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VSSCPAEGDCSAPEKPKLPGEVWVLIVANAVIALGYGVVAPVLPQYARHFGVSISAATFVITAFALMRLC FAPATGMLIQRLGERRIYVNGLVIVALSTGACAFAQTYWQLLLFRSLGGIGSTMFFVSALGLMIRISPED ARGRVAGMFSSAFLVGSVGGPVLGSLTAGLGLSAPFLIYGAALLVAAAVVFISLRHSSLAAPAPDDGPKV TVRTALRNGAYRAALVSNLATGWSAFGLRIALVPLFIAEVFHRGPGIAGLALATFAIGNVGAVIPSGYLS DRVGRRVLLIIGLTAAGVATAVVGLTDGLTPFLVSALVAGFATGIFTAPQQAAVADIIGNKARGGTAVAT FQMMADVGSIGGSLLVGLIAQYLSFAWAFGISGGMLLLAALCWTFAPETRPRPSAEHTPARPLGPEAGGE VP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2137 | - | - | 100% (422) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3373 | - | 4e-19 | 25.57% (395) | major facilitator superfamily protein MFS_1 |
| M. smegmatis MC2 155 | MSMEG_4472 | - | 1e-18 | 23.00% (387) | multidrug-efflux transporter protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 4e-20 | 23.71% (447) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_4405 | - | 1e-174 | 72.68% (421) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 4e-20 | 23.71% (447) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | MLBr_01562 | - | 1e-08 | 23.10% (381) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_3449c | - | 1e-119 | 51.12% (403) | putative transporter |
| M. marinum M | MMAR_0690 | - | 9e-31 | 30.35% (346) | putative transport protein |
| M. avium 104 | MAV_3974 | - | 1e-129 | 60.11% (376) | permease of the major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_0476 | - | 2e-15 | 24.74% (384) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_0501 | - | 3e-17 | 24.26% (408) | integral membrane drug efflux protein |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 1e-173 | 73.44% (418) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4405|M.gilvum_PYR-GCK -------------------MSST-KEGDCP-------------------T
Mvan_1951|M.vanbaalenii_PYR-1 -------------------MTSH-TEGECPGADARSNSGTADAKSSSQSA
MSMEG_2137|M.smegmatis_MC2_155 -------------------MSSCPAEGDCS------------------AP
MAV_3974|M.avium_104 --------------------------------------------------
MAB_3449c|M.abscessus_ATCC_199 -------------------MSSC-REGNADN-----------------AT
Mb0805c|M.bovis_AF2122/97 --------------MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDR
Rv0783c|M.tuberculosis_H37Rv --------------MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDR
MUL_0501|M.ulcerans_Agy99 --------------MLSTAMDEAHCTPAEVAPPDTRTGTSSPGEHVYPDR
TH_0476|M.thermoresistible__bu --------------------------------------------------
MMAR_0690|M.marinum_M -------------------------------------------------M
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mflv_4405|M.gilvum_PYR-GCK TKQRLPREVWVLVVANVVVALGYGVVAPVLPQYARHFGVSIAAATFVITA
Mvan_1951|M.vanbaalenii_PYR-1 TKQPLPREVWVLVAANFVVALGYGVVAPVLPQYARHFGVSISAATFVITA
MSMEG_2137|M.smegmatis_MC2_155 EKPKLPGEVWVLIVANAVIALGYGVVAPVLPQYARHFGVSISAATFVITA
MAV_3974|M.avium_104 -----------------MVALGYGVISPALPTFARSFGVSIKAVTFLVTV
MAB_3449c|M.abscessus_ATCC_199 VKPRLPWEIWVLVVASLVIALGFGVVAPALPQYARSFGVSVTAATAVVSS
Mb0805c|M.bovis_AF2122/97 LDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTG
Rv0783c|M.tuberculosis_H37Rv LDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTG
MUL_0501|M.ulcerans_Agy99 LDAGLLRIAGVCVLASLMSVLDATVVGIAQRTFIIEFDSTQAVVAWTMTG
TH_0476|M.thermoresistible__bu ---VRRFAFPLLAYAFAAVMVGTTVPTPMYAVYAERLGFGVLTTTVVFAG
MMAR_0690|M.marinum_M TDSSRRVVLAAVGFTFFIDMLVYGIVVPVLPRLAKPAGLEFLGVGVVFAC
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
: : . .:
Mflv_4405|M.gilvum_PYR-GCK FAVMRLVGAPPAGFLVQRLGERRVYTSGLIIVAVSTGACAFAETYWQLLL
Mvan_1951|M.vanbaalenii_PYR-1 FAVMRLVGAPPAGMLVQRLGERRVYISGLIIVALSTAACAFAETYWQLLL
MSMEG_2137|M.smegmatis_MC2_155 FALMRLCFAPATGMLIQRLGERRIYVNGLVIVALSTGACAFAQTYWQLLL
MAV_3974|M.avium_104 FSLSRLCFAPISGLLTERLGERRIYIGGLLIVAVSTAACAFSQAYWQLML
MAB_3449c|M.abscessus_ATCC_199 FAAFRLVFAPVAGALVQRLGERWVYMSGLLIVAASTGICAFVHSYWQLLV
Mb0805c|M.bovis_AF2122/97 YMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLII
Rv0783c|M.tuberculosis_H37Rv YMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLII
MUL_0501|M.ulcerans_Agy99 YTLALATVIPVAGWAADRFGTKRLWMGSVLAFALGSLLCALAPNILSLIF
TH_0476|M.thermoresistible__bu YTAGVLFALVVFGRWSDALGRRPMLLAGVGCAIVSALVFLIAGSVPQLIA
MMAR_0690|M.marinum_M YGLAYFVLTPVAGWLIDRRGSRSVFLSGAIILMLATLAFGYASSPVGLVT
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
: * : * : . .: *:
Mflv_4405|M.gilvum_PYR-GCK FRSLGGVGSAMFTVSALGLMIRISPA-DARGRVAGLFSSGFMIGSVGGPI
Mvan_1951|M.vanbaalenii_PYR-1 FRSLGGIGSAMFTVSSLGLMIRISPP-DARGRVAGLFSSGFMVGSVGGPI
MSMEG_2137|M.smegmatis_MC2_155 FRSLGGIGSTMFFVSALGLMIRISPE-DARGRVAGMFSSAFLVGSVGGPV
MAV_3974|M.avium_104 CRVFSGVGSTMFYVSALGLMIHISPA-DARGRIAGLFTTSFMVGAVGGPA
MAB_3449c|M.abscessus_ATCC_199 FRSVGGVGSTMFTVSAAALLVRIAPE-EIRGRAQGLYGSSFLLGMVAGPA
Mb0805c|M.bovis_AF2122/97 FRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGIPMLLGPVGGPI
Rv0783c|M.tuberculosis_H37Rv FRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGIPMLLGPVGGPI
MUL_0501|M.ulcerans_Agy99 FRVLQGVGGGMLMPLGFIILTRAAGP-KRLGRLMAAIGIPMLLGPIGGPI
TH_0476|M.thermoresistible__bu ARFVSGMSAGIFTGTATAAVIEAAPE-RRRSRAAAVATVANIGGLGAGPL
MMAR_0690|M.marinum_M CRVLQGGAAAATWVAGYATLVEIFPR-EQRGRAVGLASIGTALGALLGPA
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
* . * .. . : . . * *
Mflv_4405|M.gilvum_PYR-GCK LG---------------SLTAGFG---------------LAAPFLIYGAA
Mvan_1951|M.vanbaalenii_PYR-1 LG---------------ALTAGFG---------------LSAPFLIYGAA
MSMEG_2137|M.smegmatis_MC2_155 LG---------------SLTAGLG---------------LSAPFLIYGAA
MAV_3974|M.avium_104 VG---------------GLAAGWG---------------LTAPFVVYGVA
MAB_3449c|M.abscessus_ATCC_199 LG---------------SAVVGLS---------------LSAPFIIYAAA
Mb0805c|M.bovis_AF2122/97 LGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLL
Rv0783c|M.tuberculosis_H37Rv LGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLL
MUL_0501|M.ulcerans_Agy99 LGGWLISSFGWHWIFLVNLPIGLAAFALAAITFPADRPVPSESFDVIGVL
TH_0476|M.thermoresistible__bu LAG---------------ILVQYAPWP------------LHLTFWVHIVL
MMAR_0690|M.marinum_M LG---------------GLAYEASG--------------PHAPFLGAAGL
MLBr_01562|M.leprae_Br4923 VGG-ALTEVSWRLAFLVNVPIGLVMIYLAR---TALHETHKERMKLDAAG
:. :
Mflv_4405|M.gilvum_PYR-GCK LLVAATVVFVSLRNSAVVGQADDDVQVPIPFRT-----------------
Mvan_1951|M.vanbaalenii_PYR-1 LLVAATVVFVSLRHSTVVGQQDEDPEEPVPFRT-----------------
MSMEG_2137|M.smegmatis_MC2_155 LLVAAAVVFISLRHSSLAAPAPDDGPK-VTVRT-----------------
MAV_3974|M.avium_104 MLGVALVLFLGLRNSALAAPPPP-TRSTVTMRE-----------------
MAB_3449c|M.abscessus_ATCC_199 LVIVVMLVYFGLRRSTLLDVADEHHGTPVRLTS-----------------
Mb0805c|M.bovis_AF2122/97 LLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTE
Rv0783c|M.tuberculosis_H37Rv LLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTE
MUL_0501|M.ulcerans_Agy99 LLSPGLAAFLLALSLIPDRGTVADRYVLIPVIAGLSLIGGFAWHAWHRAD
TH_0476|M.thermoresistible__bu MVLAAAAIAVAPETSPRTGRLGVQRLSLPPQVR-----------------
MMAR_0690|M.marinum_M SALAVAALAASLPQAAGGQASGPGMWSGERAFP-----------------
MLBr_01562|M.leprae_Br4923 AILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAE
Mflv_4405|M.gilvum_PYR-GCK -------VFRHRAYKAALFSNFATGWASFGLRIALVPLFVVEVLGEG-PG
Mvan_1951|M.vanbaalenii_PYR-1 -------VFRHRAYRAALFSNFATGWASFGLRIALVPLFIVEVLGQS-PG
MSMEG_2137|M.smegmatis_MC2_155 -------ALRNGAYRAALVSNLATGWSAFGLRIALVPLFIAEVFHRG-PG
MAV_3974|M.avium_104 -------ALRVRAYQSALLSNFATGWSAFGLRMALVPLFVSDVMGRG-IG
MAB_3449c|M.abscessus_ATCC_199 -------ALRHRTFLAALMSNFSAGWAIFGIRGALLPLLVVEALHQR-PG
Mb0805c|M.bovis_AF2122/97 HPLIDMRLFQNRAVAQANMTMTVLSLGLFGS-FLLLPSYLQQVLHQS-PM
Rv0783c|M.tuberculosis_H37Rv HPLIDMRLFQNRAVAQANMTMTVLSLGLFGS-FLLLPSYLQQVLHQS-PM
MUL_0501|M.ulcerans_Agy99 HPLIDLHLFNNSVVTQANLTLLAFAAAYFGS-SLLIPTYLQQVLHQT-PM
TH_0476|M.thermoresistible__bu -----------KVFAIASLAAFAG-FAVTGLFTAVAPSFLAEVIGVRNHA
MMAR_0690|M.marinum_M -----------GLAVPWLVAGLAVGLALGAVEATLPIDLVARFDASG--V
MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIG-LYIQDILGYS-AL
.: . : :
Mflv_4405|M.gilvum_PYR-GCK AAGLALTAFAVGNIAVVIPSGHLSDRLGRRKLLIFGLMLAAVSTALVGFT
Mvan_1951|M.vanbaalenii_PYR-1 AAGLALTAFAVGNISVVIPSGHLSDRLGRRKLMIFGLTLAAASTALVGFT
MSMEG_2137|M.smegmatis_MC2_155 IAGLALATFAIGNVGAVIPSGYLSDRVGRRVLLIIGLTAAGVATAVVGLT
MAV_3974|M.avium_104 TIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVGLVTSGAATVWLGFV
MAB_3449c|M.abscessus_ATCC_199 AAGLVFAAFAAGDVSTAFLAGSWSDDIGRKPLVVAGLVVCGSTVVAMGFV
Mb0805c|M.bovis_AF2122/97 QSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFG
Rv0783c|M.tuberculosis_H37Rv QSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFG
MUL_0501|M.ulcerans_Agy99 QSGLYLIPQGLGAMLTMPIASAFMDRRGPGKSVLLGIVLIAVGLAMFTFG
TH_0476|M.thermoresistible__bu VAGAVAASIFAASAVTQVLGASVSPR--RAVAVGCALLIVGMVFLAAALV
MMAR_0690|M.marinum_M TVGLLFALTTVAFIVTSQYAGRLSDAGRRAPVLAAGWVTLGVALAVMGVP
MLBr_01562|M.leprae_Br4923 RAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAF
* . .. .
Mflv_4405|M.gilvum_PYR-GCK TS-----LPVFLVAAVIAGAATGIFVSPQQAAVADVVGNK---SRGGPAV
Mvan_1951|M.vanbaalenii_PYR-1 TS-----LPVFLVAAYIAGAATGIFVSPQQAAVADVVGNK---SRGGTAV
MSMEG_2137|M.smegmatis_MC2_155 DG-----LTPFLVSALVAGFATGIFTAPQQAAVADIIGNK---ARGGTAV
MAV_3974|M.avium_104 AS-----LPVFLVAAGVVGVVTGIYMSPLQAAVADILGNE---ARAGLPV
MAB_3449c|M.abscessus_ATCC_199 SS-----LPVLVVLSLIGGIGAGLYASPQQAAVADVVGSR---GRAGTAL
Mb0805c|M.bovis_AF2122/97 VARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQ-IARGSTLI
Rv0783c|M.tuberculosis_H37Rv VARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQ-IARGSTLI
MUL_0501|M.ulcerans_Agy99 VATRAQYLPTLLVGLAIMGMGTGCTMMPLAGAAVLTLKPRE-IARGSTLI
TH_0476|M.thermoresistible__bu WSS----LPALIATAVVAGAGQGLSFSRGLAAVSARTPSD----QRGEVS
MMAR_0690|M.marinum_M SA-----VGIQAAALVLLGAGLGAMIATIMPALADAMESAGGAQRPGTAA
MLBr_01562|M.leprae_Br4923 MNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDR---IGPVSA
. . : * * :
Mflv_4405|M.gilvum_PYR-GCK ATFQMMADFGSIGGSLLVGLIAQYTSYG-----------WAFLVSGIILA
Mvan_1951|M.vanbaalenii_PYR-1 ATFQMMADFGSIGGSLLVGLIAQYTSFG-----------WAFLISGVILA
MSMEG_2137|M.smegmatis_MC2_155 ATFQMMADVGSIGGSLLVGLIAQYLSFA-----------WAFGISGGMLL
MAV_3974|M.avium_104 ATVQMMSDLGAIVGSMAVGWAAEQIGYG-----------WGFFISGVVLL
MAB_3449c|M.abscessus_ATCC_199 ATFQMTSDIGLVVGPVVAGAIAEHTSYG-----------WAFVVGGAMPL
Mb0805c|M.bovis_AF2122/97 SVNQQVG--GSIGTALMSVLLTYQFNHS-----------EIIATAKKVAL
Rv0783c|M.tuberculosis_H37Rv SVNQQVG--GSIGTALMSVLLTYQFNHS-----------EIIATAKKVAL
MUL_0501|M.ulcerans_Agy99 SVTQQVG--GSIGTALMATILTNQFNRS-----------DNIWVANKVAT
TH_0476|M.thermoresistible__bu STYFVVAYVALLVPVIGEGWAAHHWGLR-----------TAGISFAVGVA
MMAR_0690|M.marinum_M AAYNLAFSAGTVAGGPLAGWMADLRSFQ-----------DAAMLIAVVTL
MLBr_01562|M.leprae_Br4923 IALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGY
. . : :
Mflv_4405|M.gilvum_PYR-GCK VAAIGWFFAPETR-PTPSTEHT--------------------------PG
Mvan_1951|M.vanbaalenii_PYR-1 VAAVGWIFAPETR-PRASTEHT--------------------------QA
MSMEG_2137|M.smegmatis_MC2_155 LAALCWTFAPETR-PRPSAEHT--------------------------PA
MAV_3974|M.avium_104 IAAVGWVMAPETR-TATELEAD--------------------------LM
MAB_3449c|M.abscessus_ATCC_199 IAAVAWVFAPETLGRLASPQVR--------------------------SM
Mb0805c|M.bovis_AF2122/97 TPESGAGRGAAVDPSSLPRQTN---FAAQLLHDLSHAYAVVFVIATALVV
Rv0783c|M.tuberculosis_H37Rv TPESGAGRGAAVDPSSLPRQTN---FAAQLLHDLSHAYAVVFVIATALVV
MUL_0501|M.ulcerans_Agy99 LEQNAAARGVTVDPSGLPPQALTPDFADNVMHDLSHAYTVVFGVVVVLVV
TH_0476|M.thermoresistible__bu VLAIGCLIAILIQESRDPQAI-----------------------------
MMAR_0690|M.marinum_M TCGVLAALVHAAVVRRAVSDA-----------------------------
MLBr_01562|M.leprae_Br4923 TYGLLWVAGAVVIVGVAALFIG-------------------YTPEQVAYA
Mflv_4405|M.gilvum_PYR-GCK RPLGPEAGGEVP----------------------
Mvan_1951|M.vanbaalenii_PYR-1 RPLGPEAGGEVP----------------------
MSMEG_2137|M.smegmatis_MC2_155 RPLGPEAGGEVP----------------------
MAV_3974|M.avium_104 AASRTSSRCEQQL---------------------
MAB_3449c|M.abscessus_ATCC_199 QEVAEDVGGPER----------------------
Mb0805c|M.bovis_AF2122/97 STLIPAAFLPKQQAS-------HRRAPLLSA---
Rv0783c|M.tuberculosis_H37Rv STLIPAAFLPKQQAS-------HRRAPLLSA---
MUL_0501|M.ulcerans_Agy99 STLIPAASLPKTPAAAPASFEQHHCDTQYGVHRV
TH_0476|M.thermoresistible__bu ----------------------------------
MMAR_0690|M.marinum_M ----------------------------------
MLBr_01562|M.leprae_Br4923 QEVKEAVDAGEL----------------------