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VAMEPECSDEVTGRTRRRVAREGPTRRALKRAERHDRVYEAAIALFVDRGFETTSMDDIAERSGLSRSTV FTHFPRKTLILEEWMRRRRDEARRSARVDGVAGRPLRDVLGAYLDTLAASNSAAREEMCALVPPALLHTT MLVDHPIGLDFAALIVESEAALKPSVQPEQVGRLLAAGYVSAMSQWIQEEPPTSDLGAELRALLDLVLSG AQRDISE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4033 | - | - | 100% (217) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4142 | - | 3e-46 | 50.27% (187) | transcriptional repressor, TetR family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6862 | - | 9e-09 | 24.86% (173) | putative transcription regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 7e-10 | 30.39% (102) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3329 | - | 6e-09 | 28.27% (191) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 7e-10 | 30.39% (102) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00815 | - | 1e-06 | 26.17% (107) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3527 | - | 9e-09 | 35.90% (78) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2873 | mce3R | 8e-10 | 31.37% (102) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2788 | - | 5e-08 | 24.38% (201) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 8e-09 | 34.62% (104) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 6e-10 | 31.37% (102) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3055 | - | 7e-09 | 28.80% (191) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3329|M.gilvum_PYR-GCK -------MPERGRSADPR--------------------------AQRVRN
Mvan_3055|M.vanbaalenii_PYR-1 -------MTERGRSADPR--------------------------AERVHT
MLBr_00815|M.leprae_Br4923 -------MNNLAKAAQRR-TVRPIDRGRLSDDIATPNQRSNRLSRDKRRG
MAB_3527|M.abscessus_ATCC_1997 -------MRDLAKLAGRRGTVN--STVATQDSTQGNTRRGGRLPRDERRG
Mb1998c|M.bovis_AF2122/97 -------MASVAQPVRRR--------------------------PKDRKK
Rv1963c|M.tuberculosis_H37Rv -------MASVAQPVRRR--------------------------PKDRKK
MMAR_2873|M.marinum_M -------MDSVVAPVRRR--------------------------PKDRKQ
MUL_2880|M.ulcerans_Agy99 -------MDSVVAPVRRR--------------------------PKDRKQ
TH_2795|M.thermoresistible__bu -------MSAAGSDAHRN----------------------GRHRPKNRKA
MSMEG_4033|M.smegmatis_MC2_155 MAMEPECSDEVTGRTRRR--------------VAREGPTRRALKRAERHD
MAV_2788|M.avium_104 -------MTGPGNRHEQR--------------------------RRSTHE
. :
Mflv_3329|M.gilvum_PYR-GCK SLRDAAFALAREHPVDTISVGDIAARADVSRQVFYRHFRDRDHAVAAAFG
Mvan_3055|M.vanbaalenii_PYR-1 RLREAAFAMAHEHPVDRITVGDLVGRAKVSRQVFYRHFRDRDDAVASAFS
MLBr_00815|M.leprae_Br4923 QLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLE
MAB_3527|M.abscessus_ATCC_1997 QLVGSASEIFVDRGYHAAGMDEIADRAGVSKPVLYQHFPSKLELYLAVLH
Mb1998c|M.bovis_AF2122/97 QILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIR
Rv1963c|M.tuberculosis_H37Rv QILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIR
MMAR_2873|M.marinum_M QILEQAVGLFIDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIR
MUL_2880|M.ulcerans_Agy99 QILEQAVGLFIDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIR
TH_2795|M.thermoresistible__bu LIARASADAFGAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVL
MSMEG_4033|M.smegmatis_MC2_155 RVYEAAIALFVDRGFETTSMDDIAERSGLSRSTVFTHFPRKTLILEEWMR
MAV_2788|M.avium_104 ALRQAALKSFARKGFANVTVTELAREAGVTERTFFRHFPTKESVLFQDYE
: : : : ::. :: ..: * :
Mflv_3329|M.gilvum_PYR-GCK HAFDDALA---------DGAGQD--ARARILDLFGFAAAHPRLCRN-VVP
Mvan_3055|M.vanbaalenii_PYR-1 RAFTDATG---------GATGGD--ARTRILDLFEFAGAHPAMCRN-IVP
MLBr_00815|M.leprae_Br4923 RHMNNLVSSVQQALRTTTNNRQR--LHAAVQAFFDFIEHDGQGYRL-IFE
MAB_3527|M.abscessus_ATCC_1997 KHADNLVSSVRQALRTTTDNRQR--LRAAVMAFFDFVEHDSQGYRL-IFE
Mb1998c|M.bovis_AF2122/97 TGQDQYQSARRLTEGETEPTPRP--LNADLEDLIAAAVASRALTVLWQRE
Rv1963c|M.tuberculosis_H37Rv TGQDQYQSARRLTEGETEPTPRP--LNADLEDLIAAAVASRALTVLWQRE
MMAR_2873|M.marinum_M TGQDQYQSARRLTEGEQEPTPRP--LSVDLPDLIAAAVASRSLTVLWQRE
MUL_2880|M.ulcerans_Agy99 TGQDQYQSARRLTEGEQEPTPRP--LSVDLPDLIAAAVASRSLTVLSQRE
TH_2795|M.thermoresistible__bu GLGQLLVDATDFGDDVDPAEDPHGLLAALVDALINVTIANRTAGGLYRWE
MSMEG_4033|M.smegmatis_MC2_155 RRRDEARRSAR----VDGVAGRP--LRDVLGAYLDTLAASNSAAREEMCA
MAV_2788|M.avium_104 TQLEWLAEALAQRPPSESLFDAVLASVAAFPHDLEVVRQAATARAELISA
. :
Mflv_3329|M.gilvum_PYR-GCK S-TVHQHVLVTYRDALYAPCRRIAGQSMEVLDAVSS-LPAEAVTRFLVGG
Mvan_3055|M.vanbaalenii_PYR-1 S-TVNQHVLATYRDALFEPCQQIAEQGMAVLDTVAP-LPAEAVTRFLVGG
MLBr_00815|M.leprae_Br4923 NDNITEPRVAAQVRVATESCIDAVFALISADSRLDP-HRARMVAVGLVGI
MAB_3527|M.abscessus_ATCC_1997 NDLVGVPQVSERVEGAISACTDAVFDLVSHDSGLDP-HHARMVAVGLVGI
Mb1998c|M.bovis_AF2122/97 ARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSP-QHSELRAWAVSST
Rv1963c|M.tuberculosis_H37Rv ARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSP-QHSELRAWAVSST
MMAR_2873|M.marinum_M ARYLNDADRIEVRRRINAIVAGMRESVLLEVPGLSP-AHSELRAWAVSST
MUL_2880|M.ulcerans_Agy99 ARYLNDADRIEVRRRINAIVAGMRESVLLEVPGLSP-AHSELRAWAVSST
TH_2795|M.thermoresistible__bu GRYLREPDRDILERQIQLVNRRLQRPLRVMRPELGS-RQRWTLTASALSA
MSMEG_4033|M.smegmatis_MC2_155 LVPPALLHTTMLVDHP--IGLDFAALIVESEAALKPSVQPEQVGRLLAAG
MAV_2788|M.avium_104 ERIAGHLR--VVQSSFARVLTDFVRARNPQLANIDL--FAEVAGSAVAAA
: .
Mflv_3329|M.gilvum_PYR-GCK LVEVLRSWMEDP--------------------------------------
Mvan_3055|M.vanbaalenii_PYR-1 FMEVLRSWMEDP--------------------------------------
MLBr_00815|M.leprae_Br4923 SVDCARYWLDTN--------------------------------------
MAB_3527|M.abscessus_ATCC_1997 SQVSARYWLDNE--------------------------------------
Mb1998c|M.bovis_AF2122/97 LTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEAD
Rv1963c|M.tuberculosis_H37Rv LTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEAD
MMAR_2873|M.marinum_M LTSLGRHSLTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGRDGQD
MUL_2880|M.ulcerans_Agy99 LTSLGRHSLTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGRDGQD
TH_2795|M.thermoresistible__bu IGSIADHSAPLSVPG-IRSFLASVVEDLLAADLPTPRRRRAPDPPPPRVT
MSMEG_4033|M.smegmatis_MC2_155 YVSAMSQWIQEEP-------------------------------------
MAV_2788|M.avium_104 LVAAVENWGRRG--------------------------------------
Mflv_3329|M.gilvum_PYR-GCK ---------------------DATDLNGRIQAALDTVDALLGIASAQKGS
Mvan_3055|M.vanbaalenii_PYR-1 ---------------------HATDLHARVSAALDTVDALLGTSPAQKGP
MLBr_00815|M.leprae_Br4923 ---------------------RPISKSDAVEGTVQFAWGGLSHVPLTRL-
MAB_3527|M.abscessus_ATCC_1997 ---------------------KPISKDDAVNATVGFAWGGLSHVPLQPHG
Mb1998c|M.bovis_AF2122/97 VLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQA
Rv1963c|M.tuberculosis_H37Rv VLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQA
MMAR_2873|M.marinum_M VLFSRYETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQA
MUL_2880|M.ulcerans_Agy99 VLFSRYETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQA
TH_2795|M.thermoresistible__bu LAAGIYECVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKAD
MSMEG_4033|M.smegmatis_MC2_155 ---------------------PTSDLGAELRALLDLVLSGAQRDISE---
MAV_2788|M.avium_104 ---------------------CSGELGDDVTASLALIRSGLAPLA-----
:
Mflv_3329|M.gilvum_PYR-GCK TRG-----------------------------------------------
Mvan_3055|M.vanbaalenii_PYR-1 THG-----------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MAB_3527|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 ILDALIRRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVA
Rv1963c|M.tuberculosis_H37Rv ILDALIRRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVA
MMAR_2873|M.marinum_M ILDALIRRLDEWRSLECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVA
MUL_2880|M.ulcerans_Agy99 ILDALIRRLDEWRSLECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVA
TH_2795|M.thermoresistible__bu ILAASLRRAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAY
MSMEG_4033|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2788|M.avium_104 --------------------------------------------------
Mflv_3329|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3055|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MAB_3527|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 VSVTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAA
Rv1963c|M.tuberculosis_H37Rv VSVTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAA
MMAR_2873|M.marinum_M VCVTELNHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAA
MUL_2880|M.ulcerans_Agy99 VCATELNHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAA
TH_2795|M.thermoresistible__bu VQHTERRNLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYC
MSMEG_4033|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2788|M.avium_104 --------------------------------------------------
Mflv_3329|M.gilvum_PYR-GCK ------------------------------------------
Mvan_3055|M.vanbaalenii_PYR-1 ------------------------------------------
MLBr_00815|M.leprae_Br4923 ------------------------------------------
MAB_3527|M.abscessus_ATCC_1997 ------------------------------------------
Mb1998c|M.bovis_AF2122/97 AISFIEDVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA
Rv1963c|M.tuberculosis_H37Rv AISFIEDVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA
MMAR_2873|M.marinum_M AISFIEDVARTWHLTRYAAVADEITAIALSILTSRS------
MUL_2880|M.ulcerans_Agy99 AISFIEDVARTWHLTRYAAVADEITEIALSILTSRS------
TH_2795|M.thermoresistible__bu AFALVTDLGRLTDSHASPSAQAAVQHLMEVVLLGG-------
MSMEG_4033|M.smegmatis_MC2_155 ------------------------------------------
MAV_2788|M.avium_104 ------------------------------------------