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VKLGLRLPQRLNVDLRHDVVWAARAAEAAGFASLWTYERLLFPADPVESYAGTDAPWPTHSRQAADPLAV LTAAAVVTETARLGTSVLVAGLHTPIQLAKALATVDQISGGRMIAGLGTGWSTDEFRAAGARRADRGPLL DETRDVLDAVWARDPVTFRSPHVIIDDAAVLPKPVAQMPVLLAGGGSLPDRSASKAMRRIAARADGWLPL LTEPGQAGATRLRTDWDRIRELAAERGRTPDAMEMIVVGNVTFTERSAGPDRPAFVGTFDQIVEDVHTAA EAGADELIVDLNLQDWFTSTPQMLETAVQIHERFVAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4398 | - | - | 100% (317) | hypothetical protein MSMEG_4398 |
| M. smegmatis MC2 155 | MSMEG_3609 | - | 1e-39 | 38.29% (269) | hydride transferase 1 |
| M. smegmatis MC2 155 | MSMEG_0196 | - | 4e-30 | 31.54% (298) | putative dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2185c | - | 1e-23 | 33.33% (186) | hypothetical protein Mb2185c |
| M. gilvum PYR-GCK | Mflv_1017 | - | 4e-23 | 34.90% (192) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2161c | - | 1e-23 | 33.33% (186) | hypothetical protein Rv2161c |
| M. leprae Br4923 | MLBr_00348 | - | 7e-10 | 28.45% (232) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4908c | - | 1e-21 | 31.80% (261) | putative luciferase-like oxidoreductase |
| M. marinum M | MMAR_1586 | - | 7e-25 | 31.73% (271) | oxidoreductase |
| M. avium 104 | MAV_1954 | - | 4e-22 | 33.50% (203) | hypothetical protein MAV_1954 |
| M. thermoresistible (build 8) | TH_4081 | - | 1e-24 | 35.57% (194) | PUTATIVE putative hydride transferase 1 |
| M. ulcerans Agy99 | MUL_3448 | - | 2e-24 | 31.73% (271) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5819 | - | 8e-24 | 33.80% (213) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2185c|M.bovis_AF2122/97 ----------MLVSLMQFVTDLTPPP---QLVAVWAEERGFAGLYVPEKT
Rv2161c|M.tuberculosis_H37Rv ----------MLVSLMQFVTDLTPPP---QLVAVWAEERGFAGLYVPEKT
Mflv_1017|M.gilvum_PYR-GCK ----------MKFGISTFPNEDTIDP---VSLARAVEERGFAALAVAEHT
Mvan_5819|M.vanbaalenii_PYR-1 ----------MKFGIATFVNDTTIDP---VALARAVEDRGFGSLAVAEHT
MAB_4908c|M.abscessus_ATCC_199 ---------MTGFGISTTSADGYVSP---DVLARAVEERGFEWLLFDDHS
MMAR_1586|M.marinum_M ----------MQLGLHALGIGAGADRSMIDAVACAADDAGFATLWAGEHV
MUL_3448|M.ulcerans_Agy99 ----------MQLGLHALEIGAGADRSMIDAVACAADDAGFATLWAGEHV
MAV_1954|M.avium_104 MRFTVYLPNTMHVSAMTQPWEHALTGSDIAHAARTAEELGYSQVFLPEHF
MSMEG_4398|M.smegmatis_MC2_155 ----------MKLGLRLPQRLNVDLRHDVVWAARAAEAAGFASLWTYERL
TH_4081|M.thermoresistible__bu ----------VKFGISLFP----LRPRQMVDVAVAAERLGYDSVWLGEHV
MLBr_00348|M.leprae_Br4923 ---MVERANAMKLGLQLGYWAAQPPGN-AAELVAAAEGAGFDAVFTGEAW
.. . .: *: : :
Mb2185c|M.bovis_AF2122/97 HVPISRSTPWP-GGELPDWYR----RCYDPVVALAAAAAVTTRLRVGTGA
Rv2161c|M.tuberculosis_H37Rv HVPISRSTPWP-GGELPDWYR----RCYDPVVALAAAAAVTTRLRVGTGA
Mflv_1017|M.gilvum_PYR-GCK HIPASRESAYPLGGELPKIYY----RTLDPFVTLAAAAAVTSEIELITGI
Mvan_5819|M.vanbaalenii_PYR-1 HIPASRESAYPLGGELPSIYY----RTLDPFVTLAAAAAVTTSIELVTGI
MAB_4908c|M.abscessus_ATCC_199 YFPVD--TPDSIDAEFRARLP----LIRDLPVVLAYAASATERLIVGSGV
MMAR_1586|M.marinum_M VMVDRHTSRYPYSEDGVIAIPP-QADWLDPMIALSFAAAASSRITVATGV
MUL_3448|M.ulcerans_Agy99 VMVDRHTSRYPYSEDGVIAIPP-QADWLDPMIALSFAAASSSRITVATGV
MAV_1954|M.avium_104 LTPIPHVELSG-------------NHYFDATTAQAFVAGATSTIQVGSMV
MSMEG_4398|M.smegmatis_MC2_155 LFPADPVESYAGTDAPWPTHS---RQAADPLAVLTAAAVVTETARLGTSV
TH_4081|M.thermoresistible__bu VTPIHSDSTFPYAEDDAHAAFHGQLPFYDPFAALGYLAAQTSTLRLVLSI
MLBr_00348|M.leprae_Br4923 G--------------------------SDAYTPLAWWGSSTQRVRLGTSV
* . : :
Mb2185c|M.bovis_AF2122/97 CLVAVHDPILLAKQIASLCAMSGERFVLGVGFGWNVEELADHGVPFADRI
Rv2161c|M.tuberculosis_H37Rv CLVAVHDPILLAKQIASLCAMSGERFVLGVGFGWNVEELADHGVPFADRI
Mflv_1017|M.gilvum_PYR-GCK ALLIQRDPIITAKEAASIDVISGGRFVFGVGAGWNIEELRHHGTDPKTRG
Mvan_5819|M.vanbaalenii_PYR-1 ALLIQRDPIITAKEAASIDLISNGRFVFGVGAGWNLEELRHHGTDPKTRG
MAB_4908c|M.abscessus_ATCC_199 ALLPQRDVLHTAKAWATVATLSGGRTVLGVGVGWNLGEVRNHGIDPAKRG
MMAR_1586|M.marinum_M LLLPEHNPVVVAKQAASLDRLSGGRLTLGVGVGWSREEFAALGVPFQDRA
MUL_3448|M.ulcerans_Agy99 LLLPEHNPVVVAKQAASLDRLSGGRLTLGVGVGWSREEFAALGVPFQDRV
MAV_1954|M.avium_104 TILPLHNPVIAAKAISTLDWFSGGRAQVTVGVGWLKDEFDIIGVPFNKRG
MSMEG_4398|M.smegmatis_MC2_155 LVAGLHTPIQLAKALATVDQISGGRMIAGLGTGWSTDEFRAAGARRADRG
TH_4081|M.thermoresistible__bu SIVPVHDPFHLARSVTTLDLFSEGRFWFGMGAGWLREEFEILQKPFDGRG
MLBr_00348|M.leprae_Br4923 VQLSARTPTACAMAALTLDHLSGGRHILGLGVSGPQVVEGWYGQPFPKPL
: * :: :* * :* .
Mb2185c|M.bovis_AF2122/97 AVTVDKLAAMRALWAAEP-VHYEGTHASVPPSWA-------WPKPAVAP-
Rv2161c|M.tuberculosis_H37Rv AVTVDKLAAMRALWAAEP-VHYEGTHASVPPSWA-------WPKPAVAP-
Mflv_1017|M.gilvum_PYR-GCK ALLDERIEAIKVLWTQEP-AEYHGRFVDFDASYQ-------RPKPVRKPH
Mvan_5819|M.vanbaalenii_PYR-1 ALLDERIEAIKALWTAEP-AEYHGKYVDFDASYL-------RPKPVQKPH
MAB_4908c|M.abscessus_ATCC_199 AVLDEQLAALHALWTQEQ-AEFHGEHVDFGPVVA-------RPRPARP--
MMAR_1586|M.marinum_M GRTAEYVAAMRTLWRDDL-ASFTGEFVRFDSVRV-------NPKPVRDRR
MUL_3448|M.ulcerans_Agy99 GRTAEYVAAMRTLWRDDL-ASFTGEFVRFDSVRV-------NPKPVRDRR
MAV_1954|M.avium_104 RITDECLAAMFELWHSDS-PSFDGEFVKFKDVAF-------GPKPIRKPH
MSMEG_4398|M.smegmatis_MC2_155 PLLDETRDVLDAVWARDP-VTFRSPHVIIDDAAV-------LPKPVAQMP
TH_4081|M.thermoresistible__bu RILDETIDIMNRLFTQDV-TTYRGRHFTVPPVGL-------QPKPLTRPH
MLBr_00348|M.leprae_Br4923 SRTREYIDIVRQVWAREAPVVSDGQHYPLPLTGAGATGLGKALKPITHPL
: : :: : . . . :*
Mb2185c|M.bovis_AF2122/97 ----PVLFGCR----PSARAFEVIARHGDGWQPIEGY------GELLGAL
Rv2161c|M.tuberculosis_H37Rv ----PVLFGCR----PSARAFEVIARHGDGWQPIEGY------GELLGAL
Mflv_1017|M.gilvum_PYR-GCK ---PPILIGG-----DSDATVRRIIRHGAGWIANP---------LPIDHL
Mvan_5819|M.vanbaalenii_PYR-1 ---PPILIGG-----DSDAAVKRIIRHEAGWISNP---------LPVDTL
MAB_4908c|M.abscessus_ATCC_199 ---LPVHVGG-----PSRAAQARALRVGDGWLPYAGT-------STPDDV
MMAR_1586|M.marinum_M ---VPVMVGG-----NSDAALRRVAAWADGWYGFNLDG----VGAVRERV
MUL_3448|M.ulcerans_Agy99 ---VPVMVGG-----NSDAALRRVAAWADGWYGFNLDG----VGAVRERV
MAV_1954|M.avium_104 ---PVIWMGG-----DADAVLRRAARFGDGWAPWLTR--------PEELP
MSMEG_4398|M.smegmatis_MC2_155 ---VLLAGGGSLPDRSASKAMRRIAARADGWLPLLTEPGQAGATRLRTDW
TH_4081|M.thermoresistible__bu ---PPYLFGG-----HSRKALERAAARGQGWLSSGMSP-----ERNAEAI
MLBr_00348|M.leprae_Br4923 RADIPIMLGAE-----GPKNVALAAEICDGWLPIFFSPR---MADMYNEW
* . **
Mb2185c|M.bovis_AF2122/97 PMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRR-------------A
Rv2161c|M.tuberculosis_H37Rv PMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRR-------------A
Mflv_1017|M.gilvum_PYR-GCK SRRIEQIREGAGGDVPLCQFGTPVKPEYWQAAEELG-------------F
Mvan_5819|M.vanbaalenii_PYR-1 RRRVDQIRAGARHEVPLSMFGTPVKPEYWQAAEDLG-------------F
MAB_4908c|M.abscessus_ATCC_199 RRACGWFAEQGRADLPVTVSGVPG--DHQLAGEYLG-------------A
MMAR_1586|M.marinum_M GTLDRLCAESGRNRDELRLSVALRCPQPCDVDALAE-------------L
MUL_3448|M.ulcerans_Agy99 GTLDRLCAESGRNRDELRLSVALRCPQPCDVDALAE-------------L
MAV_1954|M.avium_104 AKMDYLRSQPGFDDRPFSLFYSLAVLAIGQEHAIVDDPNAQFGQSAQQVI
MSMEG_4398|M.smegmatis_MC2_155 DRIRELAAERGRTPDAMEMIVVGNVTFTERSAGPDRPAFVG---TFDQIV
TH_4081|M.thermoresistible__bu AFLRRERRRLGVDDQPFECSTHLVGPVDRGLVDAYR------------EA
MLBr_00348|M.leprae_Br4923 LDEGFARTGARRSREDFEICASAQIVVTEDRAAAFAG----IKPFLALYM
Mb2185c|M.bovis_AF2122/97 GVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDDREVKSHA--------
Rv2161c|M.tuberculosis_H37Rv GVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDDREVKSHA--------
Mflv_1017|M.gilvum_PYR-GCK GQLNLLLPTKSRDVS--LRLLDDYAEQVARYIG-----------------
Mvan_5819|M.vanbaalenii_PYR-1 GQLNLLLPTKPRDES--LRLLDGYAEQVARY-------------------
MAB_4908c|M.abscessus_ATCC_199 GAERVLFDVHPLNEADTLRALDRLTEVVARLT------------------
MMAR_1586|M.marinum_M GIDELVLVETPPEAAD--AAQNWVSALAERWLSTVWVR------------
MUL_3448|M.ulcerans_Agy99 GIDELVLVETPPEAAD--AAQNWVSALAERWLSTVWVR------------
MAV_1954|M.avium_104 DNCNMLAELGVTDTWVNPPPLDDFQAYLDHMHWVAEEVIPKVG-------
MSMEG_4398|M.smegmatis_MC2_155 EDVHTAAEAGADELIVDLNLQDWFTSTPQMLETAVQIHERFVAA------
TH_4081|M.thermoresistible__bu GVDRLVVRPWRKGGQAVEAITRLADDLGVTRTDRVTDCSTHTI-------
MLBr_00348|M.leprae_Br4923 GGMGAEGTNFHADVYRRMGYAEVVDEVTALFRSNQKDKAAEIIPNELVDS
Mb2185c|M.bovis_AF2122/97 ------------------------------------------
Rv2161c|M.tuberculosis_H37Rv ------------------------------------------
Mflv_1017|M.gilvum_PYR-GCK ------------------------------------------
Mvan_5819|M.vanbaalenii_PYR-1 ------------------------------------------
MAB_4908c|M.abscessus_ATCC_199 ------------------------------------------
MMAR_1586|M.marinum_M ------------------------------------------
MUL_3448|M.ulcerans_Agy99 ------------------------------------------
MAV_1954|M.avium_104 ------------------------------------------
MSMEG_4398|M.smegmatis_MC2_155 ------------------------------------------
TH_4081|M.thermoresistible__bu ------------------------------------------
MLBr_00348|M.leprae_Br4923 TMIVGDVDYVCKQIAAWSAAGVTMMMVSASSVEQVRDLAGLF