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VWGNRVFSRYLFSDTPGAAIEPAIGRCAGYPCHVLGFALPQFGSAAFAAGGELARFASTAEQLGAQSLWV GDRLLAAVDPTVGYAGGDTIPEQFRACLDPFTALAVAAAATSTARLGSSVFVAPWYPPVQLARQLASIDA VSGGRLIPGFGIGWSPEEYQAAGAPFDGRGAQLDEILDALEALWTDDPVRHEGKRWSVPESWVGLKPVQR PRLPICLGAFTPAGLRRIGRRGDGWLPAVFVPGAVSIDALRAQRRVIDAAAEAAGRDPANIATHVRINVA PGSSVSQVADAVKILAEGGYPDAFVDLMYVETDVDAVLGWVEKLVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3609 | - | - | 100% (327) | hydride transferase 1 |
| M. smegmatis MC2 155 | MSMEG_0196 | - | 3e-45 | 36.27% (295) | putative dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4398 | - | 1e-39 | 38.29% (269) | hypothetical protein MSMEG_4398 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2185c | - | 2e-31 | 33.46% (266) | hypothetical protein Mb2185c |
| M. gilvum PYR-GCK | Mflv_4839 | - | 2e-32 | 37.27% (271) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2161c | - | 2e-31 | 33.46% (266) | hypothetical protein Rv2161c |
| M. leprae Br4923 | MLBr_00131 | - | 1e-13 | 28.99% (238) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0366 | - | 2e-29 | 36.44% (225) | hypothetical protein MAB_0366 |
| M. marinum M | MMAR_3559 | - | 4e-30 | 35.35% (198) | hypothetical protein MMAR_3559 |
| M. avium 104 | MAV_2659 | - | 7e-31 | 34.20% (269) | hypothetical protein MAV_2659 |
| M. thermoresistible (build 8) | TH_4081 | - | 2e-31 | 37.44% (211) | PUTATIVE putative hydride transferase 1 |
| M. ulcerans Agy99 | MUL_2792 | - | 5e-31 | 35.86% (198) | hypothetical protein MUL_2792 |
| M. vanbaalenii PYR-1 | Mvan_5752 | - | 8e-32 | 34.62% (260) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2185c|M.bovis_AF2122/97 --------------------------------------MLVSLMQFVTDL
Rv2161c|M.tuberculosis_H37Rv --------------------------------------MLVSLMQFVTDL
MMAR_3559|M.marinum_M --------------------------------------MKFGISTFVNDD
MUL_2792|M.ulcerans_Agy99 --------------------------------------MKFGISTFVNDD
MAB_0366|M.abscessus_ATCC_1997 ----------------------------------MKIGVVAPVELGVTAE
Mvan_5752|M.vanbaalenii_PYR-1 ----------------------------------MRIGVVFP-QTELGGD
Mflv_4839|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3609|M.smegmatis_MC2_155 MVWGNRVFSRYLFSDTPGAAIEPAIGRCAGYPCHVLGFALPQFGSAAFAA
TH_4081|M.thermoresistible__bu --------------------------------------VKFGISLFPLR-
MAV_2659|M.avium_104 -------------------------MRFTVYLPNCMHVAAITQPWEHQLS
MLBr_00131|M.leprae_Br4923 -------------------------------MAGFRFGFVDALVHTLFPP
Mb2185c|M.bovis_AF2122/97 TPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWPGG-----ELPDWYR
Rv2161c|M.tuberculosis_H37Rv TPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWPGG-----ELPDWYR
MMAR_3559|M.marinum_M SIDPVSLARAIEERGFSSLVIAEHTHIPASRETPYPGGG----ELPGVYY
MUL_2792|M.ulcerans_Agy99 SIDPVSLARAIEERGFSSLVIAEHTHIPASRETPYPGGD----ELPGVYY
MAB_0366|M.abscessus_ATCC_1997 PDKILEFARAAERLGFSEISVVEHAVVIGDTQSTYPYSPT-GQSHLPDDI
Mvan_5752|M.vanbaalenii_PYR-1 PGAVRAYGRRVEELGFTHLLAYDHVVGADPAVHTGWSGP------YDVDT
Mflv_4839|M.gilvum_PYR-GCK --MIDAVAASAERSGFETLWFGDQVVMADEDGPHHPYRDD-GEIPASAQT
MSMEG_3609|M.smegmatis_MC2_155 GGELARFASTAEQLGAQSLWVGDRLLAAVDPTVGYAGGD----TIPEQFR
TH_4081|M.thermoresistible__bu PRQMVDVAVAAERLGYDSVWLGEHVVTPIHSDSTFPYAEDDAHAAFHGQL
MAV_2659|M.avium_104 GADIARVAQHAEQLGYSMVFLPEHFLTPTAH-------------LELSGD
MLBr_00131|M.leprae_Br4923 SLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGVAAKVVPKID
* ::
Mb2185c|M.bovis_AF2122/97 RCYDPVVALAAAAAVTTRLRVGTGACLVAV--HDPILLAKQIASLCAMSG
Rv2161c|M.tuberculosis_H37Rv RCYDPVVALAAAAAVTTRLRVGTGACLVAV--HDPILLAKQIASLCAMSG
MMAR_3559|M.marinum_M RTLDPFVTLAAAAAVTSKIELFTGIALLIQ--RDPITTAKEAASIDLISG
MUL_2792|M.ulcerans_Agy99 RTLDPFVTLAAAAAVTSKIELFTGIALLIQ--RDPITTAKEAASIDLISG
MAB_0366|M.abscessus_ATCC_1997 DIPDPLELLSFVAAATTTLGLSTGVLVLPD--HHPVVLAKRLATLDRLSR
Mvan_5752|M.vanbaalenii_PYR-1 TFHEPLVMFGYLAAVTTTLELVTGVIILPQ--RQTALVAKQAAEVDLLSG
Mflv_4839|M.gilvum_PYR-GCK DWLDPLIALSFAAAATNRIELATGVLVLPE--RNPVVTAKQAASLDRMTG
MSMEG_3609|M.smegmatis_MC2_155 ACLDPFTALAVAAAATSTARLGSSVFVAPW--YPPVQLARQLASIDAVSG
TH_4081|M.thermoresistible__bu PFYDPFAALGYLAAQTSTLRLVLSISIVPV--HDPFHLARSVTTLDLFSE
MAV_2659|M.avium_104 HYFDATTAQAFVAGATSTITVGSMVTILPL--HNPIIAAKQIATFDWLSG
MLBr_00131|M.leprae_Br4923 ANYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTR
:. . *. . : : . *: : . .:
Mb2185c|M.bovis_AF2122/97 ERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAE--PVHY
Rv2161c|M.tuberculosis_H37Rv ERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAE--PVHY
MMAR_3559|M.marinum_M GRFVFGVGAGWNIEELRDHGTDPKTRGALLDERIEAIKALWTDE--PAEY
MUL_2792|M.ulcerans_Agy99 GRFVFGVGAGWNIEELRDHGTDPKTRGALLDERIEAIKALWTDE--PAEY
MAB_0366|M.abscessus_ATCC_1997 GRLRICAGVGWMREEIEACGGDFDRRGRAADEAIAVMRALWSTDG-PTSH
Mvan_5752|M.vanbaalenii_PYR-1 GRLRFGVGVGWNAVEYEALGEQFTNRGTRSEEQVELLRQLWTQR--TVTF
Mflv_4839|M.gilvum_PYR-GCK GRLTLGVGIGISPQEYDALGVPFASRGARLAEYVGAMRTLWRDD--DASF
MSMEG_3609|M.smegmatis_MC2_155 GRLIPGFGIGWSPEEYQAAGAPFDGRGAQLDEILDALEALWTDD--PVRH
TH_4081|M.thermoresistible__bu GRFWFGMGAGWLREEFEILQKPFDGRGRILDETIDIMNRLFTQD--VTTY
MAV_2659|M.avium_104 GRAQTTVGVGWLKEEYDAIGVPFTKRGRMADEYLEAMFELWHSD--SPSY
MLBr_00131|M.leprae_Br4923 GKAMLGIGVGE-REGNEPYGVEWTKPVARFQEALATIRALWDSNGELVSR
: * * : : : *:
Mb2185c|M.bovis_AF2122/97 EGTHASVPPSWAWPKPAVAP-PVLFGCRPSARAFEVIARHGDGWQPIEG-
Rv2161c|M.tuberculosis_H37Rv EGTHASVPPSWAWPKPAVAP-PVLFGCRPSARAFEVIARHGDGWQPIEG-
MMAR_3559|M.marinum_M HGKYVDFPPSYSRPKPVRQPHPPIYIGGNSDATVKRVVRHDAGWISNPLP
MUL_2792|M.ulcerans_Agy99 HGKYVDFPPSYSRPKPVRQPHPPIYIGGNSDATVKRVVRHDAGWISNPLP
MAB_0366|M.abscessus_ATCC_1997 DGEFYSFRNAYSYPKPVRPQGVPLYIGGHSKAAARRAGRLGSGFQPLGLV
Mvan_5752|M.vanbaalenii_PYR-1 DGRHHRVTGAGIAPLPVQRP-IPLWIGAAAPRGYARAGRIADGWFPLVGP
Mflv_4839|M.gilvum_PYR-GCK AGRYVAFDGVRANPKPQGRS-IPVVLGGNSDAALRRVAEWGDGWYGFDLA
MSMEG_3609|M.smegmatis_MC2_155 EGKRWSVPESWVGLKPVQRPRLPICLGAFTPAGLRRIGRRGDGWLPAVFV
TH_4081|M.thermoresistible__bu RGRHFTVPPVGLQPKPLTRPHPPYLFGGHSRKALERAAARGQGWLSSGMS
MAV_2659|M.avium_104 DGEFVKFDDVAFGPKPISTPHPTVWMGGDADAVLRRAARFGDGWAPWLTK
MLBr_00131|M.leprae_Br4923 ESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLV
. . * .:
Mb2185c|M.bovis_AF2122/97 -----YGELLGALPMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRRA
Rv2161c|M.tuberculosis_H37Rv -----YGELLGALPMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRRA
MMAR_3559|M.marinum_M -----VRQLTQRVDQLRGA---AGHDVPLAMFGTPNKPDYWRAAQDLGFG
MUL_2792|M.ulcerans_Agy99 -----VHQLTQRVDQLRSA---AGHDVPLAMFGTRNKPDYWRAAQDLGFG
MAB_0366|M.abscessus_ATCC_1997 -----GDDLTAAVGVMRAAAVDAGRDPRGLDLV-LGHGLHRVDQAALDQA
Mvan_5752|M.vanbaalenii_PYR-1 -----GPALDEAKGAVDAAAREAGRDPSEIGMEGRVRWRHDLDQTAADIG
Mflv_4839|M.gilvum_PYR-GCK D----VEEAAFRASKLRSMCREFGRDPTELKLSVALHDPVPADAVRLADA
MSMEG_3609|M.smegmatis_MC2_155 PGAVSIDALRAQRRVIDAAAEAAGRDPANIATHVRINVAPGSSVSQVADA
TH_4081|M.thermoresistible__bu -----PERNAEAIAFLRRERRRLGVDDQPFECSTHLVGPVDRGLVDAYRE
MAV_2659|M.avium_104 -----PDELPAKLDYLRSQPGFDDRPFSVFYSLAVLSVGQEHAIVDDPNA
MLBr_00131|M.leprae_Br4923 R----PTDYSCALEVVRTAASDAGRDPMSITPAAVRGIITGRTRDDVDEA
: .
Mb2185c|M.bovis_AF2122/97 GVAEVALALPS-------------AGRD--------QVLAALDRSAPLVD
Rv2161c|M.tuberculosis_H37Rv GVAEVALALPS-------------AGRD--------QVLAALDRSAPLVD
MMAR_3559|M.marinum_M ---QLALLLPT-------------CPRD--------ESLRLLDEYAALVA
MUL_2792|M.ulcerans_Agy99 PAGAAAAHLPAGGVPAAARR--IRCPGGSIPPVEVPGGPSFLREPLARVS
MAB_0366|M.abscessus_ATCC_1997 AHAGAGRMLLS-------ASRRA-------------TTLEAVLEEMAGCA
Mvan_5752|M.vanbaalenii_PYR-1 EWAEHGASHLS-------VDTMR-------------AGLRTVNEHLAVLE
Mflv_4839|M.gilvum_PYR-GCK GIDELVLVAGP--------------------------PADPIAAEAWIAD
MSMEG_3609|M.smegmatis_MC2_155 VKILAEGGYPD-------------------------AFVDLMYVETDVDA
TH_4081|M.thermoresistible__bu AGVDRLVVRPWR------------------------KGGQAVEAITRLAD
MAV_2659|M.avium_104 QFGQSAQQVIDN-----------CNMLAERGVTDTWVNPPALDGLSAYLD
MLBr_00131|M.leprae_Br4923 LDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSY
:
Mb2185c|M.bovis_AF2122/97 AFAGDDREVKSHA-------------------------------------
Rv2161c|M.tuberculosis_H37Rv AFAGDDREVKSHA-------------------------------------
MMAR_3559|M.marinum_M QYHR----------------------------------------------
MUL_2792|M.ulcerans_Agy99 CASRRKIAPRFAAQCDFASARGGRLRVGSRPR------------------
MAB_0366|M.abscessus_ATCC_1997 TRLELGGPR-----------------------------------------
Mvan_5752|M.vanbaalenii_PYR-1 AIADRVGLR-----------------------------------------
Mflv_4839|M.gilvum_PYR-GCK LAGQWMRVRT----------------------------------------
MSMEG_3609|M.smegmatis_MC2_155 VLGWVEKLVA----------------------------------------
TH_4081|M.thermoresistible__bu DLGVTRTDRVTDCSTHTI--------------------------------
MAV_2659|M.avium_104 HMQWVAEEIIPKVG------------------------------------
MLBr_00131|M.leprae_Br4923 AAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRK
Mb2185c|M.bovis_AF2122/97 ------------------
Rv2161c|M.tuberculosis_H37Rv ------------------
MMAR_3559|M.marinum_M ------------------
MUL_2792|M.ulcerans_Agy99 ------------------
MAB_0366|M.abscessus_ATCC_1997 ------------------
Mvan_5752|M.vanbaalenii_PYR-1 ------------------
Mflv_4839|M.gilvum_PYR-GCK ------------------
MSMEG_3609|M.smegmatis_MC2_155 ------------------
TH_4081|M.thermoresistible__bu ------------------
MAV_2659|M.avium_104 ------------------
MLBr_00131|M.leprae_Br4923 TVSALLPHARVLRGLKKL