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FFGFDELDITVNGVRLRGRVGPACGKPPLLLLHGHPESHLMWHRVAPALAEDFFIVAPDLRGYGNSERPQ ASPDHSTYSKREMARDCVELMAALGHQQFYVAGHDRGARVAARLAADSPECVTRVMLLDIAPTLDMYEGT TRDFASAYWHWFFLIQPAPLPETLIGADPRAYVEGVMGARHAGLAPFPRDVLDHYIAGFAGIERARGACE DYRAAATIDLDHDRRDRDQGRKIAAPLRVLWGKHGVIERLFEPLELWQNIADTVSGRALDCGHYLPEEQP EEIVAEMRAFFGDCA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1984 | - | - | 100% (296) | haloacetate dehalogenase H-1 |
| M. smegmatis MC2 155 | MSMEG_6708 | - | 7e-43 | 37.19% (285) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_6719 | - | 9e-27 | 32.22% (270) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 8e-13 | 33.61% (119) | hydrolase |
| M. gilvum PYR-GCK | Mflv_1960 | - | 1e-15 | 28.52% (284) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3617 | ephA | 6e-16 | 26.10% (318) | epoxide hydrolase EphA |
| M. leprae Br4923 | MLBr_02297 | - | 4e-10 | 26.07% (303) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 2e-19 | 29.70% (266) | epoxide hydrolase EphF |
| M. marinum M | MMAR_5114 | ephA | 2e-16 | 25.47% (318) | epoxide hydrolase EphA |
| M. avium 104 | MAV_0539 | - | 4e-17 | 27.51% (309) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_4292 | - | 1e-18 | 29.15% (295) | PUTATIVE putative epoxide hydrolase |
| M. ulcerans Agy99 | MUL_4193 | ephA | 2e-16 | 25.47% (318) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_4733 | - | 4e-15 | 27.57% (301) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5114|M.marinum_M ------------------MVATSTERLVDTNGVRLRVTEAGE--------
MUL_4193|M.ulcerans_Agy99 ------------------MVATSTERLVDTNGVRLRVTEAGE--------
Rv3617|M.tuberculosis_H37Rv -------------------MGAPTERLVDTNGVRLRVVEAGE--------
MAV_0539|M.avium_104 --------------------------------MRLRVTEAGD--------
Mflv_1960|M.gilvum_PYR-GCK -----------MTVR----------------GVDFHITEAGP--------
MAB_4522c|M.abscessus_ATCC_199 -----------MTQRSMPVLDGVEHQYVQAGDVKIHVAVAGP--------
TH_4292|M.thermoresistible__bu VVDTGAHAFDSATRDDDEFNRLFRHEFADVDGVRMHYVTGG---------
MLBr_02297|M.leprae_Br4923 --------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDC
MSMEG_1984|M.smegmatis_MC2_155 ------------------MFFGFDELDITVNGVRLRGRVGPA--------
Mvan_4733|M.vanbaalenii_PYR-1 -----------------MAETCTHYRTASIDGLDVFYREAGD--------
Mb2734|M.bovis_AF2122/97 ------MTERKRNLRPVRDVAPPTLQFRTVHGYRRAFRIAGS--------
.
MMAR_5114|M.marinum_M ----RGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSR
MUL_4193|M.ulcerans_Agy99 ----RGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSR
Rv3617|M.tuberculosis_H37Rv ----PGAPVVILAHGFPELAYSWRHQIPALADAGYHVLAPDQRGYGGSSR
MAV_0539|M.avium_104 ----RGAPVVILAHGFPELAYSWRHQIDVLADAGYHVLAPDQRGYGGSDR
Mflv_1960|M.gilvum_PYR-GCK ----EDGRPVLALHGWPQHHWAYRDLLGD-PPPGLRIIAPDLPGYGWSGP
MAB_4522c|M.abscessus_ATCC_199 ----QDGRAVVLLHGWPENWWMWHKVIPALAAAGYRVHAMDLRGAGWSEV
TH_4292|M.thermoresistible__bu -----SGDPLVLLHGWPQTWYAWRGIIPALAQK-YTVYALDLPGLGDSEG
MLBr_02297|M.leprae_Br4923 APSATARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDK
MSMEG_1984|M.smegmatis_MC2_155 ----CGKPPLLLLHGHPESHLMWHRVAPALAED-FFIVAPDLRGYGNSER
Mvan_4733|M.vanbaalenii_PYR-1 ----RSNPTLLLLHGFPSSSHMFRNLITALADD-YHLVAPDHIGFGQSSM
Mb2734|M.bovis_AF2122/97 ------GPAILLIHGIGDNSTTWNGVHAKLAQR-FTVIAPDLLGHGQSDK
:: ** . :. . : * * * * *
MMAR_5114|M.marinum_M PEA---IEDYDIHQLTADLVG-LLDDVGAERAAWVGHDWGAVVVWNAPLL
MUL_4193|M.ulcerans_Agy99 PEA---IEDYDIHQLTADLVG-LLDDVGAERAAWVGHDWGAVVVWNAPLL
Rv3617|M.tuberculosis_H37Rv PEA---IEAYDIHRLTADLVG-LLDDVGAERAVWVGHDWGAVVVWNAPLL
MAV_0539|M.avium_104 PDA---VEAYDIHQLTADLVG-LLDDVGAQRAVWVGHDWGAAVVWNAPLL
Mflv_1960|M.gilvum_PYR-GCK P-----PHRWAKEDVVTDLVA-LVDALGLDRFLLVGHDWGGYIGHLLALR
MAB_4522c|M.abscessus_ATCC_199 A-----PAGYEKEQFASDVLA-AADALGLESFDLVGHDWGGWTAQLVALK
TH_4292|M.thermoresistible__bu A-----PPSYDKATLARFVHRLLADQLGLRSIRLVAHDLGAGVGFQYAAQ
MLBr_02297|M.leprae_Br4923 P-----PRGYDGWTLAGDTAG-LIRALGHSSATLVGHAEGGLACWATALL
MSMEG_1984|M.smegmatis_MC2_155 PQASPDHSTYSKREMARDCVE-LMAALGHQQFYVAGHDRGARVAARLAAD
Mvan_4733|M.vanbaalenii_PYR-1 PSVN--QFTYSFDRLTDITEK-LIDRLGLGRFAIYIHDYGAPIGLRIASS
Mb2734|M.bovis_AF2122/97 P-----RADYSVAAYANGMRD-LLSVLDIERVTIVGHSLGGGVAMQFAYQ
. : . :. * *. .
MMAR_5114|M.marinum_M HPDRVAAVAGLSVPVLPRAQVPPIQAFRQRFGEHFFYILYFQQPGVADAE
MUL_4193|M.ulcerans_Agy99 HPDRVAAVAGLSVPVLPRAQVPPIQAFRQRFGEHFFYILYFQQPGVADAE
Rv3617|M.tuberculosis_H37Rv HADRVAAVAALSVPALPRAQVPPTQAFRSRFGENFFYILYFQEPGIADAE
MAV_0539|M.avium_104 HPDRVAAVAAMSVPVTPRPRLAPTQAWRKMFGENFFYILYFQEPGVADAE
Mflv_1960|M.gilvum_PYR-GCK IPERIDAYLALNIAHPWV----PPKVMAPHLWRFLLYQPVVASAGV-PLQ
MAB_4522c|M.abscessus_ATCC_199 AQSRIRRLVVLNIPPVWQ----QPGRVARYAHK-LAYQLVVGAPVVGPLS
TH_4292|M.thermoresistible__bu YPTEVSKYAHLDYPLPGP------ALSAARYREFSWHMAFHHQPRVPEAV
MLBr_02297|M.leprae_Br4923 HPRLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLL
MSMEG_1984|M.smegmatis_MC2_155 SPECVTRVMLLDIAPTLD----MYEGTTRDFASAYWHWFFLIQPAPLPET
Mvan_4733|M.vanbaalenii_PYR-1 RPERITGIITQSGNAYTEG--------FTPFWDRLFAHAKDRGANEDAVR
Mb2734|M.bovis_AF2122/97 FPQLVDRLILVSAGGVTK--------DVNIVFRLASLPMGSEAMALLRLP
: .
MMAR_5114|M.marinum_M LNGDPARTMRRMIGGQRSPTDQGAALRMVAPGPEGFIDRLPEPDTPPSWI
MUL_4193|M.ulcerans_Agy99 LNGDPARTMRRMIGGQRSPTDQGAALRMVAPGPEGFIDRLPEPDAPPSWI
Rv3617|M.tuberculosis_H37Rv LNGDPARTMRRMIGGLRPPGDQSAAMRMLAPGPDGFIDRLPEPAGLPAWI
MAV_0539|M.avium_104 LNADPAQVMRRMMGSLRTDGDKAAGLRMVAPGPEGFLERLPEPDGLPEWI
Mflv_1960|M.gilvum_PYR-GCK TRT---RYLEKVVFRAAAPKLDAATVGTYAERFRDPVVARTARDTYRTFL
MAB_4522c|M.abscessus_ATCC_199 HLS---PTLWWFIRRSGMPK---ESVDFFRSCFRDRDRRVAGSKIYRSMV
TH_4292|M.thermoresistible__bu VANDVREYLALFYPYVAYGGTSFGGPGAQSPFTDEQVDEFARTYNRPDVL
MLBr_02297|M.leprae_Br4923 TRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQ
MSMEG_1984|M.smegmatis_MC2_155 LIGADPRAYVEGVMGARHAGLAPFPRDVLDHYIAGFAGIERARGACEDYR
Mvan_4733|M.vanbaalenii_PYR-1 DYFTPETTKWQYTHGVPADRLDRIAPETWLLDQAGLDRKGNDAIQLQLFW
Mb2734|M.bovis_AF2122/97 LVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRTLR
MMAR_5114|M.marinum_M SRDELDHYISEFTRTGFTGGLNWYRNFDRNWETTADLEGATITVPSLFMA
MUL_4193|M.ulcerans_Agy99 SRDELDHYISEFTRTGFTGGLNWYRNFDRNWETTADLEGATITVPSLFMA
Rv3617|M.tuberculosis_H37Rv SQEELDHYIGEFTRTGFTGGLNWYRNFDRNWETTADLAGKTISVPSLFIA
MAV_0539|M.avium_104 SQDELDHYIAEFSRTGFTGGLNWYRNFDRNWETTPELDGAKIAVPCLFIG
Mflv_1960|M.gilvum_PYR-GCK TREIPKGVR-DGERR-------------------------WSTVPTRVLF
MAB_4522c|M.abscessus_ATCC_199 GKEFANLARGPYDDQ-------------------------KLTMPVRVLF
TH_4292|M.thermoresistible__bu SGGFDLYRTLDQDEHDN---------------------VAAGPITTPTLL
MLBr_02297|M.leprae_Br4923 RWAVRSQLRNEGRKFMKS-------------------MSRPFSVPLLHVR
MSMEG_1984|M.smegmatis_MC2_155 AAATIDLDHDRRDRDQ----------------------GRKIAAPLRVLW
Mvan_4733|M.vanbaalenii_PYR-1 DYQFNLDGYPKFQEYFR-----------------------VHQPPLLVTW
Mb2734|M.bovis_AF2122/97 AVVDWRGQMVTMLDRCY----------------------LTEAIPVQIIW
.
MMAR_5114|M.marinum_M GTKDPVLSFARSDRASEVITGPYREVMVEGAGHWLQQERPDEVNATLLDF
MUL_4193|M.ulcerans_Agy99 GTKDPVLSFARSDRASEVITGPYREVMVEGAGHWLQQERPDEVNATLLDF
Rv3617|M.tuberculosis_H37Rv GTADPVLTFTRTDRAAEVISGPYREVLIDGAGHWLQQERPGEVTAALLEF
MAV_0539|M.avium_104 GTADPVLSFTRADRAAEVISGPYRHVMIDGAGHWLQQERPAEVNAALLDF
Mflv_1960|M.gilvum_PYR-GCK GRSDTAIHPDLAAAETARAD-DYTIDVVDG-GHFILDEQPDLVRAKLIAV
MAB_4522c|M.abscessus_ATCC_199 GLDDVAVHPSLLDGFKDHAD-DLNITEVPNCGHFIVDEQPELVVKWLSEV
TH_4292|M.thermoresistible__bu MTAEGLLESTRLTVEPRMAN-ITRAVEVPGAGHWLVEENPAFVTNELLTF
MLBr_02297|M.leprae_Br4923 GDADPYLLADSVDRTRRYAP-HGRYVSVSDAGHFSHEEAPEEINRYLTRF
MSMEG_1984|M.smegmatis_MC2_155 G-KHGVIERLFEPLELWQNIADTVSGRALDCGHYLPEEQPEEIVAEMRAF
Mvan_4733|M.vanbaalenii_PYR-1 GRNDEIFGAAGAEAFKRDLP--DGEFHLLDTGHFALETHGDEIAGHIRDF
Mb2734|M.bovis_AF2122/97 GTKDVVLPVRHAHMAHAAMP-GSQLEIFEGSGHFPFHDDPARFIDIVERF
. . . **: . . : .
MMAR_5114|M.marinum_M LKGVQW-------------------------------------------
MUL_4193|M.ulcerans_Agy99 LKGVQW-------------------------------------------
Rv3617|M.tuberculosis_H37Rv LTGLELR------------------------------------------
MAV_0539|M.avium_104 LNGLELR------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK ADEFPERPVR---------------------------------------
MAB_4522c|M.abscessus_ATCC_199 LAEPAP-------------------------------------------
TH_4292|M.thermoresistible__bu LAD----------------------------------------------
MLBr_02297|M.leprae_Br4923 LKQVHGPRLS---------------------------------------
MSMEG_1984|M.smegmatis_MC2_155 FGDCA--------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 LGRQEGLIRE---------------------------------------
Mb2734|M.bovis_AF2122/97 MDTTEPAEYDQAALRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT