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VAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGVAAKVVPKIDA NYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGKAMLGIGVGEREGNEPYGVE WTKPVARFQEALATIRALWDSNGELVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYAD AWIPIVLVRPTDYSCALEVVRTAASDAGRDPMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGE AWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYL VVINGSLVNSSLRKTVSALLPHARVLRGLKKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00131 | - | - | 100% (382) | putative oxidoreductase |
| M. leprae Br4923 | MLBr_00269 | - | 6e-14 | 26.03% (315) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00348 | - | 1e-11 | 25.69% (288) | putative coenzyme F420-dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2975c | - | 0.0 | 85.08% (382) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3380 | - | 1e-161 | 70.71% (379) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2951c | - | 0.0 | 85.08% (382) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0366 | - | 2e-16 | 31.61% (193) | hypothetical protein MAB_0366 |
| M. marinum M | MMAR_1758 | - | 0.0 | 81.10% (381) | ketoreductase |
| M. avium 104 | MAV_0066 | - | 1e-54 | 36.55% (342) | hypothetical protein MAV_0066 |
| M. smegmatis MC2 155 | MSMEG_3301 | - | 5e-15 | 33.70% (181) | hypothetical protein MSMEG_3301 |
| M. thermoresistible (build 8) | TH_2487 | - | 2e-16 | 30.56% (216) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3202 | - | 1e-15 | 30.53% (226) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0698 | - | 1e-14 | 28.42% (292) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2975c|M.bovis_AF2122/97 ------MGG--LRFGFVDALVHS---------------RLPPTLPARSSM
Rv2951c|M.tuberculosis_H37Rv ------MGG--LRFGFVDALVHS---------------RLPPTLPARSSM
MLBr_00131|M.leprae_Br4923 ------MAG--FRFGFVDALVHT---------------LFPPSLPARASI
MMAR_1758|M.marinum_M ---MKKSSG--FRYGFVDAPVHS---------------RLPPSMIARSSM
Mflv_3380|M.gilvum_PYR-GCK MSPRPRSAGSQFRFGLLDGIVNT---------------RVSPTLLPSAAM
MAV_0066|M.avium_104 ----------------MTVQPAA---------------FLRTTLPLDLSR
MSMEG_3301|M.smegmatis_MC2_155 -----------MRFAFKTSPQN------------------TTWQDMLAVW
MUL_3202|M.ulcerans_Agy99 -----------MHENTSNPPQHGGPQFGLILALMTQGLAISDYPDMVRVS
TH_2487|M.thermoresistible__bu ------------MTDYGHDLLFG------------------TFVTPSNHP
MAB_0366|M.abscessus_ATCC_1997 -----------MKIGVVAPVELG----------------VTAEPDKILEF
Mvan_0698|M.vanbaalenii_PYR-1 --------MAELKLGYKASAEQF-------------------APRELVEL
Mb2975c|M.bovis_AF2122/97 AAATVMG-ADSYWVGDHLNALVPRSIATS-----EYLGIAAKFVPKIDAN
Rv2951c|M.tuberculosis_H37Rv AAATVMG-ADSYWVGDHLNALVPRSIATS-----EYLGIAAKFVPKIDAN
MLBr_00131|M.leprae_Br4923 VSGAVLG-ADSYWVGDHLNALVPRSVATP-----KYLGVAAKVVPKIDAN
MMAR_1758|M.marinum_M MAGAVMG-ADSYWIGDHLNALVPRSVATP-----EFLGLGARLVPKVDAN
Mflv_3380|M.gilvum_PYR-GCK LTASATG-ADSFWVGDHINSLVPRSVATP-----EHLGLAAKLVPKVDAI
MAV_0066|M.avium_104 LDEFDSGRYHSVWLPDHMVSFWPDSIWAP-----EFTDLATASASPHRHL
MSMEG_3301|M.smegmatis_MC2_155 QTADDIEVFESGWTFDHFYPIVGD---------------------SSGPC
MUL_3202|M.ulcerans_Agy99 TLAESYG-FDSVWLCDHFLTLSPDDYVTQAGISGEHERRDGRDRPGTMPL
TH_2487|M.thermoresistible__bu PHHPVEQAVVADRAGLDLVTFQDHPYVAK--------------------Y
MAB_0366|M.abscessus_ATCC_1997 ARAAERLGFSEISVVEHAVVIGDTQSTYP------YSPTGQSHLPDDIDI
Mvan_0698|M.vanbaalenii_PYR-1 AVAAEEHGMDSATVSDHFQPWRHEGGHAP---------------------
.
Mb2975c|M.bovis_AF2122/97 YEPWTMLGNLAFG-LPSRLRLGVCVTDAGRRN-PAVTAQAAATLHLLTRG
Rv2951c|M.tuberculosis_H37Rv YEPWTMLGNLAFG-LPSRLRLGVCVTDAGRRN-PAVTAQAAATLHLLTRG
MLBr_00131|M.leprae_Br4923 YEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRN-PAVTAQAAATLHLLTRG
MMAR_1758|M.marinum_M YEPWTMLGNLAAGNRINRLRLGVCVTDVGRRN-PAVTAQAAATVHLLTRG
Mflv_3380|M.gilvum_PYR-GCK LEPWTMLGHLAAR-HRGRLRFGVGVTDASRRH-PAVTAQAAATLHLLTRG
MAV_0066|M.avium_104 DG---LAVAAAAAVLTERVPLVSAVVDTVRRH-PALLAQTALTLDHLSKG
MSMEG_3301|M.smegmatis_MC2_155 LEGWTTLTALAQA--TSRLRLGTLVTGVHYRH-PAVLANMAAALDIISNG
MUL_3202|M.ulcerans_Agy99 LEAWTALSALARD--TTYIRLGTSVLCNSYRH-PAVLAKMAATLDIISEG
TH_2487|M.thermoresistible__bu HDTWTLMSYAAAR--TQRVRLSANVANLPLRP-PAVLARSAAGLDLLSGG
MAB_0366|M.abscessus_ATCC_1997 PDPLELLSFVAAA--TTTLGLSTGVLVLPDHH-PVVLAKRLATLDRLSRG
Mvan_0698|M.vanbaalenii_PYR-1 ---FSLAWMTAVGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPG
* : : * : *.: *. : : *
Mb2975c|M.bovis_AF2122/97 RAILGIGVGEREGN--EPYGVEWT---KPVARFEEALATIRALWNSNGE-
Rv2951c|M.tuberculosis_H37Rv RAILGIGVGEREGN--EPYGVEWT---KPVARFEEALATIRALWNSNGE-
MLBr_00131|M.leprae_Br4923 KAMLGIGVGEREGN--EPYGVEWT---KPVARFQEALATIRALWDSNGE-
MMAR_1758|M.marinum_M RAILGIGVGEREGN--EPYGVEWS---KPVARFEEGLATIRALWDSNGA-
Mflv_3380|M.gilvum_PYR-GCK RAILGIGVGEREGN--EPYGVEWT---KPVARFVEALATIRALWESGGE-
MAV_0066|M.avium_104 RFILGLGSGESENT--VPYGFDFA---RPVSRFEEALRVIRLLWDTDG--
MSMEG_3301|M.smegmatis_MC2_155 RLELGIGAGWNEEES-GAYGIELGSIKERLDRFEEATQVLIGLLSQDS--
MUL_3202|M.ulcerans_Agy99 RLDLGLGAGWFEREF-TAYGIPFLPVGDRVTGLGEALEVITAIWTQPD--
TH_2487|M.thermoresistible__bu RVELGLGAGAFWDGV-VAMGGERRSPGAAIKALEEAIAVIRGIWDVDAAG
MAB_0366|M.abscessus_ATCC_1997 RLRICAGVGWMREEI-EACGGDFD---RRGRAADEAIAVMRALWSTDGP-
Mvan_0698|M.vanbaalenii_PYR-1 RIFLGVGTGEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGDR--
: : * * *. : :
Mb2975c|M.bovis_AF2122/97 LISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGP-RMLRATGRYADAWI
Rv2951c|M.tuberculosis_H37Rv LISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGP-RMLRATGRYADAWI
MLBr_00131|M.leprae_Br4923 LVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHGP-RMLQATGRYADAWI
MMAR_1758|M.marinum_M LVTRESPYFPLRNALFDLPPYKGKWPEIWVAAHGP-RMLRATGRYADAWV
Mflv_3380|M.gilvum_PYR-GCK PVTRESDYFPLRHAVFDLPPYKGRWPEIWVAAHGP-RMLRATGRYADGWV
MAV_0066|M.avium_104 PVDFNGEFYSLHQARLDTEPYHDRLPPIWIGASGP-RMLDIAGRYADGWW
MSMEG_3301|M.smegmatis_MC2_155 -TDFDGAFYTLKNARNEPKGPQRPHPPIVMGGSGEKRTLRITAKYADHWN
MUL_3202|M.ulcerans_Agy99 -PVYSGRFYTLDGAICDPPPVQTPHPPLWVGGEGD-RVHRIAARSAQGIN
TH_2487|M.thermoresistible__bu VLDVDGAHYRIRGAKRGPAPAHR--ISIWIGGYGP-RMLGLVGRLADGWL
MAB_0366|M.abscessus_ATCC_1997 -TSHDGEFYSFRNAYSYPKPVRPQGVPLYIGGHSK-AAARRAGRLGSGFQ
Mvan_0698|M.vanbaalenii_PYR-1 -VDFEGEYYKTKGASIYDVPEGG--IPIYIAAGGP-QVAKYAGRAGDGFI
.. .: * : :.. . ..: ..
Mb2975c|M.bovis_AF2122/97 PIVVVRP---SDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDD
Rv2951c|M.tuberculosis_H37Rv PIVVVRP---SDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDD
MLBr_00131|M.leprae_Br4923 PIVLVRP---TDYSCALEVVRTAASDAGRDPMSITPAAVRGIITGRTRDD
MMAR_1758|M.marinum_M PIVIIRP---TDYSRALEAVRAAASDAGRDPMSITPSAVRGVVTGWSRDD
Mflv_3380|M.gilvum_PYR-GCK PFVISRP---ADYARALDAVRTAASDNGRDPMAIVPAVNRTVVTGRTRAD
MAV_0066|M.avium_104 PAGAWTP---EHYAEMLGAVRVSAERAGRDPMAITPCFIQVCLIGEDDDA
MSMEG_3301|M.smegmatis_MC2_155 -FVLGTP---EEFAHKRDVLWSHCADIGRDPKEIT---------------
MUL_3202|M.ulcerans_Agy99 -VRWWLP---QKVKQRKDFLAQTCATAQRDPTTLR---------------
TH_2487|M.thermoresistible__bu PSLQYLSGGVSDLTAMNQRIDDAAVAAGRDPRQIR---------------
MAB_0366|M.abscessus_ATCC_1997 PLGLVGD----DLTAAVGVMRAAAVDAGRDPRGLD---------------
Mvan_0698|M.vanbaalenii_PYR-1 CTSGKGEE--LYKDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPEL
: . ::* :
Mb2975c|M.bovis_AF2122/97 VEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQT
Rv2951c|M.tuberculosis_H37Rv VEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQT
MLBr_00131|M.leprae_Br4923 VDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEET
MMAR_1758|M.marinum_M VDEALDSVIVKMNALGMPAEAWARHGVEHPMGADFTGVQDLIPQTMDRET
Mflv_3380|M.gilvum_PYR-GCK VDEALDSVIVKSVALAAPAEAWARHGVEHPLGSDFSGVQDLVPQMIDKEA
MAV_0066|M.avium_104 LAEILRAPLVKAFLLQVSAKTLGEFGFEHPMGDGWRGFQDIDPAALGRDR
MSMEG_3301|M.smegmatis_MC2_155 ------------LSAHVWHNAEHDHQKLLTEVAAFG--------------
MUL_3202|M.ulcerans_Agy99 ------------FSVTALLAPTDSAEQEAQIRTEFS--------------
TH_2487|M.thermoresistible__bu ------------RLLNVGGQPSADELADIALSHGIS--------------
MAB_0366|M.abscessus_ATCC_1997 ------------LVLGHGLHRVDQAALDQAAHAGAG--------------
Mvan_0698|M.vanbaalenii_PYR-1 ALEN--TRFWAPLSLTAEQKHSIDDPIEMEKAADALP-------------
Mb2975c|M.bovis_AF2122/97 VLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNP
Rv2951c|M.tuberculosis_H37Rv VLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNP
MLBr_00131|M.leprae_Br4923 VVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNS
MMAR_1758|M.marinum_M VLSYTAKVPPGLIREVVASGTPDEVIDQVAEWRDHGLRYLLVINGSLVNP
Mflv_3380|M.gilvum_PYR-GCK ALAYTASVPASLMKEICFHGTADEVLDQVAEWRDHGLRYLLVINGSQLNP
MAV_0066|M.avium_104 IVEFLHRVRPEMVLAVVPHGTPKQVAKIVKSYVDAGLRVPKILDYG-AMA
MSMEG_3301|M.smegmatis_MC2_155 ----------EVGLDLAIIYLPPPLTPAILEPLAA----------AITAS
MUL_3202|M.ulcerans_Agy99 ----------AVPYDGLIVGPADRCIERINEYYESGVDTFLFTIPDVARS
TH_2487|M.thermoresistible__bu ----------AFILASDDTATTERFAAEVAP----------------AVR
MAB_0366|M.abscessus_ATCC_1997 ---------RMLLSASRRATTLEAVLEEMAG----------------CAT
Mvan_0698|M.vanbaalenii_PYR-1 --------IEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQR
. :
Mb2975c|M.bovis_AF2122/97 SLRKTVTAVLPHAKVLRGLKKL-----
Rv2951c|M.tuberculosis_H37Rv SLRKTVTAVLPHAKVLRGLKKL-----
MLBr_00131|M.leprae_Br4923 SLRKTVSALLPHARVLRGLKKL-----
MMAR_1758|M.marinum_M SLRKTVTAVLPHAKVLRGLKKL-----
Mflv_3380|M.gilvum_PYR-GCK KLRKGVSATLPYNRVLRGLKKL-----
MAV_0066|M.avium_104 GLSHAQSSAANVRATEDELMRLCGDGS
MSMEG_3301|M.smegmatis_MC2_155 GLLTTTKE-------------------
MUL_3202|M.ulcerans_Agy99 DLIHTVGQEVLPAFD------------
TH_2487|M.thermoresistible__bu ELVTAQR--------------------
MAB_0366|M.abscessus_ATCC_1997 RLELGGPR-------------------
Mvan_0698|M.vanbaalenii_PYR-1 RFLELFRRDLEPRLRKLG---------
: