For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TITETLQRRLFIDGEFVGSDGDTLPVTDKASGAVIGESVVATDRDVDRAVAGAVAAQREWYATPATERAA ILRRGGAILERETGRFQDILIREGGAVGPKAHGEIGASVIEFFQAAELATTPLGEIIPSGQRGRVNIVER RPVGVVGLITAWNAPVHIAMRVLAPALALGNAVVLKPAPETPFTGGLMLAEVLAEAGLPSGVVQVLTGGP AGAALVTHPQVDMIHFTGSEDTGRRINVAAAPLLKRVALELGGNNASIVLADADVALAARCGAGSSFGHQ GQVCIATGRHIVLADVAHEYIAALSAEAAKLTVGDPYTSQVDLGPMVSTRQVDKALAMVASSVDLGARVV QGGTADSVFLRPTVVDRVRPGMPLHDEEVFAPIAPVTVVDSVDEALKIVNGTRFGLSTSVFSRDLDRAWS VADQVRSGMVHVNDGTALHESQVPFGGTAASGLGDDLGGRANIDLLTERRWTSLQRNTL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4165 | - | - | 100% (480) | [NAD+] benzaldehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155] |
| M. smegmatis MC2 155 | MSMEG_4038 | - | 4e-71 | 35.90% (454) | vanillin dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6687 | - | 1e-69 | 35.12% (467) | aldehyde dehydrogenase, thermostable |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 3e-61 | 35.05% (465) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4389 | - | 9e-71 | 37.47% (459) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 4e-66 | 35.73% (473) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-46 | 30.16% (441) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 6e-67 | 34.41% (465) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 8e-66 | 35.78% (464) | aldehyde dehydrogenase |
| M. avium 104 | MAV_2608 | - | 4e-73 | 38.11% (488) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4137 | - | 1e-71 | 36.91% (466) | PUTATIVE putative [NADP+] succinate-semialdehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 3e-65 | 33.98% (465) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1856 | - | 2e-72 | 37.23% (470) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0223c|M.tuberculosis_H37Rv ---MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPAT-GEYVGKVPMAAAA
MMAR_0472|M.marinum_M ----MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPAT-GEYVGKVPLAAAA
Mflv_4389|M.gilvum_PYR-GCK ----MTQIVDTAGVFVGGEFRR--TDRTVPVFEAAT-GEILGEGPSAAAA
Mb0791|M.bovis_AF2122/97 ---MALWGDGISALLIDGKLSD-GRAGTFPTVNPAT-EEVLGVAADADAE
MAB_3328|M.abscessus_ATCC_1997 --------MSVPSSWINGRPVA-THGDTHRVINPAT-GEAVADLKLATTA
MUL_2789|M.ulcerans_Agy99 ----MTTTVSVAGSWINGAAHS-TGGRQHAVINPAT-QETIAELALATPA
MSMEG_4165|M.smegmatis_MC2_155 ---MTITETLQRRLFIDGEFVGSD-GDTLPVTDKAS-GAVIGESVVATDR
Mvan_1856|M.vanbaalenii_PYR-1 -----MTGPASVRHLIDGEWLPGG-GDALVSVNPARPTVVVAEGSCAVAS
MAV_2608|M.avium_104 MTDTATETLVQFDLLIGGESSSAASGLTYDSVDPFT-GRPWARVPNAAAA
TH_4137|M.thermoresistible__bu -------------MYIDGEWQSAASGKTFASINPAN-GAVLDSVPDGERE
MLBr_02573|M.leprae_Br4923 --------------------------MSIATINPAT-GETVKTFTPTTQD
Rv0223c|M.tuberculosis_H37Rv DVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAA
MMAR_0472|M.marinum_M DVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHFAKLLAD
Mflv_4389|M.gilvum_PYR-GCK DIDDAVAAARGE-GAAKWRAATVDERADGLKRFATALRGRAKHTSTLVSR
Mb0791|M.bovis_AF2122/97 DMGRAIEAARRAFDSTDWSRN-TELRVRCVRQLRDAMQQHVEELRELTIS
MAB_3328|M.abscessus_ATCC_1997 DVDAAVAAARAA--GPAWASSTPVDRSSVLAKLAAVLSANADTLVADEVA
MUL_2789|M.ulcerans_Agy99 DVDHAVVAARRA--LPQWAGVTTAERSAVLAELADLLEQRAPELIAEEVC
MSMEG_4165|M.smegmatis_MC2_155 DVDRAVAGAVAAQR--EWYATPATERAAILRRGGAILERETGRFQDILIR
Mvan_1856|M.vanbaalenii_PYR-1 DVDAAVGAAAAAAP--SWAATGMHQRGARLLAAAEIVERNAERWGLELAT
MAV_2608|M.avium_104 DVDRAVGAARAALNG-PWGALTATARGKLLHRLGEIIAREADQLAELEVR
TH_4137|M.thermoresistible__bu DARRAIDAAAAALP--DWRSRTAYERAEVLVEAHRIMLERRDDLAELMTR
MLBr_02573|M.leprae_Br4923 EVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTL
: *: * : * : .
Rv0223c|M.tuberculosis_H37Rv ETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETR-----TGSYGQS
MMAR_0472|M.marinum_M ETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIR-----NGSYGQT
Mflv_4389|M.gilvum_PYR-GCK ENGMPITLSRAVNGAFPSVLVNYYAK-LIRSWTAEEVR-----PALIGHT
Mb0791|M.bovis_AF2122/97 EVGAPRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPLGIATRR
MAB_3328|M.abscessus_ATCC_1997 QTGKPVRLASEFDVPGSIDNVEFFAG-AARHLEGKATA----EYSADHTS
MUL_2789|M.ulcerans_Agy99 QTGKPLRLAEEFDVPGSVDNIRFFAG-AARRLPGQATA----EYSADHTS
MSMEG_4165|M.smegmatis_MC2_155 EGGA--VGPKAHGEIGASVIEFFQAAELATTPLGEIIP----SGQRGRVN
Mvan_1856|M.vanbaalenii_PYR-1 EEGK--TRAEGVGEVRRAAQILRYYGNEGDRQAGEIYS----SPRPGEQI
MAV_2608|M.avium_104 DGGK--LVREMVGQMRSLPDYYFYYGGLADKLQGDVIP----VDKPNYFV
TH_4137|M.thermoresistible__bu EQGKP--LRMARTEVGYAADFLLWFAEEAKRVYGEVIP----SARADQRF
MLBr_02573|M.leprae_Br4923 EMGK--TLQSAKDEAMKCAKGFRYYAEKAETLLADEPA--EAAAVGASKA
: *
Rv0223c|M.tuberculosis_H37Rv IVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTA-
MMAR_0472|M.marinum_M IVHREPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPLTA-
Mflv_4389|M.gilvum_PYR-GCK VVRREPIGVVGAITPWNYPQALAVMKIAPALAAGCSVVLKASPETSLDA-
Mb0791|M.bovis_AF2122/97 TLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCA-
MAB_3328|M.abscessus_ATCC_1997 SIRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLTT-
MUL_2789|M.ulcerans_Agy99 SIRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTT-
MSMEG_4165|M.smegmatis_MC2_155 IVERRPVGVVGLITAWNAPVHIAMRVLAPALALGNAVVLKPAPETPFTGG
Mvan_1856|M.vanbaalenii_PYR-1 LVTRKPLGVVGVVTPFNFPIAIPAWKIAPALVYGNTVVWKPASTVPLLA-
MAV_2608|M.avium_104 YTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPTST-
TH_4137|M.thermoresistible__bu IVLAQPVGVCAAITPWNYPISMLTRKLAPALAAGCTSVLKPAEQTPLCA-
MLBr_02573|M.leprae_Br4923 LARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCA-
.. ** : .:* * ..* * : * : ..
Rv0223c|M.tuberculosis_H37Rv NALAEVFAEVG-LPEGVLSVVPG-GIE-TGQALTSNPDIDMFTFTGSSAV
MMAR_0472|M.marinum_M NALAEVFAEAG-LPEGVLSVVPG-GVE-TGQALTSNPGVDLFTFTGSSAV
Mflv_4389|M.gilvum_PYR-GCK LVFAEAAAEAG-LPPGVLNVVPG-DAA-AGAHLVTHPGVDKVAFTGSTNA
Mb0791|M.bovis_AF2122/97 AALGEIIVEHTDFPPGVVNIVTSSSHA-LGALLAKDPRVDMISFTGSTAT
MAB_3328|M.abscessus_ATCC_1997 LTLARLAAEAG-LPEGVLNVVTGRGDD-VGYALASHPDVDLVTFTGSTAV
MUL_2789|M.ulcerans_Agy99 LTLARLAAEAG-LPDGVLNVVTGLGAD-VGAALAAHPGVDLVTFTGSTAV
MSMEG_4165|M.smegmatis_MC2_155 LMLAEVLAEAG-LPSGVVQVLTG-GP--AGAALVTHPQVDMIHFTGSEDT
Mvan_1856|M.vanbaalenii_PYR-1 LRFAEALTDAG-LPPGVLNLVVG-GAD-IGDAIVNHPGIDGITFTGSTGV
MAV_2608|M.avium_104 LAFAKLFAEAG-FPPGVINVVTGWGPE-TGAALASHPGVDKVAFTGSTAT
TH_4137|M.thermoresistible__bu VETFKVFADAG-VPAGVVNLVTCSDPEPVADELLGDPRVRKISFTGSTEV
MLBr_02573|M.leprae_Br4923 LYLADVIARGG-FPEDCFQTLLISANG--VEAILRDPRVAAATLTGSEPA
. .* . .. : : .* : :*** .
Rv0223c|M.tuberculosis_H37Rv GREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQ
MMAR_0472|M.marinum_M GKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQ
Mflv_4389|M.gilvum_PYR-GCK GRVIGAECGRLIRPVTLELGGKSAAVILDDADLDTTVNGLRTASFVNNGQ
Mb0791|M.bovis_AF2122/97 GRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQ
MAB_3328|M.abscessus_ATCC_1997 GRKVMAAAAVHGHRTQLELGGKAPFVVFDDADMDAAIAGAVAGAIINSGQ
MUL_2789|M.ulcerans_Agy99 GRKVMAAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAGAVINSGQ
MSMEG_4165|M.smegmatis_MC2_155 GRRINVAAAPLLKRVALELGGNNASIVLADADVALAARCGAGSSFGHQGQ
Mvan_1856|M.vanbaalenii_PYR-1 GRRIAAAAAARGVPAQAEMGGKNAAVVLDDADLDLAVEQVMLGAFRSTGQ
MAV_2608|M.avium_104 GIHVGKAAIENMTRFSLELGGKSAQVVFADADLDAAANGVIAGVFAATGQ
TH_4137|M.thermoresistible__bu GRMIASRAGATMKRVSMELGGHAPFLVFPDADPEHAAKGGAAVKFLNTGQ
MLBr_02573|M.leprae_Br4923 GQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQ
* : . *:** . ::: ..* : **
Rv0223c|M.tuberculosis_H37Rv GCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQR
MMAR_0472|M.marinum_M ACVGQTRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLISEKQR
Mflv_4389|M.gilvum_PYR-GCK TCHLSSRILVPAKRYAEFVSAIAELADSLTVGDPLDEKTEIGPLVSERQR
Mb0791|M.bovis_AF2122/97 GCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQR
MAB_3328|M.abscessus_ATCC_1997 DCTAATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLISAAHR
MUL_2789|M.ulcerans_Agy99 DCTAATRAIVARELCHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHR
MSMEG_4165|M.smegmatis_MC2_155 VCIATGRHIVLADVAHEYIAALSAEAAKLTVGDPYTSQVDLGPMVSTRQV
Mvan_1856|M.vanbaalenii_PYR-1 KCTATSRLIVTAGIADAFSEALLAQARALRVGDPVDDATQMGPVVSDSAQ
MAV_2608|M.avium_104 TCLAGSRLLVDRSVADALVEKIVARAATIKLGDPKDPTTEMGPVSNLPQY
TH_4137|M.thermoresistible__bu ACICPNRFIVHRSIAEPFIATLRARIEKLVPGDGLAAGTTVGPLIDEVAL
MLBr_02573|M.leprae_Br4923 SCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGR
* * :. : * . *.:
Rv0223c|M.tuberculosis_H37Rv TRVEGYIAKGIEEGARLVCGGG--RPEGLDNGFFIQPTVFADVDNKMTIA
MMAR_0472|M.marinum_M ARVEGYIAKGIEEGARLVSGGG--RPEGLDNGFFVQPTVFADVDNKMTIA
Mflv_4389|M.gilvum_PYR-GCK ERVLDYVQVGRDSGARLVAGGS--VPTGLERGWYVAPTVFADVDNSDRLA
Mb0791|M.bovis_AF2122/97 DRVQGYLDLAVAEGGRFACGGA--RPADREVGFYIEPTVIAGLTNDARVA
MAB_3328|M.abscessus_ATCC_1997 AKVSSIVDRAPAQGGRIVTGAT--APD--LPGSFYRPTLIADVAETSEVY
MUL_2789|M.ulcerans_Agy99 DRVADILAKAPAQGARIVVGGR--IPD--LAGAFYLPTLLADVGEQSQAY
MSMEG_4165|M.smegmatis_MC2_155 DKALAMVASSVDLGARVVQGG-------TADSVFLRPTVVDRVRPGMPLH
Mvan_1856|M.vanbaalenii_PYR-1 QSITAGIDTAVTQGATVLTGGRPYQDGALAEGYFVAPTVVELGAAPVDVW
MAV_2608|M.avium_104 EKVLSHFASAREQGATVAYGGEP---ASDLGGFFVKPTVLTGVDPSMRAV
TH_4137|M.thermoresistible__bu KKMQRQVDDAVDKGAKLELGGSRLQGPAFDNGHFYAPTILTGVTPDMLIC
MLBr_02573|M.leprae_Br4923 AQVEQQVDAAAAAGAVIRCGGK----RPDRPGWFYPPTVITDITKDMALY
. . *. . *. . : **:.
Rv0223c|M.tuberculosis_H37Rv QEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQI
MMAR_0472|M.marinum_M QEEIFGPVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKI
Mflv_4389|M.gilvum_PYR-GCK QEEIFGPVITITAYADDADAVRLANDTEFGLAGTVWSQDSARATEIARAM
Mb0791|M.bovis_AF2122/97 REEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRL
MAB_3328|M.abscessus_ATCC_1997 RDEIFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQRASREI
MUL_2789|M.ulcerans_Agy99 REEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASREI
MSMEG_4165|M.smegmatis_MC2_155 DEEVFAPIAPVTVVDSVDEALKIVNGTRFGLSTSVFSRDLDRAWSVADQV
Mvan_1856|M.vanbaalenii_PYR-1 TDELFGPVLAIRRATDAEEAFALANDSEFGLSAAVFTQDMTRALQAVERI
MAV_2608|M.avium_104 AEEIFGPVLAVMTFEDEDEAVAAANGTEFGLAAAVWTKDVHRAHRVAAKL
TH_4137|M.thermoresistible__bu SEETFGPIAPVMVFDDEDEAIAMANSTEYGLAGYIYTRDISRAIRVGEAL
MLBr_02573|M.leprae_Br4923 TDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNI
:* *.*: : :*. .* : :**. : : . :
Rv0223c|M.tuberculosis_H37Rv RTGTYGIN---WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLP
MMAR_0472|M.marinum_M RTGTYAIN---WYAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMP
Mflv_4389|M.gilvum_PYR-GCK HTGSVGVN---HYQLDIQSPFGGIKSSGLGRELGPEGLDAYLVTKSIYQA
Mb0791|M.bovis_AF2122/97 RVGTVNVNGGVWYCAD--APFGGYKQSGIGREMGLLGFEEYLEAKLIATA
MAB_3328|M.abscessus_ATCC_1997 RAGCVWIN--DHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKHVMSD
MUL_2789|M.ulcerans_Agy99 SAGCVWIN--DHIPIVSEMPHGGVAASGFGNDMSEYSFDEYLTIKHVMSD
MSMEG_4165|M.smegmatis_MC2_155 RSGMVHVND-GTALHESQVPFGGTAASGLGDDLGGRANIDL-LTERRWTS
Mvan_1856|M.vanbaalenii_PYR-1 DVGVLHVNS-ESAGADPHVPFGGAKKSGLGPKEQGGAAREF-FTHTTTVY
MAV_2608|M.avium_104 RAGTVWVN--AYRVVAPHVPFGGIGYSGIGRENGIDAVKDFTETKAVWVE
TH_4137|M.thermoresistible__bu DFGMIGIN--DINPTSAAVPFGGIKQSGLGREGARAGIEEYLDTKVLGIA
MLBr_02573|M.leprae_Br4923 VAGQVFING--MTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA
* :* *.** ** * . . .
Rv0223c|M.tuberculosis_H37Rv MGYTVA------------
MMAR_0472|M.marinum_M MGYTLES-----------
Mflv_4389|M.gilvum_PYR-GCK DPFPE-------------
Mb0791|M.bovis_AF2122/97 AN----------------
MAB_3328|M.abscessus_ATCC_1997 ITGTADKDWHRTIFAKR-
MUL_2789|M.ulcerans_Agy99 ITGVAEKPWHRTIFSTRI
MSMEG_4165|M.smegmatis_MC2_155 LQRNTL------------
Mvan_1856|M.vanbaalenii_PYR-1 LRGGRAGS----------
MAV_2608|M.avium_104 LSGETRDPFTLG------
TH_4137|M.thermoresistible__bu L-----------------
MLBr_02573|M.leprae_Br4923 ------------------