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AATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLINGTFPTQAPVVTQGHEASGTIA KLGPEVDGWSEGDRVVVAAGRPCQSCPNCRRGDTVNCLRIQLMAFAYDGAWAEYTVAQAAGLTRVPDNVS LDQAAILADAVSTPFGAVVRTGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALEL GADYAFDSRDDQLHDKLAEITGGRMLDVAFDAVGLKATFEQALGSLTAGGRLVGVGMSAESPTVGPTSMF GLTHKQVLGHLGYQNVDIETLAKLVSLGRLDLSRSISEIVPLEDLPLGIEKLERQDGNPIRILVQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0343 | - | - | 100% (347) | zinc-dependent alcohol dehydrogenase |
| M. marinum M | MMAR_3350 | adhE2 | 1e-38 | 31.62% (351) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_3150 | - | 6e-38 | 31.55% (355) | zinc-containing alcohol dehydrogenase NAD- dependent |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 8e-39 | 31.71% (350) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_0125 | - | 2e-38 | 33.33% (354) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 8e-39 | 31.71% (350) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-37 | 30.29% (350) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 3e-39 | 32.68% (355) | zinc-type alcohol dehydrogenase AdhD |
| M. avium 104 | MAV_5022 | - | 6e-34 | 30.14% (365) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_5287 | - | 1e-167 | 83.57% (347) | dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 9e-41 | 32.51% (363) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4777 | - | 0.0 | 99.14% (347) | zinc-dependent alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | 3e-38 | 34.67% (349) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0343|M.marinum_M MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
MUL_4777|M.ulcerans_Agy99 MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
MSMEG_5287|M.smegmatis_MC2_155 MTATMRAERFYADTKKVVVEDVPVPEPGHGEVLVKVEFCGICHSDLSLIN
Mb2283|M.bovis_AF2122/97 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
Rv2259|M.tuberculosis_H37Rv MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
TH_4627|M.thermoresistible__bu MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
MAV_5022|M.avium_104 MLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVD
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
Mvan_0013|M.vanbaalenii_PYR-1 --MKTKAAVLWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVT
Mflv_0125|M.gilvum_PYR-GCK ----MRAAVYYGPNK-LEVDDVPEPEARPGTVKLKVGFNGICGTDLHEYY
. . : :: . . : : *:* :*
MMAR_0343|M.marinum_M GT-----------FPTQAPVVTQGHEASGTIAKLGPEVDGWSEGDRVVVA
MUL_4777|M.ulcerans_Agy99 GT-----------FPTQAPVVTQGHEASGTIVKLGPEVDGWSEGDRVVVA
MSMEG_5287|M.smegmatis_MC2_155 GT-----------FPAQVPVVTQGHEASGVIAKLGPGVTGWSEGDRVIVA
Mb2283|M.bovis_AF2122/97 GG-----------INDEYPFLLG-HEAAGIIEAVGPGVTAVEPGDFVILN
Rv2259|M.tuberculosis_H37Rv GG-----------INDEYPFLLG-HEAAGIIEAVGPGVTAVEPGDFVILN
MLBr_01784|M.leprae_Br4923 GG-----------INDRYPFLLG-HEAAGTVEVVGPGVTAVEPGDFVILN
TH_4627|M.thermoresistible__bu GG-----------INDEFPFLLG-HEAAGTVESVGSGVTNVEPGDFVVLN
MAV_5022|M.avium_104 GN-----------RVRPVPMLLG-HEAAGIVERVGPGVADLAVGARVVLV
MAB_2084|M.abscessus_ATCC_1997 GD-----------LPIPLPVVGG-HEGAGTVVECGEGVEDLSEGDSVILT
Mvan_0013|M.vanbaalenii_PYR-1 GD-----------MPMNLPVVGG-HEGAGVVVDVGPGVTEVEAGDHVVLS
Mflv_0125|M.gilvum_PYR-GCK AGPIFVPTAPHPLTGAQLPLTMG-HEFSGTITAVGDGVTGWQEGDRVAVE
. *. ** :* : * * * * :
MMAR_0343|M.marinum_M AGRPCQSCPNCRRGDTVNCLR------------------------IQLMA
MUL_4777|M.ulcerans_Agy99 AGRPCQSCPNCRRGDTVNCLR------------------------IQLMA
MSMEG_5287|M.smegmatis_MC2_155 AGRPCMSCPNCLRGDIGNCLR------------------------IQLMA
Mb2283|M.bovis_AF2122/97 WRAVCGQCRACKRGRPRYCFDTFNAEQKMTLT-----------DGTELTA
Rv2259|M.tuberculosis_H37Rv WRAVCGQCRACKRGRPRYCFDTFNAEQKMTLT-----------DGTELTA
MLBr_01784|M.leprae_Br4923 WRAVCGQCRACKRGRPSYCFDTFNAQQKMTLI-----------DGTELTP
TH_4627|M.thermoresistible__bu WRAVCGQCRACKRGRPHLCFDTFNATQKMTLG-----------DGTELTP
MAV_5022|M.avium_104 FLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLS---RAGRPVYH
MAB_2084|M.abscessus_ATCC_1997 FLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFH----ARGEDVGQ
Mvan_0013|M.vanbaalenii_PYR-1 FIPACGRCTECARGRSNLCVYGAAIVAGPQLDGTFRFHGSSGGRAYDIGQ
Mflv_0125|M.gilvum_PYR-GCK PIYKCDQCGPCRAGNYNVCQQ------------------------IGFHG
* * * * .
MMAR_0343|M.marinum_M FAYDGAWAEYTVAQAAGLTRVPDNVSLDQAAILADAVSTPFGAVVRTGKV
MUL_4777|M.ulcerans_Agy99 FAYDGAWAEYTVAQAAGLTRVPDNVSLDQAAILADAVSTPFGAVVRTGKV
MSMEG_5287|M.smegmatis_MC2_155 FAYDGAWAEYTVAQAVGLTRVPDNVPLEQAAILADAVSTPYGAVVRTGKV
Mb2283|M.bovis_AF2122/97 ALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGV
Rv2259|M.tuberculosis_H37Rv ALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGV
MLBr_01784|M.leprae_Br4923 ALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAV
TH_4627|M.thermoresistible__bu ALGIGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAV
MAV_5022|M.avium_104 HLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRP
MAB_2084|M.abscessus_ATCC_1997 MCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEV
Mvan_0013|M.vanbaalenii_PYR-1 MCVLGTFSEYTVVPIASVVKVDNDIPLDKAALVGCGVTTGYGAAVRTGEA
Mflv_0125|M.gilvum_PYR-GCK LMSDGGMAEYTVVPTGMLHRLPDTVSLELGALVEPMSVAYHAATL--GEV
. : ::. .: ..:: : .:.: .
MMAR_0343|M.marinum_M AVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALELGADY
MUL_4777|M.ulcerans_Agy99 AVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALELGADY
MSMEG_5287|M.smegmatis_MC2_155 GIGESVGVWGVGGVGTHIVQLSRLVGAAPVIAVDIKPEVLERALAVGADY
Mb2283|M.bovis_AF2122/97 TRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATH
Rv2259|M.tuberculosis_H37Rv TRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATH
MLBr_01784|M.leprae_Br4923 SRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATH
TH_4627|M.thermoresistible__bu SRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATH
MAV_5022|M.avium_104 APGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQ
MAB_2084|M.abscessus_ATCC_1997 RAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATH
Mvan_0013|M.vanbaalenii_PYR-1 ADGDTVVVMGVGGLGINAIQGAAIAGARNVVALDPVAYKRERSFEFGATH
Mflv_0125|M.gilvum_PYR-GCK SAGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRTAIEALGAR-
.::. * * * :* . :..:: .**
MMAR_0343|M.marinum_M AFDSRDDQLHDKLAEITGGRMLDVAFDAVGLKA--TFEQALGSLTAGGRL
MUL_4777|M.ulcerans_Agy99 AFDSRDDQLHDKLAEITGGRMLDVAFDAVGLKA--TFEQALGSLTAGGRL
MSMEG_5287|M.smegmatis_MC2_155 AFDARDEDLADKIAGVTGGRGLDVAFDAVGLAS--TFEQALDRLTVGGRL
Mb2283|M.bovis_AF2122/97 TVNAREVDVVQAIGGLTDGFGADVVIDAVGRPE--TYQQAFYARDLAGTV
Rv2259|M.tuberculosis_H37Rv TVNAREVDVVQAIGGLTDGFGADVVIDAVGRPE--TYQQAFYARDLAGTV
MLBr_01784|M.leprae_Br4923 TVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTV
TH_4627|M.thermoresistible__bu TIDASSTDVVEAIQELTDGFGADVVVDAVGRPE--TWEQAFYARDLAGTV
MAV_5022|M.avium_104 AYTP--------QQAVEARVKAAVVIEAVGHPA--ALQTAIDLTAPGGRT
MAB_2084|M.abscessus_ATCC_1997 TAAS-MDEAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRV
Mvan_0013|M.vanbaalenii_PYR-1 AAAD-VAEAQALITDLTRGTMADVCVVTTDSAEGAYVAQALSLVGKRGRV
Mflv_0125|M.gilvum_PYR-GCK TLDPTADDVPAFIADHTGGDGADAVFDAAGVTP--AVATALGCVGSRKPM
: . . :.. *:
MMAR_0343|M.marinum_M VGVGMSAESPTVGPTSMFGLT--HKQVLGHLG---YQNVDIETLAKLVSL
MUL_4777|M.ulcerans_Agy99 VGVGTSAESPTVGPTSMFGLT--HKQVLGHLG---YQNVDIETLAKLVSL
MSMEG_5287|M.smegmatis_MC2_155 VAVGMSAESPTVGPTSMFGLT--QKQVLGHLG---YQNVDIATLATLVSL
Mb2283|M.bovis_AF2122/97 VLVGVPTP-DMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQ
Rv2259|M.tuberculosis_H37Rv VLVGVPTP-DMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQ
MLBr_01784|M.leprae_Br4923 VLVGVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQ
TH_4627|M.thermoresistible__bu VLVGVPTP-DMRIDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQ
MAV_5022|M.avium_104 ITVGLPPP-DARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRA
MAB_2084|M.abscessus_ATCC_1997 VVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSA
Mvan_0013|M.vanbaalenii_PYR-1 VMTAIPHPTDTVVDMSLFDLTLYEKQVRGCLFGSSNPRLDIPRLLDLYGS
Mflv_0125|M.gilvum_PYR-GCK ISVAIYEK---PLETPLLNLVMNESRIQGSLC---YTGADFESVIALMAD
: .. . . : : . *: . *
MMAR_0343|M.marinum_M GRLDLSRSISEIVPLEDLPLGIEKLERQDGNPIRILVQP----
MUL_4777|M.ulcerans_Agy99 GRLDLSRSISEIVPLEDLSLGIEKLERQDGNPIRILVQP----
MSMEG_5287|M.smegmatis_MC2_155 GRLDLSRSISEIVSLEDIAAGIDKLERQEGSPIRILVRP----
Mb2283|M.bovis_AF2122/97 GRLPLQRFVSERIGLEDVEEAFHKMH--GGKVLRSVVML----
Rv2259|M.tuberculosis_H37Rv GRLPLQRFVSERIGLEDVEEAFHKMH--GGKVLRSVVML----
MLBr_01784|M.leprae_Br4923 GRLPLGKFVSERIGLGDVEEAFHKIH--GGKVLRSVVML----
TH_4627|M.thermoresistible__bu GRLPLEKFVTERIALDEVEGAFEKMQ--RGEVLRSVVVLK---
MAV_5022|M.avium_104 GRLPVESLVSSTIRLEDINEAMDHLA--DGTAVRQLIRFDA--
MAB_2084|M.abscessus_ATCC_1997 GLLKLDELVTREYSLDQINEGYQDMR--SGRNIRGLVRF----
Mvan_0013|M.vanbaalenii_PYR-1 GRLKLDELITREYTLEEINQGYEDMH--NGRNLRGVIRF----
Mflv_0125|M.gilvum_PYR-GCK GRYDTTGWVTRIPIDDVVDEGFEALH--AGTKMKVLVDPNGAQ
* :: : . . : * :: ::