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TSDVTLVHDSAYFDDLKMHYVRAGAGEPVVLLHGWPQTWYAWRKVIPLLAGEFEVIVPDLRGCGDTSKPS GGYDKKTVAHDVRRLVETLGHSAVHVVGHDIGAAVAYAYAAQWPSEVQTMTFIESSLSGFGQEELMDVAN GGSWHFGFNMAGDISEDLVRGRERLLIEYWMRRTTVGVVDPTSVEPDALDEYARAMAQPGGLRGSFALYR AIPQDRADNRELGRTKLAMPVLAVEGEHGQAGHSTETMKKVADHVTSAVIARAGHYPAEENPAELAAALR GFLLGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6720 | - | - | 100% (287) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_6719 | - | 7e-51 | 40.22% (271) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_6708 | - | 1e-34 | 33.80% (284) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 4e-14 | 39.45% (109) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1377 | - | 4e-15 | 26.42% (265) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 5e-17 | 26.99% (289) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_02297 | - | 2e-15 | 24.67% (300) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 5e-17 | 37.82% (119) | epoxide hydrolase EphF |
| M. marinum M | MMAR_0342 | ephF | 3e-18 | 25.18% (282) | epoxide hydrolase EphF |
| M. avium 104 | MAV_5163 | - | 6e-18 | 35.71% (140) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_4292 | - | 6e-42 | 37.32% (284) | PUTATIVE putative epoxide hydrolase |
| M. ulcerans Agy99 | MUL_4778 | ephF | 6e-18 | 24.82% (282) | epoxide hydrolase EphF |
| M. vanbaalenii PYR-1 | Mvan_3998 | - | 5e-17 | 34.88% (129) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1973|M.bovis_AF2122/97 --------------------MSQVHRILNCRGTRIHAVADSPPD------
Mvan_3998|M.vanbaalenii_PYR-1 ----------------------MIHRNIDCNGTRIHAVEQGS--------
MSMEG_6720|M.smegmatis_MC2_155 ----------------MTSDVTLVHDSAYFDDLKMHYVRAG---------
TH_4292|M.thermoresistible__bu VVDTGAHAFDSATRDDDEFNRLFRHEFADVDGVRMHYVTGG---------
Rv0134|M.tuberculosis_H37Rv ------------MIALPALEGVEHRHVDVAEGVRIHVADAGP--------
MAV_5163|M.avium_104 ------------MVTMPELDGVEHRYVDLGDDVTIHVADAGP--------
MMAR_0342|M.marinum_M ------------MSTLPALDGVEHRFVDLDGGITIHVADAGP--------
MUL_4778|M.ulcerans_Agy99 ------------MSTLPALDGVEHRFVDLDGGITIHVADAGP--------
MAB_4522c|M.abscessus_ATCC_199 ----------MTQRSMPVLDGVEHQYVQAG-DVKIHVAVAGP--------
Mflv_1377|M.gilvum_PYR-GCK --------MTPPDPSVVRIGGPWRHLDVHANGIRFHVVEAQ-RPSGADDV
MLBr_02297|M.leprae_Br4923 --------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDC
: . :* .
Mb1973|M.bovis_AF2122/97 ----QQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSK
Mvan_3998|M.vanbaalenii_PYR-1 ------GPLVILLHGFPESWYSWRHQIPALANAGYRVVAIDQRGFGRSSK
MSMEG_6720|M.smegmatis_MC2_155 -----AGEPVVLLHGWPQTWYAWRKVIPLLAG-EFEVIVPDLRGCGDTS-
TH_4292|M.thermoresistible__bu -----SGDPLVLLHGWPQTWYAWRGIIPALAQ-KYTVYALDLPGLGDSE-
Rv0134|M.tuberculosis_H37Rv ----ADGPAVMLVHGFPQNWWEWRDLIGPLAADGNRVLCPDLRGAGWSS-
MAV_5163|M.avium_104 ----ASGPAVMLVHGFPQNWWEWRALIGPLAADGYRVLCPDLRGAGWSS-
MMAR_0342|M.marinum_M ----ADGPAVMLVHGFPENWWEWHELIGPLAADGYRVLCPDLRGAGWSS-
MUL_4778|M.ulcerans_Agy99 ----ADGPAVMLVHGFPENWWEWHELIGPLAADGYRVLCPDLRGAGWSS-
MAB_4522c|M.abscessus_ATCC_199 ----QDGRAVVLLHGWPENWWMWHKVIPALAAAGYRVHAMDLRGAGWSE-
Mflv_1377|M.gilvum_PYR-GCK TRPLTDRPLVILLHGFGSFWWSWRHQLTGLSG--ARLVAVDLRGYGGSD-
MLBr_02297|M.leprae_Br4923 APSATARPLVMLLHGFGSFWWSWRHQLRGLTE--ARLVAVDLRGYGGSD-
::*:**: . *: *: : *: : * * * :.
Mb1973|M.bovis_AF2122/97 YRVQKAYRIKELVGDVVG-VLDSYGAEQAFVVGHDWGAPVAWTFAWLHPD
Mvan_3998|M.vanbaalenii_PYR-1 FRVNDAYRIDRVVADVEA-LIDAFGEEQAVVIGHDWGAPVAWTFAWLHPQ
MSMEG_6720|M.smegmatis_MC2_155 -KPSGGYDKKTVAHDVRR-LVETLGHSAVHVVGHDIGAAVAYAYAAQWPS
TH_4292|M.thermoresistible__bu -GAPPSYDKATLARFVHRLLADQLGLRSIRLVAHDLGAGVGFQYAAQYPT
Rv0134|M.tuberculosis_H37Rv -APRSRYTKTEMADDLAA-VLDGLGVAKVKLVAHDWGGPVAFIMMLRHPE
MAV_5163|M.avium_104 -APRSSYRKDEMADDLAG-VLDRLGVRSVDLVAHDWGGPVAFIMMLRHPE
MMAR_0342|M.marinum_M -APRSRYTKKEMADDLAG-VLDRLGIASVRLVAHDWGGPVAFIMMLRYPA
MUL_4778|M.ulcerans_Agy99 -APRSRYTKKEMADDLAG-VLDRLGIASVRLVAHDWGGPVAFIMMLRYPA
MAB_4522c|M.abscessus_ATCC_199 -VAPAGYEKEQFASDVLA-AADALGLESFDLVGHDWGGWTAQLVALKAQS
Mflv_1377|M.gilvum_PYR-GCK -KPPRGYDGWTLAGDTAG-LVRALGHNSATLVGHADGGLVCWATSVLHPR
MLBr_02297|M.leprae_Br4923 -KPPRGYDGWTLAGDTAG-LIRALGHSSATLVGHAEGGLACWATALLHPR
* .. * ::.* *. .
Mb1973|M.bovis_AF2122/97 RCAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFA
Mvan_3998|M.vanbaalenii_PYR-1 RCRGVVGVSVPFAGRGLIGLPGCPFGETRPRDYHIELAGPGRTFYQDYFS
MSMEG_6720|M.smegmatis_MC2_155 EVQTMTFIESSLSGF----------------GQEELMDVANGGSWHFGFN
TH_4292|M.thermoresistible__bu EVSKYAHLDYPLP------------------GPALSAARYREFSWHMAFH
Rv0134|M.tuberculosis_H37Rv KVTGFFGVNTVAPWV----------------KRDLGMLRNMWRFWYQIPM
MAV_5163|M.avium_104 KVTGFFGVNTSAPFV----------------KRSLSTIRNVWRFWYQIPI
MMAR_0342|M.marinum_M KVTGFFGMNTAAPWF----------------PRDLGMVRDIWRFWYQIPI
MUL_4778|M.ulcerans_Agy99 KVTGFFGMNTAAPWF----------------PRDLGMVRDIWRFWYQIPI
MAB_4522c|M.abscessus_ATCC_199 RIRRLVVLNIPPVWQ----------------QPGR-VARYAHKLAYQLVV
Mflv_1377|M.gilvum_PYR-GCK VVKAIAVVSSPHPSALRASALR---------RRDQGRALLPSMMRYQVPM
MLBr_02297|M.leprae_Br4923 LVRAIALINSPHPAALRRSMLT---------HRNQGYALLPTLLRYQLPI
:.
Mb1973|M.bovis_AF2122/97 VQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPID
Mvan_3998|M.vanbaalenii_PYR-1 AQDGILYEIEEDLRKWFLGLTYTVSGD----AVAAAIADG-HVPPADPVE
MSMEG_6720|M.smegmatis_MC2_155 MAGDISEDLVRGRERLLIEYWMRRTTVG----------------------
TH_4292|M.thermoresistible__bu HQPRVPEAVVANDVREYLALFYPYVAYGG---------------------
Rv0134|M.tuberculosis_H37Rv SLPVIGPRVISDPKGRYFRLLTGWVGGG----------------------
MAV_5163|M.avium_104 SLPVIGPRVISTPDSRFVRLLGSWVGGG----------------------
MMAR_0342|M.marinum_M MLPVIGPRVIADPKARYFRVLTSWVGGG----------------------
MUL_4778|M.ulcerans_Agy99 LLPVIGPRVIADPKARYFRVLTSWVGGG----------------------
MAB_4522c|M.abscessus_ATCC_199 GAPVVGPLSHLSPTLWWFIRRS---G------------------------
Mflv_1377|M.gilvum_PYR-GCK WPERALTRHNGAELERLVRSRASEKWQVS---------------------
MLBr_02297|M.leprae_Br4923 WPERLLTRNNAAEIERLVRSRSSAKWQAC---------------------
.
Mb1973|M.bovis_AF2122/97 VIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSG-FGGP
Mvan_3998|M.vanbaalenii_PYR-1 ALRYGPLCMVEGARLDDAFVWPESMPQWFTEDDLDFYVNEFERSG-FAGG
MSMEG_6720|M.smegmatis_MC2_155 ----------------------VVDPTSVEPDALDEYARAMAQPGGLRGS
TH_4292|M.thermoresistible__bu -----------------TSFGGPGAQSPFTDEQVDEFARTYNRPDVLSGG
Rv0134|M.tuberculosis_H37Rv --------------------------FRVPDDDVRLYLDCMREPGHAEAG
MAV_5163|M.avium_104 --------------------------YTLPEEDVRLYLECMRQPGHAEAG
MMAR_0342|M.marinum_M --------------------------FTIADEDVRMYVERMRQPGHAVAG
MUL_4778|M.ulcerans_Agy99 --------------------------FTIADEDVRMYVERMRQPGHAVAG
MAB_4522c|M.abscessus_ATCC_199 ----------------------------MPKESVDFFRSCFRDRDRRVAG
Mflv_1377|M.gilvum_PYR-GCK ---------------------------EDFAETVGHLRRAVQIPSAAHCA
MLBr_02297|M.leprae_Br4923 ---------------------------EDFAVTIDHLRIAIQIPAAAHCA
:
Mb1973|M.bovis_AF2122/97 LSFYHNIDNDWHDLADQQGKPLTPPALFIGGQYD--VGTIWGAQAIERAH
Mvan_3998|M.vanbaalenii_PYR-1 LAFYHNVDAGWEVLDGVENQPLTPPAMFIGGEYD--IATTWGAEAIARAD
MSMEG_6720|M.smegmatis_MC2_155 FALYRAIPQDRADNRELGRT-----KLAMPVLAV--EGEHGQAGHSTETM
TH_4292|M.thermoresistible__bu FDLYRTLDQDEHDNVAAG-------PITTPTLLM--TAEGLLESTRLTVE
Rv0134|M.tuberculosis_H37Rv SRWYRTFQTREMLRWLRGEYNDARVDVPVRWLHG--TGDPVITPDLLDGY
MAV_5163|M.avium_104 SRWYRSFQTREMLSWMRGEYDGARVHVPVRWLSG--TEDPVLTPDLLDGY
MMAR_0342|M.marinum_M SRWYRTFQSSEALPWMRGEYADARVDVPVRWLHG--TEDPVLTPQLLRGY
MUL_4778|M.ulcerans_Agy99 SRWYRTFQSSEALPWMRGEYADARVDVPVRWLHG--TDDPVLTPQLLRGY
MAB_4522c|M.abscessus_ATCC_199 SKIYRSMVGKEFANLARGPYDDQKLTMPVRVLFG--LDDVAVHPSLLDGF
Mflv_1377|M.gilvum_PYR-GCK LEYQRWAVRSQLRAEGRRFMRSMRAPLSVPMLHLRGDADPYVLPDPVYRT
MLBr_02297|M.leprae_Br4923 LEYQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRT
: .
Mb1973|M.bovis_AF2122/97 EVMPNYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP----
Mvan_3998|M.vanbaalenii_PYR-1 EKMSDYRGSHLIAGAGHWIQQERPAETNRLLLEFLGQLQ-----
MSMEG_6720|M.smegmatis_MC2_155 KKVADHVTSAVIARAGHYPAEENPAELAAALRGFLLGG------
TH_4292|M.thermoresistible__bu PRMANITRAVEVPGAGHWLVEENPAFVTNELLTFLAD-------
Rv0134|M.tuberculosis_H37Rv AERASDFEVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD-
MAV_5163|M.avium_104 AERIDDFQLELVDGVGHWIVDQRPDLVLDRVRAFLRRET-----
MMAR_0342|M.marinum_M EDHISDFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET-----
MUL_4778|M.ulcerans_Agy99 EDHISDFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET-----
MAB_4522c|M.abscessus_ATCC_199 KDHADDLNITEVPNCGHFIVDEQPELVVKWLSEVLAEPAP----
Mflv_1377|M.gilvum_PYR-GCK QRYAPHGRYVSIAGAGHFAHEEQPAAVNAQLSRFLSQVYT----
MLBr_02297|M.leprae_Br4923 RRYAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
: **: :: * : .*