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VSDRFSMEGRVAVITGGGTGIGRASALVLAEHGADVVLAGRRAEPLKETAAEVEALGRRALAVPTDVTDA DACQALVDTTLAEFGRLDVLLNNAGGGETKSLMKWTDDEWHHVLDLNLSSAWYLSRAAAKPMIAQGSGAI VNISSGAGLLAMPQAPIYGAAKAGLQNLTGSMAAAWTRKGVRVNCIACGAVRTPGLEADAKRQGFDIDMI GQTNGSGRIAEPDEIGYGVLFFASDASSYCSGQTLYMHGGPGPAGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1263 | - | - | 100% (256) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2001 | - | 2e-37 | 38.59% (241) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0661 | - | 2e-35 | 34.85% (241) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3589c | - | 1e-36 | 40.91% (242) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3559c | - | 2e-36 | 40.50% (242) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 4e-24 | 33.51% (188) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0833 | - | 4e-38 | 36.99% (246) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4581 | - | 2e-36 | 37.45% (251) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_1391 | - | 1e-115 | 76.17% (256) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_6626 | - | 1e-132 | 89.72% (253) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_4266 | - | 1e-133 | 90.23% (256) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4442 | - | 1e-35 | 37.05% (251) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3989 | - | 1e-36 | 37.04% (270) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3589c|M.bovis_AF2122/97 MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISD
Rv3559c|M.tuberculosis_H37Rv MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISD
Mflv_1263|M.gilvum_PYR-GCK -----MSDRFS----MEGRVAVITGGG-TGIGRASALVLAEHGADVVLAG
TH_4266|M.thermoresistible__bu -----VDDRFS----MAGRVAVITGGG-TGIGRASALVLAEYGADIVLAG
MSMEG_6626|M.smegmatis_MC2_155 ----MAVSRFS----LEGRVAVITGGG-TGIGRASALVLAEHGADIVLAG
MAV_1391|M.avium_104 -----MSDRFA----LTDRVAVITGAG-TGIGRASALVLAEHGADIVLAG
MMAR_4581|M.marinum_M ----MILDRFR----LDDQVAVITGGG-RGLGAAIALAFAEAGADVVIAS
MUL_4442|M.ulcerans_Agy99 ----MILDRFR----LDDQVAVITGGG-RGFGAAIALAFAEAGADVVIAS
MAB_0833|M.abscessus_ATCC_1997 ----MNRETFSRLFDLTGRTAIVTGGT-RGIGRALAEGYACAGANVVVAS
Mvan_3989|M.vanbaalenii_PYR-1 -----MKTLIG-------KCAVVSGSG-RGIGREIALKLAAEGASVVVND
MLBr_01740|M.leprae_Br4923 ----MVKTAQY----FVGKRCFVTGAA-SGIGRATALRLAAYGAELYLTD
: .::.. *:* * **.: : .
Mb3589c|M.bovis_AF2122/97 HHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRLDV
Rv3559c|M.tuberculosis_H37Rv HHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRLDV
Mflv_1263|M.gilvum_PYR-GCK RRAEPLKETAAEVEALGR-RALAVPTDVTDADACQALVDTTLAEFGRLDV
TH_4266|M.thermoresistible__bu RRPEPLKKTAAEIEALGR-RALAVPTDVTAPDECRALVDATVGEFGRLDV
MSMEG_6626|M.smegmatis_MC2_155 RRLEPLKNTATEIEALGR-RALAVPTDVTDPEACRSLVDATVDEFGRLDI
MAV_1391|M.avium_104 RRPDPLQATAKEVEALGR-RSLIVPTDVTETQQCQHLVDATMAEFGRLDI
MMAR_4581|M.marinum_M RTQSQLDEVADTVRSIGR-RAHVVAADLAHPEATAELAGQAVEAFGRLDI
MUL_4442|M.ulcerans_Agy99 RTQSQLDEVADTVRSIGR-RAHVVAADLAHPEATAELAGQAVEAFGRLDI
MAB_0833|M.abscessus_ATCC_1997 RKPEACTEAVERLRSLGA-RALGVPTHTGDIHSLEELVRATAEEFGGIDI
Mvan_3989|M.vanbaalenii_PYR-1 LDAEPARETVAAIEAAGG-KAVACVGSVTDSDFGERFVQTAMDSFGGLDI
MLBr_01740|M.leprae_Br4923 RHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHPSMDI
.. : * : :*:
Mb3589c|M.bovis_AF2122/97 LVNNAGLGGQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPH--
Rv3559c|M.tuberculosis_H37Rv LVNNAGLGGQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPH--
Mflv_1263|M.gilvum_PYR-GCK LLNNAGGGETKSLMKWTDDEWHHVLDLNLSSAWYLSRAAAKPMIAQG---
TH_4266|M.thermoresistible__bu LVNNAGGGATKPLMKWTDDEWHEVLNLNLSSAWYLSRAAAKPMIDQG---
MSMEG_6626|M.smegmatis_MC2_155 LLNNAGGGETKSLMKWTDDEWRQVLDLNLSSAWYLSRAAVKPMLSQG---
MAV_1391|M.avium_104 LVNNAGGGETKGITRWTEEEWHDVVDLNLGSVWFLSRCAVKPMMTQG---
MMAR_4581|M.marinum_M VVNNVGGTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEHSG--
MUL_4442|M.ulcerans_Agy99 VVNNVGGTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEHSG--
MAB_0833|M.abscessus_ATCC_1997 VVNNAANALTEPVGAFTVDGWDKSFGVNLRGPVFLVQAALPHLVASP---
Mvan_3989|M.vanbaalenii_PYR-1 IVNNAGYTWDSVIQKMTDEQWDAILDVHLKAPFHILRAAQPVISGLVKRA
MLBr_01740|M.leprae_Br4923 VMNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGR--
::* .. : : . . . : :
Mb3589c|M.bovis_AF2122/97 --------GGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAE
Rv3559c|M.tuberculosis_H37Rv --------GGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAE
Mflv_1263|M.gilvum_PYR-GCK --------SGAIVNISSGAGLLAMPQAPIYGAAKAGLQNLTGSMAAAWTR
TH_4266|M.thermoresistible__bu --------RGAIVNISSGAGLLAMPQAPVYAAAKAGLNNLTGSMAAAWTR
MSMEG_6626|M.smegmatis_MC2_155 --------KGSIVNISSGASLLAMPQAAIYGAAKAGLNNLTGSMAAAWTR
MAV_1391|M.avium_104 --------SGAIVNISSGASLIAMPQAAIYAAAKAGVNNLTGSMAAAWGR
MMAR_4581|M.marinum_M --------GGSIINITSTMGRVAGRGFAAYGTAKAALAHYTRLAALDLCP
MUL_4442|M.ulcerans_Agy99 --------GGGIINITSTMGRVAGRGFAAYGTAKVALAHYTRLAALDLCP
MAB_0833|M.abscessus_ATCC_1997 --------HAAVLNVVSVGAFMFGQGVSMYSAAKAALVSYTRSAAAELAS
Mvan_3989|M.vanbaalenii_PYR-1 RESGDHVGCRKVVNISSLAGVGGNAGQANYAAAKAGVIGLTKALAKEWGR
MLBr_01740|M.leprae_Br4923 --------GGHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLAR
::* * . . *.::* .: :
Mb3589c|M.bovis_AF2122/97 YGVRINAVSPSIARHKFLDKTASAE-----------------LLDRLVAG
Rv3559c|M.tuberculosis_H37Rv YGVRINAVSPSIARHKFLDKTASAE-----------------LLDRLAAG
Mflv_1263|M.gilvum_PYR-GCK KGVRVNCIACGAVRTPGLEADAKRQ---------------GFDIDMIGQT
TH_4266|M.thermoresistible__bu KGVRVNCIACGAIRTPGLEADAKRQ---------------GFDIDMIGQT
MSMEG_6626|M.smegmatis_MC2_155 KGVRVNCIACGAIRTPGLEADAARQ---------------GFDIDMIGQT
MAV_1391|M.avium_104 KGIRVNCIACGAIRTDGLLADAAKG---------------GFDVDQLGAM
MMAR_4581|M.marinum_M R-IRVNAIAPGSILTSALEVVAAND---------------ELRAPMEQAT
MUL_4442|M.ulcerans_Agy99 R-IRVNAIAPGSILTSALEVVAAND---------------ELRAPMEQAT
MAB_0833|M.abscessus_ATCC_1997 RGVRVNALAPGAIDTDMVRKTPPAE---------------VER--MANTN
Mvan_3989|M.vanbaalenii_PYR-1 YNVTVNSVAFGLIKTRLTETPADRQGTIDVAGREIKVGVNPGLLSAMEQM
MLBr_01740|M.leprae_Br4923 YRIGVSVVVPGAVRTPLVDTIEIAG-------------VDRQDPRFSRWV
: :. : .
Mb3589c|M.bovis_AF2122/97 EAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSCQHP-----------
Rv3559c|M.tuberculosis_H37Rv EAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSCQHP-----------
Mflv_1263|M.gilvum_PYR-GCK NGSGRIAEPDEIGYGVLFFASDASSYCSGQTLYMHGGPGPAGV-------
TH_4266|M.thermoresistible__bu NGSGRIAEPDEIGYGVLFFASDASSYCSGQTLYMHGGPGPAGV-------
MSMEG_6626|M.smegmatis_MC2_155 NGSGRIAEPDEIGYGVLFFASDASSYCSGQTLYMHGGPGPAGV-------
MAV_1391|M.avium_104 NAMGRIAEPDEIGYGVLFFASDASSYCSGQTLYIHGGPGPAGI-------
MMAR_4581|M.marinum_M P-LRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTHPNLDIPVPDL
MUL_4442|M.ulcerans_Agy99 P-LRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTHPNLDIPVPDL
MAB_0833|M.abscessus_ATCC_1997 H-LKRLGLPDEMVGTALLLTSDAGSYITGQTIIADGGLVAR---------
Mvan_3989|M.vanbaalenii_PYR-1 IPLGRSGTPAEAAGAVYLLCTPESDYISAQTVVCGGGFNF----------
MLBr_01740|M.leprae_Br4923 DRFRGHAVSAERAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGV
. . : . :
Mb3589c|M.bovis_AF2122/97 --------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------
Mflv_1263|M.gilvum_PYR-GCK --------------------------------------------
TH_4266|M.thermoresistible__bu --------------------------------------------
MSMEG_6626|M.smegmatis_MC2_155 --------------------------------------------
MAV_1391|M.avium_104 --------------------------------------------
MMAR_4581|M.marinum_M --------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------
Mvan_3989|M.vanbaalenii_PYR-1 --------------------------------------------
MLBr_01740|M.leprae_Br4923 VMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN