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M. gilvum PYR-GCK Mflv_0660 (-)

annotation: alcohol dehydrogenase
coordinates: 681423 - 682448
length: 341

EAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHEVSGRIVEVGAG
VDQSRIGEGAAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANYVAVPSRLAVRVPDVVDLEEAA
LTEPTAVAFHAVRRAELLLGETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDLGATLVLD
PHDPGTTACILEETRGVGVDVVFHVAGSAEAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQLR
MVFGYDMFDDFPAVLALIADGKLALAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0660--100% (341)alcohol dehydrogenase
M. gilvum PYR-GCKMflv_0565-0.0100.00% (341) alcohol dehydrogenase
M. gilvum PYR-GCKMflv_0638-1e-7541.35% (341) alcohol dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3753-2e-2227.42% (383) putative dehydrogenase
M. tuberculosis H37RvRv1895-3e-3232.23% (332) dehydrogenase
M. leprae Br4923MLBr_01784adhE21e-1930.33% (244) putative alcohol dehydrogenase (Zn dependent)
M. abscessus ATCC 19977MAB_2084-1e-2730.77% (351) zinc-type alcohol dehydrogenase AdhD
M. marinum MMMAR_2790-3e-3431.90% (348) dehydrogenase
M. avium 104MAV_2804-4e-3331.14% (350) zinc-binding dehydrogenase
M. smegmatis MC2 155MSMEG_5021-7e-5033.90% (351) alcohol dehydrogenase, zinc-containing
M. thermoresistible (build 8)TH_4349-8e-3134.17% (240) PUTATIVE Alcohol dehydrogenase GroES domain protein
M. ulcerans Agy99MUL_2962-9e-3331.32% (348) dehydrogenase
M. vanbaalenii PYR-1Mvan_0490-0.099.71% (341) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0660|M.gilvum_PYR-GCK          ----MEAIVLNGTNDVGLTSVPD-PAPQDGEVIIEVAATGLCGTDLH---
Mvan_0490|M.vanbaalenii_PYR-1       ----MEAIVLNGTNDVGLTSVPD-PAPQDGEVIIEVAATGLCGTDLH---
MSMEG_5021|M.smegmatis_MC2_155      ----MKAAVYHGPNKLEIADLPE-PQPGPGTVKVKVGFNGICGTDLH---
MMAR_2790|M.marinum_M               ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGSDLH---
MUL_2962|M.ulcerans_Agy99           ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH---
Rv1895|M.tuberculosis_H37Rv         ----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH---
MAV_2804|M.avium_104                ----MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGSDLH---
TH_4349|M.thermoresistible__bu      ----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHL-M
MAB_2084|M.abscessus_ATCC_1997      --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEH---
MLBr_01784|M.leprae_Br4923          MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLT---
Mb3753|M.bovis_AF2122/97            ----MKAVTCTN--AKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
                                         .                    *  .   : :   * * :*     

Mflv_0660|M.gilvum_PYR-GCK          -EYVAGPTFS----------QPPVVLGHEVSGRIVEVGAGVDQS-RIGEG
Mvan_0490|M.vanbaalenii_PYR-1       -EYVAGPTFS----------QPPVVLGHEVSGRIVEVGAGVDQS-RIGQG
MSMEG_5021|M.smegmatis_MC2_155      -EYYAGPIFVPTEPHPLTGQVMPLTMGHEFAGTITDVGAGVTGF-APGDR
MMAR_2790|M.marinum_M               --FYEGEYPLA----------EPVALGHEAVGTVVEKGPDVHTV-EVGDQ
MUL_2962|M.ulcerans_Agy99           --FYEGEYPLA----------EPVALGHEAVGTVVEKGPDVHTV-EVGDQ
Rv1895|M.tuberculosis_H37Rv         --FYEGEYPFT----------EPVALGHEAVGTIVEAGPQVRTV-GVGDL
MAV_2804|M.avium_104                --FYEADFPMP----------DPIALGHEAIGTVVEAGPQVRNV-KVGDQ
TH_4349|M.thermoresistible__bu      HDFEPGMMPWQ----------LPFTLGHENAGWVAAVGAGVGTV-TEGDA
MAB_2084|M.abscessus_ATCC_1997      --LVTGDLPIP----------LPVVGGHEGAGTVVECGEGVEDL-SEGDS
MLBr_01784|M.leprae_Br4923          --YREGGINDR----------YPFLLGHEAAGTVEVVGPGVTAV-EPGDF
Mb3753|M.bovis_AF2122/97            HCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTP
                                         .                 .  ***  * :   *  .      *  

Mflv_0660|M.gilvum_PYR-GCK          AAVIPMDFCGSCHYCHRSLYHLCQR---PGWIGFTR--------------
Mvan_0490|M.vanbaalenii_PYR-1       AAVIPMDFCGSCHYCHRSLYHLCQR---PGWIGFTR--------------
MSMEG_5021|M.smegmatis_MC2_155      VAIEPIYRCGHCAPCRAGNYNVCQQ---IGFHGLMC--------------
MMAR_2790|M.marinum_M               VMVSSVAGCGACAGCATRDPAMCVS--GPQIFGSGA--------------
MUL_2962|M.ulcerans_Agy99           VMVSSVAGCGACAGCATRDPAMCVS--GPQIFGSGA--------------
Rv1895|M.tuberculosis_H37Rv         VMVSSVAGCGVCPGCETHDPVMCFS--GPMIFGAGV--------------
MAV_2804|M.avium_104                VMVSSVAGCGSCAGCATRDPVLCHS--GFQIFGGGV--------------
TH_4349|M.thermoresistible__bu      VAVYGPWGCGTCERCMGGAENYCENPAGAPVLSGGAG-------------
MAB_2084|M.abscessus_ATCC_1997      VILTFLPSCGRCSYCARGMGNLCELG-AALMMGPQIDGTYRFHARGEDVG
MLBr_01784|M.leprae_Br4923          VILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG--------TELT
Mb3753|M.bovis_AF2122/97            VVAMPLLRRGNKEVHGIGLSTMAPG-------------------------
                                    .        *            .                           

Mflv_0660|M.gilvum_PYR-GCK          ----NGGLANYVAVP--SRLAVRVPDVVD-LEEAALTEPTAVAFHAVRR-
Mvan_0490|M.vanbaalenii_PYR-1       ----NGGLANYVAVP--SRLAVRVPDVVD-LEEAALTEPTAVAFHAVRR-
MSMEG_5021|M.smegmatis_MC2_155      ----DGGMAEYTVVP--VDMLHKLPDNVS-LQLGALVEPMSVAYHAATL-
MMAR_2790|M.marinum_M               ---LGGAQADLLAVPAADFQVLKIPAAITTEQALLLTDNLATGWAAARR-
MUL_2962|M.ulcerans_Agy99           ---LGGAQADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR-
Rv1895|M.tuberculosis_H37Rv         ---LGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR-
MAV_2804|M.avium_104                ---LGGAQADLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQR-
TH_4349|M.thermoresistible__bu      -LGMDGGMAEYLLVP-AERLVVKLPESMTPVTAAALTDAGLTPYHAIRRS
MAB_2084|M.abscessus_ATCC_1997      QMCLLGTFSEYTVVP--QASVVKIDGGIPLDRAALIGCGVTTGYGSAVR-
MLBr_01784|M.leprae_Br4923          PALGIGAFADKTLVH--SGQCTKVDPAADPAVAGLLGCGVMAGLGAAIN-
Mb3753|M.bovis_AF2122/97            ------AYAERLVVE--QSLTFPVPNGLA-PEIAALTEPMAVGWHAVRR-
                                            ::   *         :           :     .   :    

Mflv_0660|M.gilvum_PYR-GCK          -AELLLGETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDL
Mvan_0490|M.vanbaalenii_PYR-1       -AELLLGETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDL
MSMEG_5021|M.smegmatis_MC2_155      -GDVGAGDTAVVFGAGPIGIGLWFALRGKGLESVYVAEPSPTRRAAIEAL
MMAR_2790|M.marinum_M               -ADILFGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRASEW
MUL_2962|M.ulcerans_Agy99           -ADIPFGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEW
Rv1895|M.tuberculosis_H37Rv         -ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATW
MAV_2804|M.avium_104                -ADIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARW
TH_4349|M.thermoresistible__bu      WPKLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRSEALELAREM
MAB_2084|M.abscessus_ATCC_1997      TGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGF
MLBr_01784|M.leprae_Br4923          TAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTF
Mb3753|M.bovis_AF2122/97            -GEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATAC
                                       :    .. *.* * :*              : . :            

Mflv_0660|M.gilvum_PYR-GCK          GATLVLDPHDPGTTACILEETRGV-----GVDVVFHVAGSAEA-------
Mvan_0490|M.vanbaalenii_PYR-1       GATLVLDPHDPGTTACILEETRGV-----GVDVVFHVAGSAEA-------
MSMEG_5021|M.smegmatis_MC2_155      G-AQTLDPTQVDVPAFIADVTGGR-----GADAAFDAAGVAPA-------
MMAR_2790|M.marinum_M               GATAVASP----AAEAIVAATGGR-----GADSVIDAVGTDAS-------
MUL_2962|M.ulcerans_Agy99           GATAVASP----AAEAIVAATSGR-----GADSVIDAVDTDAS-------
Rv1895|M.tuberculosis_H37Rv         GATPIPSP----AAETILAATRGR-----GADSVIDAVGTDAS-------
MAV_2804|M.avium_104                GATPLKAP----ALEAILAATGGR-----GADAVIDAVATDAS-------
TH_4349|M.thermoresistible__bu      GADHVVRSDEQ-AVEAIWELTGGR-----GADVLLDFVGADAT-------
MAB_2084|M.abscessus_ATCC_1997      GATHTAAS-MDEAWSLVSDMTRGK-----LADVCILTTDVAEGSY-----
MLBr_01784|M.leprae_Br4923          GATHTVNALELEVVKTIQDLTSGF-----GVDVVIDTVGRPET-------
Mb3753|M.bovis_AF2122/97            GADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLP
                                    *      .              *        *     .            

Mflv_0660|M.gilvum_PYR-GCK          ------------------------------FTQGLDCLRKQGRFMEMSSW
Mvan_0490|M.vanbaalenii_PYR-1       ------------------------------FTQGLDCLRKQGRFMEMSSW
MSMEG_5021|M.smegmatis_MC2_155      ------------------------------IEAATASVGSRRPTISVAIY
MMAR_2790|M.marinum_M               ------------------------------MTDALNAVRAGGTVSVVGVH
MUL_2962|M.ulcerans_Agy99           ------------------------------MTDALNAVRAGGTVSVVGVH
Rv1895|M.tuberculosis_H37Rv         ------------------------------MSDALNAVRPGGTVSVVGVH
MAV_2804|M.avium_104                ------------------------------LTEALNAVRPGGTVSVVGVH
TH_4349|M.thermoresistible__bu      ------------------------------IELARAAARPLGDVTIVGIA
MAB_2084|M.abscessus_ATCC_1997      ------------------------------TAEALALVGKRGRVVVTAIG
MLBr_01784|M.leprae_Br4923          ------------------------------WKQAFYARDLAGTVVLVGVP
Mb3753|M.bovis_AF2122/97            WWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC
                                                                                   .  

Mflv_0660|M.gilvum_PYR-GCK          AGAASLDVNRHLLKEIQLRMVF-----GYDMFDDFPAVLALIADGKLALA
Mvan_0490|M.vanbaalenii_PYR-1       AGAASLDVNRHLLKEIQLRMVF-----GYDMFDDFPAVLALIADGKLALA
MSMEG_5021|M.smegmatis_MC2_155      EKPLTTPLLNLVMNESRIQGSL-----CYTS-ADFEAVIALMADGVYDTT
MMAR_2790|M.marinum_M               DLQPFPLPALTCLLRSITLRLT-----IAPVQRTWSELIPLLESGRLDVD
MUL_2962|M.ulcerans_Agy99           DLQPFPLPALTCLLRSITLRLT-----IAPVQRTWSELIPLLESGRLDVD
Rv1895|M.tuberculosis_H37Rv         DLQPFPVPALTCLLRSITLRMT-----MAPVQRTWPELIPLLQSGRLDVD
MAV_2804|M.avium_104                DMNPFPLNALGCLIRSITLRMT-----TAPVQRTWPELIPLLQSGRLDVD
TH_4349|M.thermoresistible__bu      GGS----VPLSFFSQPYEVSIQ-----TTYWG-TRPELVELLDLAARGLV
MAB_2084|M.abscessus_ATCC_1997      HPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLD
MLBr_01784|M.leprae_Br4923          TPDMRLDMPLLDFFSHGGSLKSSWYG-DCLPERDFPTLVDLYLQGRLPLG
Mb3753|M.bovis_AF2122/97            MGSDHIRPAMAINKEINLRFVLG------YTPLEFRDTLHMLADGKVNAA
                                                                          : :   .     

Mflv_0660|M.gilvum_PYR-GCK          PQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP----------------
Mvan_0490|M.vanbaalenii_PYR-1       PQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP----------------
MSMEG_5021|M.smegmatis_MC2_155      GWVTT-IGIDDVIDEGFEALHAGRK--MKVLIDPAI--------------
MMAR_2790|M.marinum_M               GIFTTSLPLDEAAKG-YSIAGSRSGNDVKVLLKV----------------
MUL_2962|M.ulcerans_Agy99           GIFTTSLPLDEAAKG-YSIAGSRSGNDVKVLLKV----------------
Rv1895|M.tuberculosis_H37Rv         GIFTTTLPLDEAAKG-YATARARSGEELRFCLRPDSRDVLGAHETVDLYV
MAV_2804|M.avium_104                GIFTTTMPLDEAAIG-YATAGSRSGDDVKILLKP----------------
TH_4349|M.thermoresistible__bu      HVESTTYPLDDALQA-YRDLRAGRVRGRAVIVP-----------------
MAB_2084|M.abscessus_ATCC_1997      ELVTREYSLDQINEG-YQDMRSGRNIRGLVRF------------------
MLBr_01784|M.leprae_Br4923          KFVSERIGLGDVEEA-FHKIHGGKVLRSVVML------------------
Mb3753|M.bovis_AF2122/97            PLITGTVGLPGVAAA--FDALGDPEAHAKIMIDPKSNAASPQPFRVE---
                                       :    :                    . .                  

Mflv_0660|M.gilvum_PYR-GCK          ---------------------------
Mvan_0490|M.vanbaalenii_PYR-1       ---------------------------
MSMEG_5021|M.smegmatis_MC2_155      ---------------------------
MMAR_2790|M.marinum_M               ---------------------------
MUL_2962|M.ulcerans_Agy99           ---------------------------
Rv1895|M.tuberculosis_H37Rv         HVRRCQSVADLQLEGAADGVDGPSMLN
MAV_2804|M.avium_104                ---------------------------
TH_4349|M.thermoresistible__bu      ---------------------------
MAB_2084|M.abscessus_ATCC_1997      ---------------------------
MLBr_01784|M.leprae_Br4923          ---------------------------
Mb3753|M.bovis_AF2122/97            ---------------------------