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VLRDDALEGTVALVTGGGTGIGRATALDLARSGSDVVVAGRRREPLEKTVADIELLGRRALAVPTDIRDD EQVSALVEHTLAKFGRIDILVNNAGGQFAAPAEEITSKGWRAVHRLAVDATWSVTREVAVTAMIPQRSGV VFFIAFSPRRGIPTFVHATSARAALENMASGLALEWSRYGIRTLCVAPGTIATDGMDANYTQEAKDRWSS AIPLGRPGAADEVSAVIAFLASPGARYVTGTTVVVDGGADAWGAGHPVPGLETHL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4074 | - | - | 100% (265) | peroxisomal trans-2-enoyl-CoA reductase |
| M. smegmatis MC2 155 | MSMEG_6626 | - | 6e-46 | 41.46% (246) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4850 | - | 5e-36 | 36.12% (263) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 7e-29 | 32.11% (246) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1263 | - | 4e-47 | 41.53% (248) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1928c | - | 7e-29 | 32.11% (246) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-20 | 30.65% (248) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4632 | - | 4e-28 | 30.08% (256) | short chain dehydrogenase |
| M. marinum M | MMAR_4756 | - | 1e-38 | 37.35% (249) | oxidoreductase |
| M. avium 104 | MAV_1391 | - | 4e-44 | 39.84% (246) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_4266 | - | 1e-46 | 40.00% (245) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0327 | - | 3e-38 | 37.05% (251) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4228 | - | 3e-34 | 33.84% (263) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1963c|M.bovis_AF2122/97 ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Rv1928c|M.tuberculosis_H37Rv ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Mflv_1263|M.gilvum_PYR-GCK ------------MSDRFSMEGRVAVITGGGTGIGRASALVLAEHGADVVL
TH_4266|M.thermoresistible__bu ------------VDDRFSMAGRVAVITGGGTGIGRASALVLAEYGADIVL
MAV_1391|M.avium_104 ------------MSDRFALTDRVAVITGAGTGIGRASALVLAEHGADIVL
MSMEG_4074|M.smegmatis_MC2_155 ------------MLRDDALEGTVALVTGGGTGIGRATALDLARSGSDVVV
MAB_4632|M.abscessus_ATCC_1997 -----------MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLI
MMAR_4756|M.marinum_M ---------MAIDPADVLLNGRVAVVTGAGSGIGRGVAAGLAAFGASVAI
MUL_0327|M.ulcerans_Agy99 ---------MAIDPADVLLNGRVAVVTGAGSGIGRGVAAGLAAFGASMAI
Mvan_4228|M.vanbaalenii_PYR-1 ---------MTIAPSDILLTGRVAVVTGGGAGIGKGIAHGLAAFGASVAI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
: . ::**.. *:* * . * : :
Mb1963c|M.bovis_AF2122/97 AARHLDALEKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGID
Rv1928c|M.tuberculosis_H37Rv AARHLDALEKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGID
Mflv_1263|M.gilvum_PYR-GCK AGRRAEPLKETAAEVEALGRRALAVPTDVTDADACQALVDTTLAEFGRLD
TH_4266|M.thermoresistible__bu AGRRPEPLKKTAAEIEALGRRALAVPTDVTAPDECRALVDATVGEFGRLD
MAV_1391|M.avium_104 AGRRPDPLQATAKEVEALGRRSLIVPTDVTETQQCQHLVDATMAEFGRLD
MSMEG_4074|M.smegmatis_MC2_155 AGRRREPLEKTVADIELLGRRALAVPTDIRDDEQVSALVEHTLAKFGRID
MAB_4632|M.abscessus_ATCC_1997 ASRTESQLREVAAKVQAAGRQAEVVVADLSDTEASAALAQKAVDRFGRLD
MMAR_4756|M.marinum_M WERDPQTCAQAAAELGGLG-----IATDVRSGDQVDAALQRTQAELGEVT
MUL_0327|M.ulcerans_Agy99 WERDPQTCAQAAAELGGLG-----IATDVRSGDQVDAALQRTQAELGAVT
Mvan_4228|M.vanbaalenii_PYR-1 WERDPQTCGEAAASVGALG-----LPTDVRDAEAVQAALERTERELGTVS
MLBr_01807|M.leprae_Br4923 THR------ASVVPDWFFG-----VECDVTDNDAIGAAFKAVEEHQGPVE
* . * : *: : . . . * :
Mb1963c|M.bovis_AF2122/97 IAVCNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQG
Rv1928c|M.tuberculosis_H37Rv IAVCNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQG
Mflv_1263|M.gilvum_PYR-GCK VLLNNAGGGETKSLMKWTDDEWHHVLDLNLSSAWYLSR-AAAKPMIAQGS
TH_4266|M.thermoresistible__bu VLVNNAGGGATKPLMKWTDDEWHEVLNLNLSSAWYLSR-AAAKPMIDQGR
MAV_1391|M.avium_104 ILVNNAGGGETKGITRWTEEEWHDVVDLNLGSVWFLSR-CAVKPMMTQGS
MSMEG_4074|M.smegmatis_MC2_155 ILVNNAGGQFAAPAEEITSKGWRAVHRLAVDATWSVTREVAVTAMIPQRS
MAB_4632|M.abscessus_ATCC_1997 VVVNNVGGTMPKPFLDTTNDDLAEAFSFNVLSGHALLR-AAVPHLLKSDN
MMAR_4756|M.marinum_M ILVNNVGGVFWSPLLQTSEKGWDALYRSNLGHVLLCTQRVARRLVAAELP
MUL_0327|M.ulcerans_Agy99 ILVNNVGGVFWSPLLQTSEKGWDALYRSNLGHVLLCTQRVARRLVAAGLP
Mvan_4228|M.vanbaalenii_PYR-1 ILVNNAGGTFNSPLLETSENGWDALYRSNLRHVLLCTQRVARRLVEVGQP
MLBr_01807|M.leprae_Br4923 VLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAK-LASRNMIKQRF
: : *.* . . : : * :
Mb1963c|M.bovis_AF2122/97 GVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNS
Rv1928c|M.tuberculosis_H37Rv GVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNS
Mflv_1263|M.gilvum_PYR-GCK GAIVNISSGAGLLAMP--QAPIYGAAKAGLQNLTGSMAAAWTRKGVRVNC
TH_4266|M.thermoresistible__bu GAIVNISSGAGLLAMP--QAPVYAAAKAGLNNLTGSMAAAWTRKGVRVNC
MAV_1391|M.avium_104 GAIVNISSGASLIAMP--QAAIYAAAKAGVNNLTGSMAAAWGRKGIRVNC
MSMEG_4074|M.smegmatis_MC2_155 GVVFFIAFSP-RRGIP--TFVHATSARAALENMASGLALEWSRYGIRTLC
MAB_4632|M.abscessus_ATCC_1997 ASVINITSTMGRLPGR--AFLGYCTAKGALAHYTRTAAMDLSPR-IRVNG
MMAR_4756|M.marinum_M GSIMAITSIEGVRAAP--GYAAYAAAKAGVVNYTKTAALELAHHGIRVNA
MUL_0327|M.ulcerans_Agy99 GSIMAITSIEGVRAAP--GYAAYAAAKAGVVNYTKTTALELAHHGIRVNA
Mvan_4228|M.vanbaalenii_PYR-1 GSVINITSIEGSRAAP--GYAAYAAAKAGVVNYTKTASFELAPHRIRVNA
MLBr_01807|M.leprae_Br4923 GRYIFMGSVVGLSGVP--GQANYAASKSGLIGMARSLARELGSRSITANV
. . :::..: : : : .
Mb1963c|M.bovis_AF2122/97 VSPGYILTELVEPYTEY----QPLWEPKIPLGRLGRPEELAGLYLYLASE
Rv1928c|M.tuberculosis_H37Rv VSPGYILTELVEPYTEY----QPLWEPKIPLGRLGRPEELAGLYLYLASE
Mflv_1263|M.gilvum_PYR-GCK IACGAVRTPGLEADAKRQGFDIDMIGQTNGSGRIAEPDEIGYGVLFFASD
TH_4266|M.thermoresistible__bu IACGAIRTPGLEADAKRQGFDIDMIGQTNGSGRIAEPDEIGYGVLFFASD
MAV_1391|M.avium_104 IACGAIRTDGLLADAAKGGFDVDQLGAMNAMGRIAEPDEIGYGVLFFASD
MSMEG_4074|M.smegmatis_MC2_155 VAPGTIATDGMDANYTQEAK--DRWSSAIPLGRPGAADEVSAVIAFLASP
MAB_4632|M.abscessus_ATCC_1997 IAPGSILTSALEVVAGNDEMR-NTLEQNTPLHRLGDPADIAAAAVYLASP
MMAR_4756|M.marinum_M IAPDITMTEGLAQLGG--AAALERIGSLVPLGRPGDIDEIASVAVFLASD
MUL_0327|M.ulcerans_Agy99 IAPDITMTEGLAQLGG--AAALERIGSLVPLGRPGDVDEIASVAVFLASD
Mvan_4228|M.vanbaalenii_PYR-1 LAPDLTMTEGLQKLAF--GDLSGTMADMVPMRRVGHVDEMASAAVFLASD
MLBr_01807|M.leprae_Br4923 VAPGFIDTEMTRAMDSK---YQEAALQAIPLGRIGAVEEIAGAVSFLASE
:: . * * . ::. ::**
Mb1963c|M.bovis_AF2122/97 ASSYMTGSDIVIDGGYTCP-----------------
Rv1928c|M.tuberculosis_H37Rv ASSYMTGSDIVIDGGYTCP-----------------
Mflv_1263|M.gilvum_PYR-GCK ASSYCSGQTLYMHGGPGPAGV---------------
TH_4266|M.thermoresistible__bu ASSYCSGQTLYMHGGPGPAGV---------------
MAV_1391|M.avium_104 ASSYCSGQTLYIHGGPGPAGI---------------
MSMEG_4074|M.smegmatis_MC2_155 GARYVTGTTVVVDGGADAWGAGHPVPGLETHL----
MAB_4632|M.abscessus_ATCC_1997 AGSFLTGKVLEVDGGLIAPNLDIPLPDLA-------
MMAR_4756|M.marinum_M MARYVTGQTIHVDGGTHAAAGWYRDPQTGEYRLGPG
MUL_0327|M.ulcerans_Agy99 MARYVTGQTIHVDGGTHAAAGWYRDPQTGEYRLGPG
Mvan_4228|M.vanbaalenii_PYR-1 MAAYITGQTIHVDGGTAAAGGWYFHPETGVPTLGPA
MLBr_01807|M.leprae_Br4923 DAGYISGAVIPVDGGLGMGH----------------
. : :* : :.**