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MTPVTINHLVAGDWVAGAGDVVVSVNPARPGDIVAEGHNATTAQVDTAVAAAAEAFRAWAATPTHQRGAV LLAAAQIVDRNAEAWGLELATEEGKTKAEGIGEVRRAAQILRYYGNEGDRQAGEIFSSPRAGEQILVTRK PLGVVGVITPFNFPIAIPAWKIAPALVYGNTVVWKPASTVPVLAIRFAQALTEAGLPAGALNLVIGDSET GTAIVDHPRIDGLTFTGSTAVGRRLASVAATCGIPMQAEMGGKNAAVVLDDADLDVAVEQVMLGAFRSTG QKCTATSRLIVTDGIADKFTEALVERARALRVGDPTDDATEMGPVITDTSRASILAGIDTAVAQGATVLA GGRPYTEGPLAEGYFIAPTVLELDGSPAKVWSEELFGPVLAVRRAADADEAFELANDSEFGLSAAIFTQD VTRVLQAMEQIDVGVLHVNSESAGADPHVPFGGDKKSGLGPKEQGAAARDFFTHTTTVYLRGGRPGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6687 | - | - | 100% (487) | aldehyde dehydrogenase, thermostable |
| M. smegmatis MC2 155 | MSMEG_1158 | - | e-102 | 44.03% (477) | 5-oxovalerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1461 | - | 1e-86 | 39.41% (477) | 5-oxovalerate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0775c | mmsA | 5e-74 | 34.97% (489) | methylmalonate-semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5010 | - | 6e-75 | 35.64% (463) | methylmalonate-semialdehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0753c | mmsA | 8e-75 | 34.97% (489) | methylmalonate-semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 8e-61 | 31.86% (452) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0823 | - | 0.0 | 71.70% (477) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 6e-75 | 36.44% (472) | aldehyde dehydrogenase NAD dependent |
| M. avium 104 | MAV_1897 | - | 2e-82 | 40.00% (440) | betaine-aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2909 | - | 5e-75 | 34.43% (485) | PUTATIVE methylmalonate-semialdehyde dehydrogenase [acylating) |
| M. ulcerans Agy99 | MUL_2789 | - | 1e-75 | 37.47% (459) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1856 | - | 0.0 | 78.51% (484) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6687|M.smegmatis_MC2_155 MT-PVTINHL----------VAGDWVAGAGDVVVSVNPARPGDIVAEGHN
Mvan_1856|M.vanbaalenii_PYR-1 MTGPASVRHL----------IDGEWLPGGGDALVSVNPARPTVVVAEGSC
MAB_0823|M.abscessus_ATCC_1997 -MHINEIQSF----------VGGRWISGGGQAVISVCPAFPDRVIAEGLA
MMAR_3556|M.marinum_M MTTTVSVAGS---------WING-AAHSTGGRQHAVINPATQETIAELAL
MUL_2789|M.ulcerans_Agy99 MTTTVSVAGS---------WING-AAHSTGGRQHAVINPATQETIAELAL
MAV_1897|M.avium_104 MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYTALPWARVPD
MLBr_02573|M.leprae_Br4923 -------------------------------MSIATINPATGETVKTFTP
Mb0775c|M.bovis_AF2122/97 --MTTQISHF----------IDGQRTAGQSTRSADVFDPNTGQIQAKVPM
Rv0753c|M.tuberculosis_H37Rv --MTTQISHF----------IDGQRTAGQSTRSADVFDPNTGQIQAKVPM
TH_2909|M.thermoresistible__bu --MTRQIHHF----------INGQHTAGQSTRTADVMNPSTGKVQAKVVM
Mflv_5010|M.gilvum_PYR-GCK --MTTRIPHF----------IDGKRSELASTRTAGVLNPSTGEVQSEVLL
. .
MSMEG_6687|M.smegmatis_MC2_155 ATTAQVDTAVAAAAEAFR-AWAATPTHQRGAVLLAAAQIVDRNAEAWGLE
Mvan_1856|M.vanbaalenii_PYR-1 AVASDVDAAVGAAAAAAP-SWAATGMHQRGARLLAAAEIVERNAERWGLE
MAB_0823|M.abscessus_ATCC_1997 AGPAEFDEAAAAARAAQP-GWAAMSLHARGAMLSHAAAVVDRNADAWGLE
MMAR_3556|M.marinum_M ATPADVDRAVVAARRALP-QWAGVTPAERSAVLAKLADLLEQRAPELIAE
MUL_2789|M.ulcerans_Agy99 ATPADVDHAVVAARRALP-QWAGVTTAERSAVLAELADLLEQRAPELIAE
MAV_1897|M.avium_104 CGPADVDRAVAAARAALRGPWGQLTGTARGKLLWRLGELIAREAESLAEL
MLBr_02573|M.leprae_Br4923 TTQDEVEDAIARAYARFD-NYRHTTFTQRAKWANATADLLEAEANQSAAL
Mb0775c|M.bovis_AF2122/97 AGKSDIDAAVASAVEAQK-GWAAWNPQRRARVLMRFIELVNDTIDELAEL
Rv0753c|M.tuberculosis_H37Rv AGKSDIDAAVASAVEAQK-GWAAWNPQRRARVLMRFIELVNDTIDELAEL
TH_2909|M.thermoresistible__bu GTAADIDAAVAGAAEAQK-EWAAWNPQRRARVLMKFIDLVNQNVDELAEL
Mflv_5010|M.gilvum_PYR-GCK ASAADVDTAVASAVEAQK-EWAAWNPQRRARVFMKFIQLVNDHVDELAEL
:.: * * : *. ::
MSMEG_6687|M.smegmatis_MC2_155 LATEEGKTKAEGIG-EVRRAAQILRYYGNEGDRQAGEIFSSPRAG--EQI
Mvan_1856|M.vanbaalenii_PYR-1 LATEEGKTRAEGVG-EVRRAAQILRYYGNEGDRQAGEIYSSPRPG--EQI
MAB_0823|M.abscessus_ATCC_1997 LAAEEGKTKAEGIA-EVRRAAQILRYYGNEGDRQTGEIFSSPRRG--EHI
MMAR_3556|M.marinum_M EVCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEYSAD--HTS
MUL_2789|M.ulcerans_Agy99 EVCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEYSAD--HTS
MAV_1897|M.avium_104 EVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGEVVPVDKPN--FFV
MLBr_02573|M.leprae_Br4923 MTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAVGASKA
Mb0775c|M.bovis_AF2122/97 LSREHGKTLADARG-DVQRGIEVIEFCLGIPHLLKGEYTEGAGPG--IDV
Rv0753c|M.tuberculosis_H37Rv LSREHGKTLADARG-DVQRGIEVIEFCLGIPHLLKGEYTEGAGPG--IDV
TH_2909|M.thermoresistible__bu LSLEHGKTLADAKG-DIQRGIEVIEFSIGIPHLQKGEYTEGAGPG--IDV
Mflv_5010|M.gilvum_PYR-GCK LSIEHGKTVADSKG-DIQRGIEVIEFAIGIPHLLKGEFTENAGTG--IDV
: ** : : .:
MSMEG_6687|M.smegmatis_MC2_155 LVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNTVVWKPASTVPVLAI
Mvan_1856|M.vanbaalenii_PYR-1 LVTRKPLGVVGVVTPFNFPIAIPAWKIAPALVYGNTVVWKPASTVPLLAL
MAB_0823|M.abscessus_ATCC_1997 LVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLWKPASTVPLLAM
MMAR_3556|M.marinum_M SIRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTTL
MUL_2789|M.ulcerans_Agy99 SIRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTTL
MAV_1897|M.avium_104 YTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPASTL
MLBr_02573|M.leprae_Br4923 LARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCAL
Mb0775c|M.bovis_AF2122/97 YSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPV
Rv0753c|M.tuberculosis_H37Rv YSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPV
TH_2909|M.thermoresistible__bu YSMRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDPSVPV
Mflv_5010|M.gilvum_PYR-GCK YSIRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDPSVPL
:.:*** : *:* * ..* * . : * :. * .:
MSMEG_6687|M.smegmatis_MC2_155 RFAQALTEAGLPAGALNLVIGDSETG-TAIVDHPRIDGLTFTGSTAVGRR
Mvan_1856|M.vanbaalenii_PYR-1 RFAEALTDAGLPPGVLNLVVGGADIG-DAIVNHPGIDGITFTGSTGVGRR
MAB_0823|M.abscessus_ATCC_1997 RLAQAFDAAGLPPGVLNLVVGDTGVG-DAMVNDSRVDALTFTGSTGVGRR
MMAR_3556|M.marinum_M TLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRK
MUL_2789|M.ulcerans_Agy99 TLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRK
MAV_1897|M.avium_104 AFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGSTATGIS
MLBr_02573|M.leprae_Br4923 YLADVIARGGFPEDCFQTLL-ISANGVEAILRDPRVAAATLTGSEPAGQA
Mb0775c|M.bovis_AF2122/97 RLAELFIEAGLPAGVFQVVHGDKEAV-DAILHHPDIKAVGFVGSSDIAQY
Rv0753c|M.tuberculosis_H37Rv RLAELFIEAGLPAGVFQVVHGDKEAV-DAILHHPDIKAVGFVGSSDIAQY
TH_2909|M.thermoresistible__bu RLAELFLQAGLPSGLFQVVHGDKEAV-DAILEHPTIQAVGFVGSSDIAQY
Mflv_5010|M.gilvum_PYR-GCK RLAELFLEAGLPAGVFQVVQGDKEAV-DAILTHPDIQAVGFVGSSDIAQY
:* .*:* . :: : *: .. : :.** .
MSMEG_6687|M.smegmatis_MC2_155 LASVAATCGIPMQAEMGGKNAAVVLDDADLDVAVEQVMLGAFRSTGQKCT
Mvan_1856|M.vanbaalenii_PYR-1 IAAAAAARGVPAQAEMGGKNAAVVLDDADLDLAVEQVMLGAFRSTGQKCT
MAB_0823|M.abscessus_ATCC_1997 IAAAGAARGIPVQAEMGGKNAAVVLDDADVDLAVEQVLLGAFRSTGQKCT
MMAR_3556|M.marinum_M VMAAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAGALINSGQDCT
MUL_2789|M.ulcerans_Agy99 VMAAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAGAVINSGQDCT
MAV_1897|M.avium_104 VGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVIAGVFAATGQTCL
MLBr_02573|M.leprae_Br4923 VGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCI
Mb0775c|M.bovis_AF2122/97 IYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCM
Rv0753c|M.tuberculosis_H37Rv IYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCM
TH_2909|M.thermoresistible__bu IYAGATAHGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCM
Mflv_5010|M.gilvum_PYR-GCK IYSTAAAHGKRSQCFGGAKNHMIIMPDADLDQAVDALIGAGYGSAGERCM
: . *.. ::: .**:* * : . *: *
MSMEG_6687|M.smegmatis_MC2_155 ATSRLIVT-DGIADKFTEALVERARALRVGDPTDDATEMGPVITDTSRAS
Mvan_1856|M.vanbaalenii_PYR-1 ATSRLIVT-AGIADAFSEALLAQARALRVGDPVDDATQMGPVVSDSAQQS
MAB_0823|M.abscessus_ATCC_1997 ATSRLVLT-EGIADAFLSLLKDRADALVVGDPTADDTQMGPVVSESAFGT
MMAR_3556|M.marinum_M AATRAIVA-RELYHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHRDR
MUL_2789|M.ulcerans_Agy99 AATRAIVA-RELCHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHRDR
MAV_1897|M.avium_104 AGSRLLVH-ESVADALVERIVARASTIKLGDPKDPATEMGPVSNQPQYEK
MLBr_02573|M.leprae_Br4923 AAKRFIAH-ADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQ
Mb0775c|M.bovis_AF2122/97 AISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALAR
Rv0753c|M.tuberculosis_H37Rv AISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALAR
TH_2909|M.thermoresistible__bu AISVAVPVGDEIADRLRARLIERVANLRVGHSLDPKADYGPLVTEAALQR
Mflv_5010|M.gilvum_PYR-GCK AISVAVPVGEETANRLRNRLVERVNQLRVGHSLDPKADYGPLVTGAALER
* . : . : . : :*.. :: **: . .
MSMEG_6687|M.smegmatis_MC2_155 ILAGIDTAVAQGATVLAGGRPYTEG-----------PLAEGYFIAPTVLE
Mvan_1856|M.vanbaalenii_PYR-1 ITAGIDTAVTQGATVLTGGRPYQDG-----------ALAEGYFVAPTVVE
MAB_0823|M.abscessus_ATCC_1997 ITAGIGGAVAQGAVTLAGGHGYGDG-----------PLAAGYFIAPTIME
MMAR_3556|M.marinum_M VADIVAKAPAQGARIVVGGRIP---------------DLAGAFYLPTLLA
MUL_2789|M.ulcerans_Agy99 VADILAKAPAQGARIVVGGRIP---------------DLAGAFYLPTLLA
MAV_1897|M.avium_104 VLSHFASAREQGATVAYGGEPAG--------------ELGGFFVKPTVLT
MLBr_02573|M.leprae_Br4923 VEQQVDAAAAAGAVIRCGGKRP---------------DRPGWFYPPTVIT
Mb0775c|M.bovis_AF2122/97 VRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANLEGGFFIGPTLFD
Rv0753c|M.tuberculosis_H37Rv VRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANLEGGFFIGPTLFD
TH_2909|M.thermoresistible__bu VRDYIGQGVEAGAELLVDGRERGSDDLQF----GDDSLEGGYFIGPTLFD
Mflv_5010|M.gilvum_PYR-GCK VRDYIGQGVEAGAELVVDGRERATDELSFD----DQDLSKGYFIGPTLFD
: . . ** .*. * * **:.
MSMEG_6687|M.smegmatis_MC2_155 LDGSPAKVWSEELFGPVLAVRRAADADEAFELANDSEFGLSAAIFTQDVT
Mvan_1856|M.vanbaalenii_PYR-1 LGAAPVDVWTDELFGPVLAIRRATDAEEAFALANDSEFGLSAAVFTQDMT
MAB_0823|M.abscessus_ATCC_1997 LGMGAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEYGLSAAIFTKDLT
MMAR_3556|M.marinum_M DVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVY
MUL_2789|M.ulcerans_Agy99 DVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVY
MAV_1897|M.avium_104 GVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVH
MLBr_02573|M.leprae_Br4923 DITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNES
Mb0775c|M.bovis_AF2122/97 HVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNGVAIFTRDGD
Rv0753c|M.tuberculosis_H37Rv HVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNGVAIFTRDGD
TH_2909|M.thermoresistible__bu RVTTDMSIYRDEIFGPVLCMVRAKNYEEALALPSEHEYGNGVAIFTRDGD
Mflv_5010|M.gilvum_PYR-GCK HVTTDMSIYTDEIFGPVLCIVRAADYDEALSLPTKHEYGNGVAIFTRDGD
:*:**** : . ::*: .. :* . :*::
MSMEG_6687|M.smegmatis_MC2_155 RVLQAMEQIDVGVLHVNSESAGADPHVPFGGDKKSGLGPKEQG--AAARD
Mvan_1856|M.vanbaalenii_PYR-1 RALQAVERIDVGVLHVNSESAGADPHVPFGGAKKSGLGPKEQG--GAARE
MAB_0823|M.abscessus_ATCC_1997 RALSAVDHVDVGILHVNSESAGADPHVPFGGAKKSGLGPKEQG--RAARE
MMAR_3556|M.marinum_M RAQRASREISAGCVWIN-DHIPIVSEMPHGGVAASGFGKDMSE--YSFEE
MUL_2789|M.ulcerans_Agy99 RAQRASREISAGCVWIN-DHIPIVSEMPHGGVAASGFGNDMSE--YSFDE
MAV_1897|M.avium_104 RAHRVAARLNAGTVWVN-AYRVVSPHVPFGGMGHSGIGRENGI--DAVKD
MLBr_02573|M.leprae_Br4923 EQRHFIDNIVAGQVFIN-GMTVSYPELPFGGIKRSGYGRELST--HGIRE
Mb0775c|M.bovis_AF2122/97 AARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF
Rv0753c|M.tuberculosis_H37Rv AARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF
TH_2909|M.thermoresistible__bu TARDFVSRVQCGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPHSILF
Mflv_5010|M.gilvum_PYR-GCK AARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPASIQF
. * : :* . ..** ** * .
MSMEG_6687|M.smegmatis_MC2_155 FFTHTTTVYLRGGRPGV-----------
Mvan_1856|M.vanbaalenii_PYR-1 FFTHTTTVYLRGGRAGS-----------
MAB_0823|M.abscessus_ATCC_1997 FFTHTTTVYLRGEEAM------------
MMAR_3556|M.marinum_M YLTIKHVMSDITGVAEKPWHRTIFSTRI
MUL_2789|M.ulcerans_Agy99 YLTIKHVMSDITGVAEKPWHRTIFSTRI
MAV_1897|M.avium_104 FTETKAVWVELSGATRDPFTLG------
MLBr_02573|M.leprae_Br4923 FCNIKTVWIA------------------
Mb0775c|M.bovis_AF2122/97 YTKVKTVTSRWPSGIKDGAEFVIPTMS-
Rv0753c|M.tuberculosis_H37Rv YTKVKTVTSRWPSGIKDGAEFVIPTMS-
TH_2909|M.thermoresistible__bu YTKTKTVTQRWPSGIKDGAEFSIPTMK-
Mflv_5010|M.gilvum_PYR-GCK YTKVKTVTERWPSGIKDGAEFVIPTMK-
: . .