFAGPDEIAAPAVFLASPEASYITGAVLPVDGGMTAGVTFRAFEAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0661 | - | - | 100% (260) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0566 | - | e-146 | 100.00% (260) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1263 | - | 2e-35 | 34.85% (241) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 2e-38 | 38.06% (247) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 2e-38 | 38.06% (247) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 2e-20 | 33.33% (186) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4680c | - | 7e-33 | 38.37% (245) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4581 | - | 2e-33 | 34.55% (246) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3714 | - | 3e-37 | 37.65% (247) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3607 | - | 2e-35 | 38.37% (245) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3898 | - | 6e-36 | 35.77% (246) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4442 | - | 1e-32 | 34.15% (246) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0489 | - | 1e-145 | 99.62% (260) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0661|M.gilvum_PYR-GCK ---------------MTAGDRRVAIVTAAAAGIGKAIALRWCREGGCCVM
Mvan_0489|M.vanbaalenii_PYR-1 MREVRPFTNRRRVSAVKAGDRRVAIVTAAAAGIGKAIALRWCREGGCCVM
MMAR_4581|M.marinum_M -----------MILDRFRLDDQVAVITGGGRGLGAAIALAFAEAGADVVI
MUL_4442|M.ulcerans_Agy99 -----------MILDRFRLDDQVAVITGGGRGFGAAIALAFAEAGADVVI
TH_3898|M.thermoresistible__bu -----------VILDRFRLDDRVAVVTGAGRGLGAAMAVAFAEAGADVLI
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
MAV_3714|M.avium_104 -----------MMDLTQRLAGRVAVITGAGGGIGLAAARRMHAEGATIVV
MSMEG_3607|M.smegmatis_MC2_155 ----MTQAQELSVDFDFRLDGKVALVTGAASGIGAAIASAYATKGARIAA
MAB_4680c|M.abscessus_ATCC_199 -----------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
MLBr_01740|M.leprae_Br4923 -----------MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYL
: .:*... *:* * . *.
Mflv_0661|M.gilvum_PYR-GCK ADTDGEGLDAAVHELAESGAAV-CGVAGDVCLSDVANSVVERALTEFGRL
Mvan_0489|M.vanbaalenii_PYR-1 ADTDGEGLDAAVHELAESGAAV-CGVAGDVCLSDVANSVVERALTEFGRL
MMAR_4581|M.marinum_M ASRTQSQLDEVADTVRSIGRRA-HVVAADLAHPEATAELAGQAVEAFGRL
MUL_4442|M.ulcerans_Agy99 ASRTQSQLDEVADTVRSIGRRA-HVVAADLAHPEATAELAGQAVEAFGRL
TH_3898|M.thermoresistible__bu SARTQAQLEEVAAQIAATGRRA-HVVAADLAHPEATAELAGAAVEAFGKL
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSG------LFVPTDVCDEDAVNGLFDGAAETYGRI
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSG------LFVPTDVCDEDAVNGLFDGAAETYGRI
MAV_3714|M.avium_104 ADIDADAGAAAADELSG------LFVPTDVADEDAVNALFDTAVRRYGRI
MSMEG_3607|M.smegmatis_MC2_155 VDLNAEGAEALAAQLGGDRGAH-RGFACDVADAASVQAAADAVAAEFGRI
MAB_4680c|M.abscessus_ATCC_199 ADVLDGDGRQLAAELGD---AA-RFTHLDVTDAEQWRELIDTTLAGFGTI
MLBr_01740|M.leprae_Br4923 TDRHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHPSM
. *: . :
Mflv_0661|M.gilvum_PYR-GCK DTLFNVVGGSLARN--VEEISEEQWRSQIDMNLGSVFQMSKPVIPLLRQG
Mvan_0489|M.vanbaalenii_PYR-1 DTLFNVVGGSLARN--VEEISEEQWRSQIDMNLGSVFQMSKPVIPLLRQG
MMAR_4581|M.marinum_M DIVVNNVGGTMPNT--LLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEH
MUL_4442|M.ulcerans_Agy99 DIVVNNVGGTMPNT--LLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEH
TH_3898|M.thermoresistible__bu DIVVNNVGGTMPGP--LLNTSAKEMRDAFTFNVGTAHALTTAAVPLMLKH
Mb2882c|M.bovis_AF2122/97 DIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLA
Rv2857c|M.tuberculosis_H37Rv DIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLA
MAV_3714|M.avium_104 DIAFNNAGISPPDDDVIENTEPPAWQRVQDVNLKSVYLCCRAALRHMVSA
MSMEG_3607|M.smegmatis_MC2_155 DILVNSAGVARLAP--AEELSLQDWDSTLAINLSGTFLMCQAVGKRMLEA
MAB_4680c|M.abscessus_ATCC_199 TGLVNNAGISSAAM--VADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAH
MLBr_01740|M.leprae_Br4923 DIVMNIAGVSVWGT--VDRLTHDQWSNVVAINLMGPIHIIETFVPAILAA
.* .* : .*: . :
Mflv_0661|M.gilvum_PYR-GCK -GGGSIVNVASTAGILAENRCSAYSASKGGVVLLTKNMALDFARDNIRVN
Mvan_0489|M.vanbaalenii_PYR-1 -GGGSIVNVASTAGILAENRCSAYSASKGGVVLLTKNMALDFARDNIRVN
MMAR_4581|M.marinum_M SGGGSIINITSTMGRVAGRGFAAYGTAKAALAHYTRLAALDLCPR-IRVN
MUL_4442|M.ulcerans_Agy99 SGGGGIINITSTMGRVAGRGFAAYGTAKVALAHYTRLAALDLCPR-IRVN
TH_3898|M.thermoresistible__bu SGGGSIINITSTMGRLAGRGFAAYGTAKAALAHYTRLAALDLAPR-IRVN
Mb2882c|M.bovis_AF2122/97 GKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVN
Rv2857c|M.tuberculosis_H37Rv GKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVN
MAV_3714|M.avium_104 RRGSIINTASFVAVMGSATSQISYTAAKGGVLALSRELGVQFARQGIRVN
MSMEG_3607|M.smegmatis_MC2_155 -GGGAIVNMASQAATVALDQHVAYCASKFGVVGVSKVLAAEWGGRGVRVN
MAB_4680c|M.abscessus_ATCC_199 -GCGSIVNISSAAGLVGLALTSGYGASKWGVRGLSKVAAIELGRERIRVN
MLBr_01740|M.leprae_Br4923 GRGGHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVS
. : . : . .* ::* .: :. : : *.
Mflv_0661|M.gilvum_PYR-GCK AIAPGGTRTPRIERFLAEHPEHASMMVDLCAMQRFAGPDEIAAPAVFLAS
Mvan_0489|M.vanbaalenii_PYR-1 AIAPGGTRTPRIERFLAEHPEHASMMVDLCAMQRFAGPDEIAAPAVFLAS
MMAR_4581|M.marinum_M AIAPGSILTSALEVVAAND-ELRAPMEQATPLRRLGDPVDIAAAAVYLAS
MUL_4442|M.ulcerans_Agy99 AIAPGSILTSALEVVAAND-ELRAPMEQATPLRRLGDPVDIAAAAVYLAS
TH_3898|M.thermoresistible__bu AIAPGSILTSALDVVASND-ELRTPMEQATPLRRLGEPADIAAAAVYLAS
Mb2882c|M.bovis_AF2122/97 ALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLAS
Rv2857c|M.tuberculosis_H37Rv ALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLAS
MAV_3714|M.avium_104 ALCPGPVNTPLLQELFAKDPQRAARRLVHVPVGRFAEPGEIAAAAAFLAS
MSMEG_3607|M.smegmatis_MC2_155 TISPTVVLTELGHKAWDGP--RGDALKKLIPTGRFAYPDEIAAAAVFLAS
MAB_4680c|M.abscessus_ATCC_199 SVHPGVIYTPMTAKEGFRE---GEGNMPIAAMGRVGNADEVAGAVAYLLS
MLBr_01740|M.leprae_Br4923 VVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILA
: * * . . . .. : :
Mflv_0661|M.gilvum_PYR-GCK PEAS-----YITGAVLPVDG---------GMTAGVTFRAFEAV-------
Mvan_0489|M.vanbaalenii_PYR-1 PEAS-----YITGAVLPVDG---------GMTAGVTFRAFEAV-------
MMAR_4581|M.marinum_M PAGS-----FLTGKTLEVDG---------GLTHPNLDIPVPDL-------
MUL_4442|M.ulcerans_Agy99 PAGS-----FLTGKTLEVDG---------GLTHPNLDIPVPDL-------
TH_3898|M.thermoresistible__bu PAGS-----YLTGKVLEVDG---------GLTRPNLDMPIPDL-------
Mb2882c|M.bovis_AF2122/97 DDAS-----FITASTFLVDG---------GISSAYVTPL-----------
Rv2857c|M.tuberculosis_H37Rv DDAS-----FITASTFLVDG---------GISSAYVTPL-----------
MAV_3714|M.avium_104 DDAS-----FITASTFLVDG---------GISAAYVTPL-----------
MSMEG_3607|M.smegmatis_MC2_155 DAAA-----MINGADLVIDG---------GYTIK----------------
MAB_4680c|M.abscessus_ATCC_199 DAAS-----YVTGAELAVDG---------GWTAGPTLTTITGQ-------
MLBr_01740|M.leprae_Br4923 GVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPAT
. . : * *
Mflv_0661|M.gilvum_PYR-GCK -------------------------
Mvan_0489|M.vanbaalenii_PYR-1 -------------------------
MMAR_4581|M.marinum_M -------------------------
MUL_4442|M.ulcerans_Agy99 -------------------------
TH_3898|M.thermoresistible__bu -------------------------
Mb2882c|M.bovis_AF2122/97 -------------------------
Rv2857c|M.tuberculosis_H37Rv -------------------------
MAV_3714|M.avium_104 -------------------------
MSMEG_3607|M.smegmatis_MC2_155 -------------------------
MAB_4680c|M.abscessus_ATCC_199 -------------------------
MLBr_01740|M.leprae_Br4923 MRCVEPIKVGVYSQPRSGEGGKSGN