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KTDVTDTGSALTLRARKRNERRDRVFAAAIALFVEKGFEETTMDDIAARSGLSRTTVFNHFPRKVHFLEE WTLRRRLRASQTFEPAGLAGQPVDEVLRSYMIALAEVSLETPAETRALQSATLEYSALLFDHPLARDLAD VVAVTGATLRPTASPDQVGRLLALGYFAAVLRWVEHDPPQFDLKDELVALAHTVLNGALVGADTRDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4142 | - | - | 100% (208) | transcriptional repressor, TetR family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4033 | - | 3e-46 | 50.27% (187) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3572 | - | 4e-08 | 29.44% (197) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2534 | - | 3e-07 | 37.70% (61) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1640 | - | 8e-08 | 31.11% (90) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2506 | - | 3e-07 | 37.70% (61) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 3e-05 | 35.42% (48) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3837 | - | 2e-07 | 42.86% (49) | transcriptional regulatory protein TetR |
| M. marinum M | MMAR_3861 | - | 9e-09 | 28.41% (176) | putative regulatory protein |
| M. avium 104 | MAV_0586 | - | 3e-10 | 30.29% (175) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1745 | - | 1e-07 | 24.73% (186) | TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) |
| M. ulcerans Agy99 | MUL_3793 | - | 1e-08 | 28.41% (176) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1513 | - | 2e-07 | 38.36% (73) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2534|M.bovis_AF2122/97 ------------------MTASAPDGRPGQPEATNRRSQLK---------
Rv2506|M.tuberculosis_H37Rv ------------------MTASAPDGRPGQPEATNRRSQLK---------
MMAR_3861|M.marinum_M -------------------MASEGDGMN-PANIGSLRDRRR---------
MUL_3793|M.ulcerans_Agy99 -------------------MASEGDGMS-PANIGSLRDRRR---------
Mflv_1640|M.gilvum_PYR-GCK ------------------------------MPQPVRQQART---------
MAB_3837|M.abscessus_ATCC_1997 -----------------------------MNAQPARVGRRP---------
MSMEG_4142|M.smegmatis_MC2_155 ----------------------MKTDVTDTGSALTLRARKR---------
MAV_0586|M.avium_104 ------------------------------------MARWE---------
TH_1745|M.thermoresistible__bu MSSSTGTNPGRGSDSTGSETNGAAATGAGSGSTGTSRTRGRQVTNVAVLT
MLBr_00815|M.leprae_Br4923 ------MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLS--------
Mvan_1513|M.vanbaalenii_PYR-1 -----------------------------MADGITAREAKR---------
Mb2534|M.bovis_AF2122/97 ---------SDRRFQLLAAAERLFAERGFLAVRLEDIGAAAGVSGPAIYR
Rv2506|M.tuberculosis_H37Rv ---------SDRRFQLLAAAERLFAERGFLAVRLEDIGAAAGVSGPAIYR
MMAR_3861|M.marinum_M ---------AELFSLIQQTAHRLFAERGFDAVTTEDIAAAAGVSISTYFR
MUL_3793|M.ulcerans_Agy99 ---------AELFSLIQQTAHRLFAERGFDAVTTEDIAAAAGVSISTYFR
Mflv_1640|M.gilvum_PYR-GCK ---------SVRKQQLSQAAARLFTDRGYHNVSMDDIASAVGLTGPALYR
MAB_3837|M.abscessus_ATCC_1997 ---------STTRDEITAVAMTLFAQHGFDEVSVDDIAAAAGIARRTVFR
MSMEG_4142|M.smegmatis_MC2_155 ---------NERRDRVFAAAIALFVEKGFEETTMDDIAARSGLSRTTVFN
MAV_0586|M.avium_104 ---------PDARARLVAAALDLFNERGYDQTTVAEIAERAGLTKSTFFR
TH_1745|M.thermoresistible__bu DSELGSEAQRERRKRILDATLAIASKGGYEAVQMRAVAERADVAVGTLYR
MLBr_00815|M.leprae_Br4923 --------RDKRRGQLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQ
Mvan_1513|M.vanbaalenii_PYR-1 ---------LQTRERLLGAAIAEFKRAGKDESDVGAIVAAAGVAHGTFFF
: .: * : .:: . :
Mb2534|M.bovis_AF2122/97 HFPNKESLLVELL----VGVSARLLAGARDVTTRSANLAAALDGLIEFHL
Rv2506|M.tuberculosis_H37Rv HFPNKESLLVELL----VGVSARLLAGARDVTTRSANLAAALDGLIEFHL
MMAR_3861|M.marinum_M HAPTKEGLLVDPV----RQAITEIVSSYRSWPADESAVEALIALFVSYAR
MUL_3793|M.ulcerans_Agy99 HAPTKEGLLVDPV----RQAITEIVSSYRSWPADESAVEASIALFVSYAR
Mflv_1640|M.gilvum_PYR-GCK HFRKKHDILMQVISEQ-LGAVEAVAARAVDAGPTDERAEVFLAALADLLL
MAB_3837|M.abscessus_ATCC_1997 YYSSKNAIVWGDFDSH-LGVMRALLDETADTVDTSTALRQAVLTFNDFPV
MSMEG_4142|M.smegmatis_MC2_155 HFPRKVHFLEEWTLRRRLRASQTFEPAGLAGQPVDEVLRSYMIALAEVSL
MAV_0586|M.avium_104 HFPDKRDVLAAGQDAIAQLLREGIAAAPADATPLALVCSGLKSAAAAFTP
TH_1745|M.thermoresistible__bu YFPSKVHLLVSALG----REFERIDAKTDRSTLVGDTPYERLNFMVSRLN
MLBr_00815|M.leprae_Br4923 HFSSKLELYLAVLERHMNNLVSSVQQALRTTTNNRQRLHAAVQAFFDFIE
Mvan_1513|M.vanbaalenii_PYR-1 HFPTKEHVLLELE----RREEDRMAKRFATFTKTHHDLASALREAAHLVM
: * . .
Mb2534|M.bovis_AF2122/97 D-------------FALGEADLIRIQDRDLAHLPAVAERQVRKAQ-----
Rv2506|M.tuberculosis_H37Rv D-------------FALGEADLIRIQDRDLAHLPAVAERQVRKAQ-----
MMAR_3861|M.marinum_M D-------------AGDLKLDTWRRAIATAPYLLSKSALVSEDDQ-----
MUL_3793|M.ulcerans_Agy99 D-------------AGDLKLDTLRRAIATAPYLLSKSALVSEDDQ-----
Mflv_1640|M.gilvum_PYR-GCK EREQVLLWKRERRQLAEEAQRQCRLKLSDVLRLSSQALGLTSGEKPSGQA
MAB_3837|M.abscessus_ATCC_1997 D--------------ETPRHRMRMRMILEVPALQAYSMLMYTGWR-----
MSMEG_4142|M.smegmatis_MC2_155 E--------------TPAETRALQSATLEYSALLFDHPLARDLAD-----
MAV_0586|M.avium_104 FN--------------KELAPRLRAAIAASAELQERNALKQIGLA-----
TH_1745|M.thermoresistible__bu R--------------AMQRNPLLTEAMTRAFVFADASAAGEVDHVG----
MLBr_00815|M.leprae_Br4923 HD-------------GQGYRLIFENDNITEPRVAAQVRVATESCID----
Mvan_1513|M.vanbaalenii_PYR-1 G--------------LERRLGVVLFKDFLALHFSPTRPPAEHGDDHP---
.
Mb2534|M.bovis_AF2122/97 --RQYVEVWVG-----VLRELNPGLAEADARLMAHAVFG-LLNSTPH--S
Rv2506|M.tuberculosis_H37Rv --RQYVEVWVG-----VLRELNPGLAEADARLMAHAVFG-LLNSTPH--S
MMAR_3861|M.marinum_M --HRFIEHVASRMGVDARTDIRPALLVHTSLATVKFVFDRWLSTDPP--S
MUL_3793|M.ulcerans_Agy99 --HRFIEHVASRMGVDARTDIRPALLVHTSLATVKFVFDRWLSTDPP--S
Mflv_1640|M.gilvum_PYR-GCK ELRTWAVLGIYSSVAPIRNRVENATAKRLLRAAALNILGCELDTGLPRSA
MAB_3837|M.abscessus_ATCC_1997 ---DVIAQFVARRSGTDPGSLLPQTVAWTLLGVALAAYEQWLADESSKLT
MSMEG_4142|M.smegmatis_MC2_155 --------VVAVTGATLRPTASPDQVGRLLALGYFAAVLRWVEHDPPQFD
MAV_0586|M.avium_104 ------LAVSEALQARGVPEPAAALAAELGALAFKTAYARWAEPDESGDL
TH_1745|M.thermoresistible__bu ---RLMDSMFARAMADGEPTEDQYHIARVISDVWLSNLLAWLTRRASATD
MLBr_00815|M.leprae_Br4923 ------AVFALISADSRLDPHRARMVAVGLVGISVDCARYWLDTNRPISK
Mvan_1513|M.vanbaalenii_PYR-1 -----LVVLVADQIDNARQRGDTAADVTPMNSAIYFLLGLYALLITTDDS
Mb2534|M.bovis_AF2122/97 MKAADSKPARTVRAR-----------------------------------
Rv2506|M.tuberculosis_H37Rv MKAADSKPARTVRAR-----------------------------------
MMAR_3861|M.marinum_M SPIFHVQMDQ----------------------------------------
MUL_3793|M.ulcerans_Agy99 SPIFHVQWTRRCGSRSPDSGNAIRHLPSSRET------------------
Mflv_1640|M.gilvum_PYR-GCK TPVTHRRQPPGRRERILSTAGRLFHAQSYHAVGIEEIAAESDTAIATFYQ
MAB_3837|M.abscessus_ATCC_1997 TLLGKG--------------------------------------------
MSMEG_4142|M.smegmatis_MC2_155 LKDELVALAHT---------------------------------------
MAV_0586|M.avium_104 GDMACQALR-----------------------------------------
TH_1745|M.thermoresistible__bu VSKRLELAVR----------------------------------------
MLBr_00815|M.leprae_Br4923 SDAVEGTVQFAWG-------------------------------------
Mvan_1513|M.vanbaalenii_PYR-1 TGRRELVDDY----------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------AVLRAMTVAALSAADRCL------------
Rv2506|M.tuberculosis_H37Rv --------------------AVLRAMTVAALSAADRCL------------
MMAR_3861|M.marinum_M ----------------------ALRIALAGFR------------------
MUL_3793|M.ulcerans_Agy99 ---EPNFVVRHDIWVRPSGSGSNPRASACSFERMRPCIHHRRHHCTR---
Mflv_1640|M.gilvum_PYR-GCK YFNGKGELLHALLNRGAEGLHYVTNHRLASAATAQDALDTVASTLIELAL
MAB_3837|M.abscessus_ATCC_1997 -----------------------FDAAEVGLRALR---------------
MSMEG_4142|M.smegmatis_MC2_155 ----------------------VLNGALVGADTRDA--------------
MAV_0586|M.avium_104 ----------------------ELHAAAADLG------------------
TH_1745|M.thermoresistible__bu ----------------------LLVGDGKNPKV-----------------
MLBr_00815|M.leprae_Br4923 ------------------------GLSHVPLTRL----------------
Mvan_1513|M.vanbaalenii_PYR-1 -----------------------LTRTLRSLQ------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3861|M.marinum_M --------------------------------------------------
MUL_3793|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK GPHQPILAILAADLVYLPDAARELIRMSEREYTDEWVAALVGVCPELTPP
MAB_3837|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4142|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0586|M.avium_104 --------------------------------------------------
TH_1745|M.thermoresistible__bu --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mvan_1513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2534|M.bovis_AF2122/97 ------------------------------------------
Rv2506|M.tuberculosis_H37Rv ------------------------------------------
MMAR_3861|M.marinum_M ------------------------------------------
MUL_3793|M.ulcerans_Agy99 ------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK HARLLARAAIGLITDITQIQKMRMRPGIATELHQLVNAVLAA
MAB_3837|M.abscessus_ATCC_1997 ------------------------------------------
MSMEG_4142|M.smegmatis_MC2_155 ------------------------------------------
MAV_0586|M.avium_104 ------------------------------------------
TH_1745|M.thermoresistible__bu ------------------------------------------
MLBr_00815|M.leprae_Br4923 ------------------------------------------
Mvan_1513|M.vanbaalenii_PYR-1 ------------------------------------------