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APEPLGSGEARNRRARIAVAALFLTNGALFANLLPRYPEIKADLAMSNAAYGAAVASFSAGALLAGPTAA ALIRRFQSSRVALATTVALAVLIVVAGLAGTPLLFAVALFAAGACDAVTDVAQNVNGLRLQRNYGRSIIN SLHAVWAVGAIVGGLMGAGAIALQIPRPIHLAAAAVLFCGVVLAAYPSLLHGPDHDDHPSTRNTDGSGVR AVVLLTLLALVGIAVAGATVEDAGSSWATLYLRDSLGAPGAVAVMGYIALVGFMFIGRMTGDRLVDRFGE RAVARSGGLITAAGMGAALAFPSVPGTIAGFAAAGLGVATVIPAAMRAADELPGLRAGTGLTVLTWLMRV GFLGAPLIVGVVADATSLRAGLLTVPVAGAALVVLAGVLGSRCRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3174 | - | - | 100% (396) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5926 | - | 2e-10 | 28.22% (404) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 2e-10 | 23.02% (391) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2871c | efpA | 3e-06 | 24.12% (398) | integral membrane efflux protein EfpA |
| M. gilvum PYR-GCK | Mflv_3420 | - | 1e-168 | 77.66% (385) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2846c | efpA | 3e-06 | 24.12% (398) | integral membrane efflux protein EfpA |
| M. leprae Br4923 | MLBr_01562 | - | 1e-08 | 24.21% (409) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_4138c | - | 4e-39 | 30.65% (385) | putative major facilitator superfamily protein |
| M. marinum M | MMAR_1887 | efpA | 6e-08 | 23.88% (402) | integral membrane efflux protein EfpA |
| M. avium 104 | MAV_4712 | - | 1e-38 | 30.14% (365) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_3671 | - | 1e-152 | 73.47% (377) | integral membrane protein |
| M. thermoresistible (build 8) | TH_3240 | - | 1e-142 | 67.25% (397) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_2115 | efpA | 7e-08 | 24.38% (402) | integral membrane efflux protein EfpA |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1887|M.marinum_M MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPTWLPSR-
MUL_2115|M.ulcerans_Agy99 MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPTWLPSR-
Mb2871c|M.bovis_AF2122/97 MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSR-
Rv2846c|M.tuberculosis_H37Rv MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSR-
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSK-YPTLLPSGR
Mvan_3174|M.vanbaalenii_PYR-1 -----------------------MAPEPLGSGEARNRRAR----------
Mflv_3420|M.gilvum_PYR-GCK ------MDAILHRPRAARDLKGAWVGSHLMASDARIRRAR----------
MSMEG_3671|M.smegmatis_MC2_155 -----------------------MVTEQR--DPVTTRRAR----------
TH_3240|M.thermoresistible__bu -----------------------MASGRVESRTRQHQRAR----------
MAB_4138c|M.abscessus_ATCC_199 -----------------------MLLAEVAVGGARSLAQRRGEDYFLTKP
MAV_4712|M.avium_104 ------------------MTDSSPPAKGTFTVEMLSRAKR----------
:
MMAR_1887|M.marinum_M ----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAGRSWVIT
MUL_2115|M.ulcerans_Agy99 ----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAGRSWVIT
Mb2871c|M.bovis_AF2122/97 ----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVIT
Rv2846c|M.tuberculosis_H37Rv ----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVIT
MLBr_01562|M.leprae_Br4923 FPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGIT
Mvan_3174|M.vanbaalenii_PYR-1 ----IAVAALFLTNGALFANLLP------RYPEIKADLAMSNAAYGAAVA
Mflv_3420|M.gilvum_PYR-GCK ----AASAALFLTNGALFANLLP------RFPEIKSDLAMSNAGYGAAVA
MSMEG_3671|M.smegmatis_MC2_155 ----VAVAALFLTNGAIFANLLP------RYPEIKTDLQLSNATYGAAVA
TH_3240|M.thermoresistible__bu ----RAVAVLFLTNGALFANLLP------RYPEIKTDLALSNTGYGVTIA
MAB_4138c|M.abscessus_ATCC_199 LRMRVAVIGVFASFGLVVATWAV------HLPTMKQATGMSSTELGFVVL
MAV_4712|M.avium_104 -----GVTAVFVAHGLLFASWAA------HIPQVKAGLGLDDAALGTALF
:: * . * :: :..: . :
MMAR_1887|M.marinum_M AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLV
MUL_2115|M.ulcerans_Agy99 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLV
Mb2871c|M.bovis_AF2122/97 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLV
Rv2846c|M.tuberculosis_H37Rv AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLV
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLV
Mvan_3174|M.vanbaalenii_PYR-1 SFS---AGALLAGPTAAALIRRFQSSRVALATTVALAVLIVVAGLAGTPL
Mflv_3420|M.gilvum_PYR-GCK AFS---AGALLAGPAAGALIRRFQSARVAVVTTVALASLIVTAAVAPTPL
MSMEG_3671|M.smegmatis_MC2_155 AFS---AGALIAGLTAGALIRRFRSSRVGVTLTVALAVFVFAAGLAPTPI
TH_3240|M.thermoresistible__bu AFS---AGALTAGLTAAMLIRRFRSARVAVVGTLVLAAAVLAAGLAGTAP
MAB_4138c|M.abscessus_ATCC_199 GLG---VGALLGMQLSGVLVDRFGSGPIAIVGGAAMALGVNIPLAAHTVW
MAV_4712|M.avium_104 GAP---LGSVLATLAGHWALPRWGSHRLIPVTVAGYAAAGTTVGLARSGP
. * : : * : : . : :
MMAR_1887|M.marinum_M IARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAVGSVMGL
MUL_2115|M.ulcerans_Agy99 IARLSQGVGSAIASPTGLALVATTFPKGPTRNAATAVFAAMTAVGSVMGL
Mb2871c|M.bovis_AF2122/97 IARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVMGL
Rv2846c|M.tuberculosis_H37Rv IARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVMGL
MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL
Mvan_3174|M.vanbaalenii_PYR-1 LFAVALFAAGACDAVTDVAQNVNGLR--LQRNYGRSIINSLHAVWAVGAI
Mflv_3420|M.gilvum_PYR-GCK VFAATLLFAGASDAITDVAQNVNALR--VQRNYGRSIINSLHAIWAAGAI
MSMEG_3671|M.smegmatis_MC2_155 LFAGALFLAGACDSIVDVAQNAHGLR--VQREYGRSIINSLHAVWAIGAV
TH_3240|M.thermoresistible__bu VLGAALFVAGAADAVTDVAQNAHGLR--VQRAYGRSIINSFHAVWSVGAL
MAB_4138c|M.abscessus_ATCC_199 VAGVGAVLCGVTVGITDVAMNAAAVD--VERFYGRPIMASFHGVFSVGNV
MAV_4712|M.avium_104 ALFAALALWGMFQGALDVAMNTQAGT--VERRAGAPMMARFHGMWSLGTL
. . .:* . * . .:: : .: : :
MMAR_1887|M.marinum_M VVGGALTEVSWRLAFMVNVPIGLVMIYLARTALRETNRERMKLDAAGAIL
MUL_2115|M.ulcerans_Agy99 VVGGALTEVSWRLAFMVNVPIGLVMIYLARTALRETNRERMKLDAAGAIL
Mb2871c|M.bovis_AF2122/97 VVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGAIL
Rv2846c|M.tuberculosis_H37Rv VVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGAIL
MLBr_01562|M.leprae_Br4923 VVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAIL
Mvan_3174|M.vanbaalenii_PYR-1 VGG-----------------------LMGAGAIALQIPRPIHLAAAAVLF
Mflv_3420|M.gilvum_PYR-GCK TGG-----------------------LMGAGAIALGVPRAIHLVVAAVLF
MSMEG_3671|M.smegmatis_MC2_155 LGG-----------------------LTGAATIAMHIPRGVHLAAIAVVF
TH_3240|M.thermoresistible__bu FGG-----------------------LMGGTAVALNIPRSVHLAVAAVLF
MAB_4138c|M.abscessus_ATCC_199 VGAG-----------------------IGSAAFALHLKVWATVLGVTVLC
MAV_4712|M.avium_104 AGA-----------------------LIGAACVGAGIGLTAQLTVLGAVV
. . . : .:
MMAR_1887|M.marinum_M ATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAAALGFVLVERTAENPV
MUL_2115|M.ulcerans_Agy99 ATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAAALGFVLVERTAENPV
Mb2871c|M.bovis_AF2122/97 ATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPV
Rv2846c|M.tuberculosis_H37Rv ATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPV
MLBr_01562|M.leprae_Br4923 ATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENPV
Mvan_3174|M.vanbaalenii_PYR-1 CGVVLAAYPSLLHGPDHDDHPSTRNTDGSGVRAVVLL-------------
Mflv_3420|M.gilvum_PYR-GCK CAIVCAAYPYLLKGPDHDDHPSARDGGTARVGPMVYL-------------
MSMEG_3671|M.smegmatis_MC2_155 SIVALAAFRFLLPGDDHDDHPAAHAPAGLRAGPRTYL-------------
TH_3240|M.thermoresistible__bu SVVVLVGYRFLLPGEDHDDRAHGVRNPGPRSGLRVYA-------------
MAB_4138c|M.abscessus_ATCC_199 LALLTCSASVLLRGKLRAGEVEAPDTVPYTMPPPVSYR------------
MAV_4712|M.avium_104 LLVVVMLTRRLLPDAADSVAAPPEPAAGRRVTP-----------------
: :
MMAR_1887|M.marinum_M VPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIG-LYVQDVLGYSALRAGV
MUL_2115|M.ulcerans_Agy99 VPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIG-LYVQDVLGYSALRAGV
Mb2871c|M.bovis_AF2122/97 VPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIG-LYVQDILGYSALRAGV
Rv2846c|M.tuberculosis_H37Rv VPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIG-LYVQDILGYSALRAGV
MLBr_01562|M.leprae_Br4923 VPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIG-LYIQDILGYSALRAGI
Mvan_3174|M.vanbaalenii_PYR-1 ----------TLLALVGIAVAGATVEDAGSSWATLYLRDSLGAPGAVAVM
Mflv_3420|M.gilvum_PYR-GCK ----------TLLALVALAMAGATVEDAGSSWATLYLRDELGAPGAVAAF
MSMEG_3671|M.smegmatis_MC2_155 ----------ILLALVVIAIAGATVEDAGSSWATLYLRDTLHTPPAVAAF
TH_3240|M.thermoresistible__bu ----------ILAALVGIAVAGAVIEDAGSTWAILYLRDNLTAPPAVAVS
MAB_4138c|M.abscessus_ATCC_199 --------RGQVVVLGLLAFLLMLSEGSATDWSSLHAQEHLGASHSEGAF
MAV_4712|M.avium_104 ----------AVAILAAVSFASFLCEGAATDWSATYLRDVVGAGPSVAAA
: : : . . . : :: : .
MMAR_1887|M.marinum_M GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLVCAMIYGWAFMQRG
MUL_2115|M.ulcerans_Agy99 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLVCAMIYGWAFMQRG
Mb2871c|M.bovis_AF2122/97 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRG
Rv2846c|M.tuberculosis_H37Rv GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRG
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
Mvan_3174|M.vanbaalenii_PYR-1 GYIALVGFMFIGRMTGDRLVDRFGERAVARSGGLITAAGMG-----AALA
Mflv_3420|M.gilvum_PYR-GCK GYVALVGFLFVGRLIGDRLVDRYGDRAVARAGGMITAVGMG-----IALA
MSMEG_3671|M.smegmatis_MC2_155 GYIALVGFMFIGRMIGDRLVDRFGETAVVRAGGLIAAVGMG-----AALA
TH_3240|M.thermoresistible__bu GYLALAGGMLIGRMTGDRLVDRFGERAVVRTGALLIAAGMG-----GALA
MAB_4138c|M.abscessus_ATCC_199 AFGVFMLAMTVGRFTVDKLVERVGRVRVLRGGCALAAVGML-----TVIA
MAV_4712|M.avium_104 SYAAYTLTMVVTRFAAGRLHARLPSRRLLPALAVLAVAGMS-----VTLA
.: : : .:* * : : .* .
MMAR_1887|M.marinum_M VPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFDRIGPVSALTLMLQS
MUL_2115|M.ulcerans_Agy99 VPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFDRIGPVSALTLMLQS
Mb2871c|M.bovis_AF2122/97 VPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQS
Rv2846c|M.tuberculosis_H37Rv VPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQS
MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS
Mvan_3174|M.vanbaalenii_PYR-1 FPSVPGTIAGFAAAGLGVATVIPAAMRAADELPGLRAGTGLTVLTWLMRV
Mflv_3420|M.gilvum_PYR-GCK FPTVPGTIVGFAAAGLGVATVIPAAMRTADELPGLRPGTGLTMLTWLMRI
MSMEG_3671|M.smegmatis_MC2_155 FPSTAGSIAGFAAAGFGVATLIPAAMHAADQLPGLRPGTGLTAVTWLMRV
TH_3240|M.thermoresistible__bu VPTVPGTIGGFAAAGLGVATLIPAAMHGADQLPGIRAGTGLMAVTWLMRV
MAB_4138c|M.abscessus_ATCC_199 APVLPLTLAGWVAVGLGLAGGVPQVFTVAGNIDEQHEGRVLSRVVGTGYV
MAV_4712|M.avium_104 TADAAAGVLGFAALGVGVALLVPTAFSAAYGARG--AGSAIAIVAATGWL
. . : . *.*:. : * : :.
MMAR_1887|M.marinum_M --LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLHALDHGYTYGLL
MUL_2115|M.ulcerans_Agy99 --LGGPLVLAGIQAVITSRTLYLGGTTGPVKFMNDAQLHALDHGYTYGLL
Mb2871c|M.bovis_AF2122/97 --LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLL
Rv2846c|M.tuberculosis_H37Rv --LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLL
MLBr_01562|M.leprae_Br4923 --LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLL
Mvan_3174|M.vanbaalenii_PYR-1 GFLGAPLIVGVVADATSLR---------------------------AGLL
Mflv_3420|M.gilvum_PYR-GCK GFLGAPLIVGVVADAVSLR---------------------------AGLL
MSMEG_3671|M.smegmatis_MC2_155 GFFGAPLLVGVVADAAGLR---------------------------AGLL
TH_3240|M.thermoresistible__bu GFLASPPVVGAIADATSLR---------------------------VGLL
MAB_4138c|M.abscessus_ATCC_199 AVLGGPALIGWVADALSLN---------------------------TALV
MAV_4712|M.avium_104 GYLLGPPLIGHLSEWVGLS---------------------------GALV
: .* ::. : .*:
MMAR_1887|M.marinum_M WVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAGEL
MUL_2115|M.ulcerans_Agy99 WVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAGEL
Mb2871c|M.bovis_AF2122/97 WVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
Rv2846c|M.tuberculosis_H37Rv WVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
MLBr_01562|M.leprae_Br4923 WVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL
Mvan_3174|M.vanbaalenii_PYR-1 TVPVAGAALVVLAGVLGSRCRG----------------
Mflv_3420|M.gilvum_PYR-GCK SVPIAGIAIIALAAALLTARRRR---------------
MSMEG_3671|M.smegmatis_MC2_155 VVPAAGVLAIVLAGALRPHRVSVGDAGQLDREHT----
TH_3240|M.thermoresistible__bu GVPLAGLVAAVLAGVLSGRRRTPRW-------------
MAB_4138c|M.abscessus_ATCC_199 LPIFAVVICGCAAGALAVTPPSKSVKPPR---------
MAV_4712|M.avium_104 TIPVMMTIVAVAIRYTPAFDTADEFHRAPAG-------