For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
DLQLTGKRAIITGGSKGIGLAIAHALATEGVDVVLAARNQETLEKAAAEVAERTGRRAIPVVADTGDDES VKALVARAVEELGGVDILVNNASNQAVGAAFPDLAGTTDEAFWGDVNVKVVGYLRAARAVAPHLKAQGWG RIINISGLGYWQTHSIVRSIRNVSVAALTKNLADELGPHGINVTVVHPGQTRTESKTAQFEAAARAAGID VADYERQIADNAIGRVVDAAEVADVVAFLASPRSVSITGDAVAVGGGLLGTVNY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2918 | - | - | 100% (265) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_3994 | - | 4e-44 | 38.72% (266) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4125 | - | 2e-29 | 33.08% (263) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 7e-29 | 36.26% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_1832 | - | 3e-29 | 34.59% (266) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2766c | fabG | 7e-29 | 36.26% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 5e-16 | 29.85% (268) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4178c | - | 2e-34 | 38.70% (261) | short chain dehydrogenase |
| M. marinum M | MMAR_1952 | fabG | 2e-30 | 37.40% (262) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5089 | - | 2e-28 | 33.58% (265) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3708 | - | 1e-27 | 31.40% (258) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2173 | fabG | 2e-30 | 37.40% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_5918 | - | 1e-28 | 35.71% (266) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2918|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1832|M.gilvum_PYR-GCK --------------------------------------------------
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1952|M.marinum_M --------------------------------------------------
MUL_2173|M.ulcerans_Agy99 --------------------------------------------------
TH_3708|M.thermoresistible__bu --------------------------------------------------
Mvan_5918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5089|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MSMEG_2918|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1832|M.gilvum_PYR-GCK --------------------------------------------------
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1952|M.marinum_M --------------------------------------------------
MUL_2173|M.ulcerans_Agy99 --------------------------------------------------
TH_3708|M.thermoresistible__bu --------------------------------------------------
Mvan_5918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5089|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
MSMEG_2918|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1832|M.gilvum_PYR-GCK --------------------------------------------------
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1952|M.marinum_M --------------------------------------------------
MUL_2173|M.ulcerans_Agy99 --------------------------------------------------
TH_3708|M.thermoresistible__bu --------------------------------------------------
Mvan_5918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5089|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
MSMEG_2918|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1832|M.gilvum_PYR-GCK ----------------------------MTTHNDAEAIAALNLDRLPHHI
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1952|M.marinum_M --------------------------------------------------
MUL_2173|M.ulcerans_Agy99 --------------------------------------------------
TH_3708|M.thermoresistible__bu --------------------------------------------------
Mvan_5918|M.vanbaalenii_PYR-1 -------------------------------------------MNSAIVA
MAV_5089|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MSMEG_2918|M.smegmatis_MC2_155 -----MDLQ-LTGKRAIITGGS-KGIGLAIAHALATEGVDVVLAARNQET
MAB_4178c|M.abscessus_ATCC_199 -----MSLLNFDGKVVVVSGIG-PGLGAALAIKFAEAGADVVLAARTQSR
Mflv_1832|M.gilvum_PYR-GCK VGKRVTDLMDLSGKKAFVTGAGGDGLGHAIANRLAGSGADIALVGRTREP
Mb2788c|M.bovis_AF2122/97 -----MTSLDLTGRTAIITGAS-RGIGLAIAQQLAAAGAHVVLTARRQE-
Rv2766c|M.tuberculosis_H37Rv -----MTSLDLTGRTAIITGAS-RGIGLAIAQQLAAAGAHVVLTARRQE-
MMAR_1952|M.marinum_M -----MTSLDLTGRTAIITGAS-RGIGLAIAQRLAGAGANVVLTARKQE-
MUL_2173|M.ulcerans_Agy99 -----MTSLDLTGRTAIITGAS-RGIGLAIAQRLAGAGANVVLTARKQE-
TH_3708|M.thermoresistible__bu MTPDPLAAFRLDGKVALVTGGS-RGLGFEMARAFAGAGADVIISSRDEES
Mvan_5918|M.vanbaalenii_PYR-1 PEVPTAPIHDLTGKNAVITGGS-KGIGAATVARFVAGGARVVTSGRSQP-
MAV_5089|M.avium_104 -----MDLGLVDTRVVVTGGAS--NIGRAIVHEFASEGARIVLNDIDEPQ
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAA-RGIGAAIAEVVARDGARVVAIDVESA-
. : .. * . .:* . .. *. :
MSMEG_2918|M.smegmatis_MC2_155 LEKAAAEVAERTGRRAIPVVADTGDDESVKALVARAVEELG-GVDILVNN
MAB_4178c|M.abscessus_ATCC_199 LDEVARQIAA-TGRRALAVATDITDEASAANLVERATEEFG-GIDVLVNN
Mflv_1832|M.gilvum_PYR-GCK LERRAAEIAQRWGVNTYPVQADMSKWDQIHRGVAEAHDKLG-RLDIMINN
Mb2788c|M.bovis_AF2122/97 ---AADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFG-SVDILINN
Rv2766c|M.tuberculosis_H37Rv ---AADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFG-SVDILINN
MMAR_1952|M.marinum_M ---SADAAAAEVGERAVGVGAHAVDEEAARGCVDLALERFG-SVDILINN
MUL_2173|M.ulcerans_Agy99 ---SADAAAAEVGERAVGVGAHAVDEEAARGCVDLALERFG-SVDILINN
TH_3708|M.thermoresistible__bu CRRAAEEIGRTFAVRAVPMPCHVGRWAELDALADRALATFG-HVDVLVNN
Mvan_5918|M.vanbaalenii_PYR-1 ---------DSLPTGVEYVVADVATLDGVDLLARRAREILG-DIDIIVNN
MAV_5089|M.avium_104 AEKVRGEALERGASAVEVVVADLTLPGSAESAVGRAVESWG-GIDVLVNN
MLBr_02565|M.leprae_Br4923 ---AEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNN
: . . * *:::**
MSMEG_2918|M.smegmatis_MC2_155 ASNQAVGAAFPDLAGTTDEAFWGDVNVKVVGYLRAARAVAPHLKAQGWGR
MAB_4178c|M.abscessus_ATCC_199 AFSIPS---MKSLEKTDYQHIRDSVELTVVGTLRLTQRVAAAL-AQSKGA
Mflv_1832|M.gilvum_PYR-GCK PVMVAAG----PFEKQTKEQIDLTVLGSLTMMMYGAHAALEYLLPQGSGV
Mb2788c|M.bovis_AF2122/97 AGTNPAYG---PLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGA
Rv2766c|M.tuberculosis_H37Rv AGTNPAYG---PLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGA
MMAR_1952|M.marinum_M AGTNPAYG---PLIEQDHARFTKIFDVNLWAPLMWTSLVVKAWMGEHGGV
MUL_2173|M.ulcerans_Agy99 AGTNPAYG---PLIEQDHARFTKIFDVNLWAPLMWTSLVVKAWMGEHGGV
TH_3708|M.thermoresistible__bu AGMSPLYD---KVADITETMWEKTLAVNLRAPFRLTALLAPAMVDNGGGS
Mvan_5918|M.vanbaalenii_PYR-1 AGATVPHLG--GVLDIEDAEWVNDLNINFLAAVRLNAALLPALYARGKGS
MAV_5089|M.avium_104 AGWTAPGF---IATDTDRTKWQRIIEINLFSALAATQAAIGPMKDAGVGA
MLBr_02565|M.leprae_Br4923 AGITRDKL----LANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGR
. . .. *
MSMEG_2918|M.smegmatis_MC2_155 IINISGLGYWQTHSIVRS--IRNVSVAALTKNLADELGPHGINVTVVHPG
MAB_4178c|M.abscessus_ATCC_199 VVNINSMVIRHSQVRYGSYKIAKAALLAMSQSLATELGPQGVRVNSVVPG
Mflv_1832|M.gilvum_PYR-GCK IINIGSVGGRVQQRGLTVYNACKSGVIGFTRNLAHEVAPRGVNVFCVAPG
Mb2788c|M.bovis_AF2122/97 VVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNAICPG
Rv2766c|M.tuberculosis_H37Rv VVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNAICPG
MMAR_1952|M.marinum_M VINTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-VRVNAICPG
MUL_2173|M.ulcerans_Agy99 VINTASIGGMHQSPAMGMYNATNAALIHVTKQLALELSPR-VRVNAICPG
TH_3708|M.thermoresistible__bu VINLSSIGAVRPTADIVPYAAAKAGLNAMTAALAKEYGPH-VRVNAIMPG
Mvan_5918|M.vanbaalenii_PYR-1 IINVSSAVTLSPPSPMLHYATAKAALATYTTGLAAEAGPRGVRVNTLTPG
MAV_5089|M.avium_104 IVFIASDAAFG-QIRQSVYGASKAAMVALARTTAREHGRHGIRSNVVCPG
MLBr_02565|M.leprae_Br4923 VIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPG
:: . : .: : * . : : : **
MSMEG_2918|M.smegmatis_MC2_155 QTRTESKTA-QFEAAARAAG--IDVAD-YERQIADNAIGRVVDAAEVADV
MAB_4178c|M.abscessus_ATCC_199 YMWGENLKG-YFEHQAKKYG--GTVEQIYEYTAANSDLKRLPTTDEVANA
Mflv_1832|M.gilvum_PYR-GCK IMIKEQMKQYLFDPQDDQQR--AGRGAIIESITHQVQLGRASLPEEAANM
Mb2788c|M.bovis_AF2122/97 VVRTRLAEALWKDHEDP--------------LAATIALGRIGEPADIASA
Rv2766c|M.tuberculosis_H37Rv VVRTRLAEALWKDHEDP--------------LAATIALGRIGEPADIASA
MMAR_1952|M.marinum_M VVRTKLAEALWKDHEDP--------------LAANIALGRIGEPVDVAEA
MUL_2173|M.ulcerans_Agy99 VVRTKLAEALWKDHEDP--------------LAANIALGRIGEPVDVAEA
TH_3708|M.thermoresistible__bu AFATDVSEYWSAEAVAR--------------VVDQTALGRIGDPREIVGT
Mvan_5918|M.vanbaalenii_PYR-1 TVGSPGADAIRRAIIDGVG------ADRPEAGGIPIPLGRKGEASDIAEA
MAV_5089|M.avium_104 LVVPEGPDAIGQSSLWSVGQDNIFNEKQIEFMLKDTPLRRLTTAEDVARA
MLBr_02565|M.leprae_Br4923 FIETQMTAAIPLATREVG--------------RRLNSLLQGGLPVDVAET
: : . : .
MSMEG_2918|M.smegmatis_MC2_155 VAFLAS-PRSVSITGDAVAVGGGLLGTVNY----------
MAB_4178c|M.abscessus_ATCC_199 VLFLAS-DLASGITGQALDVNCGEFHA-------------
Mflv_1832|M.gilvum_PYR-GCK VAFLAS-EAASYMCGQTIDVAGGQWMG-------------
Mb2788c|M.bovis_AF2122/97 VAFLVS-DAASWITGETMIIDGGLLLGNALGFRAAPSTEH
Rv2766c|M.tuberculosis_H37Rv VAFLVS-DAASWITGETMIIDGGLLLGNALGFRAAPSTEH
MMAR_1952|M.marinum_M VGFLVS-DAASWITGETMVIDGGLLLGSAAGFQSRPGSAS
MUL_2173|M.ulcerans_Agy99 VGFLVS-DAASWITGETMVIDGGLLLGSAAGFQSRPGSAS
TH_3708|M.thermoresistible__bu ALYLAS-DAASFTSGAVITVDGGRD---------------
Mvan_5918|M.vanbaalenii_PYR-1 IAFLAS-DRAAWITGSNLIVDGGQIQTR------------
MAV_5089|M.avium_104 VLWFSSPSAARQVTGQIISVSGGYTMP-------------
MLBr_02565|M.leprae_Br4923 IAYFAI-PASNAVTGNVIRVCGQAMLGA------------
:: : * : :