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DLGLKGKRALISGASDGIGLAAAELLAEEGVDVALVARRANVLKEGCDSIASKTGVKAVPLAADLSDKSV FDAVVNDAVDELGGLDILINNAGASSFGGFGDITDEQWVADINLKLFGFIRMTRAALPHLLKTGSGRIVN VAGNSGKQALEYHMPGAAANAAILNFSKSLSLQVGAQGVIINTVCPGPVRTARLVKQFAANARDWNCTPE EAEERFLAGLPLPYIPSARDIAYSIAFLASPRAAYLNGTTITNDGGITRAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3994 | - | - | 100% (262) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2918 | - | 4e-44 | 38.72% (266) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4358 | - | 3e-30 | 33.99% (253) | D-beta-hydroxybutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 6e-26 | 32.33% (266) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1905 | - | 2e-29 | 31.95% (266) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2857c | - | 6e-26 | 32.33% (266) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-20 | 26.61% (248) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4178c | - | 3e-27 | 31.87% (251) | short chain dehydrogenase |
| M. marinum M | MMAR_1568 | - | 4e-28 | 29.81% (265) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3019 | - | 2e-31 | 33.33% (264) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_3893 | - | 3e-32 | 32.96% (270) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 5e-27 | 31.05% (248) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_0789 | - | 3e-30 | 33.33% (267) | acetoin reductases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MUL_0315|M.ulcerans_Agy99 ---------MRPD-SSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
Mflv_1905|M.gilvum_PYR-GCK --------------MSGRVEGKRVLITGAARGMGRSHAVRLAQEGADLIL
MAV_3019|M.avium_104 --------------MSG-LRGRVVLVTGAGRGIGRSHCQRFAEEGADVIA
Mvan_0789|M.vanbaalenii_PYR-1 ----------------MTLNGKVALVTGAARGIGRGIALRLARDGADIAL
MSMEG_3994|M.smegmatis_MC2_155 --------------MDLGLKGKRALISGASDGIGLAAAELLAEEGVDVAL
TH_3893|M.thermoresistible__bu --------------MDFDLNGKRALVTGSSSGIGAGIVETLAAEGVSVVV
MAB_4178c|M.abscessus_ATCC_199 -------------MSLLNFDGKVVVVSGIGPGLGAALAIKFAEAGADVVL
MMAR_1568|M.marinum_M --------------MDLGFSGSKAVVTGGSKGMGLAIAETLAAEGASVAV
:::* *:* . : * :
Mb2882c|M.bovis_AF2122/97 GDVDV-----------------EAGGAAADELSGLFVPTDVCDEDAVNGL
Rv2857c|M.tuberculosis_H37Rv GDVDV-----------------EAGGAAADELSGLFVPTDVCDEDAVNGL
MLBr_01807|M.leprae_Br4923 THRAS-----------------VVPDWF------FGVECDVTDNDAIGAA
MUL_0315|M.ulcerans_Agy99 LDLK-------------------TPDGG------LAFSADVTNRSQVDAA
Mflv_1905|M.gilvum_PYR-GCK VDICESLPEVEYPLAAVEELADTAELVAQHGRRAVTHVVDVRDEQALSAA
MAV_3019|M.avium_104 VDVP----------AAAPDLAQTAAAVQQRGVRAATALADVSDFAALAAA
Mvan_0789|M.vanbaalenii_PYR-1 VDVLP------------EGLDGVADKIAGIGGKTTMFVADVSDREQVFAA
MSMEG_3994|M.smegmatis_MC2_155 VARRAN-----------VLKEGCDSIASKTGVKAVPLAADLSDKSVFDAV
TH_3893|M.thermoresistible__bu HGRNAE-----------RAEAVADRIRADGGTAATAVG-DLATEDGAAQV
MAB_4178c|M.abscessus_ATCC_199 AARTQS------------RLDEVARQIAATGRRALAVATDITDEASAANL
MMAR_1568|M.marinum_M IARGKR-----------ALDSAVERLSQAGAPDAVAISADMADAASITSA
*:
Mb2882c|M.bovis_AF2122/97 FDGAAETYGRIDIAFNNAG-ISPPEDNLIENTELAAWQRVQDVNLKSVYL
Rv2857c|M.tuberculosis_H37Rv FDGAAETYGRIDIAFNNAG-ISPPEDNLIENTELAAWQRVQDVNLKSVYL
MLBr_01807|M.leprae_Br4923 FKAVEEHQGPVEVLVANAG-ITS--DMLIMRMSEEQFQKVIDVNLTGVFR
MUL_0315|M.ulcerans_Agy99 LAAIRQRLGPVTILVNAAG-LDG--FKRFSNITFEDWQRVIDVNLNGVFH
Mflv_1905|M.gilvum_PYR-GCK VDDGVARLGGLDAAVANAG-VLTGGT--WDTTTAQQWRTVIDVNLIGTWN
MAV_3019|M.avium_104 VDEAVGRLGRLDVLVGNAG-IHPAAAPAWEIT-PQNWQQTLDVNLTGVWH
Mvan_0789|M.vanbaalenii_PYR-1 VDHAAAALGGFDIMVNNAG-IALVGP--ISDVTPEQIEKLWAINVNGVLW
MSMEG_3994|M.smegmatis_MC2_155 VNDAVDELGGLDILINNAGASSFGGFG---DITDEQWVADINLKLFGFIR
TH_3893|M.thermoresistible__bu ADTAAAAFSGIDILVNNAGGSSETGIQSWFALPVSEWGVTYQRNVMSAGY
MAB_4178c|M.abscessus_ATCC_199 VERATEEFGGIDVLVNNAF--SIPSMKSLEKTDYQHIRDSVELTVVGTLR
MMAR_1568|M.marinum_M FAAVSERWGQLNCLVHTIG----PGDGYFEELDDAAWDAAFTLGTMSGVR
. . . .
Mb2882c|M.bovis_AF2122/97 CCRAALRHMVLAG------KGSIVNTASFVAVMGSATSQISYTASKGGVL
Rv2857c|M.tuberculosis_H37Rv CCRAALRHMVLAG------KGSIVNTASFVAVMGSATSQISYTASKGGVL
MLBr_01807|M.leprae_Br4923 VAKLASRNMIKQR------FGRYIFMGSVVGLSG-VPGQANYAASKSGLI
MUL_0315|M.ulcerans_Agy99 TIQAVLPDMVAAG------WGRIVNISSSSTHSG-TPYMTHYVAAKSAVN
Mflv_1905|M.gilvum_PYR-GCK TCRAAIPHLLE-------RGGSLINVSSAAGIKG-SPLHTPYTASKAGVV
MAV_3019|M.avium_104 TVKAGVPHMSRT-----ARGGSIVIISSTSGIRG-TPGAAPYSASKHAVV
Mvan_0789|M.vanbaalenii_PYR-1 GTQAAVAKFKELKNKDKGRVSRIINASSIAGHDG-FAMLGPYSATKFAVR
MSMEG_3994|M.smegmatis_MC2_155 MTRAALPHLLKTG------SGRIVNVAGNSGKQA-LEYHMPGAAANAAIL
TH_3893|M.thermoresistible__bu LIHALVPAMKESG------WGRIIQIASAAGIIP-TSGQPDYGPSKAAMI
MAB_4178c|M.abscessus_ATCC_199 LTQRVAAALAQSK-------GAVVNINSMVIRHS-QVRYGSYKIAKAALL
MMAR_1568|M.marinum_M AIRAALPLLRAAD------WARVVTLSAHSIQRQ-NPRLVAYTASKAALS
: : . : . :: .:
Mb2882c|M.bovis_AF2122/97 AMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAK--------------
Rv2857c|M.tuberculosis_H37Rv AMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAK--------------
MLBr_01807|M.leprae_Br4923 GMARSLARELGSRSITANVVAPGFIDTEMTRAMDSK--------------
MUL_0315|M.ulcerans_Agy99 GLTKALALEYGPSGITVNAVPPGFIDTPMLRNAAAQG-------------
Mflv_1905|M.gilvum_PYR-GCK GMSKALANELAAMNIRVNTVHPTGVPTGMRP--ASLHQLLHD-------T
MAV_3019|M.avium_104 GLARTLANELGPQGIRVNTVHPGAVATAMVLNEATFRRLRPDLDNP---T
Mvan_0789|M.vanbaalenii_PYR-1 ALTQAAAKEHAADGITVNAYCPGVVGTDMWVEIDKRFAELTG---A---A
MSMEG_3994|M.smegmatis_MC2_155 NFSKSLSLQVGAQGVIINTVCPGPVRTARLVKQFA--ANARDWNCT---P
TH_3893|M.thermoresistible__bu NMSMGLSKALAGTGITVNTVMPGMIMTEGLRDFLRTFADHRGWGDD---L
MAB_4178c|M.abscessus_ATCC_199 AMSQSLATELGPQGVRVNSVVPGYMWGENLKGYFEHQAKKYG-------G
MMAR_1568|M.marinum_M SVTKNLSKSLAKEGILVNCVCPGTIVTASFTEQLKDLLAADGLDATNPYD
.: . . .: * * :
Mb2882c|M.bovis_AF2122/97 NPERAARRMVHVPLGR-FAEPDEIAAAVAFLASDDASFITASTFLVDGGI
Rv2857c|M.tuberculosis_H37Rv NPERAARRMVHVPLGR-FAEPDEIAAAVAFLASDDASFITASTFLVDGGI
MLBr_01807|M.leprae_Br4923 ---YQEAALQAIPLGR-IGAVEEIAGAVSFLASEDAGYISGAVIPVDGGL
MUL_0315|M.ulcerans_Agy99 HLGDIEQNIARTPVRR-IGKPEDIAAACAFLVSEEAGYITGQILGVNGGR
Mflv_1905|M.gilvum_PYR-GCK RSDLSPIFQN--ALPIVMAEAVDISNAVLFLISDEARHVTGLEFKVDAGV
MAV_3019|M.avium_104 ADDAAEALSARHLLPVPWVEPVDVSNAVVFLASDQARYITGTQIVVDAGL
Mvan_0789|M.vanbaalenii_PYR-1 EGETYDKFVGGIALGR-AETPDDVAGFVSYLAGPDADYMTGQSGLIDGGL
MSMEG_3994|M.smegmatis_MC2_155 EEAEERFLAG--LPLPYIPSARDIAYSIAFLASPRAAYLNGTTITNDGGI
TH_3893|M.thermoresistible__bu DKAADYILKGTGQTVHRIGQVSDVAYAVAFLASPRADFLNGINLHLDGGA
MAB_4178c|M.abscessus_ATCC_199 TVEQIYEYTAANSDLKRLPTTDEVANAVLFLASDLASGITGQALDVNCGE
MMAR_1568|M.marinum_M VMAWIDKYFHQPCDLGRAGLPEEVASITAYLVSRRNGYVTGATVNADGGS
::: :* . :.. : *
Mb2882c|M.bovis_AF2122/97 SSAYVTPL
Rv2857c|M.tuberculosis_H37Rv SSAYVTPL
MLBr_01807|M.leprae_Br4923 GMGH----
MUL_0315|M.ulcerans_Agy99 NT------
Mflv_1905|M.gilvum_PYR-GCK TIR-----
MAV_3019|M.avium_104 LAKA----
Mvan_0789|M.vanbaalenii_PYR-1 VYR-----
MSMEG_3994|M.smegmatis_MC2_155 TRAV----
TH_3893|M.thermoresistible__bu TQSIY---
MAB_4178c|M.abscessus_ATCC_199 FHA-----
MMAR_1568|M.marinum_M DFI-----