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VLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVE RVGPGVADLAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVS GFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGLGGVGMAALLTALTY DGVPVVAVDQLPEKLAAARRLGAHQAYTPQQAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGL PPPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLA DGTAVRQLIRFDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5022 | - | - | 100% (363) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. avium 104 | MAV_0705 | - | 9e-56 | 34.82% (359) | alcohol dehydrogenase B |
| M. avium 104 | MAV_2646 | - | 1e-49 | 32.31% (359) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 1e-167 | 81.44% (361) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_4588 | - | 2e-54 | 37.39% (353) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 1e-167 | 81.44% (361) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-51 | 35.21% (355) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 1e-101 | 53.19% (361) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 1e-171 | 82.27% (361) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. smegmatis MC2 155 | MSMEG_0127 | - | 1e-157 | 77.84% (361) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3466 | - | 1e-119 | 77.09% (275) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0470 | adhB | 8e-56 | 34.82% (359) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 1e-53 | 34.93% (355) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
MSMEG_0127|M.smegmatis_MC2_155 -------------MKIRGAVLERIGAPRPYAESRPLTISELDLADPGPDE
TH_3466|M.thermoresistible__bu --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 -------------MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGE
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
Mflv_4588|M.gilvum_PYR-GCK ---------------------MKTRAAVLWGLGEKWEVDEIELDPPGVDE
Mvan_5270|M.vanbaalenii_PYR-1 ---------------------MKTNAAILWEYGGDWTVEEIDLDPPGDGE
MUL_0470|M.ulcerans_Agy99 ---------------------MKTKGALIWEFNQPWSVEDIEIGDPVKDE
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDGTRVRP-VPILLGHEAAGIVEQVGDGVDGVA
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDGTRVRP-VPILLGHEAAGIVEQVGDGVDGVA
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDGNRVRP-VPMLLGHEAAGIVERVGDRVDDLA
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDGNRVRP-VPMLLGHEAAGIVERVGPGVADLA
MSMEG_0127|M.smegmatis_MC2_155 LLVRIESAGLCHSDLSVVDGNRVRP-VPMLLGHEAAGVVETPG---ADLE
TH_3466|M.thermoresistible__bu --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 VLVRIEAAGLCHSDLSVVDGNRIRP-VPMALGHEAAGVIAAVGPGVRDVS
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREGGINDR-YPFLLGHEAAGTVEVVGPGVTAVE
Mflv_4588|M.gilvum_PYR-GCK VLVQLTASGLCHSDEHLVTGDLPFP-LPVVGGHEGAGTVVEVGAGVEDLA
Mvan_5270|M.vanbaalenii_PYR-1 VLVSWEATGLCHSDEHIRTGDLPAP-LPLIGGHEGAGIVREVGPGVVGLA
MUL_0470|M.ulcerans_Agy99 VKIQMEAAGMCRSDNHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVDDIA
Mb0167c|M.bovis_AF2122/97 VGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RG
Rv0162c|M.tuberculosis_H37Rv VGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RG
MMAR_0405|M.marinum_M VGQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLLGGGIRIS-RS
MAV_5022|M.avium_104 VGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLS-RA
MSMEG_0127|M.smegmatis_MC2_155 TGQRVVMTFLPRCGSCPACGTDGLTPCGPGSVANGAGTLMNGDIRLR-RD
TH_3466|M.thermoresistible__bu ----VVMTFLPRCGHCPACATDGLTPCEPGSAANTAGTLLSGAIRLT-RD
MAB_0983c|M.abscessus_ATCC_199 PGDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLD
MLBr_01784|M.leprae_Br4923 PGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG--------
Mflv_4588|M.gilvum_PYR-GCK VGDSVILTFLPSCGHCSYCARGMGNLCDMGAAIMMGPQI-DGTYRFH-AR
Mvan_5270|M.vanbaalenii_PYR-1 PGDHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRH-VR
MUL_0470|M.ulcerans_Agy99 PGDHVVLSFIPSCGRCPTCQAGLRNLCDLGAGLLAGAAVSDGTFRIQ-AR
*: : . ** * * * : *
Mb0167c|M.bovis_AF2122/97 GRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
Rv0162c|M.tuberculosis_H37Rv GRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
MMAR_0405|M.marinum_M GQPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGAV
MAV_5022|M.avium_104 GRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAV
MSMEG_0127|M.smegmatis_MC2_155 GEPVFHHLGVSGFATHAVVDRRSIVPVPDDVPATVAALLGCAVLTGGGAV
TH_3466|M.thermoresistible__bu GQPVHHHLGISGFASHAVVDRRSVVPVDSDVPPSVAALLGCAVLTGGGAV
MAB_0983c|M.abscessus_ATCC_199 GTEVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAV
MLBr_01784|M.leprae_Br4923 -TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
Mflv_4588|M.gilvum_PYR-GCK GEDVGQMCLLGTFSEYTVVPKASLVKVDHGTPLDKAALIGCGVTTGYGSA
Mvan_5270|M.vanbaalenii_PYR-1 GQDVGVMALVGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSA
MUL_0470|M.ulcerans_Agy99 GQNVYPMTLLGTFSPYMVVHRSSVVKIDPAIPFEVAALVGCGVTTGYGSA
: :. *: * . . : * *.**.: :* *:.
Mb0167c|M.bovis_AF2122/97 LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
Rv0162c|M.tuberculosis_H37Rv LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
MMAR_0405|M.marinum_M LNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAAE
MAV_5022|M.avium_104 LNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAAR
MSMEG_0127|M.smegmatis_MC2_155 LNVGRPKPGQTVVVVGLGGVGMAAALTALAHDDVRVVGVDQLSDKLARAA
TH_3466|M.thermoresistible__bu LNVGRPRPGQRVIVVGLGGVGLAAVLTALAHPDVRVVGVDQRTDKLHTAR
MAB_0983c|M.abscessus_ATCC_199 THTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELAL
MLBr_01784|M.leprae_Br4923 INTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWAR
Mflv_4588|M.gilvum_PYR-GCK VRTGEVRAGDTVVVIGAGGIGMNAIQGARIAGALTIVAVDPVEFKREQAG
Mvan_5270|M.vanbaalenii_PYR-1 VNTADVSPGDTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAF
MUL_0470|M.ulcerans_Agy99 VRTADVRPGDDVAIVGLGGVGMAALQGAVTAGARYIFAVEPVEWKRDQAL
... .: * ::* **:* . * :. :: * *
Mb0167c|M.bovis_AF2122/97 ALGAHEIY--------TPQQATAGGVKAAVVVEAVGHP--AALHTAIGLT
Rv0162c|M.tuberculosis_H37Rv ALGAHEIY--------TPQQATAGGVKAAVVVEAVGHP--AALHTAIGLT
MMAR_0405|M.marinum_M ALGASATY--------TPQQAAAAGVKADVVIEAAGHP--AALETAIGLT
MAV_5022|M.avium_104 RLGAHQAY--------TPQQAVEARVKAAVVIEAVGHP--AALQTAIDLT
MSMEG_0127|M.smegmatis_MC2_155 ELGVHETF--------TPEQAAD--LRAEVVIEAAGHP--AALETAIGLT
TH_3466|M.thermoresistible__bu TLGAHEAY--------TPDQAVDANLKAQVVIEAAGHP--DALATAIQLT
MAB_0983c|M.abscessus_ATCC_199 ELGATSAC--------APDEAPGG---HDWVFEVVGSA--AVLEQAYALT
MLBr_01784|M.leprae_Br4923 TFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRP--ETWKQAFYAR
Mflv_4588|M.gilvum_PYR-GCK GFGATHAVAT-IDEAWSLISDITRGKLADVCVLTTDVAEGAYTAEALSLV
Mvan_5270|M.vanbaalenii_PYR-1 RFGATHFVTS-MEEATALVADLTRGVMADSAILTVGLLEGSMLEEAANII
MUL_0470|M.ulcerans_Agy99 KFGATHVYPD-MEAALMGIAEVTYGLMAKKVMITVGELQGSDIDTYLAIT
:*. . ...
Mb0167c|M.bovis_AF2122/97 APGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRF
Rv0162c|M.tuberculosis_H37Rv APGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRF
MMAR_0405|M.marinum_M APGGRTITVGLP-PPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRF
MAV_5022|M.avium_104 APGGRTITVGLP-PPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRF
MSMEG_0127|M.smegmatis_MC2_155 GPGGRTITVGLP-RPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRF
TH_3466|M.thermoresistible__bu APGGRTITVGLP-PPDARLTVSPLGLVAEGRSLIGSYLGSAVPARDIPRF
MAB_0983c|M.abscessus_ATCC_199 GRGGGTVSVGLP-HPDARISLPALNIVAEGRSILGSYMGSAQPQQDIPAM
MLBr_01784|M.leprae_Br4923 DLAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTL
Mflv_4588|M.gilvum_PYR-GCK GKRGRVVITAIGHPEDTSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRL
Mvan_5270|M.vanbaalenii_PYR-1 RKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRL
MUL_0470|M.ulcerans_Agy99 SKGGTCVVTAIGSLLDTQVNLNLAMLTLMQKNLQGTIFGGGNPQYDIPHL
* : ..: * : : .: * . *:* :
Mb0167c|M.bovis_AF2122/97 VSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL-
Rv0162c|M.tuberculosis_H37Rv VSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL-
MMAR_0405|M.marinum_M VSLWQSGRLPVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF-----
MAV_5022|M.avium_104 VELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA---
MSMEG_0127|M.smegmatis_MC2_155 VELWRAGRLPVESLVSSTIALDDINAGMDELAEGRAVRQVIDFA----
TH_3466|M.thermoresistible__bu VDLWRSGRLPVEQLVSSTITLDELNEGLDRLADGAAVRQLITLPG---
MAB_0983c|M.abscessus_ATCC_199 LALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA-
MLBr_01784|M.leprae_Br4923 VDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
Mflv_4588|M.gilvum_PYR-GCK VELYNSGQLKLDELITREYTLDEINEGYDDMRSGRNIRGLIRF-----
Mvan_5270|M.vanbaalenii_PYR-1 LSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH---
MUL_0470|M.ulcerans_Agy99 LSMYKARNLNIDDMITRQYRLEQINEGYQDMIDGKNIRGVIRFTDADR
: :: .* : . : * ::: . . : * :* ::