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MRATTLPKSTQAAVVRNFGEPLTLEEVAVPQTVAPGGLLVEIVACSLCGTDVHCWEGSLAIPVGLPLILG HEMVGRIIAIGDGADVDSAGQPLQIGDRILWTHAVCGRCVMCAKKRPTLCRNKIPYGQATMDQWPNLLGG LAQHSYVLPGSGRLRVPDGVPDDLASMASCALRSVVNAVEQAGRVGPEHTVVVQGAGPLGILATGLFAQA GAGRVITVGAPDTRLEIASEFGAHDVISLAAHPDPDDRLAMIRDATDGLGADLVAEFSGHPAAFAEGVEM AAPDGRYLVVGQLGAGVTTIAPGTITKKNLNVIGSFSGDLSHYRTALTILERYADRLPFDRLITGHYPLR DIDSVMGRMQSFQEIKPVLLPQETQA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6296 | - | - | 100% (376) | 5-exo-alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2882 | - | 3e-58 | 36.77% (359) | 5-exo-alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4400 | - | 5e-36 | 31.14% (350) | alcohol dehydrogenase, zinc-containing |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 3e-30 | 30.14% (365) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_4951 | - | 3e-27 | 30.31% (353) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1530 | adh | 3e-30 | 30.14% (365) | alcohol dehydrogenase adh |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 6e-26 | 26.27% (373) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 3e-27 | 27.12% (354) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_4911 | adhX | 9e-27 | 28.92% (332) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. avium 104 | MAV_5022 | - | 4e-24 | 27.10% (369) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4627 | - | 1e-30 | 27.01% (374) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 2e-27 | 28.92% (332) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_2879 | - | 1e-59 | 36.59% (358) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 ------------MSQTVRGVISRKKDEPVELVDIVIP-DPGPGEAVVDVT
TH_4627|M.thermoresistible__bu ------------MSQSVRGVIARKKDEPVEVVDIVIP-DPGPGEVVVKVT
MAB_1869c|M.abscessus_ATCC_199 ----------------------------MELVDIVIP-DPGPGEVVVKVQ
MAV_5022|M.avium_104 ------------MLQRIGAPRPYARSRPISITDVELA-PPGRDEVLVRIE
MMAR_4911|M.marinum_M MTQTLANPGATQATETLCAAVVTGFGEPLQIKELALP-TPGYGEALVKLE
MUL_0495|M.ulcerans_Agy99 MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALP-TPGYGEALVKLE
Mflv_4951|M.gilvum_PYR-GCK ----------------MQAAVVTAFGEPLVVEERDLP-APGPGEALVKLV
MSMEG_6296|M.smegmatis_MC2_155 -------MRATTLPKSTQAAVVRNFGEPLTLEEVAVPQTVAPGGLLVEIV
Mvan_2879|M.vanbaalenii_PYR-1 ---------MSRAPFTGRIARFDEPGKPFDIETVTLP-EVGPGEILIKVT
Mb1557|M.bovis_AF2122/97 -----------MSDGAVVRALVLEAPRRLVVRQYRLP-RIGDDDALVRVE
Rv1530|M.tuberculosis_H37Rv -----------MSDGAVVRALVLEAPRRLVVRQYRLP-RIGDDDALVRVE
. : :. . . :: :
MLBr_01784|M.leprae_Br4923 ACGVCHTDLTYREGGI--NDRY---PFLLGHEAAGTVEVVGPGVTAVEPG
TH_4627|M.thermoresistible__bu ACGVCHTDLHYREGGI--NDEF---PFLLGHEAAGTVESVGSGVTNVEPG
MAB_1869c|M.abscessus_ATCC_199 ACGVCHTDLTYREGGI--NDEF---PFLLGHEAAGIVETVGEGVTTVEPG
MAV_5022|M.avium_104 AAGICHSDLSVVDGNR--VRPV---PMLLGHEAAGIVERVGPGVADLAVG
MMAR_4911|M.marinum_M TSGVCHTDLHAAHGDWPVKPAP---PFVPGHEGCGTVVALGDGVTDLKVG
MUL_0495|M.ulcerans_Agy99 TSGVCHTDLHAAHGDWPVKPAP---PFVPGHEGCGTVVALGDGVTDLKVG
Mflv_4951|M.gilvum_PYR-GCK TSGVCHTDLHAAHGDWPVKPSP---PFIPGHEGYGTVVAVGDGVDDLSVG
MSMEG_6296|M.smegmatis_MC2_155 ACSLCGTDVHCWEGSLAIP-VG--LPLILGHEMVGRIIAIGDGADVDSAG
Mvan_2879|M.vanbaalenii_PYR-1 RANICGSDVHAWHGTFATRGLGGQLPTVLGHEMVGAVEELGAGVTADSNG
Mb1557|M.bovis_AF2122/97 ACGLCGTDHEQYTGELAGG-----FAFVPGHETVGTIAAIGPRAEQRWG-
Rv1530|M.tuberculosis_H37Rv ACGLCGTDHEQYTGELAGG-----FAFVPGHETVGTIAAIGPRAEQRWG-
..:* :* * . : *** * : :* .
MLBr_01784|M.leprae_Br4923 -----DFVILNWR-AVCGQCRACKRGRPSYCFDTFNAQQKMTLI------
TH_4627|M.thermoresistible__bu -----DFVVLNWR-AVCGQCRACKRGRPHLCFDTFNATQKMTLG------
MAB_1869c|M.abscessus_ATCC_199 -----DFVILNWR-AVCGVCRACKRGRPQYCFDTFNAAQKMTLT------
MAV_5022|M.avium_104 -----ARVVLVFL-PRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRL
MMAR_4911|M.marinum_M -----DKVGNAWLWSACGSCEQCRTGWETLCEN--QRNGGYTVN------
MUL_0495|M.ulcerans_Agy99 -----DKVGNAWLWSACGSCEQCRTGWETLCEN--QRNGGYTVN------
Mflv_4951|M.gilvum_PYR-GCK -----DMVGNAWLWSSCGRCEYCRTGWETLCEQ--QRNGGYSVD------
MSMEG_6296|M.smegmatis_MC2_155 QPLQIGDRILWTHAVCGR-CVMCAKKRPTLCRN---KIPYGQAT------
Mvan_2879|M.vanbaalenii_PYR-1 KPLELGTRVVFPYFFCCHTCRNCLAGRRNACLN---LKMAMLGR------
Mb1557|M.bovis_AF2122/97 --VSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIP------
Rv1530|M.tuberculosis_H37Rv --VSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIP------
* * *
MLBr_01784|M.leprae_Br4923 --DGTELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGL
TH_4627|M.thermoresistible__bu --DGTELTPALGIGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGV
MAB_1869c|M.abscessus_ATCC_199 --DGTELTPALGIGAFIEKTLVHAGQCTKVDPTADPAVVGLLGCGVMAGL
MAV_5022|M.avium_104 SRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGG
MMAR_4911|M.marinum_M -------------GSFGTYMLVNADYAARIPDGADPLEVAPILCAGVT-V
MUL_0495|M.ulcerans_Agy99 -------------GSFGTYMLVNADYAARIPDGADPLEVAPILCAGVT-V
Mflv_4951|M.gilvum_PYR-GCK -------------GSFGTYMLVDAAYAARIPDGVDPVEVAPILCAGVT-V
MSMEG_6296|M.smegmatis_MC2_155 ----MDQWPNLLGGLAQHSYVLPGSGRLRVPDGVPDDLASMASCALRSVV
Mvan_2879|M.vanbaalenii_PYR-1 ----ADEPPYFVGGYADYFVLPAGAVVYTVPDAVSDDIAAGANCALSQVM
Mb1557|M.bovis_AF2122/97 ----VDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIR
Rv1530|M.tuberculosis_H37Rv ----VDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIR
. : : .
MLBr_01784|M.leprae_Br4923 GAAINTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDD---T
TH_4627|M.thermoresistible__bu GAAINTGAVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDA---K
MAB_1869c|M.abscessus_ATCC_199 GAAVNTGNVGRDDTVAVIGCGGVGDAAIAGARLAGARKIIAIDTDD---T
MAV_5022|M.avium_104 GAVLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLP---E
MMAR_4911|M.marinum_M YKGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMG-LRVVAIDIDD---D
MUL_0495|M.ulcerans_Agy99 YKGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMG-LRVVAIDIDD---D
Mflv_4951|M.gilvum_PYR-GCK YKGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMG-LRVVAIDVDD---S
MSMEG_6296|M.smegmatis_MC2_155 NAVEQAGRVGPEHTVVVQGAGPLGILATGLFAQAGAGRVITVGAPD---T
Mvan_2879|M.vanbaalenii_PYR-1 YGLERVDQQLGEY-VVVQGAGALGLYAVAVAKARGAAKVIAIDGVP---E
Mb1557|M.bovis_AF2122/97 WGVTIPETKPGDV-VAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDAD
Rv1530|M.tuberculosis_H37Rv WGVTIPETKPGDV-VAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDAD
*.: * * * * . ::. .
MLBr_01784|M.leprae_Br4923 KLEWARTFGATHTVNALEL-E---VVKTIQDLTSGFGVDVVIDTVGRPET
TH_4627|M.thermoresistible__bu KLDWAREFGATHTIDASST-D---VVEAIQELTDGFGADVVVDAVGRPET
MAB_1869c|M.abscessus_ATCC_199 KLAWAKDFGATDTINARKVDD---VVTAIQELTDEFGADVVIDAVGRPET
MAV_5022|M.avium_104 KLAAARRLGAHQAY------------TPQQAVEARVKAAVVIEAVGHPAA
MMAR_4911|M.marinum_M KLALAARLGAELVVNARTS------DVVAQVQEATGGVHGVLVTAVHPQA
MUL_0495|M.ulcerans_Agy99 KLALAARLGAELVVNARTS------DVVAQVQEATGGVHGVLVTAVHPQA
Mflv_4951|M.gilvum_PYR-GCK KLDLATGLGAEVVVNARTA------DVVAEVHRATGGVHGVLVTAVHRDA
MSMEG_6296|M.smegmatis_MC2_155 RLEIASEFGAHDVISLAAHPDPDDRLAMIRDATDGLGADLVAEFSGHPAA
Mvan_2879|M.vanbaalenii_PYR-1 RLELATAFGADAVIDITATTD-KDRAKIVRSLTDGQGADVVVEVVGHPSA
Mb1557|M.bovis_AF2122/97 RLALAAQFGADLAVDVAIDDP----VAALTEQTGGLADVVVDVTAKAPAA
Rv1530|M.tuberculosis_H37Rv RLALAAQFGADLAVDVAIDDP----VAALTEQTGGLADVVVDVTAKAPAA
:* * :** . * :
MLBr_01784|M.leprae_Br4923 WKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGDCLP
TH_4627|M.thermoresistible__bu WEQAFYARDLAGTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYGDCLP
MAB_1869c|M.abscessus_ATCC_199 WKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLP
MAV_5022|M.avium_104 LQTAIDLTAPGGRTITVGLPPPDARITVSPLGFVAEGRSLIGSYLGSAVP
MMAR_4911|M.marinum_M FGQAIGLARRGGTIVFNGLPP--GDFPAPIFDIVLKGLTIRGSIVG---T
MUL_0495|M.ulcerans_Agy99 FGQAIGLARRGGTIVFNGLPP--GDFPAPIFVIVLKGLTIRGSIVG---T
Mflv_4951|M.gilvum_PYR-GCK FGQAIGLARRGGTIVFVGLPP--GDFPAPIFDIVLKGLTIRGSIVG---T
MSMEG_6296|M.smegmatis_MC2_155 FAEGVEMAAPDGRYLVVGQLGAG--VTTIAPGTITKKNLNVIGSFSGDLS
Mvan_2879|M.vanbaalenii_PYR-1 IDEGLKLLGQFGRYVEIGNINIGR-TFEFDPSRFVFANKTMVGVSLYDPS
Mb1557|M.bovis_AF2122/97 FAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDAT
Rv1530|M.tuberculosis_H37Rv FAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDAT
.. * : * . . .
MLBr_01784|M.leprae_Br4923 ERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML
TH_4627|M.thermoresistible__bu ERDFPTLINLYLQGRLPLEKFVTERIALDEVEGAFEKMQRGEVLRSVVVL
MAB_1869c|M.abscessus_ATCC_199 ERDFPTLVSLYQQGRLPLDRFVSERIGIESIEAAFEKMHHGEVLRSVVVL
MAV_5022|M.avium_104 SRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRF
MMAR_4911|M.marinum_M RQDMAEALDFYARG---LIHPTVEGAALEDINHVFERMERGQIDGRVVID
MUL_0495|M.ulcerans_Agy99 RQDMAEALDFYARG---LIHPTVEGAALEDINHVFERMERGQIDGRVVID
Mflv_4951|M.gilvum_PYR-GCK RQDMVEAIDFFARG---LVHPTVHTTRLDDINDVFDRMERGQIDGRVVID
MSMEG_6296|M.smegmatis_MC2_155 HYRTALTILERYADRLPFDRLITGHYPLRDIDSVMGRMQSFQEIKPVLLP
Mvan_2879|M.vanbaalenii_PYR-1 VLSRALAFLEEYQHRLPFDRLAAARYSLDDINEAFAAAEDKRDVRASIVP
Mb1557|M.bovis_AF2122/97 AYRAALDLLVS--GRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHG
Rv1530|M.tuberculosis_H37Rv AYRAALDLLVS--GRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHG
. . : : : :
MLBr_01784|M.leprae_Br4923 -----
TH_4627|M.thermoresistible__bu K----
MAB_1869c|M.abscessus_ATCC_199 -----
MAV_5022|M.avium_104 DA---
MMAR_4911|M.marinum_M YR---
MUL_0495|M.ulcerans_Agy99 YR---
Mflv_4951|M.gilvum_PYR-GCK YR---
MSMEG_6296|M.smegmatis_MC2_155 QETQA
Mvan_2879|M.vanbaalenii_PYR-1 -----
Mb1557|M.bovis_AF2122/97 VLTP-
Rv1530|M.tuberculosis_H37Rv VLTP-