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GDMPIVTSPARSYDFIVCGAGTAGSVVARRLAENPAVSVLLVEAGGTDQVPSVAAADQWPLNLGSERDWG FSAVATSHLNGRAVPLSMGKVLGGGSSINLMVWARGHKADWDYFAFESGDEGWGYESVLDLYRRIEDFHG DPDPDYRGTGGPVYVTPAPDPNPLAPATIEAARTVGIPTFENQNGRMMEQSAGAAISDIRARGGRRQSVF TSYVTPVLHRPNLDVLTCALVTRVSFDGDRATGVELVLDGQSRRIAVNTEVILSLGAINTPKVLLHSGIG DETELRRVGIPLHTHLSGVGRNLQDHPGFDCVWEYSEPLAPRNNASEATYFATSAAGMDAPDLQTCQAEV PKSSAENIARFGLPEFGWTLFAGVVRPKSRGHLALRSADPVDPIDIHANMLAHPDDVKAAVAAVELCREI GNSAPLRPFAKREVMPGNLRGPDLERFVRDAASSYWHQTCTAKMGRDAMSVVDAALNVYGVKGLRVADGS IMPRVTTGNTMAPCVVIGERAADIIRKEHAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0327 | - | - | 100% (522) | glucose-methanol-choline oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 0.0 | 69.55% (509) | glucose-methanol-choline oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2938 | - | 4e-63 | 31.45% (566) | glucose-methanol-choline oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 1e-72 | 35.82% (536) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 6e-71 | 34.65% (531) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 1e-72 | 35.82% (536) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 1e-64 | 33.59% (527) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4427 | - | 0.0 | 63.48% (512) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 7e-63 | 34.84% (442) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0281 | - | 0.0 | 68.11% (508) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 1e-70 | 34.99% (563) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 3e-71 | 34.91% (530) | dehydrogenase fad flavoprotein GMC oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 ---------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDK
Rv1279|M.tuberculosis_H37Rv ---------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDK
MUL_4004|M.ulcerans_Agy99 ---------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDK
MAB_0250|M.abscessus_ATCC_1997 -------MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDK
Mvan_0327|M.vanbaalenii_PYR-1 MGDMPIVTSPARSYDFIVCGAGTAGSVVARRLAENPAVSVLLVEAGGTDQ
MSMEG_0281|M.smegmatis_MC2_155 ---MNVEIN--QRYDFIVCGSGSSGSVVARRLAENPDADVLLLEAGGSDD
MMAR_4427|M.marinum_M MCSDPIAAR----YDFVVCGSGSAGSVVARRLSENSNVAVLLLEAGGTDD
MAV_4980|M.avium_104 --------------------------------------------------
TH_3275|M.thermoresistible__bu -MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGKRHSVLVLEAGGSDL
Mflv_1255|M.gilvum_PYR-GCK --------MAVTGYDYIVVGAGSAGCVLANRLSADPAIRVLLLEAGRGDR
Mb1310|M.bovis_AF2122/97 NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMN
Rv1279|M.tuberculosis_H37Rv NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMN
MUL_4004|M.ulcerans_Agy99 NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMN
MAB_0250|M.abscessus_ATCC_1997 DMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMN
Mvan_0327|M.vanbaalenii_PYR-1 VPSVAAADQWPLNLGSERDWGFSAVATSHLNGRAVPLSMGKVLGGGSSIN
MSMEG_0281|M.smegmatis_MC2_155 VPEVQQAVQWPENLGSPRDWQFEAQANPHLNGRAIPMNMGKVLGGGSSIN
MMAR_4427|M.marinum_M VAEVMDPAQWPVNLGSARDWGFASAPSAHLNGRSIPLSMGKVLGGGSSIN
MAV_4980|M.avium_104 --------------------------MQTAIGRAVPFARGRGIGGSSTIN
TH_3275|M.thermoresistible__bu SPFIRIPAGLMR-VNPRNYWHFRLEPDPTRNGAVDTWAAGRVVGGGSSVN
Mflv_1255|M.gilvum_PYR-GCK NLWLHIPKGAGKLFDSERHMWHYETTPFGPDAHVEQWMRGKVIGGSSAVN
.: :**.*::*
Mb1310|M.bovis_AF2122/97 AMMWVRGFASDYDEWAARAGPR-WSYADVLGYFRRIENVTAAWHFVSGDD
Rv1279|M.tuberculosis_H37Rv AMMWVRGFASDYDEWAARAGPR-WSYADVLGYFRRIENVTAAWHFVSGDD
MUL_4004|M.ulcerans_Agy99 AMMWVRGFAADYDEWARLAGSH-WSYGELLGYFRQIEDVTAAWHFVNGDD
MAB_0250|M.abscessus_ATCC_1997 AMMWVRGFAADYDDWAQVAGEQ-WSFANIAPYFKRIEAVEG----ATESD
Mvan_0327|M.vanbaalenii_PYR-1 LMVWARGHKADWDYFAFESGDEGWGYESVLDLYRRIEDFHGDP---DPDY
MSMEG_0281|M.smegmatis_MC2_155 VMMWSRGHRNDWDFFAAEADDEGWGYEAVLDIYRRIEDWQGKP---DPQY
MMAR_4427|M.marinum_M VMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRRIEDWHGRC---DGDR
MAV_4980|M.avium_104 AMVFARGHRDSYSRWRDN-GAAGWSFDELLPYFKRSESTCGK----DPSL
TH_3275|M.thermoresistible__bu AMLWVRGNRADFDTWAKL-GAQGWDYESLLPAMRSLETWEGG----ADRY
Mflv_1255|M.gilvum_PYR-GCK GMIYNRGHRADYDALEQMGNKG-WGWDEILPIFKGFEDHEFGP----SAT
* : ** .: . *.: : : *
Mb1310|M.bovis_AF2122/97 SGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSP----RPEGFCE
Rv1279|M.tuberculosis_H37Rv SGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSP----RPEGFCE
MUL_4004|M.ulcerans_Agy99 SGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQPNSA----EPEGFCE
MAB_0250|M.abscessus_ATCC_1997 EGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTP----EPKGFSE
Mvan_0327|M.vanbaalenii_PYR-1 RGTGGPVYVTPAPDPNPLAPATIEAARTVGIPTFENQNGRMMEQSAGAAI
MSMEG_0281|M.smegmatis_MC2_155 RGTDGNVYVQPAPDPNPIADAAVAAAASVGIPAFDHPNGAMMEGAGGAAL
MMAR_4427|M.marinum_M RGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYDSNNGIMMEGPGGASL
MAV_4980|M.avium_104 RGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFG---F
TH_3275|M.thermoresistible__bu RGGTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILADYNG---ESQFGAAW
Mflv_1255|M.gilvum_PYR-GCK RGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRDINE---SDGERIGY
* * : . : .. * .
Mb1310|M.bovis_AF2122/97 TVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEY
Rv1279|M.tuberculosis_H37Rv TVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEY
MUL_4004|M.ulcerans_Agy99 TIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHGTRATGVEY
MAB_0250|M.abscessus_ATCC_1997 TMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEY
Mvan_0327|M.vanbaalenii_PYR-1 SDIRARGGRRQSVFTSYVTPVLHRPNLDVLTCALVTRVSFDGDRATGVEL
MSMEG_0281|M.smegmatis_MC2_155 SDIRVRDGIRQSVFRSYVHPYLGRPNLTVLTGAVVTRVTLDGHRASGVEF
MMAR_4427|M.marinum_M LDLQLRNRLRESVFRSYVHPYLQQRNLTVLTGATVRRLTFSGSRVTGVEF
MAV_4980|M.avium_104 TDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIRGSRCTGVEY
TH_3275|M.thermoresistible__bu SQLSQKNGLRHSAAQAFLAPARRRGEVDVESHAVVDKVIIENGRAVGVEY
Mflv_1255|M.gilvum_PYR-GCK ATSTIRGGRRVSAATAFLKPVLHRPNLTVRTGATVRRVLFDGERADGVEI
* *. .:: * : :: . : * . :: : . * ***
Mb1310|M.bovis_AF2122/97 QSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHA
Rv1279|M.tuberculosis_H37Rv QSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHA
MUL_4004|M.ulcerans_Agy99 QREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIETVYHA
MAB_0250|M.abscessus_ATCC_1997 VRDGITHTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDA
Mvan_0327|M.vanbaalenii_PYR-1 VLDGQSRRIAVNTEVILSLGAINTPKVLLHSGIGDETELRRVGIPLHTHL
MSMEG_0281|M.smegmatis_MC2_155 VRDGVTFRVAAGSEVVLGLGAINTPKVLMLSGIGDSAELARHGIKTVVHL
MMAR_4427|M.marinum_M SHANAIRTVSATQEVVVSLGAVNTPKVLMQSGIGDANDLRGFGIPVVTHL
MAV_4980|M.avium_104 TTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGPPNHLRSFRVDVALEL
TH_3275|M.thermoresistible__bu VRRGTRKVAYAAKEVILSAGALCSPLILLRSGIGPAEELRDHGIDVIADL
Mflv_1255|M.gilvum_PYR-GCK ATGAGTEQVRAAREVVLSLGSLNSPKLLQLSGIGPSDVLGAAGVPVLVER
. *::: *:: :* :* **** * : .
Mb1310|M.bovis_AF2122/97 PEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQL------ISYLLRRRGML
Rv1279|M.tuberculosis_H37Rv PEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQL------ISYLLRRRGML
MUL_4004|M.ulcerans_Agy99 PEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQL------INYLLRRRGML
MAB_0250|M.abscessus_ATCC_1997 PQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQL------ANYFLRHRGML
Mvan_0327|M.vanbaalenii_PYR-1 SGVGRNLQDHPGFDCVWEY-----SEPLAP--------------------
MSMEG_0281|M.smegmatis_MC2_155 PGVGRNLQDHPAFGCVWEY-----DVALEP--------------------
MMAR_4427|M.marinum_M RGVGHNYQDHPRIDCVWES-----HEALAP--------------------
MAV_4980|M.avium_104 PGVGANLQDHPIVPLVYRA-----ARPVPAG-------------------
TH_3275|M.thermoresistible__bu PGVGRNLQEHPAITMTFTVTDRTLNQELTPL-------------------
Mflv_1255|M.gilvum_PYR-GCK DNVGRRMREHRCATLRYRLKEDLGYNKLLATNVGQALTGMKYLATRKGPL
** . :* : .
Mb1310|M.bovis_AF2122/97 TSNVGEAYGFVRSRPELKLPD-----------------------------
Rv1279|M.tuberculosis_H37Rv TSNVGEAYGFVRSRPELKLPD-----------------------------
MUL_4004|M.ulcerans_Agy99 TSNVGEAYGFVRSRPGLDLPD-----------------------------
MAB_0250|M.abscessus_ATCC_1997 TSNVGEAYGFLRSHPNLTLPD-----------------------------
Mvan_0327|M.vanbaalenii_PYR-1 RNNASEATYFATSAAGMDAPD-----------------------------
MSMEG_0281|M.smegmatis_MC2_155 RNTGSEATYFAKSDSRLDTPD-----------------------------
MMAR_4427|M.marinum_M RNNGAEVTVFWKSHPKLATPD-----------------------------
MAV_4980|M.avium_104 RYNHGELLGLIRRHATGGPPE-----------------------------
TH_3275|M.thermoresistible__bu SILKGAFDFVLRRRGPATAPLSHAMLFGPPLEPEGWPQYHVLMAPLGTEQ
Mflv_1255|M.gilvum_PYR-GCK AAPSFDVVGFVKDRPDSERPLG----------------------------
. *
Mb1310|M.bovis_AF2122/97 --LELIFAPAP--FYDEALVP-PAGHGVVFGPILVAPQSRGQITLRSADP
Rv1279|M.tuberculosis_H37Rv --LELIFAPAP--FYDEALVP-PAGHGVVFGPILVAPQSRGQITLRSADP
MUL_4004|M.ulcerans_Agy99 --LELIFAPAP--FYDEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADP
MAB_0250|M.abscessus_ATCC_1997 --LELIFAPAP--FFDEGIGV-ATEHAIVMGPILLKPESSGEITLTSPDP
Mvan_0327|M.vanbaalenii_PYR-1 --LQTCQAEVPKSSAENIARFGLPEFGWTLFAGVVRPKSRGHLALRSADP
MSMEG_0281|M.smegmatis_MC2_155 --LQTCQIEAPFASAETIARFGLPQAAWTMFAGIVRPESRGSVRLTGCSP
MMAR_4427|M.marinum_M --LQICVAEFPLSSPENAARYGLPAHGWTMCVGVVRPQSRGRVRLTGAHP
MAV_4980|M.avium_104 --IQIFGVDS-----ADVPGLGG-ADGYVLGVSVMQPVSRGRVGLSGPTI
TH_3275|M.thermoresistible__bu EKPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSPLHPRGRGTVRLGSPDV
Mflv_1255|M.gilvum_PYR-GCK --QVMMGPWTLPPYNTGEPVVIEREPGISCLGMVLRPTSQGYVEITSADP
: * . * : : .
Mb1310|M.bovis_AF2122/97 HAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRN
Rv1279|M.tuberculosis_H37Rv HAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRN
MUL_4004|M.ulcerans_Agy99 HAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHN
MAB_0250|M.abscessus_ATCC_1997 LAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRN
Mvan_0327|M.vanbaalenii_PYR-1 VDPIDIHANMLAHPD--DVKAAVAAVELCREIGNSAPLRPFAKREVMPGN
MSMEG_0281|M.smegmatis_MC2_155 DDPVRIDANMLSDPA--DMTAAMIAVELCREIGNAAPLSAHAKREVMPGN
MMAR_4427|M.marinum_M GAPVLIEAEMLAHPD--DMKAAAAGVQLCREIGNSAPLRPFAKREVMPGG
MAV_4980|M.avium_104 QEPPAIDPNYLSDDR--DMGLMIEGLRIGRKIGMSQALDPWRAEELAPGD
TH_3275|M.thermoresistible__bu DATPVIEHPMLADER--DVVDLTAAGRKVREIFQSPAMRPHVIAENAPSR
Mflv_1255|M.gilvum_PYR-GCK GAALRITPNYLTTEH--DRTATAALVRRMRSIFEQSPIAERISHETYPGP
* *: * . * .: *
Mb1310|M.bovis_AF2122/97 STELDEATLELALATCSHTLYHPMGTCRMGSD--EASVVDPQLRVRGVDG
Rv1279|M.tuberculosis_H37Rv STELDEATLELALATCSHTLYHPMGTCRMGSD--EASVVDPQLRVRGVDG
MUL_4004|M.ulcerans_Agy99 SSELDEATLELALTTCSHTLYHPLGTCRMGSD--EASVVDRQLRVRGVDG
MAB_0250|M.abscessus_ATCC_1997 PSDDLEETLVAALENNSHTLYHPVGTCRMGAD--DASVVTPDLTVRGVQG
Mvan_0327|M.vanbaalenii_PYR-1 ---LRGPDLERFVRDAASSYWHQTCTAKMGRD--AMSVVDAALNVYGVKG
MSMEG_0281|M.smegmatis_MC2_155 ---LKGRDLERFIRDAAVSYWHQSGTAKMGRD--EMSVVDGNLRVHGIER
MMAR_4427|M.marinum_M ---LAGAELERFVRDGASTYWHQSGTAKMGRD--DMSVVDAKLKVHGMEN
MAV_4980|M.avium_104 DA-VDDAALRSYIQRSVASYFHPVGTCAMGTG--PESVVDNQLRLHGIDN
TH_3275|M.thermoresistible__bu GV-ETDDEWAEFIRNHCFGGSHWVGTARMGADSDPDAVVDPQLRVRGVSG
Mflv_1255|M.gilvum_PYR-GCK RVDSDEELVDAALEGG-YCGYHAVGTCAMGPD--DDDVVDSHLRVRGVDG
: * *. ** . ** * : *:.
Mb1310|M.bovis_AF2122/97 LRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS----------
Rv1279|M.tuberculosis_H37Rv LRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS----------
MUL_4004|M.ulcerans_Agy99 LRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN----------
MAB_0250|M.abscessus_ATCC_1997 LRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP-------
Mvan_0327|M.vanbaalenii_PYR-1 LRVADGSIMPRVTTGNTMAPCVVIGERAADIIRKEHAL------
MSMEG_0281|M.smegmatis_MC2_155 LRIADASIMPRITTGNTMAPCVVIGERAAQLIRDTYAAQEPAHE
MMAR_4427|M.marinum_M LRVADSSIMPRITTGNTMAPCVVIGERAAEIVKADHGL------
MAV_4980|M.avium_104 LRVIDASVMPSLPSNNTAATVYAIAERGADLVRLG---------
TH_3275|M.thermoresistible__bu LRVADASVMPTLTSGNTNAPCVLIGEKAAELIRGR---------
Mflv_1255|M.gilvum_PYR-GCK LRVVDCSVMPTIVAGNLNGPIMAMAWRAADFILHGR--------
**: * *::* .: .. :. :.*:::