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VRAVVCSTVGVLPRVTEMPDPSCPSDGVLVQVAATGVCRSDWHAWRGHDPVQLPIIPGHEFAGVIAAVGA DVSGWQVGDRVTTPFVLGCGRCEFCRAGDAQVCPNQEQPGFTLPGSFAQLVAVPRAAANLVRLPDDVSFV AAASLGCRFATAFRALVNHGAVKAGQWVAVHGCGGVGLSAVMIAKAFGAKVVAVDVTADALAAAQRLGAD EIVNSTEIDDVATEIVQRTGGGAHIGVDAVGNPVSAAASVASLRRRGRHVQVGLLLGADAHTAFPMDRVI AQELAIFGSHGMPAVDYPAMLDLLASGALQPERLVTRRISLDDAPDALAGMDSFAGSGMTIIEP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2048 | - | - | 100% (344) | alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1138 | - | 1e-39 | 33.62% (351) | alcohol dehydrogenase 1 |
| M. smegmatis MC2 155 | MSMEG_5287 | - | 7e-37 | 32.33% (331) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 4e-34 | 34.45% (328) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_4951 | - | 1e-40 | 36.02% (347) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 4e-34 | 34.45% (328) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-27 | 30.45% (335) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 2e-31 | 29.74% (343) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0343 | - | 1e-38 | 33.13% (329) | zinc-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_5022 | - | 2e-33 | 31.93% (332) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_2499 | - | 4e-34 | 33.04% (339) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 3e-39 | 32.95% (346) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_0527 | - | 8e-38 | 33.65% (312) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2084|M.abscessus_ATCC_1997 --------------------MKTRAAVLWGLEQKWEVEEVDLDPPGPGEV
TH_2499|M.thermoresistible__bu --------------------MKMNAAVLWDVNGDWSIEEVELDGPQEGEV
Mb0167c|M.bovis_AF2122/97 MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGEV
Rv0162c|M.tuberculosis_H37Rv MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGEV
MAV_5022|M.avium_104 ------------------MLQRIGAPRPYARSRPISITDVELAPPGRDEV
MLBr_01784|M.leprae_Br4923 ------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEA
Mflv_4951|M.gilvum_PYR-GCK ----------------------MQAAVVTAFGEPLVVEERDLPAPGPGEA
MUL_0495|M.ulcerans_Agy99 ------MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPTPGYGEA
MMAR_0343|M.marinum_M ------------------MAATMRAERFYADSKTVVLEDVPIPEPGPGEV
MSMEG_2048|M.smegmatis_MC2_155 ----------------------MRAVVCSTVGVLPRVTEMPDPSCPSDGV
Mvan_0527|M.vanbaalenii_PYR-1 ----------------------MRAAIYHGRED-VRIEELPDPSPRAGEV
: : . .
MAB_2084|M.abscessus_ATCC_1997 LVRLAATGLCHSDEHLVTGDLPIP--LPVVGGHEGAGTVVECGEGVEDLS
TH_2499|M.thermoresistible__bu LVSFTATGMCHSDHHVRTGDFPAP--LPIIGGHEGAGVVQEVGPGVRDLK
Mb0167c|M.bovis_AF2122/97 LVRIEAAGVCHSDLSVVDGTRVRP--VPILLGHEAAGIVEQVGDGVDGVA
Rv0162c|M.tuberculosis_H37Rv LVRIEAAGVCHSDLSVVDGTRVRP--VPILLGHEAAGIVEQVGDGVDGVA
MAV_5022|M.avium_104 LVRIEAAGICHSDLSVVDGNRVRP--VPMLLGHEAAGIVERVGPGVADLA
MLBr_01784|M.leprae_Br4923 VVDVTACGVCHTDLTYREGGINDR--YPFLLGHEAAGTVEVVGPGVTAVE
Mflv_4951|M.gilvum_PYR-GCK LVKLVTSGVCHTDLHAAHGDWPVKPSPPFIPGHEGYGTVVAVGDGVDDLS
MUL_0495|M.ulcerans_Agy99 LVKLETSGVCHTDLHAAHGDWPVKPAPPFVPGHEGCGTVVALGDGVTDLK
MMAR_0343|M.marinum_M LVKVAYCGICHSDLSLINGTFPTQ-APVVTQGHEASGTIAKLGPEVDGWS
MSMEG_2048|M.smegmatis_MC2_155 LVQVAATGVCRSDWHAWRGHDPVQ--LPIIPGHEFAGVIAAVGADVSGWQ
Mvan_0527|M.vanbaalenii_PYR-1 VIEVARAGICGTDLHEYIAG-PMHAAPGVVIGHEYSGTVVGVGSGVREFT
:: . *:* :* . . *** * : * *
MAB_2084|M.abscessus_ATCC_1997 EGDSVILTFLP-SCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHAR-
TH_2499|M.thermoresistible__bu PGDHVVASFLP-ACGRCRWCATGRSNLCDLGAMLLAGTQLDGTYRRHLPD
Mb0167c|M.bovis_AF2122/97 VGQRVVLVFLP-RCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRG
Rv0162c|M.tuberculosis_H37Rv VGQRVVLVFLP-RCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRG
MAV_5022|M.avium_104 VGARVVLVFLP-RCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRA
MLBr_01784|M.leprae_Br4923 PGDFVILNWRA-VCGQCRACKRGRPSYCFDTFNAQQKMTLIDG-------
Mflv_4951|M.gilvum_PYR-GCK VGDMVGNAWLWSSCGRCEYCRTGWETLCEQ--------------------
MUL_0495|M.ulcerans_Agy99 VGDKVGNAWLWSACGSCEQCRTGWETLCEN--------------------
MMAR_0343|M.marinum_M EGDRVVVAAGR-PCQSCPNCRRGDTVNCLR--------------------
MSMEG_2048|M.smegmatis_MC2_155 VGDRVTTPFVL-GCGRCEFCRAGDAQVCPN--------------------
Mvan_0527|M.vanbaalenii_PYR-1 EGDRVCGVGVF-GCGECGFCKQGAEALCGA--------------------
* * * * * *
MAB_2084|M.abscessus_ATCC_1997 GEDVGQMCLLGTFSEYTVVP--QASVVKIDGGIPLDRAALIGCGVTTGYG
TH_2499|M.thermoresistible__bu GRDVGVALLLGTFAQYGVVS--EASLVKIDDDLPLTRACLIGCGVTTGWG
Mb0167c|M.bovis_AF2122/97 GRPVYHHLGVSGFATHVVVN--RASVVPVPHEVPPTVAALLGCAVLTGGG
Rv0162c|M.tuberculosis_H37Rv GRPVYHHLGVSGFATHVVVN--RASVVPVPHEVPPTVAALLGCAVLTGGG
MAV_5022|M.avium_104 GRPVYHHLGVSGFATHAVVN--RASAVEVPPDVPAEVAALLGCAVLTGGG
MLBr_01784|M.leprae_Br4923 -TELTPALGIGAFADKTLVH--SGQCTKVDPAADPAVAGLLGCGVMAGLG
Mflv_4951|M.gilvum_PYR-GCK -QRNGGYSVDGSFGTYMLVD--AAYAARIPDGVDPVEVAPILCAGVTVY-
MUL_0495|M.ulcerans_Agy99 -QRNGGYTVNGSFGTYMLVN--ADYAARIPDGADPLEVAPILCAGVTVY-
MMAR_0343|M.marinum_M -IQLMAFAYDGAWAEYTVAQ--AAGLTRVPDNVSLDQAAILADAVSTPFG
MSMEG_2048|M.smegmatis_MC2_155 -QEQPGFTLPGSFAQLVAVPRAAANLVRLPDDVSFVAAASLGCRFATAFR
Mvan_0527|M.vanbaalenii_PYR-1 -VGFIGFAVNGALARYASLP--TKALFRIPDEISLAEAAVVEP-IASAYH
. . : . : :
MAB_2084|M.abscessus_ATCC_1997 SAVRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQ
TH_2499|M.thermoresistible__bu SAVNTAKVQPGDTVVVIGFGGVGSGAVQGARLAGAEKIVVVDIVEDKRAK
Mb0167c|M.bovis_AF2122/97 AVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSA
Rv0162c|M.tuberculosis_H37Rv AVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSA
MAV_5022|M.avium_104 AVLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAA
MLBr_01784|M.leprae_Br4923 AAINTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEW
Mflv_4951|M.gilvum_PYR-GCK KGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMG-LRVVAIDVDDSKLDL
MUL_0495|M.ulcerans_Agy99 KGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMG-LRVVAIDIDDDKLAL
MMAR_0343|M.marinum_M AVVRTGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDR
MSMEG_2048|M.smegmatis_MC2_155 ALVNHGAVKAGQWVAVHGCGGVGLSAVMIAKAFG-AKVVAVDVTADALAA
Mvan_0527|M.vanbaalenii_PYR-1 AVRRSG-LAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVA
. . * : * * :* : : ::. :
MAB_2084|M.abscessus_ATCC_1997 ASGFGATHTAAS-MDEAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALA
TH_2499|M.thermoresistible__bu ALEFGATHFVTS-MAEATALVGDLTRGVMADSAILTVGLVEGPMIGECID
Mb0167c|M.bovis_AF2122/97 AKALGAH--------EIYTPQQATAGGVKAAVVVEAVGHPA--ALHTAIG
Rv0162c|M.tuberculosis_H37Rv AKALGAH--------EIYTPQQATAGGVKAAVVVEAVGHPA--ALHTAIG
MAV_5022|M.avium_104 ARRLGAH--------QAYTPQQAVEARVKAAVVIEAVGHPA--ALQTAID
MLBr_01784|M.leprae_Br4923 ARTFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFY
Mflv_4951|M.gilvum_PYR-GCK ATGLGAEVVVNARTADVVAEVHRATGGVHGVLVTAVHRDAFG----QAIG
MUL_0495|M.ulcerans_Agy99 AARLGAELVVNARTSDVVAQVQEATGGVHGVLVTAVHPQAFG----QAIG
MMAR_0343|M.marinum_M ALELGADYAFDSRDDQLHDKLAEITGGRMLDVAFDAVGLKAT--FEQALG
MSMEG_2048|M.smegmatis_MC2_155 AQRLGADEIVNSTEIDDVATEIVQRTGGGAHIGVDAVGNPVS--AAASVA
Mvan_0527|M.vanbaalenii_PYR-1 AHRVGATRVIDPLAEDAVEVVRMLTNGNGVDISFDAAGVQPA--LDAALG
* .** : . ..
MAB_2084|M.abscessus_ATCC_1997 LVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIP
TH_2499|M.thermoresistible__bu IIRKGGAVVLTGIAALADVTPTLPMAMFTLFQKRLLGSLYGEANPRADIP
Mb0167c|M.bovis_AF2122/97 LTAPGGRTITVGLPPP-DVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIP
Rv0162c|M.tuberculosis_H37Rv LTAPGGRTITVGLPPP-DVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIP
MAV_5022|M.avium_104 LTAPGGRTITVGLPPP-DARITVSPLGFVAEGRSLIGSYLGSAVPSRDIP
MLBr_01784|M.leprae_Br4923 ARDLAGTVVLVGVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFP
Mflv_4951|M.gilvum_PYR-GCK LARRGGTIVFVGLPPG---DFPAPIFDIVLKGLTIRGSIVG---TRQDMV
MUL_0495|M.ulcerans_Agy99 LARRGGTIVFNGLPPG---DFPAPIFVIVLKGLTIRGSIVG---TRQDMA
MMAR_0343|M.marinum_M SLTAGGRLVGVGMSAE-----SPTVGPTSMFGLTHKQVLGHLGYQNVDIE
MSMEG_2048|M.smegmatis_MC2_155 SLRRRGRHVQVGLLLGADAHTAFPMDRVIAQELAIFG---SHGMPAVDYP
Mvan_0527|M.vanbaalenii_PYR-1 VLRPRGRLMVVAIWEA---PAGIDINRSVMREANIGFSFCY--EAQRQVP
* : .: :
MAB_2084|M.abscessus_ATCC_1997 RLVELYSAGLLKLDELVTREYSLDQIN-EGYQDMR--SGRNIRGLVRF--
TH_2499|M.thermoresistible__bu RLLSLYREGKLLLDETVTHEYKLHDIN-QGYDDML--AGRIIRGVIVHDH
Mb0167c|M.bovis_AF2122/97 RFVSLWQSGRLPVESLVTSTIRLDDIN-EAMDHLA--DGIAVRQLISFTG
Rv0162c|M.tuberculosis_H37Rv RFVSLWQSGRLPVESLVTSTIRLDDIN-EAMDHLA--DGIAVRQLISFTG
MAV_5022|M.avium_104 RFVELWRAGRLPVESLVSSTIRLEDIN-EAMDHLA--DGTAVRQLIRFDA
MLBr_01784|M.leprae_Br4923 TLVDLYLQGRLPLGKFVSERIGLGDVE-EAFHKIH--GGKVLRSVVML--
Mflv_4951|M.gilvum_PYR-GCK EAIDFFARG---LVHPTVHTTRLDDIN-DVFDRME--RGQIDGRVVIDYR
MUL_0495|M.ulcerans_Agy99 EALDFYARG---LIHPTVEGAALEDIN-HVFERME--RGQIDGRVVIDYR
MMAR_0343|M.marinum_M TLAKLVSLGRLDLSRSISEIVPLEDLP-LGIEKLERQDGNPIRILVQP--
MSMEG_2048|M.smegmatis_MC2_155 AMLDLLASGALQPERLVTRRISLDDAP-DALAGMDSFAGSGMTIIEP---
Mvan_0527|M.vanbaalenii_PYR-1 AILDLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA
.: * * : . :
MAB_2084|M.abscessus_ATCC_1997 --
TH_2499|M.thermoresistible__bu S-
Mb0167c|M.bovis_AF2122/97 DL
Rv0162c|M.tuberculosis_H37Rv DL
MAV_5022|M.avium_104 --
MLBr_01784|M.leprae_Br4923 --
Mflv_4951|M.gilvum_PYR-GCK --
MUL_0495|M.ulcerans_Agy99 --
MMAR_0343|M.marinum_M --
MSMEG_2048|M.smegmatis_MC2_155 --
Mvan_0527|M.vanbaalenii_PYR-1 --