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SDRFALTDRVAVITGAGTGIGRASALVLAEHGADIVLAGRRPDPLQATAKEVEALGRRSLIVPTDVTETQ QCQHLVDATMAEFGRLDILVNNAGGGETKGITRWTEEEWHDVVDLNLGSVWFLSRCAVKPMMTQGSGAIV NISSGASLIAMPQAAIYAAAKAGVNNLTGSMAAAWGRKGIRVNCIACGAIRTDGLLADAAKGGFDVDQLG AMNAMGRIAEPDEIGYGVLFFASDASSYCSGQTLYIHGGPGPAGI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1391 | - | - | 100% (256) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_3012 | - | 5e-34 | 33.47% (251) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_0311 | - | 5e-34 | 38.25% (251) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3589c | - | 9e-34 | 39.34% (244) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1263 | - | 1e-115 | 76.17% (256) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3559c | - | 4e-34 | 39.34% (244) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 5e-21 | 34.05% (185) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4913c | - | 1e-39 | 40.24% (246) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_5048 | - | 8e-34 | 38.93% (244) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6626 | - | 1e-115 | 77.87% (253) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_4266 | - | 1e-114 | 75.39% (256) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0327 | - | 5e-34 | 37.14% (245) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0489 | - | 8e-36 | 36.10% (241) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1263|M.gilvum_PYR-GCK -----------MSDRFSMEGRVAVITGGG-TGIGRASALVLAEHGADVVL
TH_4266|M.thermoresistible__bu -----------VDDRFSMAGRVAVITGGG-TGIGRASALVLAEYGADIVL
MSMEG_6626|M.smegmatis_MC2_155 ----------MAVSRFSLEGRVAVITGGG-TGIGRASALVLAEHGADIVL
MAV_1391|M.avium_104 -----------MSDRFALTDRVAVITGAG-TGIGRASALVLAEHGADIVL
MAB_4913c|M.abscessus_ATCC_199 ----------------MLQDKVVVVTGGS-RGLGRAMVRAFAAHGADVVI
Mb3589c|M.bovis_AF2122/97 --MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVI
Rv3559c|M.tuberculosis_H37Rv --MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVI
MMAR_5048|M.marinum_M --MSLSEAPKEIAGHGLLVDKVVVVTAAAGTGIGSATARRALAEGADVVI
MUL_0327|M.ulcerans_Agy99 --------MAIDPADVLLNGRVAVVTGAG-SGIGRGVAAGLAAFGASMAI
Mvan_0489|M.vanbaalenii_PYR-1 MREVRPFTNRRRVSAVKAGDRRVAIVTAAAAGIGKAIALRWCREGGCCVM
MLBr_01740|M.leprae_Br4923 ----------MVKTAQYFVGKRCFVTGAA-SGIGRATALRLAAYGAELYL
.: :. .. *:* . . *. :
Mflv_1263|M.gilvum_PYR-GCK AGRRAEPLKETAAEVEAL-GRRALAVPTDVTDADACQALVDTTLAEFGRL
TH_4266|M.thermoresistible__bu AGRRPEPLKKTAAEIEAL-GRRALAVPTDVTAPDECRALVDATVGEFGRL
MSMEG_6626|M.smegmatis_MC2_155 AGRRLEPLKNTATEIEAL-GRRALAVPTDVTDPEACRSLVDATVDEFGRL
MAV_1391|M.avium_104 AGRRPDPLQATAKEVEAL-GRRSLIVPTDVTETQQCQHLVDATMAEFGRL
MAB_4913c|M.abscessus_ATCC_199 ASRKIDSCQELAAQVEAEHGRRALPVACNVSSWEQCDHLVDTVYREFGRV
Mb3589c|M.bovis_AF2122/97 SDHHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRL
Rv3559c|M.tuberculosis_H37Rv SDHHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRL
MMAR_5048|M.marinum_M SDHHERRLGETAAELSALGLGRVESVLCDVSSTAQVDALIDSTTARMGRL
MUL_0327|M.ulcerans_Agy99 WERDPQTCAQAAAELGGL------GIATDVRSGDQVDAALQRTQAELGAV
Mvan_0489|M.vanbaalenii_PYR-1 ADTDGEGLDAAVHELAES-GAAVCGVAGDVCLSDVANSVVERALTEFGRL
MLBr_01740|M.leprae_Br4923 TDRHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHPSM
. : :: . :
Mflv_1263|M.gilvum_PYR-GCK DVLLNNAGGG-ETKSLMKWTDDEWHHVLDLNLSSAWYLSRAAAKPMIAQ-
TH_4266|M.thermoresistible__bu DVLVNNAGGG-ATKPLMKWTDDEWHEVLNLNLSSAWYLSRAAAKPMIDQ-
MSMEG_6626|M.smegmatis_MC2_155 DILLNNAGGG-ETKSLMKWTDDEWRQVLDLNLSSAWYLSRAAVKPMLSQ-
MAV_1391|M.avium_104 DILVNNAGGG-ETKGITRWTEEEWHDVVDLNLGSVWFLSRCAVKPMMTQ-
MAB_4913c|M.abscessus_ATCC_199 DVLVNNAGLSPLYPSLDQVSEALFDKVIGVNLKGPFRLSASIATKMAAG-
Mb3589c|M.bovis_AF2122/97 DVLVNNAGLG-GQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAP
Rv3559c|M.tuberculosis_H37Rv DVLVNNAGLG-GQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAP
MMAR_5048|M.marinum_M DVLVNNAGLG-GQTPVADMTDDEWDRVLDVTLTSVFRATRAALRYFREAP
MUL_0327|M.ulcerans_Agy99 TILVNNVGGV-FWSPLLQTSEKGWDALYRSNLGHVLLCTQRVARRLVAAG
Mvan_0489|M.vanbaalenii_PYR-1 DTLFNVVGGS-LARNVEEISEEQWRSQIDMNLGSVFQMSKPVIPLLRQG-
MLBr_01740|M.leprae_Br4923 DIVMNIAGVS-VWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAG
:.* .* : :. : .* :
Mflv_1263|M.gilvum_PYR-GCK GSGAIVNISSGAGLLAMPQAPIYGAAKAGLQNLTGSMAAAWTRKGVRVNC
TH_4266|M.thermoresistible__bu GRGAIVNISSGAGLLAMPQAPVYAAAKAGLNNLTGSMAAAWTRKGVRVNC
MSMEG_6626|M.smegmatis_MC2_155 GKGSIVNISSGASLLAMPQAAIYGAAKAGLNNLTGSMAAAWTRKGVRVNC
MAV_1391|M.avium_104 GSGAIVNISSGASLIAMPQAAIYAAAKAGVNNLTGSMAAAWGRKGIRVNC
MAB_4913c|M.abscessus_ATCC_199 AGGSIINISSIEAVRPDATALPYAAAKAGLNALTLGLSHTFG-PTVRTNT
Mb3589c|M.bovis_AF2122/97 HGGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINA
Rv3559c|M.tuberculosis_H37Rv HGGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINA
MMAR_5048|M.marinum_M HGGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAMEAAEYGVRINA
MUL_0327|M.ulcerans_Agy99 LPGSIMAITSIEGVRAAPGYAAYAAAKAGVVNYTKTTALELAHHGIRVNA
Mvan_0489|M.vanbaalenii_PYR-1 GGGSIVNVASTAGILAENRCSAYSASKGGVVLLTKNMALDFARDNIRVNA
MLBr_01740|M.leprae_Br4923 RGGHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSV
* :: :* . . *.*:* *: : : .
Mflv_1263|M.gilvum_PYR-GCK IACGAVRTPGLEADAKR--QGFDIDMIGQTNGSGRIAEPDEIGYGVLFFA
TH_4266|M.thermoresistible__bu IACGAIRTPGLEADAKR--QGFDIDMIGQTNGSGRIAEPDEIGYGVLFFA
MSMEG_6626|M.smegmatis_MC2_155 IACGAIRTPGLEADAAR--QGFDIDMIGQTNGSGRIAEPDEIGYGVLFFA
MAV_1391|M.avium_104 IACGAIRTDGLLADAAK--GGFDVDQLGAMNAMGRIAEPDEIGYGVLFFA
MAB_4913c|M.abscessus_ATCC_199 IQCGLFNTD--IAAAWP--EGFAEALIPSIP-LRRVGEPEDIVGAALYLA
Mb3589c|M.bovis_AF2122/97 VSPSIARHKFLDKTASA--ELLDR--LVAGEAFGRAAEPWEVAATIAFLA
Rv3559c|M.tuberculosis_H37Rv VSPSIARHKFLDKTASA--ELLDR--LAAGEAFGRAAEPWEVAATIAFLA
MMAR_5048|M.marinum_M VSPSIARHKFLDKTTSA--ELLDR--LSAGEAFGRAAEPWEVAATIAFLA
MUL_0327|M.ulcerans_Agy99 IAPDITMTEGLAQLGGA--AALER--IGSLVPLGRPGDVDEIASVAVFLA
Mvan_0489|M.vanbaalenii_PYR-1 IAPGGTRTPRIERFLAE--HPEHASMMVDLCAMQRFAGPDEIAAPAVFLA
MLBr_01740|M.leprae_Br4923 VVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAG
: . . : .
Mflv_1263|M.gilvum_PYR-GCK SDASSYCS--GQTLYMHGGPGPAGV-------------------------
TH_4266|M.thermoresistible__bu SDASSYCS--GQTLYMHGGPGPAGV-------------------------
MSMEG_6626|M.smegmatis_MC2_155 SDASSYCS--GQTLYMHGGPGPAGV-------------------------
MAV_1391|M.avium_104 SDASSYCS--GQTLYIHGGPGPAGI-------------------------
MAB_4913c|M.abscessus_ATCC_199 SEASAYCT--GTTIRLDGGIL-----------------------------
Mb3589c|M.bovis_AF2122/97 SDYSSYLT--GEVISVSCQHP-----------------------------
Rv3559c|M.tuberculosis_H37Rv SDYSSYLT--GEVISVSCQHP-----------------------------
MMAR_5048|M.marinum_M SEYSSYLT--GEVISVSSQHP-----------------------------
MUL_0327|M.ulcerans_Agy99 SDMARYVT--GQTIHVDGGTHAAAGWYRDPQTGEYRLGPG----------
Mvan_0489|M.vanbaalenii_PYR-1 SPEASYIT--GAVLPVDGGMTAGVTFRAFEAV------------------
MLBr_01740|M.leprae_Br4923 VAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATM
* . : :
Mflv_1263|M.gilvum_PYR-GCK ------------------------
TH_4266|M.thermoresistible__bu ------------------------
MSMEG_6626|M.smegmatis_MC2_155 ------------------------
MAV_1391|M.avium_104 ------------------------
MAB_4913c|M.abscessus_ATCC_199 ------------------------
Mb3589c|M.bovis_AF2122/97 ------------------------
Rv3559c|M.tuberculosis_H37Rv ------------------------
MMAR_5048|M.marinum_M ------------------------
MUL_0327|M.ulcerans_Agy99 ------------------------
Mvan_0489|M.vanbaalenii_PYR-1 ------------------------
MLBr_01740|M.leprae_Br4923 RCVEPIKVGVYSQPRSGEGGKSGN