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LLAEVAVGGARSLAQRRGEDYFLTKPLRMRVAVIGVFASFGLVVATWAVHLPTMKQATGMSSTELGFVVL GLGVGALLGMQLSGVLVDRFGSGPIAIVGGAAMALGVNIPLAAHTVWVAGVGAVLCGVTVGITDVAMNAA AVDVERFYGRPIMASFHGVFSVGNVVGAGIGSAAFALHLKVWATVLGVTVLCLALLTCSASVLLRGKLRA GEVEAPDTVPYTMPPPVSYRRGQVVVLGLLAFLLMLSEGSATDWSSLHAQEHLGASHSEGAFAFGVFMLA MTVGRFTVDKLVERVGRVRVLRGGCALAAVGMLTVIAAPVLPLTLAGWVAVGLGLAGGVPQVFTVAGNID EQHEGRVLSRVVGTGYVAVLGGPALIGWVADALSLNTALVLPIFAVVICGCAAGALAVTPPSKSVKPPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4138c | - | - | 100% (420) | putative major facilitator superfamily protein |
| M. abscessus ATCC 19977 | MAB_3449c | - | 4e-09 | 23.45% (388) | putative transporter |
| M. abscessus ATCC 19977 | MAB_1299c | - | 4e-09 | 24.94% (401) | multidrug ABC transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 6e-07 | 26.42% (159) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_3420 | - | 2e-42 | 30.91% (385) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 6e-07 | 26.42% (159) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4785 | - | 5e-08 | 23.72% (409) | integral membrane protein |
| M. avium 104 | MAV_4712 | - | 1e-43 | 32.57% (393) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_3671 | - | 6e-38 | 29.95% (384) | integral membrane protein |
| M. thermoresistible (build 8) | TH_3240 | - | 3e-38 | 29.58% (382) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0354 | - | 7e-08 | 24.80% (371) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3174 | - | 5e-39 | 30.65% (385) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3420|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------------------
TH_3240|M.thermoresistible__bu --------------------------------------------------
MMAR_4785|M.marinum_M --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
Mb0805c|M.bovis_AF2122/97 --------------------------------------------------
Rv0783c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4712|M.avium_104 --------------------------------------------------
MAB_4138c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3420|M.gilvum_PYR-GCK ---------------------MDAILHRPRAARDLKGAWVGSHLMASDAR
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------MAPEPLGSGEAR
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------MVTEQR--DPVT
TH_3240|M.thermoresistible__bu --------------------------------------MASGRVESRTRQ
MMAR_4785|M.marinum_M -----------------------------MAAPLGGARPLGERAGGRHRP
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
Mb0805c|M.bovis_AF2122/97 ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS
Rv0783c|M.tuberculosis_H37Rv ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS
MAV_4712|M.avium_104 -------------------------------------MTDSSPPAKGTFT
MAB_4138c|M.abscessus_ATCC_199 ---------------------------MLLAEVAVGGARSLAQRRGEDYF
Mflv_3420|M.gilvum_PYR-GCK IRR---ARAASAALFLTNGALFANLLPRFPEIKSDLA---------MSNA
Mvan_3174|M.vanbaalenii_PYR-1 NRR---ARIAVAALFLTNGALFANLLPRYPEIKADLA---------MSNA
MSMEG_3671|M.smegmatis_MC2_155 TRR---ARVAVAALFLTNGAIFANLLPRYPEIKTDLQ---------LSNA
TH_3240|M.thermoresistible__bu HQR---ARRAVAVLFLTNGALFANLLPRYPEIKTDLA---------LSNT
MMAR_4785|M.marinum_M ARE---GYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAG------RGFAAA
MUL_0354|M.ulcerans_Agy99 ARE---GYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAG------RGFAAA
Mb0805c|M.bovis_AF2122/97 GQRSYPDRLDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQA
Rv0783c|M.tuberculosis_H37Rv GQRSYPDRLDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQA
MAV_4712|M.avium_104 VEMLSRAKRGVTAVFVAHGLLFASWAAHIPQVKAGLG---------LDDA
MAB_4138c|M.abscessus_ATCC_199 LTKPLRMRVAVIGVFASFGLVVATWAVHLPTMKQATG---------MSST
: :. :
Mflv_3420|M.gilvum_PYR-GCK GYGAAVAAFSAGALLAGPAAGALIRRFQS-ARVAVVTTVALASLIVTAAV
Mvan_3174|M.vanbaalenii_PYR-1 AYGAAVASFSAGALLAGPTAAALIRRFQS-SRVALATTVALAVLIVVAGL
MSMEG_3671|M.smegmatis_MC2_155 TYGAAVAAFSAGALIAGLTAGALIRRFRS-SRVGVTLTVALAVFVFAAGL
TH_3240|M.thermoresistible__bu GYGVTIAAFSAGALTAGLTAAMLIRRFRS-ARVAVVGTLVLAAAVLAAGL
MMAR_4785|M.marinum_M AVGAVLAAFGVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAGVLVGMAEA
MUL_0354|M.ulcerans_Agy99 AVGAVLAAFGVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAGVLVGMAEA
Mb0805c|M.bovis_AF2122/97 VVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVA
Rv0783c|M.tuberculosis_H37Rv VVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVA
MAV_4712|M.avium_104 ALGTALFGAPLGSVLATLAGHWALPRWGS-HRLIPVTVAGYAAAGTTVGL
MAB_4138c|M.abscessus_ATCC_199 ELGFVVLGLGVGALLGMQLSGVLVDRFGS-GPIAIVGGAAMALGVNIPLA
. .: . . . .
Mflv_3420|M.gilvum_PYR-GCK APTPLVFAATLLFAGASDAITDVAQNVNALRVQRNYGRSIINSLHAIWAA
Mvan_3174|M.vanbaalenii_PYR-1 AGTPLLFAVALFAAGACDAVTDVAQNVNGLRLQRNYGRSIINSLHAVWAV
MSMEG_3671|M.smegmatis_MC2_155 APTPILFAGALFLAGACDSIVDVAQNAHGLRVQREYGRSIINSLHAVWAI
TH_3240|M.thermoresistible__bu AGTAPVLGAALFVAGAADAVTDVAQNAHGLRVQRAYGRSIINSFHAVWSV
MMAR_4785|M.marinum_M RSVAALLVGAMITGMVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIV
MUL_0354|M.ulcerans_Agy99 RSVAALLVGAMITGVVYDAPRPVMGAAIAELIPEPSRRAKLDAWRFGWIV
Mb0805c|M.bovis_AF2122/97 PNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVGIPMLL
Rv0783c|M.tuberculosis_H37Rv PNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVGIPMLL
MAV_4712|M.avium_104 ARSGPALFAALALWGMFQGALDVAMNTQAGTVERRAGAPMMARFHGMWSL
MAB_4138c|M.abscessus_ATCC_199 AHTVWVAGVGAVLCGVTVGITDVAMNAAAVDVERFYGRPIMASFHGVFSV
* . :
Mflv_3420|M.gilvum_PYR-GCK G---------AITGGLMGAGAIALGVPRAIHL-VVAAVLFCAIVCAAYP-
Mvan_3174|M.vanbaalenii_PYR-1 G---------AIVGGLMGAGAIALQIPRPIHL-AAAAVLFCGVVLAAYP-
MSMEG_3671|M.smegmatis_MC2_155 G---------AVLGGLTGAATIAMHIPRGVHL-AAIAVVFSIVALAAFR-
TH_3240|M.thermoresistible__bu G---------ALFGGLMGGTAVALNIPRSVHL-AVAAVLFSVVVLVGYR-
MMAR_4785|M.marinum_M SIGR------AITGGVGGLLAAWSGVPVLFWINAVACALLALVAARCIP-
MUL_0354|M.ulcerans_Agy99 SIGR------AITGGVGGLLAAWSGVPVLFWINAVACALLALVAARCIP-
Mb0805c|M.bovis_AF2122/97 GPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASEN
Rv0783c|M.tuberculosis_H37Rv GPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASEN
MAV_4712|M.avium_104 G---------TLAGALIGAACVGAGIGLTAQLTVLGAVVLLVVVMLTRR-
MAB_4138c|M.abscessus_ATCC_199 G---------NVVGAGIGSAAFALHLKVWATVLGVTVLCLALLTCSASV-
. : *. : :
Mflv_3420|M.gilvum_PYR-GCK -----YLLKGPDHDDHPSARDGGTAR-VGPMVYLT--LLALVALAMAGAT
Mvan_3174|M.vanbaalenii_PYR-1 -----SLLHGPDHDDHPSTRNTDGSG-VRAVVLLT--LLALVGIAVAGAT
MSMEG_3671|M.smegmatis_MC2_155 -----FLLPGDDHDDHPAAHAPAGLR-AGPRTYLI--LLALVVIAIAGAT
TH_3240|M.thermoresistible__bu -----FLLPGEDHDDRAHGVRNPGPR-SGLRVYAI--LAALVGIAVAGAV
MMAR_4785|M.marinum_M -----ATAHRPPVAPAVHVRAARISY-RRAFSDGR--LVLLFASSLATLT
MUL_0354|M.ulcerans_Agy99 -----ATAHRPPVAPAVHVRAAHNSY-RRAFSDGR--LVLLFASSLATLT
Mb0805c|M.bovis_AF2122/97 FDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVL--IPAITGLALIAAF
Rv0783c|M.tuberculosis_H37Rv FDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVL--IPAITGLALIAAF
MAV_4712|M.avium_104 --------LLPDAADSVAAPPEPAAG---RRVTPA--VAILAAVSFASFL
MAB_4138c|M.abscessus_ATCC_199 ------LLRGKLRAGEVEAPDTVPYTMPPPVSYRRGQVVVLGLLAFLLML
: : :.
Mflv_3420|M.gilvum_PYR-GCK VEDAGSSWATLYLRDELGAPGAVAAFGYVALVG-------FLFVGRLIGD
Mvan_3174|M.vanbaalenii_PYR-1 VEDAGSSWATLYLRDSLGAPGAVAVMGYIALVG-------FMFIGRMTGD
MSMEG_3671|M.smegmatis_MC2_155 VEDAGSSWATLYLRDTLHTPPAVAAFGYIALVG-------FMFIGRMIGD
TH_3240|M.thermoresistible__bu IEDAGSTWAILYLRDNLTAPPAVAVSGYLALAG-------GMLIGRMTGD
MMAR_4785|M.marinum_M AVRGLYATVPMLMADSGLGAGEFGWTQVANAAAGI---GLTPVITPWLGR
MUL_0354|M.ulcerans_Agy99 AVRGLYATVPMLMADSGLGAGEFGWAQVANAAAGI---GLTPVITPWLGR
Mb0805c|M.bovis_AF2122/97 VAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQ
Rv0783c|M.tuberculosis_H37Rv VAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQ
MAV_4712|M.avium_104 CEGAATDWSATYLRDVVGAGPSVAAASYAAYTLT-------MVVTRFAAG
MAB_4138c|M.abscessus_ATCC_199 SEGSATDWSSLHAQEHLGASHSEGAFAFGVFMLA-------MTVGRFTVD
. . :
Mflv_3420|M.gilvum_PYR-GCK RLVDRYG--DRAVARA--GGMITAVGMGIALAFP-TVPGTIVGFAAAGLG
Mvan_3174|M.vanbaalenii_PYR-1 RLVDRFG--ERAVARS--GGLITAAGMGAALAFP-SVPGTIAGFAAAGLG
MSMEG_3671|M.smegmatis_MC2_155 RLVDRFG--ETAVVRA--GGLIAAVGMGAALAFP-STAGSIAGFAAAGFG
TH_3240|M.thermoresistible__bu RLVDRFG--ERAVVRT--GALLIAAGMGGALAVP-TVPGTIGGFAAAGLG
MMAR_4785|M.marinum_M KVAARINPRLDILAIA--GGWTALTMAGAALAHT-TFGFAIAVAASAPGE
MUL_0354|M.ulcerans_Agy99 KVAARINPRLDILAIA--GGWTALTMAGAALAHT-TFGFAIAVAASAAGE
Mb0805c|M.bovis_AF2122/97 VLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAG
Rv0783c|M.tuberculosis_H37Rv VLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAG
MAV_4712|M.avium_104 RLHARLP--SRRLLPA--LAVLAVAGMSVTLATA-DAAAGVLGFAALGVG
MAB_4138c|M.abscessus_ATCC_199 KLVERVG--RVRVLRG--GCALAAVGMLTVIAAP-VLPLTLAGWVAVGLG
: : : :
Mflv_3420|M.gilvum_PYR-GCK VATVIPAAMRTADELPGLRPGTGLTMLTWLMRIGFLGAPLIVGVVADAVS
Mvan_3174|M.vanbaalenii_PYR-1 VATVIPAAMRAADELPGLRAGTGLTVLTWLMRVGFLGAPLIVGVVADATS
MSMEG_3671|M.smegmatis_MC2_155 VATLIPAAMHAADQLPGLRPGTGLTAVTWLMRVGFFGAPLLVGVVADAAG
TH_3240|M.thermoresistible__bu VATLIPAAMHGADQLPGIRAGTGLMAVTWLMRVGFLASPPVVGAIADATS
MMAR_4785|M.marinum_M IAWFVIAAGIVHRIAPPASGGRYHGIWSMTLAIASVVAPIVSSCSLTHGG
MUL_0354|M.ulcerans_Agy99 IAWFVIAVGTVHRIAPPASGGRYHGIWSMTLAIASVVAPIVSSCSLTHGG
Mb0805c|M.bovis_AF2122/97 LGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQIA
Rv0783c|M.tuberculosis_H37Rv LGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQIA
MAV_4712|M.avium_104 VALLVPTAFSAAYGARG--AGSAIAIVAATGWLGYLLGPPLIGHLSEWVG
MAB_4138c|M.abscessus_ATCC_199 LAGGVPQVFTVAGNIDEQHEGRVLSRVVGTGYVAVLGGPALIGWVADALS
:. . * : . .. : .
Mflv_3420|M.gilvum_PYR-GCK LRAGLLSV--PIAGIAIIALAAALLTARRRR-------------------
Mvan_3174|M.vanbaalenii_PYR-1 LRAGLLTV--PVAGAALVVLAGVLGSRCRG--------------------
MSMEG_3671|M.smegmatis_MC2_155 LRAGLLVV--PAAGVLAIVLAGALRPHRVSVGDAGQLDREHT--------
TH_3240|M.thermoresistible__bu LRVGLLGV--PLAGLVAAVLAGVLSGRRRTPRW-----------------
MMAR_4785|M.marinum_M HRLVALVT--VTVGLAGAALCLPLARALNRSGDVGVRDSQYTAVAGAA--
MUL_0354|M.ulcerans_Agy99 HRLVALVT--VTVGLAGAALCLP----LNRSGDVGVRDSQYTAVAAAA--
Mb0805c|M.bovis_AF2122/97 RGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGAG
Rv0783c|M.tuberculosis_H37Rv RGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGAG
MAV_4712|M.avium_104 LSGALVTIP-VMMTIVAVAIRYTPAFDTADEFHRAPAG------------
MAB_4138c|M.abscessus_ATCC_199 LNTALVLP--IFAVVICGCAAGALAVTPPSKSVKPPR-------------
:
Mflv_3420|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------------------
TH_3240|M.thermoresistible__bu --------------------------------------------------
MMAR_4785|M.marinum_M --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 --------------------------------------------------
Mb0805c|M.bovis_AF2122/97 RGAAVDPSSLPRQTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFLP
Rv0783c|M.tuberculosis_H37Rv RGAAVDPSSLPRQTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFLP
MAV_4712|M.avium_104 --------------------------------------------------
MAB_4138c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3420|M.gilvum_PYR-GCK --------------
Mvan_3174|M.vanbaalenii_PYR-1 --------------
MSMEG_3671|M.smegmatis_MC2_155 --------------
TH_3240|M.thermoresistible__bu --------------
MMAR_4785|M.marinum_M --------------
MUL_0354|M.ulcerans_Agy99 --------------
Mb0805c|M.bovis_AF2122/97 KQQASHRRAPLLSA
Rv0783c|M.tuberculosis_H37Rv KQQASHRRAPLLSA
MAV_4712|M.avium_104 --------------
MAB_4138c|M.abscessus_ATCC_199 --------------