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VVNDVVFRPVRGGNIVEETVDRLVGAITLGVIPFGGQLPVERDLSQKLGVSRTTLRQAIRTLEERGVVEV RLGRGGGTFVRHRSTLPPAEEARARVVAMGDDLDDTLDYRQVLEPAAAELAARRRKPGAGEWLESLLSDT RPPTLAEYRINDARFHLAIAELAGVPSLTAAVADVEVRIAAPLALLPPWDDALERSDREHHALAYAIGRG NADEARQIMTEHLSCTAHLLRDLRLPSPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1117 | - | - | 100% (239) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2599 | - | 8e-36 | 41.48% (229) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6700 | - | 2e-26 | 38.39% (211) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0505 | - | 4e-15 | 38.76% (129) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4061 | - | 7e-38 | 41.92% (229) | regulatory protein GntR, HTH |
| M. tuberculosis H37Rv | Rv0494 | - | 4e-15 | 38.76% (129) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4644c | - | 3e-13 | 31.48% (216) | GntR family transcriptional regulator |
| M. marinum M | MMAR_1630 | - | 3e-14 | 28.93% (197) | transcriptional regulatory protein |
| M. avium 104 | MAV_2560 | - | 2e-14 | 32.54% (209) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_1959 | - | 3e-14 | 30.17% (242) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (GNTR-FAMILY) |
| M. ulcerans Agy99 | MUL_4564 | - | 3e-14 | 33.10% (145) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2282 | - | 3e-36 | 41.13% (231) | regulatory protein GntR, HTH |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4061|M.gilvum_PYR-GCK -MAAPDPADS------------------------------SD--------
Mvan_2282|M.vanbaalenii_PYR-1 MSAVPEPTDERLREEQTASDERLREEQTASDERLREEQTASDGADATAEQ
MSMEG_1117|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 ----------------------------------------------MVEP
Rv0494|M.tuberculosis_H37Rv ----------------------------------------------MVEP
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1959|M.thermoresistible__bu --------------------------------------------------
MMAR_1630|M.marinum_M -------------------------------------------------M
MAV_2560|M.avium_104 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK -ASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPPERELAARLGV
Mvan_2282|M.vanbaalenii_PYR-1 IAADALLRPVRPLNAFEDTVERLLQTIRLGVLRPGESLPPERELATRLGV
MSMEG_1117|M.smegmatis_MC2_155 MVNDVVFRPVRGGNIVEETVDRLVGAITLGVIPFGGQLPVERDLSQKLGV
Mb0505|M.bovis_AF2122/97 MNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGV
Rv0494|M.tuberculosis_H37Rv MNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGV
MUL_4564|M.ulcerans_Agy99 MNQSSILQPPDRQRVDEQIATSIADAILDGVFPPGSALPPERELAEQLGV
MAB_4644c|M.abscessus_ATCC_199 -----MHPRLSSQSLAEQVANILAAQIGDGRWSTGAKLPGEVALCEEFGV
TH_1959|M.thermoresistible__bu ----MALQPVNRRSVPEDVFDQIVGEVLSGQMQPGDALPSERRLAEVLGV
MMAR_1630|M.marinum_M GQLSVEPDVIRADKRAARVARHIEAEIVRRGWTVGASLGSEGALQQRYGV
MAV_2560|M.avium_104 ----MEVTSLREPKMADRVATVLRRMFIRGEITEGTMLPPESELMERFGV
: . * * * * **
Mflv_4061|M.gilvum_PYR-GCK SRDTVREAIKSLADAGYLVSRRGRY-GGTFLAD--ALP---APRADGTEM
Mvan_2282|M.vanbaalenii_PYR-1 SRDTVREAIKSLADAGYLVSRRGRY-GGTFIAD--ALP---APRTGDVAF
MSMEG_1117|M.smegmatis_MC2_155 SRTTLRQAIRTLEERGVVEVRLGRG-GGTFVRHRSTLPPAEEARARVVAM
Mb0505|M.bovis_AF2122/97 NRTSLRQGLARLQQMGLIEVRHG---SGSVVRDPEGLTHPAVVEALVRKL
Rv0494|M.tuberculosis_H37Rv NRTSLRQGLARLQQMGLIEVRHG---SGSVVRDPEGLTHPAVVEALVRKL
MUL_4564|M.ulcerans_Agy99 NRTSLRQGLARLQQMGLIETRQG---SGNVVRDPQSLTHPAVVEALVRKL
MAB_4644c|M.abscessus_ATCC_199 SRATVREAIRDLKTKGLVSTRQG---AGVFVTSDRPLG------QWDRVL
TH_1959|M.thermoresistible__bu SRPAVREALKRLSAAGLVEVRQGEITTVRDYRRHAGLDLLPRLLFRAGEL
MMAR_1630|M.marinum_M SRSVLREAVRLVEHHQVARMRRGPN-GGLLICAPDAGPATRAVVIYLEYL
MAV_2560|M.avium_104 SRPTLREAFRVLESESLIQVQRGVR-GGARVTRPRRETLARYAGLILEYE
.* :*:.. : : *
Mflv_4061|M.gilvum_PYR-GCK HRDDIDDAVRLREILEVGAARMAAVRTLAAVEREALRSRLTDVRGADPAD
Mvan_2282|M.vanbaalenii_PYR-1 SRTDIDDALRLREILETGAARMAACRTLSATEREALWSRLLDVRGAAPQD
MSMEG_1117|M.smegmatis_MC2_155 G-DDLDDTLDYRQVLEPAAAELAARRRKPGAG-EWLESLLSDTRPPTLAE
Mb0505|M.bovis_AF2122/97 GPDFLVELLEIRAALGPLIGRLAAARS-TPEDAEALCAALEVVQQADTAA
Rv0494|M.tuberculosis_H37Rv GPDFLVELLEIRAALGPLIGRLAAARS-TPEDAEALCAALEVVQQADTAA
MUL_4564|M.ulcerans_Agy99 GPDFLVEVLEIRAALGPLIGRLAAERN-SSEDAEALRAALAEVADADTAP
MAB_4644c|M.abscessus_ATCC_199 AAAEIDAVVEIRRLLEVQAAGLAAERRNRSDVAAIRRALVARAKAESAGD
TH_1959|M.thermoresistible__bu DVTVVRSILETRLHNGPKVAELAARRRPPGLGALLDEAVQTLAAETDPVE
MMAR_1630|M.marinum_M G-ITLGELLDARLVFEPLAASLAAEHIDEAGIDRLRAVLRAEEQRKPGLP
MAV_2560|M.avium_104 G-VTVKDVYDARVTLEVPMVEQLAKDRNPKVIAELEQIVERESQLNPGSE
: * *
Mflv_4061|M.gilvum_PYR-GCK YR---RLDSRLHLAIAEAAGVPSLVPLVAQNR-----MRLNELLDRIPLM
Mvan_2282|M.vanbaalenii_PYR-1 YR---RLDSRLHLAITEAAGVPSLVPLVAQNR-----MRLNEMLDCIPLL
MSMEG_1117|M.smegmatis_MC2_155 YR---INDARFHLAIAELAGVPSLTAAVADVE-----VRIAAPLALLPPW
Mb0505|M.bovis_AF2122/97 ARQ--AADLAYFRVLIHSTRNRALGLLYRWVE-----HAFGGREHALTGA
Rv0494|M.tuberculosis_H37Rv ARQ--AADLAYFRVLIHSTRNRALGLLYRWVE-----HAFGGREHALTGA
MUL_4564|M.ulcerans_Agy99 ARQ--AADLAYFRVLIHGTRNRALGLLYRWVE-----QAFGGREHDLTGA
MAB_4644c|M.abscessus_ATCC_199 DIEYVDADLEFHRAVVAAVHNPLLDELFDSFS-----VRMREAMLALLAG
TH_1959|M.thermoresistible__bu RQR---HALRFWDHVVDGADSIAFRLMYNTLR-----ATYEPALPALATM
MMAR_1630|M.marinum_M AVR-----DEFHVALARQSKNPVLQLFIEILMRLTRRYALTSRTDTVAEA
MAV_2560|M.avium_104 AVD---QLTDFHAAIARLSGNSTLQIVSDMLHHIIEKANRSLQPTKGTRA
: :
Mflv_4061|M.gilvum_PYR-GCK TRNIAHSDEQHEAIVSAILAGDADTAAQTMAAHVWGSAALLHGFLD----
Mvan_2282|M.vanbaalenii_PYR-1 PRNIAHSDEQHEAIVMAILAGDADGAAQTMAAHVWGSAALLHGFLD----
MSMEG_1117|M.smegmatis_MC2_155 DDALERSDREHHALAYAIGRGNADEARQIMTEHLSCTAHLLRDLRLPSPS
Mb0505|M.bovis_AF2122/97 YDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRDRA-
Rv0494|M.tuberculosis_H37Rv YDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRDRA-
MUL_4564|M.ulcerans_Agy99 YEDADPVIADLTAINDAVLAGDPETAAAAVEGYLNASALRMIMCYRAAYA
MAB_4644c|M.abscessus_ATCC_199 SAERPHDQEHHQWLFDAIVDGSTRRAVELATDQLQHVRMR----------
TH_1959|M.thermoresistible__bu MAAEVGRPQAYRALAAAIEAGDPTAAEQSARDLLEPATAALLSALDELEA
MMAR_1630|M.marinum_M FEAVDQMHNDHAAIAAAVTAGDSARAKTLSEQHVQQVTGWLQQHQPGGDA
MAV_2560|M.avium_104 EQAVRRSAKTHRMVLDMIKEGDAEKAGELWKRHLQKAEEFVLTGAELSTV
: : *.. * :
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1117|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 GEDPER--------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1959|M.thermoresistible__bu QK------------------------------------------------
MMAR_1630|M.marinum_M KLAHVPRRSLRLDSETPPGKLAEVLAATIADDIAASGWQLDSVFGTETAL
MAV_2560|M.avium_104 VDLLE---------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1117|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1959|M.thermoresistible__bu --------------------------------------------------
MMAR_1630|M.marinum_M LQRYRVSRAALREAVRLLEYHSVARMRRGPGGGLVVTKPQSQASIDTIAL
MAV_2560|M.avium_104 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1117|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1959|M.thermoresistible__bu --------------------------------------------------
MMAR_1630|M.marinum_M YLQYRQPSREDLRCVRDAIEIANVAKVVEQRARPEVASVLDELVVASDFA
MAV_2560|M.avium_104 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1117|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1959|M.thermoresistible__bu --------------------------------------------------
MMAR_1630|M.marinum_M FEDAADAARKVAVEEFGFHVGLAQLAGNALLDLFLRIIVELFQRHWSSTE
MAV_2560|M.avium_104 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK -----------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 -----------------------------------------------
MSMEG_1117|M.smegmatis_MC2_155 -----------------------------------------------
Mb0505|M.bovis_AF2122/97 -----------------------------------------------
Rv0494|M.tuberculosis_H37Rv -----------------------------------------------
MUL_4564|M.ulcerans_Agy99 -----------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 -----------------------------------------------
TH_1959|M.thermoresistible__bu -----------------------------------------------
MMAR_1630|M.marinum_M HQQPTFNDVGAVEHAHQRIREAIIAGDDSLARYRIRRHLDAAASWWL
MAV_2560|M.avium_104 -----------------------------------------------