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MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIPLPVVGGHEGAGTVVEC GEGVEDLSEGDSVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQMCLLGTFS EYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGAL AIVAVDPVNFKREQASGFGATHTAASMDEAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGR VVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTREYSLDQIN EGYQDMRSGRNIRGLVRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2084 | - | - | 100% (368) | zinc-type alcohol dehydrogenase AdhD |
| M. abscessus ATCC 19977 | MAB_4560 | - | 3e-97 | 47.97% (369) | alcohol dehydrogenase B |
| M. abscessus ATCC 19977 | MAB_0983c | - | 5e-62 | 38.72% (359) | zinc-containing alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 1e-109 | 50.55% (366) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_4588 | - | 0.0 | 85.60% (368) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 1e-109 | 50.55% (366) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 8e-48 | 34.28% (353) | putative alcohol dehydrogenase (Zn dependent) |
| M. marinum M | MMAR_3150 | - | 0.0 | 86.96% (368) | zinc-containing alcohol dehydrogenase NAD- dependent |
| M. avium 104 | MAV_0705 | - | 1e-105 | 49.19% (370) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 1e-105 | 49.73% (370) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_2499 | - | 1e-114 | 55.59% (367) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0470 | adhB | 1e-106 | 50.27% (370) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | 1e-149 | 66.13% (372) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3113|M.bovis_AF2122/97 --MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTD
Rv3086|M.tuberculosis_H37Rv --MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTD
Mflv_4588|M.gilvum_PYR-GCK --MKTRAAVLWGLGEKWEVDEIELDPPGVDEVLVQLTASGLCHSDEHLVT
MMAR_3150|M.marinum_M --MKTRAAVLWGLGEKWEVEDIELDPPGPDEVLVQLTATGLCHSDEHLVT
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
Mvan_0013|M.vanbaalenii_PYR-1 --MKTKAAVLWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVT
MAV_0705|M.avium_104 --MKTKGALIWEFNQPWSIEEIEIGDPQAHEVKIQMEAAGMCHSDHHLVT
MUL_0470|M.ulcerans_Agy99 --MKTKGALIWEFNQPWSVEDIEIGDPVKDEVKIQMEAAGMCRSDNHLVT
MSMEG_5866|M.smegmatis_MC2_155 --MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCHSDHHLVT
TH_2499|M.thermoresistible__bu --MKMNAAVLWDVNGDWSIEEVELDGPQEGEVLVSFTATGMCHSDHHVRT
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
. ..: .: :: : * *. : * *:*::*
Mb3113|M.bovis_AF2122/97 GDLPPR-FPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYC
Rv3086|M.tuberculosis_H37Rv GDLPPR-FPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYC
Mflv_4588|M.gilvum_PYR-GCK GDLPFP-LPVVGGHEGAGTVVEVGAGVEDLAVGDSVILTFLPSCGHCSYC
MMAR_3150|M.marinum_M GDLPIP-LPVVGGHEGAGTVVEVGAGVENVAEGDSVILTFLPSCGHCSYC
MAB_2084|M.abscessus_ATCC_1997 GDLPIP-LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYC
Mvan_0013|M.vanbaalenii_PYR-1 GDMPMN-LPVVGGHEGAGVVVDVGPGVTEVEAGDHVVLSFIPACGRCTEC
MAV_0705|M.avium_104 GGIPMAGFPVLGGHEGAGIVTEVGPGVEDIAPGDHVVLSFIPSCGSCPTC
MUL_0470|M.ulcerans_Agy99 GGIPMAGFPVLGGHEGAGVVTEVGPGVDDIAPGDHVVLSFIPSCGRCPTC
MSMEG_5866|M.smegmatis_MC2_155 GGIPMGGFPVLGGHEGAGIVTEVGPGVEGIEPGDHVVLSFIPSCGSCPSC
TH_2499|M.thermoresistible__bu GDFPAP-LPIIGGHEGAGVVQEVGPGVRDLKPGDHVVASFLPACGRCRWC
MLBr_01784|M.leprae_Br4923 GGINDR-YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC
*.: *.: ***.:* : * ** : ** *: .: . ** * *
Mb3113|M.bovis_AF2122/97 CTGRQNLCDMGATILEGCMP-DGSFRFH----SQGTDFGAMCMLGTFAER
Rv3086|M.tuberculosis_H37Rv CTGRQNLCDMGATILEGCMP-DGSFRFH----SQGTDFGAMCMLGTFAER
Mflv_4588|M.gilvum_PYR-GCK ARGMGNLCDMGAAIMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFSEY
MMAR_3150|M.marinum_M ARGMGNMCDLGAALMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFSEY
MAB_2084|M.abscessus_ATCC_1997 ARGMGNLCELGAALMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFSEY
Mvan_0013|M.vanbaalenii_PYR-1 ARGRSNLCVYGAAIVAGPQL-DGTFRFHGSSGGRAYDIGQMCVLGTFSEY
MAV_0705|M.avium_104 QAGMRNLCDLGAGLLGGEAVSDGTFRIQ----ARGQNVYPMTLLGTFSPY
MUL_0470|M.ulcerans_Agy99 QAGLRNLCDLGAGLLAGAAVSDGTFRIQ----ARGQNVYPMTLLGTFSPY
MSMEG_5866|M.smegmatis_MC2_155 QAGLRNLCDLGAGLLGGVAVADGTHRIH----ANGKPVFPMTLLGTFSPY
TH_2499|M.thermoresistible__bu ATGRSNLCDLGAMLLAGTQL-DGTYRRH---LPDGRDVGVALLLGTFAQY
MLBr_01784|M.leprae_Br4923 KRGRPSYCFDTFNAQQKMTLIDGTELTP------------ALGIGAFADK
* . * **: :*:*:
Mb3113|M.bovis_AF2122/97 ATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYG
Rv3086|M.tuberculosis_H37Rv ATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYG
Mflv_4588|M.gilvum_PYR-GCK TVVPKASLVKVDHGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVVVIG
MMAR_3150|M.marinum_M TVVPKASLVKIDQGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVAVIG
MAB_2084|M.abscessus_ATCC_1997 TVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVVVG
Mvan_0013|M.vanbaalenii_PYR-1 TVVPIASVVKVDNDIPLDKAALVGCGVTTGYGAAVRTGEAADGDTVVVMG
MAV_0705|M.avium_104 MVVHRSSVVKIDPSIPFEVAALVGCGVTTGYGSAVRTADIRPGQDVAIVG
MUL_0470|M.ulcerans_Agy99 MVVHRSSVVKIDPAIPFEVAALVGCGVTTGYGSAVRTADVRPGDDVAIVG
MSMEG_5866|M.smegmatis_MC2_155 MVVHKSSVVKIDKSIPFEVACLVGCGVTTGYGSAVRSGDIRPGDDVAIFG
TH_2499|M.thermoresistible__bu GVVSEASLVKIDDDLPLTRACLIGCGVTTGWGSAVNTAKVQPGDTVVVIG
MLBr_01784|M.leprae_Br4923 TLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIG
* . .*:* * *:**** :* *:*:.:. .: ..: *
Mb3113|M.bovis_AF2122/97 VGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASAAA
Rv3086|M.tuberculosis_H37Rv VGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASAAA
Mflv_4588|M.gilvum_PYR-GCK AGGIGMNAIQGARIAGALTIVAVDPVEFKREQAGGFGATHAVATIDEAWS
MMAR_3150|M.marinum_M AGGIGMNAIQGARIAGALNIVAVDPVAFKREQAGGFGATHAVATIDEAWS
MAB_2084|M.abscessus_ATCC_1997 AGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEAWS
Mvan_0013|M.vanbaalenii_PYR-1 VGGLGINAIQGAAIAGARNVVALDPVAYKRERSFEFGATHAAADVAEAQA
MAV_0705|M.avium_104 VGGVGMAALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDIMAAMA
MUL_0470|M.ulcerans_Agy99 LGGVGMAALQGAVTAGARYIFAVEPVEWKRDQALKFGATHVYPDMEAALM
MSMEG_5866|M.smegmatis_MC2_155 IGGVGMGALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDVFSAMA
TH_2499|M.thermoresistible__bu FGGVGSGAVQGARLAGAEKIVVVDIVEDKRAKALEFGATHFVTSMAEATA
MLBr_01784|M.leprae_Br4923 CGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVV
**:* *:.** .*. :..:: * : *****
Mb3113|M.bovis_AF2122/97 K-VDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAK
Rv3086|M.tuberculosis_H37Rv K-VDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAK
Mflv_4588|M.gilvum_PYR-GCK L-ISDITRGKLADVCVLTTDVAEGAYTAEALSLVGKRGRVVITAIGHPED
MMAR_3150|M.marinum_M L-ISDITRGKLADVCVLTTDVAEGSYIGEALSLVGKRGRVVVTAIGHPED
MAB_2084|M.abscessus_ATCC_1997 L-VSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDE
Mvan_0013|M.vanbaalenii_PYR-1 L-ITDLTRGTMADVCVVTTDSAEGAYVAQALSLVGKRGRVVMTAIPHPTD
MAV_0705|M.avium_104 G-MAEVTYGLMAHKVVVTVGELQGADVDNYLNITQKGGTCVLTAIGSLLD
MUL_0470|M.ulcerans_Agy99 G-IAEVTYGLMAKKVMITVGELQGSDIDTYLAITSKGGTCVVTAIGSLLD
MSMEG_5866|M.smegmatis_MC2_155 G-IAEVTAGGMAKKVIVTVGELHGEDIDNYLNVTSKGGTCVVTAVGSMLD
TH_2499|M.thermoresistible__bu L-VGDLTRGVMADSAILTVGLVEGPMIGECIDIIRKGGAVVLTGIAALAD
MLBr_01784|M.leprae_Br4923 KTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVGVPTP-D
: ::* * .. : .. . * *:..: .
Mb3113|M.bovis_AF2122/97 LTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVT
Rv3086|M.tuberculosis_H37Rv LTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVT
Mflv_4588|M.gilvum_PYR-GCK TSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRLVELYNSGQLKLDELIT
MMAR_3150|M.marinum_M TSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRLVELYNAGHLKLDELIT
MAB_2084|M.abscessus_ATCC_1997 SSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVT
Mvan_0013|M.vanbaalenii_PYR-1 TVVDMSLFDLTLYEKQVRGCLFGSSNPRLDIPRLLDLYGSGRLKLDELIT
MAV_0705|M.avium_104 TNVTLNLAMLTLMQKNLQGTIFGGGNPQYDIPQLLSMYKAGKLNLDDMIT
MUL_0470|M.ulcerans_Agy99 TQVNLNLAMLTLMQKNLQGTIFGGGNPQYDIPHLLSMYKARNLNIDDMIT
MSMEG_5866|M.smegmatis_MC2_155 TNANINLAMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGKLNLDDMVT
TH_2499|M.thermoresistible__bu VTPTLPMAMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVT
MLBr_01784|M.leprae_Br4923 MRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVS
: : . :* . *: *: :* * :.. ::
Mb3113|M.bovis_AF2122/97 TTYNLEQVNQGYQDLRDGKNIRGVIVH-----
Rv3086|M.tuberculosis_H37Rv TTYNLEQVNQGYQDLRDGKNIRGVIVH-----
Mflv_4588|M.gilvum_PYR-GCK REYTLDEINEGYDDMRSGRNIRGLIRF-----
MMAR_3150|M.marinum_M REYTLDQINEGYADMRSGRNIRGLIRF-----
MAB_2084|M.abscessus_ATCC_1997 REYSLDQINEGYQDMRSGRNIRGLVRF-----
Mvan_0013|M.vanbaalenii_PYR-1 REYTLEEINQGYEDMHNGRNLRGVIRF-----
MAV_0705|M.avium_104 RQYRLEQINDGYQDMLDGKNIRGVIRYTDADR
MUL_0470|M.ulcerans_Agy99 RQYRLEQINEGYQDMIDGKNIRGVIRFTDADR
MSMEG_5866|M.smegmatis_MC2_155 RQYRLEQINDGYQDMLEGRNIRGVIRYTDADR
TH_2499|M.thermoresistible__bu HEYKLHDINQGYDDMLAGRIIRGVIVHDHS--
MLBr_01784|M.leprae_Br4923 ERIGLGDVEEAFHKIHGGKVLRSVVML-----
* ::::.: .: *: :*.::