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RPDVDWNLTETFDTAEGVIRWQRLGSDSSGDEPVVLVHGTPYSSYLWRDIAPALAQHRSVYVFDLLGYGQ SEQREGQDLTIAAQARRLADLLEHWGLKRPSMIANDIGAAIALHASLVNGAAYRDLVIFDAVTGSDWEMG LFHLVRRNAGVFEALPGYAHRALITSHLQRATHSGFRPGVLERYLQPWLGADGQAAFYRQYQQLSVDDTR VFEDKLAGIDIPVKILWGRDDLIMAPKYGEWIRDQIPHAEFHWIDDAGHVLQEDVPVQLLTHLTAPFAQS VNRSVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2913 | - | - | 100% (287) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_1984 | - | 1e-14 | 25.70% (284) | haloacetate dehalogenase H-1 |
| M. smegmatis MC2 155 | MSMEG_6720 | - | 1e-13 | 28.46% (267) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0079c | - | 3e-11 | 24.45% (274) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2367 | - | 2e-11 | 25.28% (269) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0077c | - | 3e-11 | 24.45% (274) | oxidoreductase |
| M. leprae Br4923 | MLBr_00685 | - | 9e-06 | 21.97% (264) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2289 | - | 2e-12 | 29.63% (243) | putative hydrolase, alpha/beta hydrolase fold |
| M. marinum M | MMAR_4428 | - | 7e-10 | 24.53% (265) | haloalkane dehalogenase |
| M. avium 104 | MAV_4567 | - | 2e-10 | 22.76% (268) | dihydrolipoyllysine-residue acetyltransferase component of |
| M. thermoresistible (build 8) | TH_4292 | - | 2e-10 | 43.53% (85) | PUTATIVE putative epoxide hydrolase |
| M. ulcerans Agy99 | MUL_3052 | - | 1e-10 | 23.94% (284) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_1079 | - | 6e-14 | 26.30% (270) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2367|M.gilvum_PYR-GCK ------------------------MTDLRYLDLHGDRCAYRDEG------
MAV_4567|M.avium_104 ------------------------MSELKFLELHGDRVAFRDQG------
Mb0079c|M.bovis_AF2122/97 ---------------------------MSTIDISAGTIHYEATGP-----
Rv0077c|M.tuberculosis_H37Rv ---------------------------MSTIDISAGTIHYEATGP-----
MAB_2289|M.abscessus_ATCC_1997 MGVAAHQQIYRPVSGHGGAMSLGLEKHRRSVDIERGRISYLDIG------
MSMEG_2913|M.smegmatis_MC2_155 ------------------MRPDVDWNLTETFDTAEGVIRWQRLGSD----
Mvan_1079|M.vanbaalenii_PYR-1 ---------------------------MESFDFRGMRIAYEHTGQ-----
MLBr_00685|M.leprae_Br4923 -------------------MPACQHQRHRPVVACGTRGTTFRVGSMRQPI
MUL_3052|M.ulcerans_Agy99 --------MGRQFTPDFTPDPKLYPFASRWFDSSRGRLHYIDESD-----
MMAR_4428|M.marinum_M -----------MTRAQVARLLEQHRASGRRFTAAGIESFVLDSGAR----
TH_4292|M.thermoresistible__bu ---VVDTGAHAFDSATRDDDEFNRLFRHEFADVDGVRMHYVTGGS-----
.
Mflv_2367|M.gilvum_PYR-GCK --DGEETLLLLHGMAGSSETWRAVIPHLAKR-YRVIAP--DLLGHGSSAK
MAV_4567|M.avium_104 --EGE-VLLLIHGMAGSSETWRSVIPPLAKK-FRVIAP--DLLGHGESAK
Mb0079c|M.bovis_AF2122/97 --ETGRPVVFVHGYMMGGQLWRRVSERLAGRGLRCIAPTWPLGAHPKPLR
Rv0077c|M.tuberculosis_H37Rv --ETGRPVVFVHGYMMGGQLWRRVSERLAGRGLRCIAPTWPLGAHPKPLR
MAB_2289|M.abscessus_ATCC_1997 ---AGSPTVFVHGVLTNSLLWRDVVTAVAATGRRCIALDLPGHGHSPVPA
MSMEG_2913|M.smegmatis_MC2_155 -SSGDEPVVLVHGTPYSSYLWRDIAPALAQH--RSVYVFDLLGYGQSEQR
Mvan_1079|M.vanbaalenii_PYR-1 ----GEPVIMLHNGGSSHAIWQDVANRLAGK---YELFAFDLLGFGNSAK
MLBr_00685|M.leprae_Br4923 HLGSGEPVLLLHPFMMSQTVWEIVAPQLANTERYEVFAPTMAAHHGGPSA
MUL_3052|M.ulcerans_Agy99 ----GPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSEHPG
MMAR_4428|M.marinum_M ---DAPPVICVHGVPASSFLYRKVVAAMAQRGLRGIAIDLPGLGLAERPS
TH_4292|M.thermoresistible__bu ----GDPLVLLHGWPQTWYAWRGIIPALAQK---YTVYALDLPGLGDSEG
: * :. : :
Mflv_2367|M.gilvum_PYR-GCK PRGDYSLGAFAAWLRDLLD-ELGIRSVTVVGQSLGGGVAMQFVYQHPDYC
MAV_4567|M.avium_104 PRTDYSLGAFAVWLRDFLD-ELGVSRATVVGHSLGGGVAMQFVYQHPDYA
Mb0079c|M.bovis_AF2122/97 PGADQTIGGVAGIVADVLA-ALELKDVVLVGNDTGGVVTQLVAVHYPERL
Rv0077c|M.tuberculosis_H37Rv PGADQTIGGVAGIVADVLA-ALELKDVVLVGNDTGGVVTQLVAVHYPERL
MAB_2289|M.abscessus_ATCC_1997 DGIDVTLSGLAQLIAEFLD-SIGIDEFDLVANDTGGAVAQIMVARQPDRI
MSMEG_2913|M.smegmatis_MC2_155 EGQDLTIAAQARRLADLLE-HWGLKRPSMIANDIGAAIALHASLVNGAAY
Mvan_1079|M.vanbaalenii_PYR-1 PGAGYTLDNYVAMLEEFVS-SRGLEKVAVVGNCMGSAIALAFTDRHRDQV
MLBr_00685|M.leprae_Br4923 SSWMMSVSTLADHVEQQLD-ELGWDTAHLVGNSLGGWVVFELERR--GRA
MUL_3052|M.ulcerans_Agy99 -TFGYKVDEHAQVVGEFVD-HLGLDNYLTMGQDWGGPISMAVAVERAERV
MMAR_4428|M.marinum_M -DADYTWSGLGRWLGAAID-ALGIGRFHLVVHDIGGPIGFDVANAAPDRV
TH_4292|M.thermoresistible__bu APPSYDKATLARFVHRLLADQLGLRSIRLVAHDLGAGVGFQYAAQYPTEV
: : : : *. :
Mflv_2367|M.gilvum_PYR-GCK RRLVLISSGGLGQDVG-WTLR-----LLSAPGSELLLPLIAPSPVVRAGD
MAV_4567|M.avium_104 QRLILISSGGLGPDVG-WVLR-----LLSAPGAELVLPVIAPTPVLSVGN
Mb0079c|M.bovis_AF2122/97 GALVLTSCDAFEHFPP-PILKPV---ILAAKSATLFRAAIQVMRAPAARN
Rv0077c|M.tuberculosis_H37Rv GALVLTSCDAFEHFPP-PILKPV---ILAAKSATLFRAAIQVMRAPAARN
MAB_2289|M.abscessus_ATCC_1997 RTLALTNCDTEGHVPP-KLFKPV---VALARPPLMALIGPRLFARRKVLR
MSMEG_2913|M.smegmatis_MC2_155 RDLVIFDAVTGSDWEM-GLFH------LVRRNAGVFEALPGYAHRALITS
Mvan_1079|M.vanbaalenii_PYR-1 KALVLCNPLTESTFLGGWLGPFL---WLRERMPGINRQVYRLLGRLKLTN
MLBr_00685|M.leprae_Br4923 RSVTGIAPAGGWTRWSLAKFEVI---AKFVAGMPLVAVARGLGSRALSLP
MUL_3052|M.ulcerans_Agy99 RGIVLGNTWFWPADTL-----------TMKAFSTVMSSLPMQYAILHHNF
MMAR_4428|M.marinum_M LSMTLLNTIIAVQRFHRPWPMEP---FAHRAVGEMWLGLLRVPGAFESIM
TH_4292|M.thermoresistible__bu SKYAHLDYPLPGPALSAARYREFSWHMAFHHQPRVPEAVVANDVREYLAL
:
Mflv_2367|M.gilvum_PYR-GCK RVRAWFSARNIQSPRGAEMWSAYASLSDAHTRHAFLRTLRSVVDYRGQAV
MAV_4567|M.avium_104 KLRSWLRGAGIQSPRGAELWNAYSSLSDGETRQSFLKTLRSVVDYRGQAV
Mb0079c|M.bovis_AF2122/97 RAYAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLR------TEVT
Rv0077c|M.tuberculosis_H37Rv RAYAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLR------TEVT
MAB_2289|M.abscessus_ATCC_1997 ALLGAGYRKPGRLPDSIVESYGQPVFGTAESSRFLSKMLR---AMHTRDL
MSMEG_2913|M.smegmatis_MC2_155 HLQRATHSG---FRPGVLERYLQPWLGADGQAAFYRQYQQ----LSVDDT
Mvan_1079|M.vanbaalenii_PYR-1 GIGSVATLFQLGPRGRALKLHRNAELCGCYAATGQVESLLGVLDDLENYS
MLBr_00685|M.leprae_Br4923 FSHRLASLPLTGSPAGLSEHQLRNIVEDAGHCPAYFLLLIK------TLL
MUL_3052|M.ulcerans_Agy99 FVERLIPAGTTHRPSSAVMEHYRGVQPTASARVGVAEMPKQILAARPLLA
MMAR_4428|M.marinum_M RLVGVSSRVP-----SAEIACWKPLLFGDDGGRAFLEIMRGFELTPEKQH
TH_4292|M.thermoresistible__bu FYPYVAYGGTSFGGPGAQSPFTDEQVDEFARTYNRPDVLSGGFDLYRTLD
Mflv_2367|M.gilvum_PYR-GCK SALNKLHLTT-ELPLMVIWGDQDRIIP-VDHGFALDQHRPG-CRLEILDG
MAV_4567|M.avium_104 SALNRLRLRE-ELPVMAIWGERDGIIP-VDHAYAAHEARTD-ARLEVLPD
Mb0079c|M.bovis_AF2122/97 TAVAARLPEF-DKPALIAWSADDVFFA-LENGQRLAATIPR-ARFEVIEG
Rv0077c|M.tuberculosis_H37Rv TAVAARLPEF-DKPALIAWSADDVFFA-LENGQRLAATIPR-ARFEVIEG
MAB_2289|M.abscessus_ATCC_1997 EAARAGLVTF-TKPTLIAWGLGDYFFP-LKYGQRLAELFGGPVTFETVPD
MSMEG_2913|M.smegmatis_MC2_155 RVFEDKLAGI-DIPVKILWGRDDLIMA-PKYGEWIRDQIPH-AEFHWIDD
Mvan_1079|M.vanbaalenii_PYR-1 VVDNLAPQQG-FPPICTIWGLKNKIVS-PEAGRRLNSTLHP-ARQEWLPD
MLBr_00685|M.leprae_Br4923 QPGLRELADI-TVPVLLVLCEKDRVLPPPKYSRHFTDHLPERTQVTKFDG
MUL_3052|M.ulcerans_Agy99 RLASEVPAQLGTKPALLVWGMKDFAFRPEPMLARMRAVFAD-HILVELPE
MMAR_4428|M.marinum_M NYIAAVQDTR--YPVQIVWGVRDTMLSWRRYGAEARQLAGT-QRVTTLP-
TH_4292|M.thermoresistible__bu QDEHDNVAAGPITTPTLLMTAEGLLES---TRLTVEPRMANITRAVEVPG
. . .
Mflv_2367|M.gilvum_PYR-GCK VGHFPHVEKPDAVVDLLDDFIATTHASVRPADVPER-
MAV_4567|M.avium_104 VGHFAQVEAPMRVVELIEDFIATGER--RDATSPQPG
Mb0079c|M.bovis_AF2122/97 ARTFSMVDSPDRLADQLSTVAVRT-------------
Rv0077c|M.tuberculosis_H37Rv ARTFSMVDSPDRLADQLSTVAVRT-------------
MAB_2289|M.abscessus_ATCC_1997 GRLYFPDEDADRLLPLLYRHWHSAGRQESSTEVGS--
MSMEG_2913|M.smegmatis_MC2_155 AGHVLQEDVPVQLLTHLTAPFAQSVNRSVG-------
Mvan_1079|M.vanbaalenii_PYR-1 CGHLLMLERPDEVASIIDGFLQAPAETQA--------
MLBr_00685|M.leprae_Br4923 MGHVPMFEAPEVITKLITNFINQCSKPAEAASPAS--
MUL_3052|M.ulcerans_Agy99 AKHLIQEDAPDEIAAAIIARFG---------------
MMAR_4428|M.marinum_M AKHFLQEDFPEEIAAAVQRLAQSS-------------
TH_4292|M.thermoresistible__bu AGHWLVEENPAFVTNELLTFLAD--------------
: . : :