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DAILHRPRAARDLKGAWVGSHLMASDARIRRARAASAALFLTNGALFANLLPRFPEIKSDLAMSNAGYGA AVAAFSAGALLAGPAAGALIRRFQSARVAVVTTVALASLIVTAAVAPTPLVFAATLLFAGASDAITDVAQ NVNALRVQRNYGRSIINSLHAIWAAGAITGGLMGAGAIALGVPRAIHLVVAAVLFCAIVCAAYPYLLKGP DHDDHPSARDGGTARVGPMVYLTLLALVALAMAGATVEDAGSSWATLYLRDELGAPGAVAAFGYVALVGF LFVGRLIGDRLVDRYGDRAVARAGGMITAVGMGIALAFPTVPGTIVGFAAAGLGVATVIPAAMRTADELP GLRPGTGLTMLTWLMRIGFLGAPLIVGVVADAVSLRAGLLSVPIAGIAIIALAAALLTARRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3420 | - | - | 100% (414) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_5163 | - | 4e-08 | 27.33% (333) | protein of unknown function DUF894, DitE |
| M. gilvum PYR-GCK | Mflv_1033 | - | 9e-06 | 29.55% (247) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0872 | - | 3e-06 | 26.62% (154) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv0849 | - | 3e-06 | 26.62% (154) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 6e-09 | 21.77% (395) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_4138c | - | 1e-42 | 30.91% (385) | putative major facilitator superfamily protein |
| M. marinum M | MMAR_0690 | - | 1e-12 | 24.50% (400) | putative transport protein |
| M. avium 104 | MAV_4712 | - | 1e-39 | 30.16% (378) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_3671 | - | 1e-149 | 69.50% (377) | integral membrane protein |
| M. thermoresistible (build 8) | TH_3240 | - | 1e-133 | 62.66% (383) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0240 | - | 7e-06 | 23.50% (366) | hypothetical protein MUL_0240 |
| M. vanbaalenii PYR-1 | Mvan_3174 | - | 1e-168 | 77.66% (385) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3420|M.gilvum_PYR-GCK -------------------------MDAILHRPRAARDLKGAWVGSHLMA
Mvan_3174|M.vanbaalenii_PYR-1 ------------------------------------------MAPEPLGS
MSMEG_3671|M.smegmatis_MC2_155 ------------------------------------------MVTEQR--
TH_3240|M.thermoresistible__bu ------------------------------------------MASGRVES
Mb0872|M.bovis_AF2122/97 --------------------------------------------MGARAI
Rv0849|M.tuberculosis_H37Rv --------------------------------------------MGARAI
MAB_4138c|M.abscessus_ATCC_199 ----------------------------MLLAEVAVGGARSLAQRRGEDY
MAV_4712|M.avium_104 --------------------------------------MTDSSPPAKGTF
MMAR_0690|M.marinum_M -------------------------------------------------M
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MUL_0240|M.ulcerans_Agy99 ----------------------------------------MGARVRGVVL
Mflv_3420|M.gilvum_PYR-GCK SDARIRRARAASAALFLTNGALFANLLPRFPEIKSDLAMSNAGYGAAVAA
Mvan_3174|M.vanbaalenii_PYR-1 GEARNRRARIAVAALFLTNGALFANLLPRYPEIKADLAMSNAAYGAAVAS
MSMEG_3671|M.smegmatis_MC2_155 DPVTTRRARVAVAALFLTNGAIFANLLPRYPEIKTDLQLSNATYGAAVAA
TH_3240|M.thermoresistible__bu RTRQHQRARRAVAVLFLTNGALFANLLPRYPEIKTDLALSNTGYGVTIAA
Mb0872|M.bovis_AF2122/97 FRGFNRPSRVLMINQFGINIGFYMLMPYLADYLAGPLGLAAWAVGLVMGV
Rv0849|M.tuberculosis_H37Rv FRGFNRPSRVLMINQFGINIGFYMLMPYLADYLAGPLGLAAWAVGLVMGV
MAB_4138c|M.abscessus_ATCC_199 FLTKPLRMRVAVIGVFASFGLVVATWAVHLPTMKQATGMSSTELGFVVLG
MAV_4712|M.avium_104 TVEMLSRAKRGVTAVFVAHGLLFASWAAHIPQVKAGLGLDDAALGTALFG
MMAR_0690|M.marinum_M TDSSRRVVLAAVGFTFFIDMLVYGIVVPVLPRLAKPAGLEFLGVGVVFAC
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MUL_0240|M.ulcerans_Agy99 VTGRVRELAVGLTAGFIVYLDTTVLLVAFGAISASFPEASSSARSWVLDA
. .
Mflv_3420|M.gilvum_PYR-GCK FSAGALLAGPAAGALIRRFQSARVAVVTTVALASLIVTAAVAPTPLVFAA
Mvan_3174|M.vanbaalenii_PYR-1 FSAGALLAGPTAAALIRRFQSSRVALATTVALAVLIVVAGLAGTPLLFAV
MSMEG_3671|M.smegmatis_MC2_155 FSAGALIAGLTAGALIRRFRSSRVGVTLTVALAVFVFAAGLAPTPILFAG
TH_3240|M.thermoresistible__bu FSAGALTAGLTAAMLIRRFRSARVAVVGTLVLAAAVLAAGLAGTAPVLGA
Mb0872|M.bovis_AF2122/97 RNFSQQGMFFVGGTLADRFGYKPLIIAGCLIRTGGFALLVVAQSLPSVLI
Rv0849|M.tuberculosis_H37Rv RNFSQQGMFFVGGTLADRFGYKPLIIAGCLIRTGGFALLVVAQSLPSVLI
MAB_4138c|M.abscessus_ATCC_199 LGVGALLGMQLSGVLVDRFGSGPIAIVGGAAMALGVNIPLAAHTVWVAGV
MAV_4712|M.avium_104 APLGSVLATLAGHWALPRWGSHRLIPVTVAGYAAAGTTVGLARSGPALFA
MMAR_0690|M.marinum_M YGLAYFVLTPVAGWLIDRRGSRSVFLSGAIILMLATLAFGYASSPVGLVT
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
MUL_0240|M.ulcerans_Agy99 YFIVFAALMVPGGRWADQFGSRNVFAIGVSTFILSSVGCAVAPTLGALVA
. *
Mflv_3420|M.gilvum_PYR-GCK TLLFAGASDAITDVAQNVNALRVQRN-YGRSIINSLHAI-WAAGAITGGL
Mvan_3174|M.vanbaalenii_PYR-1 ALFAAGACDAVTDVAQNVNGLRLQRN-YGRSIINSLHAV-WAVGAIVGGL
MSMEG_3671|M.smegmatis_MC2_155 ALFLAGACDSIVDVAQNAHGLRVQRE-YGRSIINSLHAV-WAIGAVLGGL
TH_3240|M.thermoresistible__bu ALFVAGAADAVTDVAQNAHGLRVQRA-YGRSIINSFHAV-WSVGALFGGL
Mb0872|M.bovis_AF2122/97 AAAATGFAGALFNPAVRGYLAAEAGE-RKIEAFAMFNVF-YQSGILLGPL
Rv0849|M.tuberculosis_H37Rv AAAATGFAGALFNPAVRGYLAAEAGE-RKIEAFAMFNVF-YQSGILLGPL
MAB_4138c|M.abscessus_ATCC_199 GAVLCGVTVGITDVAMNAAAVDVERF-YGRPIMASFHGV-FSVGNVVGAG
MAV_4712|M.avium_104 ALALWGMFQGALDVAMNTQAGTVERR-AGAPMMARFHGM-WSLGTLAGAL
MMAR_0690|M.marinum_M CRVLQGGAAAATWVAGYATLVEIFPR-EQRGRAVGLASIGTALGALLGPA
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
MUL_0240|M.ulcerans_Agy99 ARAAQAVGAALMGPASLALILPYFGR-GSRATAVSLWGTSAALAAALGPP
. . : . . *
Mflv_3420|M.gilvum_PYR-GCK MGAGAIALGVPRAIHLVVAAVLFCAIVCAAYPYLLKGPDHDDHPS-----
Mvan_3174|M.vanbaalenii_PYR-1 MGAGAIALQIPRPIHLAAAAVLFCGVVLAAYPSLLHGPDHDDHPS-----
MSMEG_3671|M.smegmatis_MC2_155 TGAATIAMHIPRGVHLAAIAVVFSIVALAAFRFLLPGDDHDDHPA-----
TH_3240|M.thermoresistible__bu MGGTAVALNIPRSVHLAVAAVLFSVVVLVGYRFLLPGEDHDDRAH-----
Mb0872|M.bovis_AF2122/97 VGLVLLALDFRITVLAAAGVFGLLTVAQLVALPQHRADSEREKTS-----
Rv0849|M.tuberculosis_H37Rv VGLVLLALDFRITVLAAAGVFGLLTVAQLVALPQHRADSEREKTS-----
MAB_4138c|M.abscessus_ATCC_199 IGSAAFALHLKVWATVLGVTVLCLALLTCSASVLLRGKLRAGEVE-----
MAV_4712|M.avium_104 IGAACVGAGIGLTAQLTVLGAVVLLVVVMLTRRLLPDAADSVAAP-----
MMAR_0690|M.marinum_M LGGLAYEASGPHAPFLGAAGLSALAVAALAASLPQAAGGQASGPG-----
MLBr_01562|M.leprae_Br4923 VGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAILA
MUL_0240|M.ulcerans_Agy99 LGGFLADTVGWRGIFLINVPIGLAVLAGLRNVDNRGDAVAGQLVNTSAIV
*
Mflv_3420|M.gilvum_PYR-GCK ------ARDGGTARVGPMV-YLTLLALVA--LAMAGATVEDAGSSWAT--
Mvan_3174|M.vanbaalenii_PYR-1 ------TRNTDGSGVRAVV-LLTLLALVG--IAVAGATVEDAGSSWAT--
MSMEG_3671|M.smegmatis_MC2_155 ------AHAPAGLRAGPRT-YLILLALVV--IAIAGATVEDAGSSWAT--
TH_3240|M.thermoresistible__bu ------GVRNPGPRSGLRV-YAILAALVG--IAVAGAVIEDAGSTWAI--
Mb0872|M.bovis_AF2122/97 ------ILQDWRVVVRNRP-FLTLAAAMTGCYALSFQIYLALPMQASI--
Rv0849|M.tuberculosis_H37Rv ------ILQDWRVVVRNRP-FLTLAAAMTGCYALSFQIYLALPMQASI--
MAB_4138c|M.abscessus_ATCC_199 ------APDTVPYTMPPPVSYRRGQVVVLGLLAFLLMLSEGSATDWSS--
MAV_4712|M.avium_104 ------PEPAAGRRVTPAV-------AILAAVSFASFLCEGAATDWSA--
MMAR_0690|M.marinum_M ------MWSGERAFPGLAVPWLVAGLAVG---LALGAVEATLPIDLVA--
MLBr_01562|M.leprae_Br4923 TLAC--TAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP
MUL_0240|M.ulcerans_Agy99 LIASGVGALTAGILEGPSWGWGQRRTLLLLIAGAILLATAMVGVARHHRR
Mflv_3420|M.gilvum_PYR-GCK ----------------------------------LYLRDELGAPGAVAAF
Mvan_3174|M.vanbaalenii_PYR-1 ----------------------------------LYLRDSLGAPGAVAVM
MSMEG_3671|M.smegmatis_MC2_155 ----------------------------------LYLRDTLHTPPAVAAF
TH_3240|M.thermoresistible__bu ----------------------------------LYLRDNLTAPPAVAVS
Mb0872|M.bovis_AF2122/97 ----------------------------------LMPRNQYLLIAAMFAV
Rv0849|M.tuberculosis_H37Rv ----------------------------------LMPRNQYLLIAAMFAV
MAB_4138c|M.abscessus_ATCC_199 ----------------------------------LHAQEHLGASHSEGAF
MAV_4712|M.avium_104 ----------------------------------TYLRDVVGAGPSVAAA
MMAR_0690|M.marinum_M ----------------------------------RFDASGVTVGLLFALT
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI
MUL_0240|M.ulcerans_Agy99 AEPIHDFDKGRFFAANAATAIFGAGFYGLLLAVVFFLTSHWHYSTFEAGL
.
Mflv_3420|M.gilvum_PYR-GCK GYVALVGFLFVGRLIGDRLVDRYGDRAVARAGGMITAVGMGIALAFP---
Mvan_3174|M.vanbaalenii_PYR-1 GYIALVGFMFIGRMTGDRLVDRFGERAVARSGGLITAAGMGAALAFP---
MSMEG_3671|M.smegmatis_MC2_155 GYIALVGFMFIGRMIGDRLVDRFGETAVVRAGGLIAAVGMGAALAFP---
TH_3240|M.thermoresistible__bu GYLALAGGMLIGRMTGDRLVDRFGERAVVRTGALLIAAGMGGALAVP---
Mb0872|M.bovis_AF2122/97 SGLVAVGGQLR---ITRWFAVRWGAERSLVVGATILAASFIPVAVIPNGQ
Rv0849|M.tuberculosis_H37Rv SGLVAVGGQLR---ITRWFAVRWGAERSLVVGATILAASFIPVAVIPNGQ
MAB_4138c|M.abscessus_ATCC_199 AFGVFMLAMTVGRFTVDKLVERVGRVRVLRGGCALAAVGMLTVIAAP---
MAV_4712|M.avium_104 SYAAYTLTMVVTRFAAGRLHARLPSRRLLPALAVLAVAGMSVTLATA---
MMAR_0690|M.marinum_M TVAFIVTSQYAGRLSDAGRRAPVLAAGWVTLGVALAVMGVPSAVGIQ---
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
MUL_0240|M.ulcerans_Agy99 AMMPIFVAAALAAIPAGRIADARGHRWAVIPGCWVFALGVFLFWLLTTSR
: ..
Mflv_3420|M.gilvum_PYR-GCK ------TVPGTIVGFAAAGLGVATVIPAAMRTADELPG-LRPGTGLTMLT
Mvan_3174|M.vanbaalenii_PYR-1 ------SVPGTIAGFAAAGLGVATVIPAAMRAADELPG-LRAGTGLTVLT
MSMEG_3671|M.smegmatis_MC2_155 ------STAGSIAGFAAAGFGVATLIPAAMHAADQLPG-LRPGTGLTAVT
TH_3240|M.thermoresistible__bu ------TVPGTIGGFAAAGLGVATLIPAAMHGADQLPG-IRAGTGLMAVT
Mb0872|M.bovis_AF2122/97 RFGVAVAVMALVLSASLLAVASAALFPFEMRAVVALSGDRLVATHYGFYS
Rv0849|M.tuberculosis_H37Rv RFGVAVAVMALVLSASLLAVASAALFPFEMRAVVALSGDRLVATHYGFYS
MAB_4138c|M.abscessus_ATCC_199 ------VLPLTLAGWVAVGLGLAGGVPQVFTVAGNIDE-QHEGRVLSRVV
MAV_4712|M.avium_104 ------DAAAGVLGFAALGVGVALLVPTAFSAAYGARG---AGSAIAIVA
MMAR_0690|M.marinum_M -------AAALVLLGAGLGAMIATIMPALADAMESAGGAQRPGTAAAAYN
MLBr_01562|M.leprae_Br4923 ----VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIAL
MUL_0240|M.ulcerans_Agy99 ----ADYASRWLPGSILCGIGIRCVMPVLASAAIDAMPGQLLGTANALNS
: . . .
Mflv_3420|M.gilvum_PYR-GCK WLMRIG-----------------FLGAPLIVGVVADAVS-------LRAG
Mvan_3174|M.vanbaalenii_PYR-1 WLMRVG-----------------FLGAPLIVGVVADATS-------LRAG
MSMEG_3671|M.smegmatis_MC2_155 WLMRVG-----------------FFGAPLLVGVVADAAG-------LRAG
TH_3240|M.thermoresistible__bu WLMRVG-----------------FLASPPVVGAIADATS-------LRVG
Mb0872|M.bovis_AF2122/97 TIVGVG-----------------VLVGNLAIGSLMSAARRLNTDEIVWGG
Rv0849|M.tuberculosis_H37Rv TIVGVG-----------------VLVGNLAIGSLMSAARRLNTDEIVWGG
MAB_4138c|M.abscessus_ATCC_199 GTGYVA-----------------VLGGPALIGWVADALSLN---TALVLP
MAV_4712|M.avium_104 ATGWLG-----------------YLLGPPLIGHLSEWVG-------LSGA
MMAR_0690|M.marinum_M LAFSAG-----------------TVAGGPLAGWMADLRS-------FQDA
MLBr_01562|M.leprae_Br4923 MLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYG
MUL_0240|M.ulcerans_Agy99 MLRQFG-----------------AALGTAAVGTLLVERSGHSPIDVGSFR
. . .
Mflv_3420|M.gilvum_PYR-GCK LLSVPIAGIAIIALAAALLTARRRR-------------------------
Mvan_3174|M.vanbaalenii_PYR-1 LLTVPVAGAALVVLAGVLGSRCRG--------------------------
MSMEG_3671|M.smegmatis_MC2_155 LLVVPAAGVLAIVLAGALRPHRVSVGDAGQLDREHT--------------
TH_3240|M.thermoresistible__bu LLGVPLAGLVAAVLAGVLSGRRRTPRW-----------------------
Mb0872|M.bovis_AF2122/97 LILVGIVAVAGLRRLDTFTSGSQNMTGRWAAPR-----------------
Rv0849|M.tuberculosis_H37Rv LILVGIVAVAGLRRLDTFTSGSQNMTGRWAAPR-----------------
MAB_4138c|M.abscessus_ATCC_199 IFAVVICGCAAGALAVTPPSKSVKPPR-----------------------
MAV_4712|M.avium_104 LVTIPVMMTIVAVAIRYTPAFDTADEFHRAPAG-----------------
MMAR_0690|M.marinum_M AMLIAVVTLTCGVLAALVHAAVVRRAVSDA--------------------
MLBr_01562|M.leprae_Br4923 LLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL----------
MUL_0240|M.ulcerans_Agy99 VVWAFLGTLTIATIPFALRLIRPGVATTGRGAPTGSRRMRIATLAVSRST
.
Mflv_3420|M.gilvum_PYR-GCK -----------
Mvan_3174|M.vanbaalenii_PYR-1 -----------
MSMEG_3671|M.smegmatis_MC2_155 -----------
TH_3240|M.thermoresistible__bu -----------
Mb0872|M.bovis_AF2122/97 -----------
Rv0849|M.tuberculosis_H37Rv -----------
MAB_4138c|M.abscessus_ATCC_199 -----------
MAV_4712|M.avium_104 -----------
MMAR_0690|M.marinum_M -----------
MLBr_01562|M.leprae_Br4923 -----------
MUL_0240|M.ulcerans_Agy99 FRKKHLRANDQ