For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RRPVMPGDLAGRDLDEFLRNAGGSFWHQVGTAKMGRGPMSVVDAHLKVHGLDGLRVADGSVLPRLTTGNT MAPCVVIGELASQALIAEHRGSVPRPVTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3431 | - | - | 100% (100) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0281 | - | 1e-30 | 65.88% (85) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5305 | - | 9e-14 | 45.71% (70) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 7e-14 | 41.86% (86) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3230 | - | 2e-10 | 35.48% (93) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 8e-14 | 41.86% (86) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 3e-13 | 40.91% (88) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4427 | - | 6e-31 | 64.04% (89) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 9e-14 | 47.37% (76) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 1e-16 | 58.11% (74) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 2e-13 | 41.86% (86) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0327 | - | 5e-30 | 65.17% (89) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 ---------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDK
Rv1279|M.tuberculosis_H37Rv ---------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDK
MUL_4004|M.ulcerans_Agy99 ---------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDK
MAB_0250|M.abscessus_ATCC_1997 -------MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDK
Mflv_3230|M.gilvum_PYR-GCK ----------MPEYDYIIVGAGSAGCLLANRLSADPDHRVLLIEAGGKDD
MAV_4980|M.avium_104 --------------------------------------------------
MMAR_4427|M.marinum_M MCSDPIAAR----YDFVVCGSGSAGSVVARRLSENSNVAVLLLEAGGTDD
Mvan_0327|M.vanbaalenii_PYR-1 MGDMPIVTSPARSYDFIVCGAGTAGSVVARRLAENPAVSVLLVEAGGTDQ
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu -MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGKRHSVLVLEAGGSDL
Mb1310|M.bovis_AF2122/97 NRFIGVPAAFS-KLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSM
Rv1279|M.tuberculosis_H37Rv NRFIGVPAAFS-KLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSM
MUL_4004|M.ulcerans_Agy99 NRFIGIPAAFP-KLFRSEVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSM
MAB_0250|M.abscessus_ATCC_1997 DMGIHIPAAFS-KLFRSDVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSM
Mflv_3230|M.gilvum_PYR-GCK WFWIKVPVGYLYTIANPRTDWCYTTEPDPGLAGRSILYARGRVVGGSSSI
MAV_4980|M.avium_104 ---------------------------MQTAIGRAVPFARGRGIGGSSTI
MMAR_4427|M.marinum_M VAEVMDPAQWPVNLGS-ARDWGFASAPSAHLNGRSIPLSMGKVLGGGSSI
Mvan_0327|M.vanbaalenii_PYR-1 VPSVAAADQWPLNLGS-ERDWGFSAVATSHLNGRAVPLSMGKVLGGGSSI
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu SPFIRIPAG-LMRVNP-RNYWHFRLEPDPTRNGAVDTWAAGRVVGGGSSV
Mb1310|M.bovis_AF2122/97 NAMMWVRGFASDYDEWAARAG-PRWSYA------DVLGYFRRIENVTAAW
Rv1279|M.tuberculosis_H37Rv NAMMWVRGFASDYDEWAARAG-PRWSYA------DVLGYFRRIENVTAAW
MUL_4004|M.ulcerans_Agy99 NAMMWVRGFAADYDEWARLAG-SHWSYG------ELLGYFRQIEDVTAAW
MAB_0250|M.abscessus_ATCC_1997 NAMMWVRGFAADYDDWAQVAG-EQWSFA------NIAPYFKRIEAVEG--
Mflv_3230|M.gilvum_PYR-GCK NAMIHMRGQASDYELWAQATGDERWLWGGPDRPGDTLAIYKDLEDYFG--
MAV_4980|M.avium_104 NAMVFARGHRDSYSRWRDNGA-AGWSFD------ELLPYFKRSESTCG--
MMAR_4427|M.marinum_M NVMAWARGHRNDWAHFAAEAGDPSWGYES------VLDVYRRIEDWHGR-
Mvan_0327|M.vanbaalenii_PYR-1 NLMVWARGHKADWDYFAFESGDEGWGYES------VLDLYRRIEDFHGD-
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu NAMLWVRGNRADFDTWAK-LGAQGWDYES------LLPAMRSLETWEGG-
Mb1310|M.bovis_AF2122/97 HFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECG---FAAARP-NSP
Rv1279|M.tuberculosis_H37Rv HFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECG---FAAARP-NSP
MUL_4004|M.ulcerans_Agy99 HFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCG---FAPVQP-NSA
MAB_0250|M.abscessus_ATCC_1997 --ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAG---FDVERA-NTP
Mflv_3230|M.gilvum_PYR-GCK --GADDWHGARGEIRVERPRVRWKILDAWQAAAAESG---IAPIDEFNRG
MAV_4980|M.avium_104 --KDPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQG---YPRAADISGG
MMAR_4427|M.marinum_M --CDGDRRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYDSNNGIMME
Mvan_0327|M.vanbaalenii_PYR-1 --PDPDYRGTGGPVYVTPAPDPNPLAPATIEAARTVGIPTFENQNGRMME
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu --ADRYRGGTG-PQHVSRIRLHHPLVQKWLTGAAQTGMPILADYNG---E
Mb1310|M.bovis_AF2122/97 RPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDG-
Rv1279|M.tuberculosis_H37Rv RPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDG-
MUL_4004|M.ulcerans_Agy99 EPEGFCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHG-
MAB_0250|M.abscessus_ATCC_1997 EPKGFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDG-
Mflv_3230|M.gilvum_PYR-GCK DNSGSAYFHVNQRRGRRWSMADAFLHPVAHRPNLTVYTQTQALRLLTDDQ
MAV_4980|M.avium_104 LEVGFGFTDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIRG-
MMAR_4427|M.marinum_M GPGGASLLDLQLRNRLRESVFRSYVHPYLQQRNLTVLTGATVRRLTFSG-
Mvan_0327|M.vanbaalenii_PYR-1 QSAGAAISDIRARGGRRQSVFTSYVTPVLHRPNLDVLTCALVTRVSFDG-
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu SQFGAAWSQLSQKNGLRHSAAQAFLAPARRRGEVDVESHAVVDKVIIEN-
Mb1310|M.bovis_AF2122/97 --------------DRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLL
Rv1279|M.tuberculosis_H37Rv --------------DRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLL
MUL_4004|M.ulcerans_Agy99 --------------TRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLL
MAB_0250|M.abscessus_ATCC_1997 --------------IRAVGVEYVRDGITHTVHARREVILSGGAINSPQLL
Mflv_3230|M.gilvum_PYR-GCK VRDDQRCGAWTTATHRATGLRVLKDGQIVDVRARREVILSAGAIGSPHLM
MAV_4980|M.avium_104 --------------SRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLL
MMAR_4427|M.marinum_M --------------SRVTGVEFSHANAIRTVSATQEVVVSLGAVNTPKVL
Mvan_0327|M.vanbaalenii_PYR-1 --------------DRATGVELVLDGQSRRIAVNTEVILSLGAINTPKVL
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu --------------GRAVGVEYVRRGTRKVAYAAKEVILSAGALCSPLIL
Mb1310|M.bovis_AF2122/97 MLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVE----KDSL
Rv1279|M.tuberculosis_H37Rv MLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVE----KDSL
MUL_4004|M.ulcerans_Agy99 MLSGIGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVA----GDSL
MAB_0250|M.abscessus_ATCC_1997 MLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVK----SDSL
Mflv_3230|M.gilvum_PYR-GCK QVSGLGPAELLARHDVPVTVDLPGVGENLQDHLQLRTVYRVRGARTVNTL
MAV_4980|M.avium_104 LASGIGPPNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAA--------
MMAR_4427|M.marinum_M MQSGIGDANDLRGFGIPVVTHLRGVGHNYQDHPRIDCVWES-----HEAL
Mvan_0327|M.vanbaalenii_PYR-1 LHSGIGDETELRRVGIPLHTHLSGVGRNLQDHPGFDCVWEY-----SEPL
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu LRSGIGPAEELRDHGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLNQEL
Mb1310|M.bovis_AF2122/97 FA--AEKPGQLISYLLRRRGMLTSNVGEAYGFVRSR--------------
Rv1279|M.tuberculosis_H37Rv FA--AEKPGQLISYLLRRRGMLTSNVGEAYGFVRSR--------------
MUL_4004|M.ulcerans_Agy99 AA--AEKPMQLINYLLRRRGMLTSNVGEAYGFVRSR--------------
MAB_0250|M.abscessus_ATCC_1997 FG--AEKPLQLANYFLRHRGMLTSNVGEAYGFLRSH--------------
Mflv_3230|M.gilvum_PYR-GCK YRNWITRAGMGIQYLLLRSGPLTMPPSTLGAFAKSD--------------
MAV_4980|M.avium_104 ------RP--------VPAG--RYNHGELLGLIRRH--------------
MMAR_4427|M.marinum_M APRNNGAEVTVFWK----------SHPKLATPDLQI--------------
Mvan_0327|M.vanbaalenii_PYR-1 APRNNASEATYFAT----------SAAGMDAPDLQT--------------
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu TPLSILKGAFDFVLRRRGPATAPLSHAMLFGPPLEPEGWPQYHVLMAPLG
Mb1310|M.bovis_AF2122/97 PELKLPDLELIFAPAPFYDEALVP-PAGHGVVFGPILVAPQSRGQITLRS
Rv1279|M.tuberculosis_H37Rv PELKLPDLELIFAPAPFYDEALVP-PAGHGVVFGPILVAPQSRGQITLRS
MUL_4004|M.ulcerans_Agy99 PGLDLPDLELIFAPAPFYDEGLPAHPPGHGVVFGPILVAPQSRGQITLRS
MAB_0250|M.abscessus_ATCC_1997 PNLTLPDLELIFAPAPFFDEGIGV-ATEHAIVMGPILLKPESSGEITLTS
Mflv_3230|M.gilvum_PYR-GCK PVLASPDLEWHVQPLSLTKFGEPL-HPYGAITPSVCNLRPTSRGHVRLAD
MAV_4980|M.avium_104 ATGGPPEIQIFGVDS----ADVPGLGGADGYVLGVSVMQPVSRGRVGLSG
MMAR_4427|M.marinum_M CVAEFPLSSPENAARYGLPAHGWTM--------CVGVVRPQSRGRVRLTG
Mvan_0327|M.vanbaalenii_PYR-1 CQAEVPKSSAENIARFGLPEFGWTL--------FAGVVRPKSRGHLALRS
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------------
TH_3275|M.thermoresistible__bu TEQEKPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSPLHPRGRGTVRLGS
Mb1310|M.bovis_AF2122/97 ADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIAR
Rv1279|M.tuberculosis_H37Rv ADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIAR
MUL_4004|M.ulcerans_Agy99 ADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVAR
MAB_0250|M.abscessus_ATCC_1997 PDPLAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILR
Mflv_3230|M.gilvum_PYR-GCK ADPLTHPKIFCNYLS--TDADRDIAVRGLRMTRKIMASPVLARYRPEEML
MAV_4980|M.avium_104 PTIQEPPAIDPNYLSD--DRDMGLMIEGLRIGRKIGMSQALDPWRAEELA
MMAR_4427|M.marinum_M AHPGAPVLIEAEMLAH--PDDMKAAAAGVQLCREIGNSAPLRPFAKREVM
Mvan_0327|M.vanbaalenii_PYR-1 ADPVDPIDIHANMLAH--PDDVKAAVAAVELCREIGNSAPLRPFAKREVM
MSMEG_3431|M.smegmatis_MC2_155 --------------------------------------------MRRPVM
TH_3275|M.thermoresistible__bu PDVDATPVIEHPMLAD--ERDVVDLTAAGRKVREIFQSPAMRPHVIAENA
Mb1310|M.bovis_AF2122/97 PRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEAS--------VVDP
Rv1279|M.tuberculosis_H37Rv PRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEAS--------VVDP
MUL_4004|M.ulcerans_Agy99 PHNSSELDEATLELALTTCSHTLYHPLGTCRMGSDEAS--------VVDR
MAB_0250|M.abscessus_ATCC_1997 PRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDAS--------VVTP
Mflv_3230|M.gilvum_PYR-GCK P-GPHLVSDDDLQAAARELGTTIFHPVGTCAMGAFDARGLPRSATTVLDT
MAV_4980|M.avium_104 P-GDDAVDDAALRSYIQRSVASYFHPVGTCAMGTGPES--------VVDN
MMAR_4427|M.marinum_M P--GGLAGAE-LERFVRDGASTYWHQSGTAKMGRD--DM------SVVDA
Mvan_0327|M.vanbaalenii_PYR-1 P--GNLRGPD-LERFVRDAASSYWHQTCTAKMGRD--AM------SVVDA
MSMEG_3431|M.smegmatis_MC2_155 P--GDLAGRD-LDEFLRNAGGSFWHQVGTAKMGRG--PM------SVVDA
TH_3275|M.thermoresistible__bu PSRGVETDDE-WAEFIRNHCFGGSHWVGTARMGADSDPD------AVVDP
* * *. ** *:
Mb1310|M.bovis_AF2122/97 QLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS-------
Rv1279|M.tuberculosis_H37Rv QLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS-------
MUL_4004|M.ulcerans_Agy99 QLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN-------
MAB_0250|M.abscessus_ATCC_1997 DLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP----
Mflv_3230|M.gilvum_PYR-GCK DCRVFRVAGLRVVDASAMPTITSGNTNAPVMLIAERAARAILH-------
MAV_4980|M.avium_104 QLRLHGIDNLRVIDASVMPSLPSNNTAATVYAIAERGADLVRLG------
MMAR_4427|M.marinum_M KLKVHGMENLRVADSSIMPRITTGNTMAPCVVIGERAAEIVKADHGL---
Mvan_0327|M.vanbaalenii_PYR-1 ALNVYGVKGLRVADGSIMPRVTTGNTMAPCVVIGERAADIIRKEHAL---
MSMEG_3431|M.smegmatis_MC2_155 HLKVHGLDGLRVADGSVLPRLTTGNTMAPCVVIGELASQALIAEHRGSVP
TH_3275|M.thermoresistible__bu QLRVRGVSGLRVADASVMPTLTSGNTNAPCVLIGEKAAELIRGR------
: : .*** *.* :* .:* *. :. .: :
Mb1310|M.bovis_AF2122/97 -----
Rv1279|M.tuberculosis_H37Rv -----
MUL_4004|M.ulcerans_Agy99 -----
MAB_0250|M.abscessus_ATCC_1997 -----
Mflv_3230|M.gilvum_PYR-GCK -----
MAV_4980|M.avium_104 -----
MMAR_4427|M.marinum_M -----
Mvan_0327|M.vanbaalenii_PYR-1 -----
MSMEG_3431|M.smegmatis_MC2_155 RPVTA
TH_3275|M.thermoresistible__bu -----