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SSTTLDSVPSFDVTDPAFSITSDEVHEAREKSWYATTPYGLAVLRYEQVNRLIKHPKLRQGSAAWPAHNG VTEGPFAEWFASWILNKEGEEHHRLRRLMNPAFSPKLIGSLVPRFQALANELIDNFAEPDRCEFVSEFAE PYAARVIAIMLGLPEEEWKVISTESATIGLALGVTLREDLPKIEAAVQRLYEYSDELIADRRANPRDDFM TTLVNASRPDDGRLSDKELRDAILLLIFGGFDTTRNQLGLAMQTFMKHPDQWRLLGERPDLGGKAVEEVM RVNPTVRWVTREVVEDFEYEGVTLKAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGVHHCLGH FVARSDMSEALPLLARRLRDPHELPGATWLPDSGNTGPNTLPIGFTPAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6695 | - | - | 100% (400) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-52 | 35.03% (354) | cytochrome P450 hydroxylase |
| M. smegmatis MC2 155 | MSMEG_5918 | - | 2e-36 | 32.32% (328) | P450 heme-thiolate protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 1e-34 | 32.17% (314) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_0363 | - | 5e-64 | 36.67% (409) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 4e-37 | 32.92% (322) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-32 | 26.45% (363) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 1e-33 | 29.56% (318) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 2e-60 | 35.43% (381) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 6e-65 | 37.69% (398) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_3500 | - | 2e-42 | 30.49% (410) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_4077 | cyp142A3 | 6e-33 | 30.84% (321) | cytochrome P450 142A3 Cyp142A3 |
| M. vanbaalenii PYR-1 | Mvan_1848 | - | 0.0 | 88.72% (399) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6695|M.smegmatis_MC2_155 ---------------------MSSTTLD--SVPSFDVTDPAFSITSDEVH
Mvan_1848|M.vanbaalenii_PYR-1 ---------------------MSSATVG--SVPAFAVTDPGFSITSAEVH
Mflv_0363|M.gilvum_PYR-GCK ---------------------MTASTT---ARNVFDADLPALTYDLSSTP
MAV_4569|M.avium_104 ---------------------MTVGAA---PPSVFDSDLPTLHYHSDETP
MMAR_0122|M.marinum_M ---------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Rv3518c|M.tuberculosis_H37Rv ---------------------MTE---APDVDLADGNFYAS-REARAAYR
MUL_4077|M.ulcerans_Agy99 -------------------MAMTKPLIKPDVDLTDGNFYAS-RQAREAYR
TH_3500|M.thermoresistible__bu ---------------------MTS--TAPDIDLTDGRFYADSASARAAYR
Mb0801|M.bovis_AF2122/97 ---------------------MTTAAGLSGIDLTDLDNFAD-GFPHHLFA
.
MSMEG_6695|M.smegmatis_MC2_155 --------EAREKSWYATTPYGLAVLR-YEQVNRLIKHPKLRQGS-AAWP
Mvan_1848|M.vanbaalenii_PYR-1 --------AARERSWYATTEYGLAVLR-YEQVNRLLKHPKLRQGS-AAWP
Mflv_0363|M.gilvum_PYR-GCK AEVWPSLREARSLAPVAVGPLGPEVLS-YDMARAILRDPRFAIPP-GINL
MAV_4569|M.avium_104 AQVYPRLREAQRRAAVAIGPHGPEVLS-YHLVRSVLRDPRFQIPP-GINL
MMAR_0122|M.marinum_M DEAHQILAEARCRSPIALGPHGPELLT-YDLVHTVLRDPRFRMPP-GMFL
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATL
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLRHPQASSDRRKSNI
Rv3518c|M.tuberculosis_H37Rv WMRANQPVFRDR--------NGLAAASTYQAVIDAERQPELFSNAGG---
MUL_4077|M.ulcerans_Agy99 WMRANQPVFRDR--------NGLAAASTYQAVIDAERQPELFSNAGG---
TH_3500|M.thermoresistible__bu WMRQNQPVFRDR--------NGLAAAATYQAIIESERNPELFSNTGG---
Mb0801|M.bovis_AF2122/97 IHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQR
: :.*
MSMEG_6695|M.smegmatis_MC2_155 AHNGVTEG-PFAEWFASWILNKEGEEHHRLRRLMNPAFSPKLIGSLVPRF
Mvan_1848|M.vanbaalenii_PYR-1 AHNGVTEG-PFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRF
Mflv_0363|M.gilvum_PYR-GCK AAQGVTSG-PLFDKVMSSLLCLEGAEHQRLRKLVSKAFSPRATERLHDTI
MAV_4569|M.avium_104 LAQGIDSG-PLWDKVANSLLCLEGDAHHRLRSLCSKAFTPRTVARLHDTM
MMAR_0122|M.marinum_M AAQGITSG-PLWDRLAANLISLDGPAHHRLRRLVSQAFTPRATGRLNTTI
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
MAB_0276|M.abscessus_ATCC_1997 VQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAEDI
Rv3518c|M.tuberculosis_H37Rv --------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASI
MUL_4077|M.ulcerans_Agy99 --------IRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDKEHSI
TH_3500|M.thermoresistible__bu --------IRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDREDSI
Mb0801|M.bovis_AF2122/97 RFG--GTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDL
: : * * * . .:: : :
MSMEG_6695|M.smegmatis_MC2_155 QALANELIDNFAEPDRCEFVSEFAEPYAARVIAIMLGLPEEE----WKVI
Mvan_1848|M.vanbaalenii_PYR-1 QALAAELIDGFAEPGRCEFVGEFAEPYAARVIAIMLGLPESE----WKVI
Mflv_0363|M.gilvum_PYR-GCK VAVVDELIDQVVDAGRCDVVADIARPYPIPIICALLGAPRED----WRLF
MAV_4569|M.avium_104 AAVMNELVDRVAAAGRCDVVTDIARPYPVPIICALLGAPRED----WRRF
MMAR_0122|M.marinum_M TEVITDLVDRCADRGRCDVVADIARRYPIPIICALLGAPAGD----WKLF
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
MAB_0276|M.abscessus_ATCC_1997 QTFVDKMLDDIALRGTFNLVTEFAYPLPVAVICRMLGVPIEDEPEFGRAS
Rv3518c|M.tuberculosis_H37Rv AALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQ-----RDM
MUL_4077|M.ulcerans_Agy99 AQLCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVLPEQ-----REM
TH_3500|M.thermoresistible__bu ARLCDTLIDNVCERGECDFVRDIAAPLPMAVIGDMLGVAPED-----RGQ
Mb0801|M.bovis_AF2122/97 RRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETD-----RHW
::* :.: ::* . :* :** : :
MSMEG_6695|M.smegmatis_MC2_155 S--TESATIGLALGVTLREDLPKIEAAVQRLYEYSDELIADRRANPRDDF
Mvan_1848|M.vanbaalenii_PYR-1 A--TESATIGLALGVTILDDLPRIEAALAHLYEYCDELIADRRASPRDDF
Mflv_0363|M.gilvum_PYR-GCK SQWAEDVVRVFGFSVDVAARQDHVMRAWNALDDYVDAMVEDRRTRLTDDL
MAV_4569|M.avium_104 SSWADDVFKAFSFTVDLREVEPVVMRAWRELDDYVDEMVARRRHSLTDDL
MMAR_0122|M.marinum_M SGWTDDILKAFSW--DAAAQQPAILAAWDELDAYIDDMVAARRGSLTEDL
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDL
MAB_0276|M.abscessus_ATCC_1997 ALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGDDL
Rv3518c|M.tuberculosis_H37Rv FLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDL
MUL_4077|M.ulcerans_Agy99 FLRWSDDLVTFLSSQVSQEDFQVTIDAFAAYNDFTRATIAARRAEPTDDL
TH_3500|M.thermoresistible__bu LLKWSDDLVTGLSTTADEATVQAVMDAFAGYTAYTMEIIGKRRAEPTDDL
Mb0801|M.bovis_AF2122/97 LFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDM
* : : :* :*:
MSMEG_6695|M.smegmatis_MC2_155 MTTLVNASRPDD---GRLSDKELRDAILLLIFGGFDTTRNQLGLAMQTFM
Mvan_1848|M.vanbaalenii_PYR-1 VTTLVNASRPED---GRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFM
Mflv_0363|M.gilvum_PYR-GCK ISELIRAEDDGD----RLSSAELQMLAVSLLMAGTDTTRNQLAASVQALS
MAV_4569|M.avium_104 LSDLIRAGDEGD----RLDAAELRMLAGGLLLAGTDTTRNQVAASVQVLC
MMAR_0122|M.marinum_M ISALIRAEDDGD----CLSSDELRMLVAGLLIGGTDTTRNQLAASAQALC
MLBr_02088|M.leprae_Br4923 ISRLIELDESGD----QLTEEEIIATCGLLLVAGHETTVNLIANAVLAML
MAB_0276|M.abscessus_ATCC_1997 LSALIQVEEAGD----QLTEEEIISTCTLLLIAGHETTVNLIANASLAML
Rv3518c|M.tuberculosis_H37Rv VSVLVSSEVD---GE-RLSDDELVMETLLILIGGDETTRHTLSGGTEQLL
MUL_4077|M.ulcerans_Agy99 VSVLVSSEVD---GE-RLSDDELVMETLLILIGGDETTRHTLSGGSEQLL
TH_3500|M.thermoresistible__bu FSILINAEVE---GQ-RMSDEEIVFETLLILIGGDETTRHTLSGGVEQLL
Mb0801|M.bovis_AF2122/97 LSVVANATIDDPDAP-ALSDAELYLFFHLLFSAGAETTRNSIAGGLLALA
.: : : *: :: .* :** : :. . :
MSMEG_6695|M.smegmatis_MC2_155 KHPDQWRLLGERPDLGGKAVEEVMRVNPTVRWVTREVVEDFEYEGVTLKA
Mvan_1848|M.vanbaalenii_PYR-1 AHPDQWRLLAERPELGGNAVEEVMRVNPTVRWVTREVLEDFEYEGVELAA
Mflv_0363|M.gilvum_PYR-GCK EQPDQWALLAEQPDLAMRAVEETMRHSPVVCGTPRIVVADVEFAGYLFPA
MAV_4569|M.avium_104 EHPHQWELLRQRPELAMRAVEETMRHSPIACGTLRLVVEDAELDGHLFPA
MMAR_0122|M.marinum_M DHPDQWVLLAQHPDLAANAAEETMRHSPITFSTLRIALDDVELAGVMIPT
MLBr_02088|M.leprae_Br4923 RNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTE
MAB_0276|M.abscessus_ATCC_1997 RHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVARVADGEMAIRDFILPD
Rv3518c|M.tuberculosis_H37Rv RNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCA
MUL_4077|M.ulcerans_Agy99 RNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALSK
TH_3500|M.thermoresistible__bu RHPDQWQRLRNDPDLVPGAIEEMLRWTSPVKNMCRTLTADTEFHGTQLRK
Mb0801|M.bovis_AF2122/97 ENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEA
: * * . . ** :* . * :
MSMEG_6695|M.smegmatis_MC2_155 GTTVHLYSESAGTDPRVFEPGFDITAERK---PHFGFGGGVHHCLGHFVA
Mvan_1848|M.vanbaalenii_PYR-1 GTTVHLYSESAGTDPRVFEPGFDITAERK---PHFGFGGGVHHCLGHFVA
Mflv_0363|M.gilvum_PYR-GCK GTFVFVNTFTANRDPALYDDAERLDLRREGAPAILTFGGGVHYCLGANLA
MAV_4569|M.avium_104 GTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGVHYCLGANLA
MMAR_0122|M.marinum_M GTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGMHYCLGANLA
MLBr_02088|M.leprae_Br4923 GDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGSHFCLGAALA
MAB_0276|M.abscessus_ATCC_1997 GEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHGPHFCLGAPLA
Rv3518c|M.tuberculosis_H37Rv GEKMMLLFESANFDEAVFCEPEKFDVQRNPN-SHLAFGFGTHFCLGNQLA
MUL_4077|M.ulcerans_Agy99 GEKIMLLFESANFDEAVFTDPEKFDIQRNPN-SHLAFGFGTHFCMGNQLA
TH_3500|M.thermoresistible__bu GEKMLLLFESANFDETVFENPDDFRIDRDPN-PHIAFGFGTHFCLGNQLA
Mb0801|M.bovis_AF2122/97 GQKVVVWEGSANRDPSVFDRADEFDITRKPN-PHLGFGQGVHYCLGANLA
* : :* * : . * *. * *.*:* :*
MSMEG_6695|M.smegmatis_MC2_155 RSDMSEALPLLARRLRDPHELPGAT---WLPDSGNTGPNTLPIGFTPAP-
Mvan_1848|M.vanbaalenii_PYR-1 RSDMSEALPLLARRMLDPHELPGAT---WLPDSGNTGPITLPIGFTPAS-
Mflv_0363|M.gilvum_PYR-GCK RRELAEALRILAARLPNPRISGEAP---WKPMLGMTGPTALELEFGA---
MAV_4569|M.avium_104 RREIAEALNVLANRLRNPRLAGPAP---WKPMVSLSGPTSLPIEFDR---
MMAR_0122|M.marinum_M RRELTEALRIITQRMPGARRTGAAP---WKSLTGLSGPTTLPIEFDAGH-
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAGELV---YKPNVAMRGMSALPVQV-----
MAB_0276|M.abscessus_ATCC_1997 RLEARLALSSITARFPGARLMDEPT---YKPNVTLRGLAELPVSIA----
Rv3518c|M.tuberculosis_H37Rv RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
MUL_4077|M.ulcerans_Agy99 RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
TH_3500|M.thermoresistible__bu RLELTLMLRRLLQRLPDLRLASDDP-LPLRPANFVSGPEAMPVVFTPTEP
Mb0801|M.bovis_AF2122/97 RLELRVLFEELLSRFGSVRVVEPAE---WTRSNRHTGIRHLVVELRGG--
* : : *: : * : : .
MSMEG_6695|M.smegmatis_MC2_155 ---
Mvan_1848|M.vanbaalenii_PYR-1 ---
Mflv_0363|M.gilvum_PYR-GCK ---
MAV_4569|M.avium_104 ---
MMAR_0122|M.marinum_M ---
MLBr_02088|M.leprae_Br4923 ---
MAB_0276|M.abscessus_ATCC_1997 ---
Rv3518c|M.tuberculosis_H37Rv LG-
MUL_4077|M.ulcerans_Agy99 LR-
TH_3500|M.thermoresistible__bu VSA
Mb0801|M.bovis_AF2122/97 ---