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MNGKTAVQRHRKLTEKGQATRARILEQAAELIHTKGVAATNNEQLRRVTGISGSQLNHYFPTKESLVMAV IEWQTEQVMRFYGSEQFAGFDTIEALRSWVDYYVTHESAYRDGCTLGSLASQIIKSDLQVHDELARAFDQ WRNIFRDGLRRMQSLGRLSATADPTQLADLLLSAFQGGMLLTQVQRDVTPLKNALHAAIDHVQTFAE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3312 | - | - | 100% (207) | TetR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1881c | - | 3e-30 | 35.75% (207) | TetR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3437c | - | 1e-07 | 25.90% (139) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0202 | - | 1e-07 | 26.06% (188) | putative transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3237 | - | 3e-09 | 25.27% (182) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0196 | - | 1e-07 | 26.06% (188) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2960 | - | 7e-08 | 23.43% (175) | transcriptional regulatory protein |
| M. avium 104 | MAV_0149 | - | 3e-09 | 23.24% (185) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4024 | - | 5e-35 | 38.97% (195) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2602 | - | 2e-06 | 23.89% (180) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1086 | - | 1e-06 | 26.16% (172) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4594 | - | 1e-18 | 33.86% (189) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0202|M.bovis_AF2122/97 --------------------------------------------------
Rv0196|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1086|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2960|M.marinum_M --------------------------------------------------
Mflv_3237|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0149|M.avium_104 --------------------------------------------------
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 MTAADALPTRGFTAKGLATRDRILRCAADVLLSGGLQGFNVEKVRQAASV
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2602|M.thermoresistible__bu --------------------------------------------------
Mb0202|M.bovis_AF2122/97 --------------------------------------------------
Rv0196|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1086|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2960|M.marinum_M --------------------------------------------------
Mflv_3237|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0149|M.avium_104 --------------------------------------------------
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 SGSQINHYFGDRGDLIRAVLRRQLDIVLDFHRQPALGGLDTFEDWQRWAD
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2602|M.thermoresistible__bu --------------------------------------------------
Mb0202|M.bovis_AF2122/97 --------------------------------------------------
Rv0196|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1086|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2960|M.marinum_M --------------------------------------------------
Mflv_3237|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0149|M.avium_104 --------------------------------------------------
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 LNVRYLRKIGYRGTATYHALAGQLAKTDEDTRKTFAEGYWRWITLLEDGF
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2602|M.thermoresistible__bu --------------------------------------------------
Mb0202|M.bovis_AF2122/97 --------------------------------------------------
Rv0196|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1086|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2960|M.marinum_M --------------------------------------------------
Mflv_3237|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0149|M.avium_104 --------------------------------------------------
MAB_3312|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4024|M.smegmatis_MC2_155 HRMRSAGLLRPDADPRHLAVIVVGIHQGAGLLAFTYRQEWPLVDATQFLV
Mvan_4594|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2602|M.thermoresistible__bu --------------------------------------------------
Mb0202|M.bovis_AF2122/97 -----------------------------------------MQGPRERMV
Rv0196|M.tuberculosis_H37Rv -----------------------------------------MQGPRERMV
MUL_1086|M.ulcerans_Agy99 ------------------------------------------------MV
MMAR_2960|M.marinum_M ---------------------------------------MAEDSGRQRMV
Mflv_3237|M.gilvum_PYR-GCK ---------------------------------------MTEPTTRDRIL
MAV_0149|M.avium_104 ----------------------------------------MATATRERFL
MAB_3312|M.abscessus_ATCC_1997 ----MNGKTAVQR------HRK---------------LTEKGQATRARIL
MSMEG_4024|M.smegmatis_MC2_155 NYIRMFAKDPQQRRVQPIPRRRDRPRGRPPQETAALGFTRKGLATRSRIL
Mvan_4594|M.vanbaalenii_PYR-1 ------------------------------MDSQVHKLTVKGRATRDRIV
TH_2602|M.thermoresistible__bu --------------------------------VPRNNQTVPKAEREAAVL
.:
Mb0202|M.bovis_AF2122/97 VSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYA
Rv0196|M.tuberculosis_H37Rv VSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYA
MUL_1086|M.ulcerans_Agy99 ISAVLLIRERGACATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYA
MMAR_2960|M.marinum_M AGAAEMISRRGLNATSVRELAKHTQAPLGSTYHYFPGGKYDLATEAVRWA
Mflv_3237|M.gilvum_PYR-GCK DAAAELYRRQGMSATGLKQISAAARAPFGSIYHHFPGGKEAISAEVIRSE
MAV_0149|M.avium_104 TAATGLFRRQGYSGTGLKQIVAESRAPLGSLYHFFPGGKQDLAVQAIAHT
MAB_3312|M.abscessus_ATCC_1997 EQAAELIHTKGVAATNNEQLRRVTGISGSQLNHYFPT-KESLVMAVIEWQ
MSMEG_4024|M.smegmatis_MC2_155 EGAAQLILQHGVNGTSLDDVRAEVGVSGSQMSHYFAT-KQDLVRQVIAAR
Mvan_4594|M.vanbaalenii_PYR-1 EGAAAEIRERGVAATTLDDIRARTQTSKSQLFHYFPDGKDQLLLAVAEHE
TH_2602|M.thermoresistible__bu MRAVELFKAYGYRATSIAAVAKAAGLAPAAVHWYFPTKDDLFAAVLRHMI
*. * .* : . . .*. :
Mb0202|M.bovis_AF2122/97 GEHVAAMIN------EAEGGLELLDALIDKYRQQLLSTDFRAG--CPIAA
Rv0196|M.tuberculosis_H37Rv GEHVAAMIN------EAEGGLELLDALIDKYRQQLLSTDFRAG--CPIAA
MUL_1086|M.ulcerans_Agy99 GAHVAKIIG------SATRSLDLLDTLIDQYREQLRATDFRAG--CPVAA
MMAR_2960|M.marinum_M DDLTVGVLAR----ELAAGPQAGLSAFLAMWRKIVIDSNFHAG--CPVLA
Mflv_3237|M.gilvum_PYR-GCK GIRYAAFVG---AQLADINPANGIEAVFASAAELLESQDYSEA--CSIET
MAV_0149|M.avium_104 AERYRELLDRVFAKSTDIGQAT--VTWFNWAARALQETDYADG--CPIGT
MAB_3312|M.abscessus_ATCC_1997 TEQVMRFYGS--EQFAGFDTIEALRSWVDYYVTH--ESAYRDG--CTLGS
MSMEG_4024|M.smegmatis_MC2_155 TDFVLAFHAQ--PEMGGLRNISSLHKWAELCWLQGGENYLRNG--CVYGS
Mvan_4594|M.vanbaalenii_PYR-1 AHMVLEDQQP------HLGELTSWAAWR-RWRDAVVDRYRRQGQHCPLAV
TH_2602|M.thermoresistible__bu GETQRRIESDPDVAGDPYLELTTFLDLLAPYRSLHREAYERMDDSAALHA
.
Mb0202|M.bovis_AF2122/97 VSVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADG-----IPPDR
Rv0196|M.tuberculosis_H37Rv VSVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADG-----IPPDR
MUL_1086|M.ulcerans_Agy99 VSVEAGEPSDRERMAPVVEHAAAVFDRWSDLIAQRFVSDG-----IPLDS
MMAR_2960|M.marinum_M VSVEDLPEEHHAPRR----AAATAFQRWTSMLADSLRDAG-----AAEQD
Mflv_3237|M.gilvum_PYR-GCK IALEVASTNERLRGE-----AAEVFETWLHQLAGWFGQLD-----IGDEQ
MAV_0149|M.avium_104 VACEVASSNEALRQA-----TQAVLASWQSRVAAELIGAG-----VPTAQ
MAB_3312|M.abscessus_ATCC_1997 LASQIIKSDLQVHDE-----LARAFDQWRNIFRDGLRRMQSLGRLSATAD
MSMEG_4024|M.smegmatis_MC2_155 LTSELLEADDEVLDD-----IAAGYDRWLALFYDGMTAMVRQHDLRDDAD
Mvan_4594|M.vanbaalenii_PYR-1 LMSEIGRTTPGAEAVS-----AALVTKWHGEIATGIRDMQAQGKIADRVD
TH_2602|M.thermoresistible__bu VYTET--------------------HDWLQERLMAVVSPELP----ADVD
: : * .
Mb0202|M.bovis_AF2122/97 AHELAVLATSTLEGAILLARVRRDLTPLDLVHRQLRNLLLAELPERSR--
Rv0196|M.tuberculosis_H37Rv AHELAVLATSTLEGAILLARVRRDLTPLDLVHRQLRNLLLAELPERSR--
MUL_1086|M.ulcerans_Agy99 AHELAVTAMSTLEGALLLARVRRDLTPLYVVHRQLRSMLLAQLPEGNRND
MMAR_2960|M.marinum_M AQQVATLIVASVEGTVAMCRAQQSIAPLDLVTAQLGRAIDAVLPGATSPD
Mflv_3237|M.gilvum_PYR-GCK SRRLATVMLTALEGAFVLCRTLRSVEPMLIAGHGVQAAVHAVLASAQ---
MAV_0149|M.avium_104 ARRLATFAVASLEGAILLARAHRSTRPLRETGRVVADTLRAATDRG----
MAB_3312|M.abscessus_ATCC_1997 PTQLADLLLSAFQGGMLLTQVQRDVTPLKNALHAAIDHVQTFAE------
MSMEG_4024|M.smegmatis_MC2_155 PRHLAAVLVIAHQGSTMLTHITSSSEPFKAAMTGALNYVGNFATSKSPRR
Mvan_4594|M.vanbaalenii_PYR-1 ADRTAAALLAGIQGGVGIMLSTGDLGFLEAALDVGIAALRD---------
TH_2602|M.thermoresistible__bu PAHVVDVANFFFEG--LLVSVRRVDKPAAHYIDLVTSAVVGAAAARPRSG
. . . :* : :
Mb0202|M.bovis_AF2122/97 -----
Rv0196|M.tuberculosis_H37Rv -----
MUL_1086|M.ulcerans_Agy99 HN---
MMAR_2960|M.marinum_M AHS--
Mflv_3237|M.gilvum_PYR-GCK -----
MAV_0149|M.avium_104 -----
MAB_3312|M.abscessus_ATCC_1997 -----
MSMEG_4024|M.smegmatis_MC2_155 ERRRG
Mvan_4594|M.vanbaalenii_PYR-1 -----
TH_2602|M.thermoresistible__bu QQHPA