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PAPDTIRPHSTSIRAAVFDGTISVEPVDLADPRPGEVRVKIAAAGVCHSDLHVTTGAWDVPAPVVLGHEG SGVVTAVGEGVDDLEPGDHVVLSWVPGCGECRYCKAGRPAQCSLVASVVAVKGTLYDGTTRLSNERGTVH HYLGVSSYAEQVVVPRNGAIKVRKDAPLEDIAIVGCAIATGVGAVRNTAGVEPGSTVAVIGCGGVGLACV QGARLAGASRIVAVDVVAEKLELARKLGATDAVDASATDDVVAAMREVLPDGYDYVFDAIGKIATTEQAI AALGLGGAAVIVGLPPQGERASFDPLTLAEADQRILGSNYGSAVPERDIPALVDEVMAGNLDLASMISGR RPLEEAAAALDDLAAGHALRQLLIPSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1138 | - | - | 100% (378) | alcohol dehydrogenase 1 |
| M. smegmatis MC2 155 | MSMEG_4167 | - | 4e-62 | 38.08% (365) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_0127 | - | 5e-62 | 38.92% (352) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 4e-63 | 41.08% (353) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_1486 | - | 3e-60 | 37.57% (362) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 4e-63 | 41.08% (353) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-61 | 39.15% (355) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 2e-82 | 47.61% (355) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 2e-61 | 40.23% (353) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 1e-65 | 42.33% (352) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4627 | - | 4e-69 | 40.81% (370) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 2e-61 | 39.44% (355) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | 3e-62 | 38.87% (355) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
MUL_1292|M.ulcerans_Agy99 -------------------MSQTVRGVISRKKGEPVELVDIVVPDPGPGE
Mvan_3767|M.vanbaalenii_PYR-1 -------------------MTQTVRGVISRTKGQPVEVVEIVIPDPGPGE
TH_4627|M.thermoresistible__bu -------------------MSQSVRGVIARKKDEPVEVVDIVIPDPGPGE
Mflv_1486|M.gilvum_PYR-GCK ---------------------MKTNAAILWEYGGDWTVEEIDLDPPGDGE
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
MAB_0983c|M.abscessus_ATCC_199 -------------MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGE
MSMEG_1138|M.smegmatis_MC2_155 -------------MPAPDTIRPHSTSIRAAVFDGTISVEPVDLADPRPGE
: : : * .*
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREGGINDRYPFLLGHEAAGTVEVVGPGVTAVEP
MUL_1292|M.ulcerans_Agy99 AVVDISACGVCHTDLTYREGGINDEYPFLLGHEAAGTVEAVGPGVTNVEP
Mvan_3767|M.vanbaalenii_PYR-1 VVVDIQACGVCHTDLHYREGGINDEFPFLLGHEAAGTVESVGAGVTNVAP
TH_4627|M.thermoresistible__bu VVVKVTACGVCHTDLHYREGGINDEFPFLLGHEAAGTVESVGSGVTNVEP
Mflv_1486|M.gilvum_PYR-GCK VLVSWQATGLCHSDEHIRTGDLPAPLPLIGGHEGAGIVREVGAGVVGLAP
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAV
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAV
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGDRVDDLAV
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLAV
MAB_0983c|M.abscessus_ATCC_199 VLVRIEAAGLCHSDLSVVDGNRIRPVPMALGHEAAGVIAAVGPGVRDVSP
MSMEG_1138|M.smegmatis_MC2_155 VRVKIAAAGVCHSDLHVTTGAWDVPAPVVLGHEGSGVVTAVGEGVDDLEP
. * * *:**:* * *. ***.:* : ** * :
MLBr_01784|M.leprae_Br4923 GDFVILNWRAVCGQCRACKRGRPSYCF--DTFNAQQKMTLI--------D
MUL_1292|M.ulcerans_Agy99 GDFVILNWRAVCGQCRACKRGRPSYCF--DTFNAEQKMTLT--------D
Mvan_3767|M.vanbaalenii_PYR-1 GDFVVLNWRAVCGQCRACKRGRPHLCF--DTFNAEQKMTLT--------D
TH_4627|M.thermoresistible__bu GDFVVLNWRAVCGQCRACKRGRPHLCF--DTFNATQKMTLG--------D
Mflv_1486|M.gilvum_PYR-GCK GDHVVASFLPACGRCRFCSTGHQNLCD--LGAMIMAGTQLDGTYRRH-IN
Mb0167c|M.bovis_AF2122/97 GQRVVLVFLPRCGQCAACATDGRTPCE-PGSAANKAGTLLGGGIRLS-RG
Rv0162c|M.tuberculosis_H37Rv GQRVVLVFLPRCGQCAACATDGRTPCE-PGSAANKAGTLLGGGIRLS-RG
MMAR_0405|M.marinum_M GQRVVLVFLPRCGHCPSCATEGITPCA-PGSATNAAGTLLGGGIRIS-RS
MAV_5022|M.avium_104 GARVVLVFLPRCGRCAACATEGLTPCE-PGSAANGAGTLLGGDIRLS-RA
MAB_0983c|M.abscessus_ATCC_199 GDHVVLVYVPSCGACRYCSSGRPALCP-DAAAANGRGDLIRGGTRLHDLD
MSMEG_1138|M.smegmatis_MC2_155 GDHVVLSWVPGCGECRYCKAGRPAQCSLVASVVAVKGTLYDGTTRLS-NE
* *: : . ** * * *
MLBr_01784|M.leprae_Br4923 GTELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
MUL_1292|M.ulcerans_Agy99 GTELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
Mvan_3767|M.vanbaalenii_PYR-1 GTELTPALGIGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAA
TH_4627|M.thermoresistible__bu GTELTPALGIGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAA
Mflv_1486|M.gilvum_PYR-GCK GQDVGVMALVGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSA
Mb0167c|M.bovis_AF2122/97 GRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
Rv0162c|M.tuberculosis_H37Rv GRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
MMAR_0405|M.marinum_M GQPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGAV
MAV_5022|M.avium_104 GRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAV
MAB_0983c|M.abscessus_ATCC_199 GTEVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAV
MSMEG_1138|M.smegmatis_MC2_155 RGTVHHYLGVSSYAEQVVVPRNGAIKVRKDAPLEDIAIVGCAIATGVGAV
: :. :: * : :.**.: :* *:.
MLBr_01784|M.leprae_Br4923 INTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWAR
MUL_1292|M.ulcerans_Agy99 VNTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWAR
Mvan_3767|M.vanbaalenii_PYR-1 INTGAVNRDDTVAVIGCGGVGDAAIAGARLVGAKRIIAVDMDNRKLDWAR
TH_4627|M.thermoresistible__bu INTGAVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAR
Mflv_1486|M.gilvum_PYR-GCK VNTADVSPGDTVVIIGLGGIGSGAIQGARLAGAEKIVVVEPVETKRDLAF
Mb0167c|M.bovis_AF2122/97 LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
Rv0162c|M.tuberculosis_H37Rv LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
MMAR_0405|M.marinum_M LNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAAE
MAV_5022|M.avium_104 LNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAAR
MAB_0983c|M.abscessus_ATCC_199 THTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELAL
MSMEG_1138|M.smegmatis_MC2_155 RNTAGVEPGSTVAVIGCGGVGLACVQGARLAGASRIVAVDVVAEKLELAR
:.. ..:*.::* **:* . : * :. :: * *
MLBr_01784|M.leprae_Br4923 TFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYAR
MUL_1292|M.ulcerans_Agy99 AFGATHTVNARELDVVETIQDLTGGFGVDVVIDAVGRPE--TWKQAFYAR
Mvan_3767|M.vanbaalenii_PYR-1 EFGATHTINAGELDAVKTIQDLTDGFGADVVIDAVGRPE--TWKQAFYAR
TH_4627|M.thermoresistible__bu EFGATHTIDASSTDVVEAIQELTDGFGADVVVDAVGRPE--TWEQAFYAR
Mflv_1486|M.gilvum_PYR-GCK RFGATHFVTS-MEEATALVAELTRGVMADSAILTVGLLAGSMLEEAANII
Mb0167c|M.bovis_AF2122/97 ALGAHEIYTP---QQATAGG-----VKAAVVVEAVGHPA--ALHTAIGLT
Rv0162c|M.tuberculosis_H37Rv ALGAHEIYTP---QQATAGG-----VKAAVVVEAVGHPA--ALHTAIGLT
MMAR_0405|M.marinum_M ALGASATYTP---QQAAAAG-----VKADVVIEAAGHPA--ALETAIGLT
MAV_5022|M.avium_104 RLGAHQAYTP---QQAVEAR-----VKAAVVIEAVGHPA--ALQTAIDLT
MAB_0983c|M.abscessus_ATCC_199 ELGATSACAP---DEAPGG--------HDWVFEVVGSAA--VLEQAYALT
MSMEG_1138|M.smegmatis_MC2_155 KLGATDAVDASATDDVVAAMREVLPDGYDYVFDAIGKIA--TTEQAIAAL
:** . : . .. . * . *
MLBr_01784|M.leprae_Br4923 DLAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTL
MUL_1292|M.ulcerans_Agy99 DLAGTVVLVGVP-TPDMRLDMPLVDFFSRGGALKSSWYGDCLPERDFPTL
Mvan_3767|M.vanbaalenii_PYR-1 DLAGTVVLVGVP-TPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTL
TH_4627|M.thermoresistible__bu DLAGTVVLVGVP-TPDMRIDMPLIDFFSRGGSLKSSWYGDCLPERDFPTL
Mflv_1486|M.gilvum_PYR-GCK RKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRL
Mb0167c|M.bovis_AF2122/97 APGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRF
Rv0162c|M.tuberculosis_H37Rv APGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRF
MMAR_0405|M.marinum_M APGGRTITVGLP-PPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRF
MAV_5022|M.avium_104 APGGRTITVGLP-PPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRF
MAB_0983c|M.abscessus_ATCC_199 GRGGGTVSVGLP-HPDARISLPALNIVAEGRSILGSYMGSAQPQQDIPAM
MSMEG_1138|M.smegmatis_MC2_155 GLGGAAVIVGLP-PQGERASFDPLTLAEADQRILGSNYGSAVPERDIPAL
.* .: ..:. . . : : : .* *.. * *:* :
MLBr_01784|M.leprae_Br4923 VDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML----
MUL_1292|M.ulcerans_Agy99 IDLYLQGRLPLDKFVSEQIGLGGIEEAFEKMHAGKVLRSVVVL----
Mvan_3767|M.vanbaalenii_PYR-1 ISLYLQGRFPLDKFVSERIGLDQIEDAFDKMHAGEVLRSVVVL----
TH_4627|M.thermoresistible__bu INLYLQGRLPLEKFVTERIALDEVEGAFEKMQRGEVLRSVVVLK---
Mflv_1486|M.gilvum_PYR-GCK LSLYREGKLLLDETVTHEYKLAEVNEGYEDMREGRNIRGVILHDH--
Mb0167c|M.bovis_AF2122/97 VSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
Rv0162c|M.tuberculosis_H37Rv VSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
MMAR_0405|M.marinum_M VSLWQSGRLPVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF----
MAV_5022|M.avium_104 VELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA--
MAB_0983c|M.abscessus_ATCC_199 LALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA
MSMEG_1138|M.smegmatis_MC2_155 VDEVMAGNLDLASMISGRRPLEEAAAALDDLAAGHALRQLLIPSA--
: *.: : . : * . . : * :* ::