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VTEQRDPVTTRRARVAVAALFLTNGAIFANLLPRYPEIKTDLQLSNATYGAAVAAFSAGALIAGLTAGAL IRRFRSSRVGVTLTVALAVFVFAAGLAPTPILFAGALFLAGACDSIVDVAQNAHGLRVQREYGRSIINSL HAVWAIGAVLGGLTGAATIAMHIPRGVHLAAIAVVFSIVALAAFRFLLPGDDHDDHPAAHAPAGLRAGPR TYLILLALVVIAIAGATVEDAGSSWATLYLRDTLHTPPAVAAFGYIALVGFMFIGRMIGDRLVDRFGETA VVRAGGLIAAVGMGAALAFPSTAGSIAGFAAAGFGVATLIPAAMHAADQLPGLRPGTGLTAVTWLMRVGF FGAPLLVGVVADAAGLRAGLLVVPAAGVLAIVLAGALRPHRVSVGDAGQLDREHT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3671 | - | - | 100% (406) | integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_2137 | - | 4e-12 | 25.07% (379) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_0232 | - | 2e-09 | 26.73% (404) | sugar transporter family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1282 | - | 6e-05 | 27.07% (181) | drug-transport integral membrane protein |
| M. gilvum PYR-GCK | Mflv_3420 | - | 1e-149 | 69.50% (377) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1250 | - | 6e-05 | 27.07% (181) | drug-transport integral membrane protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-05 | 21.53% (367) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_4138c | - | 4e-38 | 29.95% (384) | putative major facilitator superfamily protein |
| M. marinum M | MMAR_0690 | - | 3e-10 | 24.50% (404) | putative transport protein |
| M. avium 104 | MAV_4712 | - | 2e-41 | 31.40% (379) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_3240 | - | 1e-142 | 67.45% (381) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0354 | - | 1e-07 | 23.14% (376) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3174 | - | 1e-152 | 73.47% (377) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3420|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------------------
TH_3240|M.thermoresistible__bu --------------------------------------------------
Mb1282|M.bovis_AF2122/97 --------------------------------------------------
Rv1250|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4138c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4712|M.avium_104 --------------------------------------------------
MMAR_0690|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 -------------------------------------------------M
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
Mflv_3420|M.gilvum_PYR-GCK ---------------------MDAILHRPRAARDLKGAWVGSHLMASDAR
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------MAPEPLGSGEAR
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------MVTEQR--DPVT
TH_3240|M.thermoresistible__bu --------------------------------------MASGRVESRTRQ
Mb1282|M.bovis_AF2122/97 -------------------------------------MTTAIRRAAGSSY
Rv1250|M.tuberculosis_H37Rv -------------------------------------MTTAIRRAAGSSY
MAB_4138c|M.abscessus_ATCC_199 ------------------------MLLAEVAVGGARSLAQRRGEDYFLTK
MAV_4712|M.avium_104 ----------------------------------MTDSSPPAKGTFTVEM
MMAR_0690|M.marinum_M ----------------------------------------------MTDS
MLBr_01562|M.leprae_Br4923 VTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRFP
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
Mflv_3420|M.gilvum_PYR-GCK IRRARAASAALFLTNGALFAN---LLPRFPEIKSDLAMSNAGYGAAVAAF
Mvan_3174|M.vanbaalenii_PYR-1 NRRARIAVAALFLTNGALFAN---LLPRYPEIKADLAMSNAAYGAAVASF
MSMEG_3671|M.smegmatis_MC2_155 TRRARVAVAALFLTNGAIFAN---LLPRYPEIKTDLQLSNATYGAAVAAF
TH_3240|M.thermoresistible__bu HQRARRAVAVLFLTNGALFAN---LLPRYPEIKTDLALSNTGYGVTIAAF
Mb1282|M.bovis_AF2122/97 FRNPWPALWAMMVGFFMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAY
Rv1250|M.tuberculosis_H37Rv FRNPWPALWAMMVGFFMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAY
MAB_4138c|M.abscessus_ATCC_199 PLRMRVAVIGVFASFGLVVAT---WAVHLPTMKQATGMSSTELGFVVLGL
MAV_4712|M.avium_104 LSRAKRGVTAVFVAHGLLFAS---WAAHIPQVKAGLGLDDAALGTALFGA
MMAR_0690|M.marinum_M SRRVVLAAVGFTFFIDMLVYG--IVVPVLPRLAKPAGLEFLGVGVVFACY
MLBr_01562|M.leprae_Br4923 SGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITAY
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
. . . . :
Mflv_3420|M.gilvum_PYR-GCK SAGALLAGPAAGALIRRFQSARVAVVTTVALASLIVTAAVAPTPLVFAAT
Mvan_3174|M.vanbaalenii_PYR-1 SAGALLAGPTAAALIRRFQSSRVALATTVALAVLIVVAGLAGTPLLFAVA
MSMEG_3671|M.smegmatis_MC2_155 SAGALIAGLTAGALIRRFRSSRVGVTLTVALAVFVFAAGLAPTPILFAGA
TH_3240|M.thermoresistible__bu SAGALTAGLTAAMLIRRFRSARVAVVGTLVLAAAVLAAGLAGTAPVLGAA
Mb1282|M.bovis_AF2122/97 LLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLSSGAGMLIAA
Rv1250|M.tuberculosis_H37Rv LLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLSSGAGMLIAA
MAB_4138c|M.abscessus_ATCC_199 GVGALLGMQLSGVLVDRFGSGPIAIVGGAAMALGVNIPLAAHTVWVAGVG
MAV_4712|M.avium_104 PLGSVLATLAGHWALPRWGSHRLIPVTVAGYAAAGTTVGLARSGPALFAA
MMAR_0690|M.marinum_M GLAYFVLTPVAGWLIDRRGSRSVFLSGAIILMLATLAFGYASSPVGLVTC
MLBr_01562|M.leprae_Br4923 VLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVIA
MUL_0354|M.ulcerans_Agy99 GVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAGVLVGMAEARSVAALLVG
:
Mflv_3420|M.gilvum_PYR-GCK LLFAGASDAITDVAQNVNALRVQRN-YGR-SIINS-LHAIWAAGAITGGL
Mvan_3174|M.vanbaalenii_PYR-1 LFAAGACDAVTDVAQNVNGLRLQRN-YGR-SIINS-LHAVWAVGAIVGGL
MSMEG_3671|M.smegmatis_MC2_155 LFLAGACDSIVDVAQNAHGLRVQRE-YGR-SIINS-LHAVWAIGAVLGGL
TH_3240|M.thermoresistible__bu LFVAGAADAVTDVAQNAHGLRVQRA-YGR-SIINS-FHAVWSVGALFGGL
Mb1282|M.bovis_AF2122/97 RVVQGVGAGLLTPQTLSTITRIFPA-HRRGVALGA-WGTVASVASLVGPL
Rv1250|M.tuberculosis_H37Rv RVVQGVGAGLLTPQTLSTITRIFPA-HRRGVALGA-WGTVASVASLVGPL
MAB_4138c|M.abscessus_ATCC_199 AVLCGVTVGITDVAMNAAAVDVERF-YGR-PIMAS-FHGVFSVGNVVGAG
MAV_4712|M.avium_104 LALWGMFQGALDVAMNTQAGTVERR-AGA-PMMAR-FHGMWSLGTLAGAL
MMAR_0690|M.marinum_M RVLQGGAAAATWVAGYATLVEIFPR-EQRGRAVGL-ASIGTALGALLGPA
MLBr_01562|M.leprae_Br4923 RLLQGIGSAIASPTGLALVATTFSKGSARNTATAV-FAAMTAIGSVMGLV
MUL_0354|M.ulcerans_Agy99 AMITGVVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGRAITGG
* : .
Mflv_3420|M.gilvum_PYR-GCK MGAGAIALGVPRAIHLVV-AAVLFCAIVCAAYPYLLKGPDHDDHPSARDG
Mvan_3174|M.vanbaalenii_PYR-1 MGAGAIALQIPRPIHLAA-AAVLFCGVVLAAYPSLLHGPDHDDHPSTRNT
MSMEG_3671|M.smegmatis_MC2_155 TGAATIAMHIPRGVHLAA-IAVVFSIVALAAFRFLLPGDDHDDHPAAHAP
TH_3240|M.thermoresistible__bu MGGTAVALNIPRSVHLAV-AAVLFSVVVLVGYRFLLPGEDHDDRAHGVRN
Mb1282|M.bovis_AF2122/97 AGGALVDSMGWEWIFFVN-VPVGVIGLILAAY--LIPALPHHPHRFDWFG
Rv1250|M.tuberculosis_H37Rv AGGALVDSMGWEWIFFVN-VPVGVIGLILAAY--LIPALPHHPHRFDWFG
MAB_4138c|M.abscessus_ATCC_199 IGSAAFALHLKVWATVLG-VTVLCLALLTCSASVLLRGKLRAGEVEAPDT
MAV_4712|M.avium_104 IGAACVGAGIGLTAQLTV-LGAVVLLVVVMLTRRLLPDAADSVAAPPEPA
MMAR_0690|M.marinum_M LGGLAYEASGPHAPFLGA-AGLSALAVAALAASLPQAAGGQASGPGMWSG
MLBr_01562|M.leprae_Br4923 VGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAILA
MUL_0354|M.ulcerans_Agy99 VGGLLAAWSGVPVLFWIN--AVACALLALVAARCIPATAHRPPVAPAVHV
*. :
Mflv_3420|M.gilvum_PYR-GCK GTARVGPMVYLTL-------------------------------------
Mvan_3174|M.vanbaalenii_PYR-1 DGSGVRAVVLLTL-------------------------------------
MSMEG_3671|M.smegmatis_MC2_155 AGLRAGPRTYLIL-------------------------------------
TH_3240|M.thermoresistible__bu PGPRSGLRVYAIL-------------------------------------
Mb1282|M.bovis_AF2122/97 VGLSGAGMFLIVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAR
Rv1250|M.tuberculosis_H37Rv VGLSGAGMFLIVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAR
MAB_4138c|M.abscessus_ATCC_199 VPYTMPPPVSYRRG------------------------------------
MAV_4712|M.avium_104 AGRRVTPAVAILA-------------------------------------
MMAR_0690|M.marinum_M ERAFPGLAVPWLVAG-----------------------------------
MLBr_01562|M.leprae_Br4923 TLACTAAVFAFSMGPEKGWISLTTIGSG----------------------
MUL_0354|M.ulcerans_Agy99 RAAHNSYRRAFSDGR-----------------------------------
Mflv_3420|M.gilvum_PYR-GCK -------------LALVALAMAGATVEDAGSSWATLYLRDELG-------
Mvan_3174|M.vanbaalenii_PYR-1 -------------LALVGIAVAGATVEDAGSSWATLYLRDSLG-------
MSMEG_3671|M.smegmatis_MC2_155 -------------LALVVIAIAGATVEDAGSSWATLYLRDTLH-------
TH_3240|M.thermoresistible__bu -------------AALVGIAVAGAVIEDAGSTWAILYLRDNLT-------
Mb1282|M.bovis_AF2122/97 EPLIPLEVFNDRNFSLSNLGIAIIAFAGTGMMLPVTFYAQAVCGLSPTHT
Rv1250|M.tuberculosis_H37Rv EPLIPLEVFNDRNFSLSNLRIAIIAFAGTGMMLPVTFYAQAVCGLSPTHT
MAB_4138c|M.abscessus_ATCC_199 -----------QVVVLGLLAFLLMLSEGSATDWSSLHAQEHLG-------
MAV_4712|M.avium_104 -----------------AVSFASFLCEGAATDWSATYLRDVVG-------
MMAR_0690|M.marinum_M ---------------LAVGLALGAVEATLPIDLVARFDASGVTVG-----
MLBr_01562|M.leprae_Br4923 ---------LVALVAAIAFAVVERTAENPVVPFDLFRDRNRLVTFIAIFL
MUL_0354|M.ulcerans_Agy99 -----------LVLLFASSLATLTAVRGLYATVPMLMADSGLGAG-----
. :
Mflv_3420|M.gilvum_PYR-GCK -------------------------APGAVAAFGY---------------
Mvan_3174|M.vanbaalenii_PYR-1 -------------------------APGAVAVMGY---------------
MSMEG_3671|M.smegmatis_MC2_155 -------------------------TPPAVAAFGY---------------
TH_3240|M.thermoresistible__bu -------------------------APPAVAVSGY---------------
Mb1282|M.bovis_AF2122/97 AVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLGFGFSVLAIAMTWLLCEMA
Rv1250|M.tuberculosis_H37Rv AVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLGFGFSVLAIAMTWLLCEMA
MAB_4138c|M.abscessus_ATCC_199 -------------------------ASHSEGAFAFG--------------
MAV_4712|M.avium_104 -------------------------AGPSVAAASY---------------
MMAR_0690|M.marinum_M -------------------------LLFALTTVAF---------------
MLBr_01562|M.leprae_Br4923 AG-------------GVIFSLTVSIGLYIQDILGYSALRAGIG-------
MUL_0354|M.ulcerans_Agy99 ---------------------EFGWAQVANAAAGIG--------------
.
Mflv_3420|M.gilvum_PYR-GCK --------------VALVGFLFVGRLIGDRLVDRYGDRAVARAGGMITAV
Mvan_3174|M.vanbaalenii_PYR-1 --------------IALVGFMFIGRMTGDRLVDRFGERAVARSGGLITAA
MSMEG_3671|M.smegmatis_MC2_155 --------------IALVGFMFIGRMIGDRLVDRFGETAVVRAGGLIAAV
TH_3240|M.thermoresistible__bu --------------LALAGGMLIGRMTGDRLVDRFGERAVVRTGALLIAA
Mb1282|M.bovis_AF2122/97 PGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGASSGVFNAVR
Rv1250|M.tuberculosis_H37Rv PGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGASSGVFNAVR
MAB_4138c|M.abscessus_ATCC_199 ---------------VFMLAMTVGRFTVDKLVERVGRVRVLRGGCALAAV
MAV_4712|M.avium_104 --------------AAYTLTMVVTRFAAGRLHARLPSRRLLPALAVLAVA
MMAR_0690|M.marinum_M ----------------IVTSQYAGRLSDAGRRAPVLAAGWVTLGVALAVM
MLBr_01562|M.leprae_Br4923 -------------FIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMV
MUL_0354|M.ulcerans_Agy99 --------------LTPVITPWLGRKVAARINPRLDILAIAGGWTALTMA
Mflv_3420|M.gilvum_PYR-GCK GMG-------IALAFPTVPGTIVGFAAAGLG-------------------
Mvan_3174|M.vanbaalenii_PYR-1 GMG-------AALAFPSVPGTIAGFAAAGLG-------------------
MSMEG_3671|M.smegmatis_MC2_155 GMG-------AALAFPSTAGSIAGFAAAGFG-------------------
TH_3240|M.thermoresistible__bu GMG-------GALAVPTVPGTIGGFAAAGLG-------------------
Mb1282|M.bovis_AF2122/97 QLG-------AVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQL
Rv1250|M.tuberculosis_H37Rv QLG-------AVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQL
MAB_4138c|M.abscessus_ATCC_199 GML-------TVIAAPVLPLTLAGWVAVGLG-------------------
MAV_4712|M.avium_104 GMS-------VTLATADAAAGVLGFAALGVG-------------------
MMAR_0690|M.marinum_M GVP-------SAVGIQAAALVLLG---AGLG-------------------
MLBr_01562|M.leprae_Br4923 AMLYGWA--FMNRGVPYFPNLLAPIVVGGIG-------------------
MUL_0354|M.ulcerans_Agy99 GAALAHTTFGFAIAVAASAAGEIAWFVIAVG-------------------
. . .
Mflv_3420|M.gilvum_PYR-GCK ---VATVIPAAMRTADELPGLRPGTGLTMLTWLMRIG-------------
Mvan_3174|M.vanbaalenii_PYR-1 ---VATVIPAAMRAADELPGLRAGTGLTVLTWLMRVG-------------
MSMEG_3671|M.smegmatis_MC2_155 ---VATLIPAAMHAADQLPGLRPGTGLTAVTWLMRVG-------------
TH_3240|M.thermoresistible__bu ---VATLIPAAMHGADQLPGIRAGTGLMAVTWLMRVG-------------
Mb1282|M.bovis_AF2122/97 PEFVREPFAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESD
Rv1250|M.tuberculosis_H37Rv PEFVREPFAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESD
MAB_4138c|M.abscessus_ATCC_199 ---LAGGVPQVFTVAGNIDEQHEGRVLSRVVGTGYVA-------------
MAV_4712|M.avium_104 ---VALLVPTAFSAAYGARGAGSAIAIVAATGW--LG-------------
MMAR_0690|M.marinum_M --AMIATIMPALADAMESAGGAQRPGTAAAAYNLAFSAG-----------
MLBr_01562|M.leprae_Br4923 --IGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQSLGGPLVLAVIQAVIT
MUL_0354|M.ulcerans_Agy99 ---TVHRIAPPASGGRYHGIWSMTLAIASVVAPIVSSCS-----------
.
Mflv_3420|M.gilvum_PYR-GCK --------------------FLGAPLIVGVVADAVSLRA----GLLSVPI
Mvan_3174|M.vanbaalenii_PYR-1 --------------------FLGAPLIVGVVADATSLRA----GLLTVPV
MSMEG_3671|M.smegmatis_MC2_155 --------------------FFGAPLLVGVVADAAGLRA----GLLVVPA
TH_3240|M.thermoresistible__bu --------------------FLASPPVVGAIADATSLRV----GLLGVPL
Mb1282|M.bovis_AF2122/97 GDADDDDYVEYILRREPEEDCDTQPLRASRPAAAAASRS----GAGGPLA
Rv1250|M.tuberculosis_H37Rv GDADDDDYVEYILRREPEEDCDTQPLRASRPAAAAASRS----GAGGPLA
MAB_4138c|M.abscessus_ATCC_199 --------------------VLGGPALIGWVADALSLNT----ALVLPIF
MAV_4712|M.avium_104 --------------------YLLGPPLIGHLSEWVGLSG----ALVTIPV
MMAR_0690|M.marinum_M --------------------TVAGGPLAGWMADLRSFQD----AAMLIAV
MLBr_01562|M.leprae_Br4923 SRTLYLG-------------GTTGPVKFMNDAQLRALDHGYTYGLLWVAG
MUL_0354|M.ulcerans_Agy99 -------------------LTHGGHRLVALVTVTVGLAG---AALCLPLN
: . .
Mflv_3420|M.gilvum_PYR-GCK AGIAIIALAAALLTARRRR---------------
Mvan_3174|M.vanbaalenii_PYR-1 AGAALVVLAGVLGSRCRG----------------
MSMEG_3671|M.smegmatis_MC2_155 AGVLAIVLAGALRPHRVSVGDAGQLDREHT----
TH_3240|M.thermoresistible__bu AGLVAAVLAGVLSGRRRTPRW-------------
Mb1282|M.bovis_AF2122/97 VSWSTSAQGMPPGPPGRRAWQADTESTAPSAL--
Rv1250|M.tuberculosis_H37Rv VSWSTSAQGMPPGPPGRRAWQADTESTAPSAL--
MAB_4138c|M.abscessus_ATCC_199 AVVICGCAAGALAVTPPSKSVKPPR---------
MAV_4712|M.avium_104 MMTIVAVAIRYTPAFDTADEFHRAPAG-------
MMAR_0690|M.marinum_M VTLTCGVLAALVHAAVVRRAVSDA----------
MLBr_01562|M.leprae_Br4923 AVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL
MUL_0354|M.ulcerans_Agy99 RSGDVGVRDSQYTAVAAAA---------------