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TTTSGRGRPRLEQPRRPGQTAREEILDAAAELFTTHGYGSTSTRRIADEVGVRQASLYHHFATKDDILDA LLAGTVDEPLELAHGLLGESGPAAPRLHALVIYDASQLCAGRWNLGALYLLPELRTDRFAPFRRRRAELR SAYRSLAAAVIAECGGPPEADDLPFRLVESVINSRSDDAVVPPEQPWVIGEGALRVLGFDGDFAELAAAT ASRLGVRPPGRAAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4300 | - | - | 100% (225) | transcription regulator AmtR |
| M. smegmatis MC2 155 | MSMEG_1611 | - | 1e-12 | 35.65% (115) | transcriptional regulator, TetR family protein, putative |
| M. smegmatis MC2 155 | MSMEG_3425 | - | 9e-10 | 41.43% (70) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3185c | - | 6e-18 | 35.35% (215) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0973 | - | 5e-11 | 34.09% (88) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3160c | - | 6e-18 | 35.35% (215) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 1e-06 | 31.52% (92) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4089c | - | 1e-53 | 52.63% (209) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5046 | - | 2e-09 | 36.54% (104) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0603 | - | 5e-11 | 34.00% (100) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2975 | - | 4e-48 | 52.11% (213) | PUTATIVE putative transcription regulator AmtR |
| M. ulcerans Agy99 | MUL_0990 | - | 9e-09 | 43.59% (78) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0170 | - | 4e-14 | 39.08% (87) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5046|M.marinum_M -----------------------------MERMTGQANSRRGELLGLAAV
MAV_0603|M.avium_104 --------------------------------MTGPANSRRDELLELAAA
MSMEG_4300|M.smegmatis_MC2_155 ------------------MTTTSGRGRPRLEQPRRPGQTAREEILDAAAE
MAB_4089c|M.abscessus_ATCC_199 ------------------MS-----GRPRRISPIREGNSTRDEILDASAE
TH_2975|M.thermoresistible__bu -----------VTAGGHPAAAPVTCGRPRSQERRRPGATARDEVLDAAAE
Mb3185c|M.bovis_AF2122/97 --------------------------MPRQAGRWSPTALR---ILGAAAE
Rv3160c|M.tuberculosis_H37Rv --------------------------MPRQAGRWSPTALR---ILGAAAE
Mflv_0973|M.gilvum_PYR-GCK --------------------------MSGDSTRAGGP--TRRRLIDVAIE
Mvan_0170|M.vanbaalenii_PYR-1 --------------------------MTTASSAQMPPQSARQRVLDVALA
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MUL_0990|M.ulcerans_Agy99 --------------------------MRRARAPRGSGDLLRHEILDAATE
:: :
MMAR_5046|M.marinum_M MFAERGLR-ATTVRDIADGAGILSGSLYHHFASKEEMVDELLREFLDWLF
MAV_0603|M.avium_104 MFAERGLR-ATTVRDIADSAGILSGSLYHHFSSKEEMVDEVLRSFLDWLF
MSMEG_4300|M.smegmatis_MC2_155 LFTTHGYG-STSTRRIADEVGVRQASLYHHFATKDDILDALLAGTVDEPL
MAB_4089c|M.abscessus_ATCC_199 LFTTDGFA-ATTTRRIAESVGIQQASLYYHFKTKDDILDALLAMTIDQPL
TH_2975|M.thermoresistible__bu LFTTLGVA-ATSTRQIAESVGVRQASLYHHFRTKDEILATLLDATVAPSV
Mb3185c|M.bovis_AF2122/97 LIALRGYS-STSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPL
Rv3160c|M.tuberculosis_H37Rv LIALRGYS-STSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPL
Mflv_0973|M.gilvum_PYR-GCK LFKRYSVA-GTSLQMISDELGLTKSAIYHHFRTRDELLTAVMEPLIAEVA
Mvan_0170|M.vanbaalenii_PYR-1 LFTRHGYA-GTSLQMIADEMGVTKGSLYYHFRAREDLLRALVGPLIEQLR
MLBr_00815|M.leprae_Br4923 VFVDHGYH-AAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLV
MUL_0990|M.ulcerans_Agy99 LLLQTRQARAVSIRSVAERVGVTSPSIYLHFQDKDALLDAVCARYLARLD
:: .. :: *: . :* ** : : : :
MMAR_5046|M.marinum_M ARYLEIVDGEPNPLERLKGLFLASFEAIEHRHAQVVIYQDEAQRLSSQPR
MAV_0603|M.avium_104 ARYREIIDSESNPLERLKGLFMASFEAIEHRHAQVVIYQDEAKRLLSQPR
MSMEG_4300|M.smegmatis_MC2_155 ELAHGLLGESGPAAPRLHALVIYDASQLCAGRWNLGALYLLPE--LRTDR
MAB_4089c|M.abscessus_ATCC_199 HYAALIADRPEAPVVRLYALALGDAAQLAASRWNLGALYLLPD--LRAER
TH_2975|M.thermoresistible__bu TAARRLRGRPEPPAVLLHALVWLDARLLWDSPHNLGILYLLPE--VRDRR
Mb3185c|M.bovis_AF2122/97 ELFGHITAMPVPAVVKLHRWLTESLDHLHASPYVLVSILITPD--LHQES
Rv3160c|M.tuberculosis_H37Rv ELFGHITAMPVPAVVKLHRWLTESLDHLHASPYVLVSILITPD--LHQES
Mflv_0973|M.gilvum_PYR-GCK EIVDAAEEQRTPHARADHMLVGYAS--IAARHRTLIPLLSGDP--GVVAL
Mvan_0170|M.vanbaalenii_PYR-1 AIVEHAEAQRSPSVRAEHVLTGYAR--LAAANRALVAVTSGDP--SVVEV
MLBr_00815|M.leprae_Br4923 SSVQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDN--ITEPR
MUL_0990|M.ulcerans_Agy99 EEMERAAMGHTCVVEVLRAQGLAYVRFALQTPELYRLATMGEWRSGSNVD
MMAR_5046|M.marinum_M FSYLEDRNKEQRKMWVDVLNQGIEEGYFR---------PDLDVDLVYRFI
MAV_0603|M.avium_104 FSYIEDMNRQQRKMWLEVLNQGVDEGYFR---------PDLDVDLVYRFI
MSMEG_4300|M.smegmatis_MC2_155 FAPFRRRRAELRSAYRSLAAAVIAECGGPPEA------DDLPFRLVESVI
MAB_4089c|M.abscessus_ATCC_199 FSAFRRKRDQLRTHYQELAAAACRASMLRAGV------ERLPFRLVESVI
TH_2975|M.thermoresistible__bu FGGFHRRRSELRAAYRDLAERVAAAGATPSSVPDVVIDPDVVFRLVETLP
Mb3185c|M.bovis_AF2122/97 FVAERELVAEMERALVGLIETGQGEGDVRAMH------PLSAARLVQALF
Rv3160c|M.tuberculosis_H37Rv FVAERELVAEMERALVGLIETGQGEGDVRAMH------PLSAARLVQALF
Mflv_0973|M.gilvum_PYR-GCK LRTRSEWGDLVRRQLALFSEVEPGLGG------------QVKAALAMSGI
Mvan_0170|M.vanbaalenii_PYR-1 IHADPDWADLIDRQIGLLAAVQPGLAG------------RVRATIVMAGI
MLBr_00815|M.leprae_Br4923 VAAQVRVATES--CIDAVFALISADSRLDP----------HRARMVAVGL
MUL_0990|M.ulcerans_Agy99 SALDSSAFRHMCASVQAMMDEGIYRADDPTTI-------ALELWTAAHGV
. .
MMAR_5046|M.marinum_M RDTTWVSVRWYKPGG------ALTAQQVGQKYLAIVLGGIQKEGV-----
MAV_0603|M.avium_104 RDTTWVSVRWYQPGG------PLTAEQVGQQYLAIVLGGITVDAKKD---
MSMEG_4300|M.smegmatis_MC2_155 N-SRSDDAVVPPEQPWVIGEGALRVLGFDGDFAELAAATASRLGVR--PP
MAB_4089c|M.abscessus_ATCC_199 M-LRADGDSIAPEA---LADATLRVVGVTGDAGEIEGAARVLLGQLGWPV
TH_2975|M.thermoresistible__bu N-LRMDG-LGEPDQPRRTADLAVHVLGWRGDWPRLRSESATVAAAVG---
Mb3185c|M.bovis_AF2122/97 DALALPEFAVSPDE---IVEFAMTALLSDPDRLAEIRAAADALEIQTAPP
Rv3160c|M.tuberculosis_H37Rv DALALPEFAVSPDE---IVEFAMTALLSDPDRLAEIRAAADALEIQTAPP
Mflv_0973|M.gilvum_PYR-GCK ASAAGVDYGGDVDDD----TLRDQLIAAGRRALGLRNSRTGAVTARR---
Mvan_0170|M.vanbaalenii_PYR-1 AATAAPGVV-EADEA----ELCRQLIDAGRRTLGLRAPRA----------
MLBr_00815|M.leprae_Br4923 VGISVDCARYWLDTN-----RPISKSDAVEGTVQFAWGGLSHVPLTRL--
MUL_0990|M.ulcerans_Agy99 AALLIAKPHLPFGDVAAFADRVLGAVLCGHMVAGLVGPQATSRDLMDWVV
MMAR_5046|M.marinum_M ----------
MAV_0603|M.avium_104 ----------
MSMEG_4300|M.smegmatis_MC2_155 GRAAR-----
MAB_4089c|M.abscessus_ATCC_199 AIPKR-----
TH_2975|M.thermoresistible__bu --DCR-----
Mb3185c|M.bovis_AF2122/97 DRGL------
Rv3160c|M.tuberculosis_H37Rv DRGL------
Mflv_0973|M.gilvum_PYR-GCK ----------
Mvan_0170|M.vanbaalenii_PYR-1 ----------
MLBr_00815|M.leprae_Br4923 ----------
MUL_0990|M.ulcerans_Agy99 QHRPSEESRV