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MTATMRAERFYADTKKVVVEDVPVPEPGHGEVLVKVEFCGICHSDLSLINGTFPAQVPVVTQGHEASGVI AKLGPGVTGWSEGDRVIVAAGRPCMSCPNCLRGDIGNCLRIQLMAFAYDGAWAEYTVAQAVGLTRVPDNV PLEQAAILADAVSTPYGAVVRTGKVGIGESVGVWGVGGVGTHIVQLSRLVGAAPVIAVDIKPEVLERALA VGADYAFDARDEDLADKIAGVTGGRGLDVAFDAVGLASTFEQALDRLTVGGRLVAVGMSAESPTVGPTSM FGLTQKQVLGHLGYQNVDIATLATLVSLGRLDLSRSISEIVSLEDIAAGIDKLERQEGSPIRILVRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5287 | - | - | 100% (347) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1138 | - | 5e-41 | 34.82% (359) | alcohol dehydrogenase 1 |
| M. smegmatis MC2 155 | MSMEG_4340 | - | 1e-38 | 31.83% (355) | NAD/mycothiol-dependent formaldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 1e-41 | 33.62% (351) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_2766 | - | 2e-39 | 32.19% (351) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 1e-41 | 33.62% (351) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-37 | 31.34% (351) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-40 | 33.88% (369) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0343 | - | 1e-167 | 83.57% (347) | zinc-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_5022 | - | 1e-38 | 31.97% (366) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4627 | - | 7e-41 | 33.04% (339) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4777 | - | 1e-166 | 83.00% (347) | zinc-dependent alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | 1e-39 | 33.61% (363) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2766|M.gilvum_PYR-GCK MTQTVRGVIARAKGRPVEVVDVVIPDPGPGEVVVDIQACGVCHTDLTYRD
TH_4627|M.thermoresistible__bu MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
Mb2283|M.bovis_AF2122/97 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
Rv2259|M.tuberculosis_H37Rv MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MAV_5022|M.avium_104 MLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVD
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
Mvan_0013|M.vanbaalenii_PYR-1 --MKTKAAVLWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVT
MMAR_0343|M.marinum_M MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
MUL_4777|M.ulcerans_Agy99 MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
MSMEG_5287|M.smegmatis_MC2_155 MTATMRAERFYADTKKVVVEDVPVPEPGHGEVLVKVEFCGICHSDLSLIN
. . : :: : * *.:* : *:**:*
Mflv_2766|M.gilvum_PYR-GCK GGINDEFPFLLG-HEAAGIVETVGQGVTNVAPGDFVILNWRAVCGQCRAC
TH_4627|M.thermoresistible__bu GGINDEFPFLLG-HEAAGTVESVGSGVTNVEPGDFVVLNWRAVCGQCRAC
Mb2283|M.bovis_AF2122/97 GGINDEYPFLLG-HEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRAC
Rv2259|M.tuberculosis_H37Rv GGINDEYPFLLG-HEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRAC
MLBr_01784|M.leprae_Br4923 GGINDRYPFLLG-HEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC
MAV_5022|M.avium_104 GNRVRPVPMLLG-HEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAAC
MAB_2084|M.abscessus_ATCC_1997 GDLPIPLPVVGG-HEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYC
Mvan_0013|M.vanbaalenii_PYR-1 GDMPMNLPVVGG-HEGAGVVVDVGPGVTEVEAGDHVVLSFIPACGRCTEC
MMAR_0343|M.marinum_M GTFPTQAPVVTQGHEASGTIAKLGPEVDGWSEGDRVVVAAGRPCQSCPNC
MUL_4777|M.ulcerans_Agy99 GTFPTQAPVVTQGHEASGTIVKLGPEVDGWSEGDRVVVAAGRPCQSCPNC
MSMEG_5287|M.smegmatis_MC2_155 GTFPAQVPVVTQGHEASGVIAKLGPGVTGWSEGDRVIVAAGRPCMSCPNC
* *.: **.:* : * * * *:: * * *
Mflv_2766|M.gilvum_PYR-GCK KRGRPHLCFDTHNAAQKMTLT-----------DGTELTPALGIGAFADKT
TH_4627|M.thermoresistible__bu KRGRPHLCFDTFNATQKMTLG-----------DGTELTPALGIGAFAEKT
Mb2283|M.bovis_AF2122/97 KRGRPRYCFDTFNAEQKMTLT-----------DGTELTAALGIGAFADKT
Rv2259|M.tuberculosis_H37Rv KRGRPRYCFDTFNAEQKMTLT-----------DGTELTAALGIGAFADKT
MLBr_01784|M.leprae_Br4923 KRGRPSYCFDTFNAQQKMTLI-----------DGTELTPALGIGAFADKT
MAV_5022|M.avium_104 ATEGLTPCEPGSAANGAGTLLGGDIRLS---RAGRPVYHHLGVSGFATHA
MAB_2084|M.abscessus_ATCC_1997 ARGMGNLCELGAALMMGPQIDGTYRFH----ARGEDVGQMCLLGTFSEYT
Mvan_0013|M.vanbaalenii_PYR-1 ARGRSNLCVYGAAIVAGPQLDGTFRFHGSSGGRAYDIGQMCVLGTFSEYT
MMAR_0343|M.marinum_M RRGDTVNCLR------------------------IQLMAFAYDGAWAEYT
MUL_4777|M.ulcerans_Agy99 RRGDTVNCLR------------------------IQLMAFAYDGAWAEYT
MSMEG_5287|M.smegmatis_MC2_155 LRGDIGNCLR------------------------IQLMAFAYDGAWAEYT
* : . :: :
Mflv_2766|M.gilvum_PYR-GCK LVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGGITRDDTVAVIGC
TH_4627|M.thermoresistible__bu LVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSRDDTVAVIGC
Mb2283|M.bovis_AF2122/97 LVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGC
Rv2259|M.tuberculosis_H37Rv LVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGC
MLBr_01784|M.leprae_Br4923 LVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGC
MAV_5022|M.avium_104 VVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGL
MAB_2084|M.abscessus_ATCC_1997 VVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGA
Mvan_0013|M.vanbaalenii_PYR-1 VVPIASVVKVDNDIPLDKAALVGCGVTTGYGAAVRTGEAADGDTVVVMGV
MMAR_0343|M.marinum_M VAQAAGLTRVPDNVSLDQAAILADAVSTPFGAVVRTGKVAVGESVGVWGV
MUL_4777|M.ulcerans_Agy99 VAQAAGLTRVPDNVSLDQAAILADAVSTPFGAVVRTGKVAVGESVGVWGV
MSMEG_5287|M.smegmatis_MC2_155 VAQAVGLTRVPDNVPLEQAAILADAVSTPYGAVVRTGKVGIGESVGVWGV
:. ..: *.::. .* : *:.:... .::* * *
Mflv_2766|M.gilvum_PYR-GCK GGVGDAAIAGAALVGAKTIIAVDTDNRKLDWARQFGATHTINAKDLDPVK
TH_4627|M.thermoresistible__bu GGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATHTIDASSTDVVE
Mb2283|M.bovis_AF2122/97 GGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVDVVQ
Rv2259|M.tuberculosis_H37Rv GGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVDVVQ
MLBr_01784|M.leprae_Br4923 GGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVK
MAV_5022|M.avium_104 GGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTP-------
MAB_2084|M.abscessus_ATCC_1997 GGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAAS-MDEAWS
Mvan_0013|M.vanbaalenii_PYR-1 GGLGINAIQGAAIAGARNVVALDPVAYKRERSFEFGATHAAAD-VAEAQA
MMAR_0343|M.marinum_M GGVGTHIVQLARLVGAVPVIALDINPVVLDRALELGADYAFDSRDDQLHD
MUL_4777|M.ulcerans_Agy99 GGVGTHIVQLARLVGAVPVIALDINPVVLDRALELGADYAFDSRDDQLHD
MSMEG_5287|M.smegmatis_MC2_155 GGVGTHIVQLSRLVGAAPVIAVDIKPEVLERALAVGADYAFDARDEDLAD
**:* : : .. ::*:* : .** :
Mflv_2766|M.gilvum_PYR-GCK TIQDLTDGFGTDVVIDAVGRPE--TWKQAFYARDLAGTVVLVGVPTP-DM
TH_4627|M.thermoresistible__bu AIQELTDGFGADVVVDAVGRPE--TWEQAFYARDLAGTVVLVGVPTP-DM
Mb2283|M.bovis_AF2122/97 AIGGLTDGFGADVVIDAVGRPE--TYQQAFYARDLAGTVVLVGVPTP-DM
Rv2259|M.tuberculosis_H37Rv AIGGLTDGFGADVVIDAVGRPE--TYQQAFYARDLAGTVVLVGVPTP-DM
MLBr_01784|M.leprae_Br4923 TIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVGVPTP-DM
MAV_5022|M.avium_104 -QQAVEARVKAAVVIEAVGHPA--ALQTAIDLTAPGGRTITVGLPPP-DA
MAB_2084|M.abscessus_ATCC_1997 LVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDES
Mvan_0013|M.vanbaalenii_PYR-1 LITDLTRGTMADVCVVTTDSAEGAYVAQALSLVGKRGRVVMTAIPHPTDT
MMAR_0343|M.marinum_M KLAEITGGRMLDVAFDAVGLKA--TFEQALGSLTAGGRLVGVGMSAESPT
MUL_4777|M.ulcerans_Agy99 KLAEITGGRMLDVAFDAVGLKA--TFEQALGSLTAGGRLVGVGTSAESPT
MSMEG_5287|M.smegmatis_MC2_155 KIAGVTGGRGLDVAFDAVGLAS--TFEQALDRLTVGGRLVAVGMSAESPT
: * . :.. *: * : ..
Mflv_2766|M.gilvum_PYR-GCK TLDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSE
TH_4627|M.thermoresistible__bu RIDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQGRLPLEKFVTE
Mb2283|M.bovis_AF2122/97 RLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSE
Rv2259|M.tuberculosis_H37Rv RLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSE
MLBr_01784|M.leprae_Br4923 RLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSE
MAV_5022|M.avium_104 RITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSS
MAB_2084|M.abscessus_ATCC_1997 SISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTR
Mvan_0013|M.vanbaalenii_PYR-1 VVDMSLFDLTLYEKQVRGCLFGSSNPRLDIPRLLDLYGSGRLKLDELITR
MMAR_0343|M.marinum_M VGPTSMFGLT--HKQVLGHLG---YQNVDIETLAKLVSLGRLDLSRSISE
MUL_4777|M.ulcerans_Agy99 VGPTSMFGLT--HKQVLGHLG---YQNVDIETLAKLVSLGRLDLSRSISE
MSMEG_5287|M.smegmatis_MC2_155 VGPTSMFGLT--QKQVLGHLG---YQNVDIATLATLVSLGRLDLSRSISE
. . : : . *: : * * : : ::
Mflv_2766|M.gilvum_PYR-GCK RITLDQIEDAFHKMHAGSDDVVLRSVVVL--
TH_4627|M.thermoresistible__bu RIALDEVEGAFEKMQRGE---VLRSVVVLK-
Mb2283|M.bovis_AF2122/97 RIGLEDVEEAFHKMHGGK---VLRSVVML--
Rv2259|M.tuberculosis_H37Rv RIGLEDVEEAFHKMHGGK---VLRSVVML--
MLBr_01784|M.leprae_Br4923 RIGLGDVEEAFHKIHGGK---VLRSVVML--
MAV_5022|M.avium_104 TIRLEDINEAMDHLADGT---AVRQLIRFDA
MAB_2084|M.abscessus_ATCC_1997 EYSLDQINEGYQDMRSGR---NIRGLVRF--
Mvan_0013|M.vanbaalenii_PYR-1 EYTLEEINQGYEDMHNGR---NLRGVIRF--
MMAR_0343|M.marinum_M IVPLEDLPLGIEKLERQDGN-PIRILVQP--
MUL_4777|M.ulcerans_Agy99 IVPLEDLSLGIEKLERQDGN-PIRILVQP--
MSMEG_5287|M.smegmatis_MC2_155 IVSLEDIAAGIDKLERQEGS-PIRILVRP--
* :: . ..: :* ::