For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TRAQVARLLEQHRASGRRFTAAGIESFVLDSGARDAPPVICVHGVPASSFLYRKVVAAMAQRGLRGIAID LPGLGLAERPSDADYTWSGLGRWLGAAIDALGIGRFHLVVHDIGGPIGFDVANAAPDRVLSMTLLNTIIA VQRFHRPWPMEPFAHRAVGEMWLGLLRVPGAFESIMRLVGVSSRVPSAEIACWKPLLFGDDGGRAFLEIM RGFELTPEKQHNYIAAVQDTRYPVQIVWGVRDTMLSWRRYGAEARQLAGTQRVTTLPAKHFLQEDFPEEI AAAVQRLAQSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4428 | - | - | 100% (292) | haloalkane dehalogenase |
| M. marinum M | MMAR_2710 | - | 1e-17 | 28.62% (276) | haloalkane dehalogenase |
| M. marinum M | MMAR_3472 | - | 2e-15 | 28.15% (270) | haloalkane dehalogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 2e-19 | 29.57% (257) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4848 | - | 7e-14 | 33.61% (119) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1833c | - | 2e-19 | 29.57% (257) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-09 | 25.75% (299) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2289 | - | 3e-17 | 31.05% (248) | putative hydrolase, alpha/beta hydrolase fold |
| M. avium 104 | MAV_2130 | - | 2e-16 | 27.97% (261) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6151 | - | 2e-18 | 38.84% (121) | alpha/beta hydrolase fold-1 |
| M. thermoresistible (build 8) | TH_2421 | - | 1e-13 | 27.53% (287) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3052 | - | 6e-17 | 28.15% (270) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 8e-20 | 30.07% (276) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1864c|M.bovis_AF2122/97 ---------MSIDFTPDP-----QLYPFESRWFDSSRG-----RIHYVDE
Rv1833c|M.tuberculosis_H37Rv ---------MSIDFTPDP-----QLYPFESRWFDSSRG-----RIHYVDE
MUL_3052|M.ulcerans_Agy99 -----MGRQFTPDFTPDP-----KLYPFASRWFDSSRG-----RLHYIDE
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDE
Mvan_2384|M.vanbaalenii_PYR-1 ---------MDILRTPDERFADLPDFPFAPHYVEVDG-----LRMHYLDE
Mflv_4848|M.gilvum_PYR-GCK ------------------------MTVVHHRIDTVDG-----HQVFYREA
MSMEG_6151|M.smegmatis_MC2_155 ------------------------MSPVTHHRVLVDG-----VDTFYRTA
MMAR_4428|M.marinum_M -------------MTRAQVARLLEQHRASGRRFTAAG-----IESFVLDS
MAB_2289|M.abscessus_ATCC_1997 ----MGVAAHQQIYRPVSGHGGAMSLGLEKHRRSVDIER---GRISYLDI
TH_2421|M.thermoresistible__bu ---------------------------VRRSFVEARG-----VRFHVTES
MLBr_00862|M.leprae_Br4923 ------------------MPATQSIHKVPHQFVESPDG----VRLAIYQS
Mb1864c|M.bovis_AF2122/97 G--TGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPS
Rv1833c|M.tuberculosis_H37Rv G--TGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPS
MUL_3052|M.ulcerans_Agy99 S--DGPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSEHPG
MAV_2130|M.avium_104 GPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPDLIGFGRSDKPS
Mvan_2384|M.vanbaalenii_PYR-1 GPADGPVVLLLHGEPSWSYLYRRMIPVLVDAGLRAVAIDLVGFGRSDKPT
Mflv_4848|M.gilvum_PYR-GCK GDPDAPVIVLLHGFPTSSFMFRNLIPELADR-YRVIAPDYLGFGYSDAPT
MSMEG_6151|M.smegmatis_MC2_155 GPVDAPIVLLPHGYPASSYVYRNLMAALGGR-WRLIAPDLPGFGYSATPS
MMAR_4428|M.marinum_M GARDAPPVICVHGVPASSFLYRKVVAAMAQRGLRGIAIDLPGLGLAERPS
MAB_2289|M.abscessus_ATCC_1997 G--AGSPTVFVHGVLTNSLLWRDVVTAVAATGRRCIALDLPGHGHSPVPA
TH_2421|M.thermoresistible__bu GPADGRPVLALHGWPQHHWAYRDLLADPPAG-LRIIAPDLPGYGWSG-PA
MLBr_00862|M.leprae_Br4923 GQPEGPAIVLVHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPK
. . : ** : :: * : * * * : *
Mb1864c|M.bovis_AF2122/97 GFG--YQIDEHARVIGEFVDHLGLDR-YLSMGQDWGGPISMAVAVERADR
Rv1833c|M.tuberculosis_H37Rv GFG--YQIDEHARVIGEFVDHLGLDR-YLSMGQDWGGPISMAVAVERADR
MUL_3052|M.ulcerans_Agy99 TFG--YKVDEHAQVVGEFVDHLGLDN-YLTMGQDWGGPISMAVAVERAER
MAV_2130|M.avium_104 RIED-YSYQRHVDWVVSWFEHLNLSD-VTLFVQDWGSLIGLRIAAEQPDR
Mvan_2384|M.vanbaalenii_PYR-1 RRED-YTYQAHVDWTWAAIEAIGLTG-ITLVCQDWGGLIGLRLVGEHPDR
Mflv_4848|M.gilvum_PYR-GCK VEDFDYTFDALTDSVAGLLTQLGIRR-YAIYVQDYGAPVGWRLALRDPAA
MSMEG_6151|M.smegmatis_MC2_155 AQEFAYTFAAYSAFLQSFVETLGLGR-YVIWLHDYGSQFGFQLALAKPER
MMAR_4428|M.marinum_M DAD--YTWSGLGRWLGAAIDALGIGR-FHLVVHDIGGPIGFDVANAAPDR
MAB_2289|M.abscessus_ATCC_1997 DGID-VTLSGLAQLIAEFLDSIGIDE-FDLVANDTGGAVAQIMVARQPDR
TH_2421|M.thermoresistible__bu PHR--WAKEDVASDLLALMDELGLGR-TLLIGHDWGGYIGFLMILRAPER
MLBr_00862|M.leprae_Br4923 PVS-AYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGAS
. :. :* *.
Mb1864c|M.bovis_AF2122/97 VRGVVLGNTWFWPADTLAM---KAFSRVMSSPPVQYAILRRNFFVERLIP
Rv1833c|M.tuberculosis_H37Rv VRGVVLGNTWFWPADTLAM---KAFSRVMSSPPVQYAILRRNFFVERLIP
MUL_3052|M.ulcerans_Agy99 VRGIVLGNTWFWPADTLTM---KAFSTVMSSLPMQYAILHHNFFVERLIP
MAV_2130|M.avium_104 VGRLVVANGFLPTAQRRTP---PAFYAWR-----AFARYSPVLPAGRIVS
Mvan_2384|M.vanbaalenii_PYR-1 FARVVAANTTLPTGDQRPG---EAFLAWQ-----RFSQETPDFAVGHIVN
Mflv_4848|M.gilvum_PYR-GCK ITAIITQNGNGYNDGFVAEGWQPAWDYQREQTPETEAALRGILTFETTRM
MSMEG_6151|M.smegmatis_MC2_155 VAGLIIQNGDIYEDAFGPK-YDFLKESWNNPGPAARRRIAQHVTLHGFET
MMAR_4428|M.marinum_M VLSMTLLNTIIAVQRFHRPWPMEPFAHRAVGEMWLGLLRVPGAFESIMRL
MAB_2289|M.abscessus_ATCC_1997 IRTLALTN--CDTEGHVPP--KLFKPVVALARPPLMALIGPRLFARRKVL
TH_2421|M.thermoresistible__bu FDGYIPLNIAHPWVSTGTVLKHIWRFSYQPPMAAFGVPLQQRTRVLERVV
MLBr_00862|M.leprae_Br4923 DRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLF
.
Mb1864c|M.bovis_AF2122/97 AGTEHRPS----SAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLA
Rv1833c|M.tuberculosis_H37Rv AGTEHRPS----SAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLA
MUL_3052|M.ulcerans_Agy99 AGTTHRPS----SAVMEHYRGVQPTASARVGVAEMPKQILAARPLLARLA
MAV_2130|M.avium_104 VGTVRRVS----SKVRAGYDAPFPDKTYQAGARAFPQLVPTSPADPAIPA
Mvan_2384|M.vanbaalenii_PYR-1 GGCVSTLA----PEVIAAYDAPFPDDSYKAGARQFPTLVPTSPDDPAAPA
Mflv_4848|M.gilvum_PYR-GCK QYTAGVPD--PSVVSPDTWHHDFALLSRPGNDRIQLKLFLDYSTNPKIYP
MSMEG_6151|M.smegmatis_MC2_155 EFRGELPDDVAERISPDLWTLHWSLMSTPERVANLIRLLEDQPTTLGWFA
MMAR_4428|M.marinum_M VGVSSRVP-------SAEIACWKPLLFGDDGGRAFLEIMRGFELTPEKQH
MAB_2289|M.abscessus_ATCC_1997 RALLGAGYRKPGRLPDSIVESYGQPVFGTAESSRFLSKMLRAMHTRDLEA
TH_2421|M.thermoresistible__bu FGKGSALD----AETAKVYADRFRDPVCARAGRDTYRTFLVREMPAAARN
MLBr_00862|M.leprae_Br4923 SIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYP
Mb1864c|M.bovis_AF2122/97 REVPATLG---TKPTLLIWGMKDVAFR-PKTIIPRLSATFPD-----HVL
Rv1833c|M.tuberculosis_H37Rv REVPATLG---TKPTLLIWGMKDVAFR-PKTIIPRLSATFPD-----HVL
MUL_3052|M.ulcerans_Agy99 SEVPAQLG---TKPALLVWGMKDFAFR-PEPMLARMRAVFAD-----HIL
MAV_2130|M.avium_104 NRKAWEALGRWEKPFLAIFGARDPILGHADSPLIKHIPGAAG-----QPH
Mvan_2384|M.vanbaalenii_PYR-1 NRAAWEVLRTFDRPFLCAFSDSDPITRGADAPLRKFIPGAQG-----RPE
Mflv_4848|M.gilvum_PYR-GCK ALHDYLRAS--GVPLLAVWGDKDPFFG---PDGARAFAKDAV-----DSE
MSMEG_6151|M.smegmatis_MC2_155 AEQAYLREQ--HPRVLIVWGPHDGYMP---EASARAYLRDLP-----DAD
MMAR_4428|M.marinum_M NYIAAVQDT--RYPVQIVWGVRDTMLS--WRRYGAEARQLAG-----TQR
MAB_2289|M.abscessus_ATCC_1997 ARAGLVTFT---KPTLIAWGLGDYFFP---LKYGQRLAELFGG---PVTF
TH_2421|M.thermoresistible__bu PEKRRATVP-----IRALFGTRDLAIH---PSLAAPETALAD-----DYT
MLBr_00862|M.leprae_Br4923 ANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLW
.
Mb1864c|M.bovis_AF2122/97 VELPNAKHFIQEDAPDRIAAAIIERFG-----------------------
Rv1833c|M.tuberculosis_H37Rv VELPNAKHFIQEDAPDRIAAAIIERFG-----------------------
MUL_3052|M.ulcerans_Agy99 VELPEAKHLIQEDAPDEIAAAIIARFG-----------------------
MAV_2130|M.avium_104 ARIN-ASHFIQEDRGPELAERILSWQQALL--------------------
Mvan_2384|M.vanbaalenii_PYR-1 VTIAGGGHFLQEDKGPELAAVVVDFIAANPV-------------------
Mflv_4848|M.gilvum_PYR-GCK IHLIDGGHFLLESELTRVANLIRDFLERRL--------------------
MSMEG_6151|M.smegmatis_MC2_155 IHLLGGGHWLLETHLDEVVPLIDAFLADVYARR-----------------
MMAR_4428|M.marinum_M VTTLPAKHFLQEDFPEEIAAAVQRLAQSS---------------------
MAB_2289|M.abscessus_ATCC_1997 ETVPDGRLYFPDEDADRLLPLLYRHWHSAGRQESSTEVGS----------
TH_2421|M.thermoresistible__bu LETVDCSHFIVDERPDLVRARLVALAEETA--------------------
MLBr_00862|M.leprae_Br4923 RRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTF
: :
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASG
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPP
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 EEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLS
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTA
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 KQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYAL
Mb1864c|M.bovis_AF2122/97 --------------------
Rv1833c|M.tuberculosis_H37Rv --------------------
MUL_3052|M.ulcerans_Agy99 --------------------
MAV_2130|M.avium_104 --------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------
MMAR_4428|M.marinum_M --------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------
TH_2421|M.thermoresistible__bu --------------------
MLBr_00862|M.leprae_Br4923 YGISRVLPQVLRSTARIRVI