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SELKFLELHGDRVAFRDQGEGEVLLLIHGMAGSSETWRSVIPPLAKKFRVIAPDLLGHGESAKPRTDYSL GAFAVWLRDFLDELGVSRATVVGHSLGGGVAMQFVYQHPDYAQRLILISSGGLGPDVGWVLRLLSAPGAE LVLPVIAPTPVLSVGNKLRSWLRGAGIQSPRGAELWNAYSSLSDGETRQSFLKTLRSVVDYRGQAVSALN RLRLREELPVMAIWGERDGIIPVDHAYAAHEARTDARLEVLPDVGHFAQVEAPMRVVELIEDFIATGERR DATSPQPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4567 | - | - | 100% (289) | dihydrolipoyllysine-residue acetyltransferase component of acetoincleaving system |
| M. avium 104 | MAV_3609 | - | 7e-62 | 45.42% (284) | hydrolase |
| M. avium 104 | MAV_0592 | - | 8e-20 | 29.35% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 2e-60 | 44.37% (284) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2367 | - | 1e-115 | 70.14% (278) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 2e-60 | 44.37% (284) | hydrolase |
| M. leprae Br4923 | MLBr_00685 | - | 5e-12 | 26.32% (285) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 1e-59 | 44.80% (279) | hydrolase |
| M. marinum M | MMAR_1997 | - | 3e-60 | 43.40% (288) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 1e-17 | 25.10% (259) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 2e-20 | 26.81% (276) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3358 | - | 2e-60 | 43.40% (288) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_4279 | - | 1e-121 | 74.46% (278) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2367|M.gilvum_PYR-GCK ------------------------------------------------MT
Mvan_4279|M.vanbaalenii_PYR-1 ------------------------------------------------MS
MAV_4567|M.avium_104 ------------------------------------------------MS
MMAR_1997|M.marinum_M ---------------MTERKRNLRPVRE------------------VTAP
MUL_3358|M.ulcerans_Agy99 ---------------MTERKRNLRPVRE------------------VTAP
Mb2734|M.bovis_AF2122/97 ---------------MTERKRNLRPVRD------------------VAPP
Rv2715|M.tuberculosis_H37Rv ---------------MTERKRNLRPVRD------------------VAPP
MAB_3034|M.abscessus_ATCC_1997 ---------------MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRP
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFESIWSDLQG-----------------------VAF
TH_4528|M.thermoresistible__bu -----------------VWSDLQG-----------------------VAF
MLBr_00685|M.leprae_Br4923 --------------MPACQHQRHRP---------------------VVAC
Mflv_2367|M.gilvum_PYR-GCK DLRYLDLHG----DRCAYRDEGDGEE-TLLLLHGMAGSSETWRAVIPHLA
Mvan_4279|M.vanbaalenii_PYR-1 DLKYLDLHG----DRVAYRDVGRGEE-TLLLLHGMAGSSDTWRAVLPQLA
MAV_4567|M.avium_104 ELKFLELHG----DRVAFRDQGEGE--VLLLIHGMAGSSETWRSVIPPLA
MMAR_1997|M.marinum_M SLQFRTIHG----YKRAFRIAGSGP--AILLIHGIGDNSTTWTGIHAKLA
MUL_3358|M.ulcerans_Agy99 SLQFRTIHG----YKRAFRIAGSGP--AILLIHGIGDNSTTWTGIHAKLA
Mb2734|M.bovis_AF2122/97 TLQFRTVHG----YRRAFRIAGSGP--AILLIHGIGDNSTTWNGVHAKLA
Rv2715|M.tuberculosis_H37Rv TLQFRTVHG----YRRAFRIAGSGP--AILLIHGIGDNSTTWNGVHAKLA
MAB_3034|M.abscessus_ATCC_1997 RLAFRTIHG----YRRAYRIAGSGP--VLLLIHGIGDNSATWDSVHAQLA
MSMEG_4867|M.smegmatis_MC2_155 SQGYLDVPVGDRKIRTRYLHAGNPQAPALLFLHGSGGHAEAYVRNLAAHA
TH_4528|M.thermoresistible__bu TQGYLDAGG----VRTRYLHAGEADKPVLIFLHGSGGHAEAYVRNLEAHA
MLBr_00685|M.leprae_Br4923 GTRGTTFRVG---SMRQPIHLGSGE--PVLLLHPFMMSQTVWEIVAPQLA
* ::::* .: *
Mflv_2367|M.gilvum_PYR-GCK --KRYRVIAPDLLG-HGSSAKPRGDYSLGAFAAWLRDLLDELGIRSVTVV
Mvan_4279|M.vanbaalenii_PYR-1 --KRYRVIAPDLLG-HGQSAKPRSDYSLGAFAVGLRDFLDELGISRVTVV
MAV_4567|M.avium_104 --KKFRVIAPDLLG-HGESAKPRTDYSLGAFAVWLRDFLDELGVSRATVV
MMAR_1997|M.marinum_M --QRFTVIAPDLLG-HGRSDKPRADYSIAAYANGMRDLLSVLDIERVTII
MUL_3358|M.ulcerans_Agy99 --QRFTVIAPDLLG-HGRSDKPRADYSIAAYANGMRDLLSVLDIERVTII
Mb2734|M.bovis_AF2122/97 --QRFTVIAPDLLG-HGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIV
Rv2715|M.tuberculosis_H37Rv --QRFTVIAPDLLG-HGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIV
MAB_3034|M.abscessus_ATCC_1997 --EHFTVIAPDLLG-HGQSDKPRADYSVAAYANGMRDLLAVLDIERVTVV
MSMEG_4867|M.smegmatis_MC2_155 --EHFSTWSIDMLG-HGYTDKPGHPLEVAHYVDHVIAFLDTIGAQRAHIS
TH_4528|M.thermoresistible__bu --EHFSTWSIDMLG-HGYTDKPGHPLEVRHYVEHLAAVLDAIGADRAHIS
MLBr_00685|M.leprae_Br4923 NTERYEVFAPTMAAHHGGPSASSWMMSVSTLADHVEQQLDELGWDTAHLV
::: . : : . ** . . .: . : * :. . :
Mflv_2367|M.gilvum_PYR-GCK GQSLGGGVAMQFVYQHPDYCRRLVLISSGGLGQDVGWTLRLLSAPG---S
Mvan_4279|M.vanbaalenii_PYR-1 GQSLGGGVAMQFVYQHPDYCQRLVLISSGGLGQDVGWTLRLLSAPG---A
MAV_4567|M.avium_104 GHSLGGGVAMQFVYQHPDYAQRLILISSGGLGPDVGWVLRLLSAPG---A
MMAR_1997|M.marinum_M GHSLGGGVAMQFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEA
MUL_3358|M.ulcerans_Agy99 GHSLGGGVAMQFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEA
Mb2734|M.bovis_AF2122/97 GHSLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEA
Rv2715|M.tuberculosis_H37Rv GHSLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEA
MAB_3034|M.abscessus_ATCC_1997 GHSLGGGVAMQFTYQFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDA
MSMEG_4867|M.smegmatis_MC2_155 GESLGGWVAARVAVDHPDRVEKLVLNTAGGSQADPEVMKRIITLSMAAAE
TH_4528|M.thermoresistible__bu GESLGGWVASRFAIDRPDRLDRLVLNTAGGSQADPEVMKRIITLSMAAAE
MLBr_00685|M.leprae_Br4923 GNSLGGWVVFELERRGRARSVTGIAPAGGWTRWSLAKFEVIAKFVAGMPL
*.**** *. .. : * . .
Mflv_2367|M.gilvum_PYR-GCK ELLLP-LIAPSPVVRAGDRVRAWFSARNIQS--PRGAEMWSAYASLSDAH
Mvan_4279|M.vanbaalenii_PYR-1 ELLMP-VIAPPPVVRVGNTLRNWFSAVNIQS--PRGAEMWSAYSSLSDAQ
MAV_4567|M.avium_104 ELVLP-VIAPTPVLSVGNKLRSWLRGAGIQS--PRGAELWNAYSSLSDGE
MMAR_1997|M.marinum_M LALLR-LPMVLPTVQLAGKVLGMALGSTALG--QDLPNVLRILDDLPEPT
MUL_3358|M.ulcerans_Agy99 LALLR-LPMVLPTVQLAGKVLGMALGSTALG--QDLPNVLRILDDLPEPT
Mb2734|M.bovis_AF2122/97 MALLR-LPLVLPAVQIAGRIVGKAIGTTSLG--HDLPNVLRILDDLPEPT
Rv2715|M.tuberculosis_H37Rv MALLR-LPLVLPAVQIAGRIVGKAIGTTSLG--HDLPNVLRILDDLPEPT
MAB_3034|M.abscessus_ATCC_1997 LGLLR-LPMAMPMLRLGGAVARATFGRASMA--RDIPDVLRVLADLPEPR
MSMEG_4867|M.smegmatis_MC2_155 NPTWD-TVQARIKWLMADKSKDYDDIVASRQRVYRQPGFVAAMSDIMALQ
TH_4528|M.thermoresistible__bu NPSWD-TVQARITWLMADKSKGYDDIVASRQKIYRQPGFVDAMRNIMALQ
MLBr_00685|M.leprae_Br4923 VAVARGLGSRALSLPFSHRLASLPLTGSPAG--LSEHQLRNIVEDAG--H
. . .
Mflv_2367|M.gilvum_PYR-GCK TRHAFLRTLRSVVDYRGQAVSALNKLHLTTELPLMVIWGDQDRIIP-VDH
Mvan_4279|M.vanbaalenii_PYR-1 TRQAFLRTLRSVVDYRGQAVSALNRLHLTSDLPLLVIWGDEDRIIP-VEH
MAV_4567|M.avium_104 TRQSFLKTLRSVVDYRGQAVSALNRLRLREELPVMAIWGERDGIIP-VDH
MMAR_1997|M.marinum_M ASSAFTRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVP-VRH
MUL_3358|M.ulcerans_Agy99 ASSAFTRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVP-VRH
Mb2734|M.bovis_AF2122/97 ASAAFGRTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLP-VRH
Rv2715|M.tuberculosis_H37Rv ASAAFGRTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLP-VRH
MAB_3034|M.abscessus_ATCC_1997 ASAAFTRTLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIP-VSH
MSMEG_4867|M.smegmatis_MC2_155 DPQIRARNLLGQAEYG------------SITAPTLVVWTSDDPTAD-VAE
TH_4528|M.thermoresistible__bu DPEIRARNLLGPEEYG------------AITAPTLVVWTSDDPTAD-VDE
MLBr_00685|M.leprae_Br4923 CPAYFLLLIKTLLQPG-------LRELADITVPVLLVLCEKDRVLPPPKY
: : * : *
Mflv_2367|M.gilvum_PYR-GCK GFALDQHRPG-CRLEILDGVGHFPHVEKPDAVVDLLDDFIATTHASVRPA
Mvan_4279|M.vanbaalenii_PYR-1 GYALNEARPG-CRLEILAGVGHFPHVEKPTEVVDLLEDFISTTGQSS-AV
MAV_4567|M.avium_104 AYAAHEARTD-ARLEVLPDVGHFAQVEAPMRVVELIEDFIATGERRDATS
MMAR_1997|M.marinum_M AEMAHAAMPG-SKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQ
MUL_3358|M.ulcerans_Agy99 AEMAHAAMPG-SKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQ
Mb2734|M.bovis_AF2122/97 AHMAHAAMPG-SQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQ
Rv2715|M.tuberculosis_H37Rv AHMAHAAMPG-SQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQ
MAB_3034|M.abscessus_ATCC_1997 GHLAHAAMPG-SALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNE
MSMEG_4867|M.smegmatis_MC2_155 GRRIASMIPG-ARFEVMPGCGHWPQYEDPATFNALHLDFLLGR-------
TH_4528|M.thermoresistible__bu GKRIASMIPG-ARFEVMPGCGHWPQYEDPATFNRLHIDFLLGRS------
MLBr_00685|M.leprae_Br4923 SRHFTDHLPERTQVTKFDGMGHVPMFEAPEVITKLITNFINQCSKPAEAA
. . . : ** . : * . : *:
Mflv_2367|M.gilvum_PYR-GCK DVPER---------------------------------
Mvan_4279|M.vanbaalenii_PYR-1 ETPTH---------------------------------
MAV_4567|M.avium_104 PQPG----------------------------------
MMAR_1997|M.marinum_M AALRELLRTGGGERTVSGPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 AALRELLRTGGGERTVSDPADTRVAVLSAMGSDERSAT
Mb2734|M.bovis_AF2122/97 AALRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv AALRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
MAB_3034|M.abscessus_ATCC_1997 DELRRLLRTGVTEHAISGAARTRMAVLDAMGTDERSAT
MSMEG_4867|M.smegmatis_MC2_155 --------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------
MLBr_00685|M.leprae_Br4923 SPAS----------------------------------